JP2004536047A - 糖尿病処置用ｃ−アリールグルコシドのアミノ酸複合体および方法 - Google Patents

糖尿病処置用ｃ−アリールグルコシドのアミノ酸複合体および方法 Download PDF

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JP2004536047A
JP2004536047A JP2002580871A JP2002580871A JP2004536047A JP 2004536047 A JP2004536047 A JP 2004536047A JP 2002580871 A JP2002580871 A JP 2002580871A JP 2002580871 A JP2002580871 A JP 2002580871A JP 2004536047 A JP2004536047 A JP 2004536047A
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compound
agent
inhibitor
amino acid
alkyl
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JP2004536047A5 (cg-RX-API-DMAC10.html
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ジャック・ゼット・グーグータス
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Bristol Myers Squibb Co
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
JP2002580871A 2001-04-11 2002-04-08 糖尿病処置用ｃ−アリールグルコシドのアミノ酸複合体および方法 Pending JP2004536047A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28309701P 2001-04-11 2001-04-11
PCT/US2002/011066 WO2002083066A2 (en) 2001-04-11 2002-04-08 Amino acid complexes of c-aryl glucosides for treatment of diabetes and method

Publications (2)

Publication Number Publication Date
JP2004536047A true JP2004536047A (ja) 2004-12-02
JP2004536047A5 JP2004536047A5 (cg-RX-API-DMAC10.html) 2005-12-22

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US (1) US6774112B2 (cg-RX-API-DMAC10.html)
EP (1) EP1385856B1 (cg-RX-API-DMAC10.html)
JP (1) JP2004536047A (cg-RX-API-DMAC10.html)
AT (1) ATE318272T1 (cg-RX-API-DMAC10.html)
AU (1) AU2002254567B2 (cg-RX-API-DMAC10.html)
CA (1) CA2444481A1 (cg-RX-API-DMAC10.html)
CY (1) CY1105038T1 (cg-RX-API-DMAC10.html)
DE (1) DE60209343T2 (cg-RX-API-DMAC10.html)
DK (1) DK1385856T3 (cg-RX-API-DMAC10.html)
ES (1) ES2258141T3 (cg-RX-API-DMAC10.html)
HU (1) HUP0600232A2 (cg-RX-API-DMAC10.html)
WO (1) WO2002083066A2 (cg-RX-API-DMAC10.html)

Cited By (17)

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JP2008540374A (ja) * 2005-05-03 2008-11-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １−クロロ−４−（β−Ｄ−グルコピラノス−１−イル）−２−［４−（（Ｒ）−テトラヒドロフラン−３−イルオキシ）ベンジル］ベンゼンの結晶形、その調製方法及び薬剤を調製するための使用
JP2009507898A (ja) * 2005-09-15 2009-02-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング グルコピラノシル置換（エチニル−ベンジル）‐ベンゼン誘導体及びその中間体の製造方法
JP2009507809A (ja) * 2005-09-08 2009-02-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １−クロロ−４−（β−Ｄ−グルコピラノス−１−イル）−２−（４−エチニル−ベンジル）−ベンゼンの結晶形態、その製造方法及び薬剤製造のためのそれらの使用
JP2009545525A (ja) * 2006-06-28 2009-12-24 ブリストル−マイヤーズ スクイブ カンパニー 糖尿病の治療用ｓｇｌｔ２阻害剤としてのアミノ酸を有する（１ｓ）−１，５−アンヒドロ−１−ｃ−（３−（（フェニル）メチル）フェニル）−ｄ−グルシトール誘導体の結晶性溶媒和物および複合体
JP2010500394A (ja) * 2006-08-15 2010-01-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング グルコピラノシル−置換シクロプロピルベンゼン誘導体、そのような化合物を含む医薬組成物、ｓｇｌｔ阻害剤としてのそれらの使用及びそれらの製造方法
JP2010534661A (ja) * 2007-07-26 2010-11-11 レクシコン ファーマシューティカルズ インコーポレイテッド ナトリウム・グルコース共輸送体２阻害剤の調製に有用な方法及び化合物
JP4834080B2 (ja) * 2005-05-10 2011-12-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング グルコピラノシル置換ベンジル−ベンゼン誘導体の調製方法及びこれらの方法における中間体
JP2012500803A (ja) * 2008-08-22 2012-01-12 セラコス・インコーポレイテッド Ｓｇｌｔ２阻害剤の製造方法
JP2012524710A (ja) * 2009-04-16 2012-10-18 大正製薬株式会社 併用医薬
JP5210154B2 (ja) * 2006-04-05 2013-06-12 アステラス製薬株式会社 Ｃ−グリコシド誘導体とｌ−プロリンとの共結晶
JP2013533291A (ja) * 2010-08-10 2013-08-22 シャンハイ ヘンルイ ファーマスーティカル カンパニー リミテッド Ｃ−アリールグルコシド誘導体、製造法およびその医薬用途
JP2014513693A (ja) * 2011-05-09 2014-06-05 ヤンセン ファーマシューティカ エヌ．ベー． （２ｓ，３ｒ，４ｒ，５ｓ，６ｒ）−２−（３−（（５−（４−フルオロフェニル）チオフェン−２−イル）メチル）−４−メチルフェニル）−６−（ヒドロキシメチル）テトラヒドロ−２ｈ−ピラン−３，４，５−トリオールのｌ−プロリン及びクエン酸との共結晶
JP2014532639A (ja) * 2011-10-31 2014-12-08 サイノファーム タイワン，リミティド Ｓｇｌｔ２阻害剤の結晶および非結晶形態
JP2015522644A (ja) * 2012-07-26 2015-08-06 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハーＢｏｅｈｒｉｎｇｅｒ Ｉｎｇｅｌｈｅｉｍ Ｖｅｔｍｅｄｉｃａ ＧｍｂＨ １−シアノ−２−（４−シクロプロピル−ベンジル）−４−（β−Ｄ−グルコピラノース−１−イル）−ベンゼンの結晶性錯体、その調製方法及び薬物を調製するためのその使用
JP2017052787A (ja) * 2009-02-13 2017-03-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １型糖尿病、２型糖尿病、耐糖能障害又は高血糖の治療用ｓｇｌｔ−２阻害薬
JP2019517575A (ja) * 2016-05-28 2019-06-24 ハイナン・シュエンジュウ・ファーマ・カンパニー・リミテッドＨａｉｎａｎ Ｘｕａｎｚｈｕ Ｐｈａｒｍａ Ｃｏ．， Ｌｔｄ． ナトリウム−グルコース共輸送体２阻害剤の結晶形
JP2022502393A (ja) * 2018-09-26 2022-01-11 レクシコン ファーマシューティカルズ インコーポレイテッド Ｎ−（１−（（２−（ジメチルアミノ）エチル）アミノ）−２−メチル−１−オキソプロパン−２−イル）−４−（４−（２−メチル−５−（（２ｓ，３ｒ，４ｒ，５ｓ，６ｒ）−３，４，５−トリヒドロキシ−６−（メチルチオ）テトラヒドロ−２ｈ−ピラン−２−イル）ベンジル）フェニル）ブタンアミドの結晶形態及びそれらの合成方法

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US6774112B2 (en) 2004-08-10
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WO2002083066A2 (en) 2002-10-24
EP1385856A2 (en) 2004-02-04
EP1385856A4 (en) 2005-05-11
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AU2002254567B2 (en) 2007-10-11

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