JP2004536047A - 糖尿病処置用ｃ−アリールグルコシドのアミノ酸複合体および方法 - Google Patents

糖尿病処置用ｃ−アリールグルコシドのアミノ酸複合体および方法 Download PDF

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JP2004536047A
JP2004536047A JP2002580871A JP2002580871A JP2004536047A JP 2004536047 A JP2004536047 A JP 2004536047A JP 2002580871 A JP2002580871 A JP 2002580871A JP 2002580871 A JP2002580871 A JP 2002580871A JP 2004536047 A JP2004536047 A JP 2004536047A
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compound
agent
inhibitor
amino acid
alkyl
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JP2004536047A5 (enExample
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ジャック・ゼット・グーグータス
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
JP2002580871A 2001-04-11 2002-04-08 糖尿病処置用ｃ−アリールグルコシドのアミノ酸複合体および方法 Pending JP2004536047A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28309701P 2001-04-11 2001-04-11
PCT/US2002/011066 WO2002083066A2 (en) 2001-04-11 2002-04-08 Amino acid complexes of c-aryl glucosides for treatment of diabetes and method

Publications (2)

Publication Number Publication Date
JP2004536047A true JP2004536047A (ja) 2004-12-02
JP2004536047A5 JP2004536047A5 (enExample) 2005-12-22

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JP2002580871A Pending JP2004536047A (ja) 2001-04-11 2002-04-08 糖尿病処置用ｃ−アリールグルコシドのアミノ酸複合体および方法

Country Status (12)

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US (1) US6774112B2 (enExample)
EP (1) EP1385856B1 (enExample)
JP (1) JP2004536047A (enExample)
AT (1) ATE318272T1 (enExample)
AU (1) AU2002254567B2 (enExample)
CA (1) CA2444481A1 (enExample)
CY (1) CY1105038T1 (enExample)
DE (1) DE60209343T2 (enExample)
DK (1) DK1385856T3 (enExample)
ES (1) ES2258141T3 (enExample)
HU (1) HUP0600232A2 (enExample)
WO (1) WO2002083066A2 (enExample)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008540374A (ja) * 2005-05-03 2008-11-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １−クロロ−４−（β−Ｄ−グルコピラノス−１−イル）−２−［４−（（Ｒ）−テトラヒドロフラン−３−イルオキシ）ベンジル］ベンゼンの結晶形、その調製方法及び薬剤を調製するための使用
JP2009507898A (ja) * 2005-09-15 2009-02-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング グルコピラノシル置換（エチニル−ベンジル）‐ベンゼン誘導体及びその中間体の製造方法
JP2009507809A (ja) * 2005-09-08 2009-02-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １−クロロ−４−（β−Ｄ−グルコピラノス−１−イル）−２−（４−エチニル−ベンジル）−ベンゼンの結晶形態、その製造方法及び薬剤製造のためのそれらの使用
JP2009545525A (ja) * 2006-06-28 2009-12-24 ブリストル−マイヤーズ スクイブ カンパニー 糖尿病の治療用ｓｇｌｔ２阻害剤としてのアミノ酸を有する（１ｓ）−１，５−アンヒドロ−１−ｃ−（３−（（フェニル）メチル）フェニル）−ｄ−グルシトール誘導体の結晶性溶媒和物および複合体
JP2010500394A (ja) * 2006-08-15 2010-01-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング グルコピラノシル−置換シクロプロピルベンゼン誘導体、そのような化合物を含む医薬組成物、ｓｇｌｔ阻害剤としてのそれらの使用及びそれらの製造方法
JP2010534661A (ja) * 2007-07-26 2010-11-11 レクシコン ファーマシューティカルズ インコーポレイテッド ナトリウム・グルコース共輸送体２阻害剤の調製に有用な方法及び化合物
JP4834080B2 (ja) * 2005-05-10 2011-12-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング グルコピラノシル置換ベンジル−ベンゼン誘導体の調製方法及びこれらの方法における中間体
JP2012500803A (ja) * 2008-08-22 2012-01-12 セラコス・インコーポレイテッド Ｓｇｌｔ２阻害剤の製造方法
JP2012524710A (ja) * 2009-04-16 2012-10-18 大正製薬株式会社 併用医薬
JP5210154B2 (ja) * 2006-04-05 2013-06-12 アステラス製薬株式会社 Ｃ−グリコシド誘導体とｌ−プロリンとの共結晶
JP2013533291A (ja) * 2010-08-10 2013-08-22 シャンハイ ヘンルイ ファーマスーティカル カンパニー リミテッド Ｃ−アリールグルコシド誘導体、製造法およびその医薬用途
JP2014513693A (ja) * 2011-05-09 2014-06-05 ヤンセン ファーマシューティカ エヌ．ベー． （２ｓ，３ｒ，４ｒ，５ｓ，６ｒ）−２−（３−（（５−（４−フルオロフェニル）チオフェン−２−イル）メチル）−４−メチルフェニル）−６−（ヒドロキシメチル）テトラヒドロ−２ｈ−ピラン−３，４，５−トリオールのｌ−プロリン及びクエン酸との共結晶
JP2014532639A (ja) * 2011-10-31 2014-12-08 サイノファーム タイワン，リミティド Ｓｇｌｔ２阻害剤の結晶および非結晶形態
JP2015522644A (ja) * 2012-07-26 2015-08-06 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハーＢｏｅｈｒｉｎｇｅｒ Ｉｎｇｅｌｈｅｉｍ Ｖｅｔｍｅｄｉｃａ ＧｍｂＨ １−シアノ−２−（４−シクロプロピル−ベンジル）−４−（β−Ｄ−グルコピラノース−１−イル）−ベンゼンの結晶性錯体、その調製方法及び薬物を調製するためのその使用
JP2017052787A (ja) * 2009-02-13 2017-03-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １型糖尿病、２型糖尿病、耐糖能障害又は高血糖の治療用ｓｇｌｔ−２阻害薬
JP2019517575A (ja) * 2016-05-28 2019-06-24 ハイナン・シュエンジュウ・ファーマ・カンパニー・リミテッドＨａｉｎａｎ Ｘｕａｎｚｈｕ Ｐｈａｒｍａ Ｃｏ．， Ｌｔｄ． ナトリウム−グルコース共輸送体２阻害剤の結晶形
JP2022502393A (ja) * 2018-09-26 2022-01-11 レクシコン ファーマシューティカルズ インコーポレイテッド Ｎ−（１−（（２−（ジメチルアミノ）エチル）アミノ）−２−メチル−１−オキソプロパン−２−イル）−４−（４−（２−メチル−５−（（２ｓ，３ｒ，４ｒ，５ｓ，６ｒ）−３，４，５−トリヒドロキシ−６−（メチルチオ）テトラヒドロ−２ｈ−ピラン−２−イル）ベンジル）フェニル）ブタンアミドの結晶形態及びそれらの合成方法

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