ZA200407944B - Heteroaryl compounds which inhibit leukocyte adhesion mediated by Alpha-4 integrins - Google Patents
Heteroaryl compounds which inhibit leukocyte adhesion mediated by Alpha-4 integrins Download PDFInfo
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- ZA200407944B ZA200407944B ZA200407944A ZA200407944A ZA200407944B ZA 200407944 B ZA200407944 B ZA 200407944B ZA 200407944 A ZA200407944 A ZA 200407944A ZA 200407944 A ZA200407944 A ZA 200407944A ZA 200407944 B ZA200407944 B ZA 200407944B
- Authority
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- South Africa
- Prior art keywords
- diethylamino
- ylamino
- pyrimidin
- dimethylcarbamoyloxyphenyl
- propionic acid
- Prior art date
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- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
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- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38324402P | 2002-05-24 | 2002-05-24 |
Publications (1)
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| ZA200407944B true ZA200407944B (en) | 2006-07-26 |
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| ZA200407944A ZA200407944B (en) | 2002-05-24 | 2004-10-01 | Heteroaryl compounds which inhibit leukocyte adhesion mediated by Alpha-4 integrins |
Country Status (17)
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| JP (1) | JP4413135B2 (enExample) |
| CN (1) | CN1311829C (enExample) |
| AT (1) | ATE464298T1 (enExample) |
| AU (1) | AU2003237302B8 (enExample) |
| BR (1) | BR0309619A (enExample) |
| CA (1) | CA2480756A1 (enExample) |
| DE (1) | DE60332109D1 (enExample) |
| EA (1) | EA008180B1 (enExample) |
| IL (1) | IL164323A (enExample) |
| MX (1) | MXPA04011657A (enExample) |
| NO (1) | NO20045276L (enExample) |
| NZ (1) | NZ535723A (enExample) |
| TW (1) | TW200307671A (enExample) |
| WO (1) | WO2003099231A2 (enExample) |
| ZA (1) | ZA200407944B (enExample) |
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| BR0007663A (pt) * | 1999-01-22 | 2002-05-07 | Elan Pharm Inc | Derivados de acila para uso no tratamento de doenças relacionadas com o vla-4 |
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| AU2005222074B2 (en) * | 2004-03-10 | 2011-02-17 | Merck Sharp & Dohme Corp. | VLA-4 antagonists |
| AR050425A1 (es) * | 2004-07-08 | 2006-10-25 | Elan Pharm Inc | Antagonistas multivalentes de vla-4 que comprende fracciones polimericas. composiciones farmaceuticas |
| CN101006097B (zh) * | 2004-08-16 | 2012-07-11 | 默沙东公司 | Vla-4拮抗剂 |
| US7727996B2 (en) | 2005-09-29 | 2010-06-01 | Elan Pharmaceuticals, Inc. | Carbamate compounds which inhibit leukocyte adhesion mediated by VLA-4 |
| CA2624450C (en) * | 2005-09-29 | 2014-02-04 | Elan Pharmaceuticals, Inc. | Pyrimidinyl amide compounds which inhibit leukocyte adhesion mediated by vla-4 |
| MY151045A (en) | 2006-02-27 | 2014-03-31 | Elan Pharm Inc | Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by vla-4 |
| WO2007100770A2 (en) * | 2006-02-28 | 2007-09-07 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with natalizumab |
| US8410115B2 (en) * | 2006-02-28 | 2013-04-02 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds |
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| CA2708262A1 (en) * | 2007-12-07 | 2009-06-18 | Elan Pharmaceuticals, Inc. | Methods and compositions for treating liquid tumors |
| CN102459179A (zh) * | 2009-04-27 | 2012-05-16 | 艾伦药物公司 | α-4整联蛋白的吡啶酮拮抗剂 |
| RS63744B1 (sr) | 2010-01-11 | 2022-12-30 | Biogen Ma Inc | Test za antitela protiv jc virusa |
| US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
| US8343706B2 (en) * | 2010-01-25 | 2013-01-01 | International Business Machines Corporation | Fluorine-free fused ring heteroaromatic photoacid generators and resist compositions containing the same |
| ES2729945T3 (es) | 2011-05-31 | 2019-11-07 | Biogen Ma Inc | Procedimiento para valorar el riesgo de LMP |
| HK1216546A1 (zh) | 2013-05-28 | 2016-11-18 | Biogen Ma Inc. | 评估pml风险的方法 |
| WO2019246455A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
| DK3873884T3 (da) | 2018-10-30 | 2025-02-17 | Gilead Sciences Inc | 3-(quinolin-8-yl)-1,4-dihydropyrido[3,4-d]pyrimidin-2,4-dion-derivater som alpha4beta7-integrinhæmmere til behandling af inflammatoriske sygdomme |
| PL3873605T3 (pl) | 2018-10-30 | 2025-03-03 | Gilead Sciences, Inc. | Związki hamujące integrynę alfa4beta7 |
| WO2020092394A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
| EP3873897B1 (en) | 2018-10-30 | 2024-08-14 | Gilead Sciences, Inc. | N-benzoyl-phenylalanine derivatives as alpha4beta7 integrin inhibitors for treating inflammatory diseases |
| CN111197057B (zh) * | 2018-11-19 | 2024-04-19 | 中国科学院分子细胞科学卓越创新中心 | 调控免疫细胞迁移的组合物和方法 |
| US11578069B2 (en) | 2019-08-14 | 2023-02-14 | Gilead Sciences, Inc. | Compounds for inhibition of α4 β7 integrin |
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-
2003
- 2003-05-26 TW TW092114184A patent/TW200307671A/zh unknown
- 2003-05-27 DE DE60332109T patent/DE60332109D1/de not_active Expired - Lifetime
- 2003-05-27 WO PCT/US2003/017150 patent/WO2003099231A2/en not_active Ceased
- 2003-05-27 US US10/447,208 patent/US7008949B2/en not_active Expired - Fee Related
- 2003-05-27 BR BR0309619-0A patent/BR0309619A/pt not_active IP Right Cessation
- 2003-05-27 MX MXPA04011657A patent/MXPA04011657A/es active IP Right Grant
- 2003-05-27 CN CNB038112582A patent/CN1311829C/zh not_active Expired - Fee Related
- 2003-05-27 EP EP03736768A patent/EP1507533B1/en not_active Expired - Lifetime
- 2003-05-27 CA CA002480756A patent/CA2480756A1/en not_active Abandoned
- 2003-05-27 EA EA200401561A patent/EA008180B1/ru not_active IP Right Cessation
- 2003-05-27 AT AT03736768T patent/ATE464298T1/de not_active IP Right Cessation
- 2003-05-27 NZ NZ535723A patent/NZ535723A/en unknown
- 2003-05-27 US US10/494,788 patent/US7335663B2/en not_active Expired - Fee Related
- 2003-05-27 JP JP2004506758A patent/JP4413135B2/ja not_active Expired - Fee Related
- 2003-05-27 AU AU2003237302A patent/AU2003237302B8/en not_active Ceased
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2004
- 2004-09-28 IL IL164323A patent/IL164323A/en not_active IP Right Cessation
- 2004-10-01 ZA ZA200407944A patent/ZA200407944B/en unknown
- 2004-12-01 NO NO20045276A patent/NO20045276L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1507533B1 (en) | 2010-04-14 |
| US7335663B2 (en) | 2008-02-26 |
| CA2480756A1 (en) | 2003-12-04 |
| US7008949B2 (en) | 2006-03-07 |
| AU2003237302A1 (en) | 2003-12-12 |
| AU2003237302B8 (en) | 2008-04-03 |
| EP1507533A2 (en) | 2005-02-23 |
| MXPA04011657A (es) | 2005-08-18 |
| NZ535723A (en) | 2005-08-26 |
| WO2003099231A3 (en) | 2004-01-22 |
| US20040142954A1 (en) | 2004-07-22 |
| CN1311829C (zh) | 2007-04-25 |
| WO2003099231A2 (en) | 2003-12-04 |
| US20050130999A1 (en) | 2005-06-16 |
| EA008180B1 (ru) | 2007-04-27 |
| BR0309619A (pt) | 2005-06-28 |
| DE60332109D1 (de) | 2010-05-27 |
| IL164323A (en) | 2010-02-17 |
| JP4413135B2 (ja) | 2010-02-10 |
| CN1652789A (zh) | 2005-08-10 |
| EP1507533A4 (en) | 2007-05-23 |
| NO20045276L (no) | 2004-12-01 |
| IL164323A0 (en) | 2005-12-18 |
| JP2005529155A (ja) | 2005-09-29 |
| ATE464298T1 (de) | 2010-04-15 |
| TW200307671A (en) | 2003-12-16 |
| AU2003237302B2 (en) | 2008-03-06 |
| EA200401561A1 (ru) | 2005-06-30 |
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