JP2004527264A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004527264A5 JP2004527264A5 JP2003500240A JP2003500240A JP2004527264A5 JP 2004527264 A5 JP2004527264 A5 JP 2004527264A5 JP 2003500240 A JP2003500240 A JP 2003500240A JP 2003500240 A JP2003500240 A JP 2003500240A JP 2004527264 A5 JP2004527264 A5 JP 2004527264A5
- Authority
- JP
- Japan
- Prior art keywords
- influenza virus
- inactivated
- influenza
- preparation
- virus preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 claims 18
- 241000712461 unidentified influenza virus Species 0.000 claims 13
- 239000000427 antigen Substances 0.000 claims 9
- 102000036639 antigens Human genes 0.000 claims 9
- 108091007433 antigens Proteins 0.000 claims 9
- 101710154606 Hemagglutinin Proteins 0.000 claims 6
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 6
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 6
- 101710176177 Protein A56 Proteins 0.000 claims 6
- 239000000185 hemagglutinin Substances 0.000 claims 6
- IELOKBJPULMYRW-NJQVLOCASA-N D-alpha-Tocopheryl Acid Succinate Chemical compound OC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C IELOKBJPULMYRW-NJQVLOCASA-N 0.000 claims 4
- 229940099418 d- alpha-tocopherol succinate Drugs 0.000 claims 4
- 206010022000 influenza Diseases 0.000 claims 4
- 229960003971 influenza vaccine Drugs 0.000 claims 4
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 4
- 229940087168 alpha tocopherol Drugs 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 claims 2
- 229960004906 thiomersal Drugs 0.000 claims 2
- 229960000984 tocofersolan Drugs 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 210000000605 viral structure Anatomy 0.000 claims 2
- 239000002076 α-tocopherol Substances 0.000 claims 2
- 235000004835 α-tocopherol Nutrition 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0113083A GB0113083D0 (en) | 2001-05-30 | 2001-05-30 | Novel compounds |
| GB0204116A GB0204116D0 (en) | 2002-02-21 | 2002-02-21 | Novel vaccine composition |
| PCT/EP2002/005883 WO2002097072A2 (en) | 2001-05-30 | 2002-05-29 | Influenza vaccine composition |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004527264A JP2004527264A (ja) | 2004-09-09 |
| JP2004527264A5 true JP2004527264A5 (enExample) | 2005-12-22 |
| JP4074582B2 JP4074582B2 (ja) | 2008-04-09 |
Family
ID=30445235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003500240A Expired - Lifetime JP4074582B2 (ja) | 2001-05-30 | 2002-05-29 | 新規なワクチン |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US7316813B2 (enExample) |
| EP (3) | EP1407008B1 (enExample) |
| JP (1) | JP4074582B2 (enExample) |
| KR (1) | KR100871021B1 (enExample) |
| CN (2) | CN1279165C (enExample) |
| AR (1) | AR036039A1 (enExample) |
| AT (1) | ATE420159T1 (enExample) |
| AU (2) | AU2002344182C1 (enExample) |
| BR (1) | BRPI0210076B8 (enExample) |
| CA (1) | CA2448208C (enExample) |
| CO (1) | CO5540349A2 (enExample) |
| CY (1) | CY1108930T1 (enExample) |
| CZ (1) | CZ298697B6 (enExample) |
| DE (1) | DE60230760D1 (enExample) |
| DK (1) | DK1407008T3 (enExample) |
| ES (1) | ES2318020T3 (enExample) |
| FR (1) | FR13C0072I1 (enExample) |
| HU (1) | HU229368B1 (enExample) |
| IL (2) | IL158931A (enExample) |
| MX (1) | MXPA03010944A (enExample) |
| MY (1) | MY134424A (enExample) |
| NO (1) | NO335212B1 (enExample) |
| NZ (1) | NZ529755A (enExample) |
| PL (1) | PL206435B1 (enExample) |
| PT (1) | PT1407008E (enExample) |
| SI (1) | SI1407008T1 (enExample) |
| TW (1) | TWI228420B (enExample) |
| WO (1) | WO2002097072A2 (enExample) |
| ZA (1) | ZA200309250B (enExample) |
Families Citing this family (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60036952T2 (de) * | 1999-09-24 | 2008-08-07 | Glaxosmithkline Biologicals S.A. | Influenzavirus-impfstoffzusammensetzung zur nasalen anwendung |
| GB9923176D0 (en) | 1999-09-30 | 1999-12-01 | Smithkline Beecham Biolog | Novel composition |
| US20100221284A1 (en) * | 2001-05-30 | 2010-09-02 | Saech-Sisches Serumwerk Dresden | Novel vaccine composition |
| TWI228420B (en) * | 2001-05-30 | 2005-03-01 | Smithkline Beecham Pharma Gmbh | Novel vaccine composition |
| EP1597400B8 (en) | 2003-02-25 | 2013-10-09 | MedImmune, LLC | Methods of producing influenza vaccine compositions |
| US20060110406A1 (en) | 2003-02-25 | 2006-05-25 | Medimmune Vaccines, Inc. | Refrigerator-temperature stable influenza vaccine compositions |
| SI2236155T1 (sl) | 2004-09-09 | 2012-09-28 | Novartis Vaccines & Diagnostic | Zmanjšanje potencialnih iatrogenih tveganj, povezanih s cepivi proti influenci |
| EP2769735B1 (en) * | 2004-10-06 | 2017-04-19 | MedImmune, LLC | Refrigerator-temperature stable influenza vaccine compositions |
| JP2008519042A (ja) * | 2004-11-03 | 2008-06-05 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス， インコーポレイテッド | インフルエンザワクチン接種 |
| US9161905B2 (en) * | 2005-01-12 | 2015-10-20 | Ocular Research Of Boston, Inc. | Dry eye treatment |
| AR053833A1 (es) * | 2005-03-23 | 2007-05-23 | Glaxosmithkline Biolog Sa | Composicion inmunogenetica |
| EA014314B1 (ru) * | 2005-08-02 | 2010-10-29 | Новартис Вэксинес Энд Дайэгностикс Срл | Пониженная интерференция между маслосодержащими адъювантами и антигенами, содержащими поверхностно-активные вещества |
| EP2842572A1 (en) | 2005-11-01 | 2015-03-04 | Novartis Vaccines and Diagnostics GmbH | Cell-derived viral vaccines with low levels of residual cell dna |
| US11707520B2 (en) | 2005-11-03 | 2023-07-25 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| NZ592713A (en) | 2005-11-04 | 2012-12-21 | Novartis Vaccines & Diagnostic | Adjuvanted influenza vaccines including a cytokine-inducing agents other than an agonist of Toll-Like Receptor 9 |
| JP2009514850A (ja) * | 2005-11-04 | 2009-04-09 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル | アジュバントとして減少した量の水中油型エマルションを有するインフルエンザワクチン |
| BRPI0618254A2 (pt) * | 2005-11-04 | 2011-08-23 | Novartis Vaccines & Diagnostic | emulsões com agente tensoativo de fase aquosa livre para fornecer adjuvante às vacinas contra influenza dividido |
| HUE051122T2 (hu) | 2005-11-04 | 2021-03-01 | Seqirus Uk Ltd | Sejttenyészetben növesztett influenzavírusból elõállított nemvirion anti-géneket tartalmazó adjuvált vakcinák |
| US8697087B2 (en) | 2005-11-04 | 2014-04-15 | Novartis Ag | Influenza vaccines including combinations of particulate adjuvants and immunopotentiators |
| TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| PL1976559T6 (pl) | 2006-01-27 | 2020-08-10 | Novartis Influenza Vaccines Marburg Gmbh | Szczepionki przeciw grypie zawierające hemaglutyninę i białka macierzy |
| CN101448523A (zh) * | 2006-03-24 | 2009-06-03 | 诺华疫苗和诊断有限两合公司 | 无需冷藏储存流感疫苗 |
| US20100015168A1 (en) | 2006-06-09 | 2010-01-21 | Novartis Ag | Immunogenic compositions for streptococcus agalactiae |
| PL2043682T3 (pl) | 2006-07-17 | 2014-09-30 | Glaxosmithkline Biologicals Sa | Szczepionka przeciw grypie |
| CN105727276A (zh) | 2006-07-17 | 2016-07-06 | 葛兰素史密丝克莱恩生物有限公司 | 流感疫苗 |
| GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
| EP2066345B1 (en) | 2006-09-11 | 2015-02-25 | Novartis AG | Making influenza virus vaccines without using eggs |
| US9481912B2 (en) | 2006-09-12 | 2016-11-01 | Longhorn Vaccines And Diagnostics, Llc | Compositions and methods for detecting and identifying nucleic acid sequences in biological samples |
| US8652782B2 (en) | 2006-09-12 | 2014-02-18 | Longhorn Vaccines & Diagnostics, Llc | Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids |
| US8097419B2 (en) | 2006-09-12 | 2012-01-17 | Longhorn Vaccines & Diagnostics Llc | Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009 |
| US8080645B2 (en) | 2007-10-01 | 2011-12-20 | Longhorn Vaccines & Diagnostics Llc | Biological specimen collection/transport compositions and methods |
| SI2086582T1 (sl) | 2006-10-12 | 2013-02-28 | Glaxosmithkline Biologicals S.A. | Cepivo, ki obsega emulzijo olja v vodi kot adjuvans |
| EP2532362A1 (en) | 2006-12-06 | 2012-12-12 | Novartis AG | Vaccines including antigen from four strains of influenza virus |
| AR066405A1 (es) | 2007-04-20 | 2009-08-19 | Glaxosmithkline Biolog Sa | Vacuna |
| EA201070066A1 (ru) | 2007-06-27 | 2010-06-30 | Новартис Аг | Вакцины против гриппа с низким содержанием добавок |
| US9683256B2 (en) | 2007-10-01 | 2017-06-20 | Longhorn Vaccines And Diagnostics, Llc | Biological specimen collection and transport system |
| US11041215B2 (en) | 2007-08-24 | 2021-06-22 | Longhorn Vaccines And Diagnostics, Llc | PCR ready compositions and methods for detecting and identifying nucleic acid sequences |
| US10004799B2 (en) | 2007-08-27 | 2018-06-26 | Longhorn Vaccines And Diagnostics, Llc | Composite antigenic sequences and vaccines |
| AU2008293504B2 (en) | 2007-08-27 | 2012-04-12 | Longhorn Vaccines & Diagnostics, Llc | Immunogenic compositions and methods |
| WO2009029695A1 (en) * | 2007-08-28 | 2009-03-05 | Baxter International Inc. | Method for producing viral vaccines |
| DK2535428T3 (en) | 2007-10-01 | 2015-11-23 | Longhorn Vaccines & Diagnostics Llc | Biological prøvesamlings- and transport system, and methods of using |
| US11041216B2 (en) | 2007-10-01 | 2021-06-22 | Longhorn Vaccines And Diagnostics, Llc | Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples |
| GB0810305D0 (en) | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
| GB0818453D0 (en) | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
| WO2009081172A1 (en) * | 2007-12-24 | 2009-07-02 | Novartis Ag | Assays for adsorbed influenza vaccines |
| US8506966B2 (en) * | 2008-02-22 | 2013-08-13 | Novartis Ag | Adjuvanted influenza vaccines for pediatric use |
| US20110014230A1 (en) | 2008-03-18 | 2011-01-20 | Novartis Ag | preparation of influenza virus vaccine antigens |
| DK2271360T3 (en) | 2008-04-16 | 2015-12-14 | Glaxosmithkline Biolog Sa | Vaccine |
| CA2741961A1 (en) | 2008-11-05 | 2010-05-14 | Glaxosmithkline Biologicals S.A. | Novel method |
| EP3173097A3 (en) | 2009-02-10 | 2017-07-12 | Seqirus UK Limited | Influenza vaccines with reduced amounts of squalene |
| EP2396030B1 (en) | 2009-02-10 | 2015-08-12 | Novartis AG | Influenza vaccine regimens for pandemic-associated strains |
| WO2010092477A1 (en) | 2009-02-10 | 2010-08-19 | Novartis Ag | Influenza vaccines with increased amounts of h3 antigen |
| JP2012525370A (ja) | 2009-04-27 | 2012-10-22 | ノバルティス アーゲー | インフルエンザに対して防御するためのアジュバント添加ワクチン |
| EP2401384B1 (en) | 2009-05-21 | 2012-10-03 | Novartis AG | Reverse genetics using non-endogenous pol i promoters |
| CA2803282C (en) | 2009-07-06 | 2018-05-01 | David E. Anderson | Methods for preparing vesicles and formulations produced therefrom |
| EP2451950B9 (en) | 2009-07-06 | 2016-11-23 | Variation Biotechnologies Inc. | Methods for preparing vesicles and formulations produced therefrom |
| JP2013500712A (ja) | 2009-07-31 | 2013-01-10 | ノバルティス アーゲー | 逆遺伝学系 |
| CA2773637A1 (en) | 2009-09-10 | 2011-03-17 | Novartis Ag | Combination vaccines against respiratory tract diseases |
| NZ599479A (en) | 2009-10-20 | 2013-11-29 | Novartis Ag | Improved reverse genetics methods for virus rescue |
| GB0918830D0 (en) * | 2009-10-27 | 2009-12-09 | Glaxosmithkline Biolog Niederl | Process |
| GB0919117D0 (en) | 2009-10-30 | 2009-12-16 | Glaxosmithkline Biolog Sa | Process |
| DE102009056871A1 (de) | 2009-12-03 | 2011-06-22 | Novartis AG, 4056 | Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben |
| EP4410306A3 (en) | 2009-12-03 | 2024-11-13 | Seqirus UK Limited | Circulation of components during homogenization of emulsions |
| US10213383B2 (en) | 2009-12-03 | 2019-02-26 | Novartis Ag | Hydrophilic filtration during manufacture of vaccine adjuvants |
| EP2506833B1 (en) | 2009-12-03 | 2014-04-16 | Novartis AG | Arranging interaction and back pressure chambers for microfluidization |
| DE102009056884B4 (de) | 2009-12-03 | 2021-03-18 | Novartis Ag | Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben |
| DE102009056883B4 (de) | 2009-12-03 | 2012-08-16 | Novartis Ag | Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben |
| CN102946900A (zh) | 2010-03-11 | 2013-02-27 | 免疫设计公司 | 用于大流行流感的疫苗 |
| KR20130079398A (ko) | 2010-05-06 | 2013-07-10 | 노파르티스 아게 | 미생물 불활성화를 위한 유기 과산화 화합물 |
| ES2453316T5 (es) | 2010-05-12 | 2017-07-18 | Novartis Ag | Procedimientos mejorados para preparar escualeno |
| CA2800150C (en) | 2010-05-21 | 2018-09-04 | Novartis Ag | Influenza virus reassortment method |
| ES2825712T3 (es) | 2010-06-01 | 2021-05-17 | Seqirus Uk Ltd | Concentración de antígenos de vacuna contra la influenza sin liofilización |
| CN102939104A (zh) | 2010-06-01 | 2013-02-20 | 诺华有限公司 | 用冻干浓缩疫苗抗原 |
| WO2011154976A2 (en) | 2010-06-08 | 2011-12-15 | Panacea Biotec Limited | Improved influenza vaccine |
| CA2840079C (en) | 2010-07-06 | 2018-07-03 | Variation Biotechnologies Inc. | Compositions and methods for treating influenza |
| ES2531577T3 (es) | 2010-08-20 | 2015-03-17 | Novartis Ag | Conjuntos de agujas para la administración de vacuna soluble contra la gripe |
| AU2011300402B2 (en) | 2010-09-07 | 2015-01-22 | Novartis Ag | Generic assays for detection of mammalian reovirus |
| WO2012055951A2 (en) | 2010-10-27 | 2012-05-03 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
| WO2012097347A1 (en) | 2011-01-13 | 2012-07-19 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
| BR112013017939B1 (pt) | 2011-01-13 | 2022-11-16 | Variation Biotechnologies Inc | Composição imunogênica liofilizada termoestável, uso e método para preparação da mesma |
| JP5798356B2 (ja) * | 2011-04-06 | 2015-10-21 | 一般財団法人化学及血清療法研究所 | 新規インフルエンザワクチン安定化剤 |
| GB201216121D0 (en) | 2012-09-10 | 2012-10-24 | Novartis Ag | Sample quantification by disc centrifugation |
| EP2768528A1 (en) | 2011-10-20 | 2014-08-27 | Novartis AG | Adjuvanted influenza b virus vaccines for pediatric priming |
| CA2890084C (en) | 2011-11-18 | 2021-05-04 | Maura Ellen Campbell | Synthetic derivatives of mpl and uses thereof |
| CA2894442C (en) | 2012-01-12 | 2020-01-21 | Variation Biotechnologies Inc. | Compositions and methods for treating viral infections |
| WO2013112916A1 (en) | 2012-01-26 | 2013-08-01 | Longhorn Vaccines And Diagnostics, Llc | Composite antigenic sequences and vaccines |
| EP2806894A4 (en) | 2012-01-27 | 2015-11-04 | Variation Biotechnologies Inc | METHODS AND COMPOSITIONS FOR THERAPEUTIC AGENTS |
| CA2813723A1 (en) | 2012-03-02 | 2013-09-02 | Novartis Ag | Influenza virus reassortment |
| GB201205189D0 (en) | 2012-03-23 | 2012-05-09 | Glaxosmithkline Biolog Sa | Novel medical use |
| US20130315955A1 (en) * | 2012-04-13 | 2013-11-28 | Protein Sciences Corporation | Stability and potency of hemagglutinin |
| AU2013270793A1 (en) | 2012-06-04 | 2014-12-11 | Novartis Ag | Improved safety testing |
| GB201218195D0 (en) | 2012-10-10 | 2012-11-21 | Istituto Zooprofilattico Sperimentale Delle Venezie | Composition |
| EP2925356A2 (en) | 2012-12-03 | 2015-10-07 | Novartis AG | Reassortant influenza a viren |
| RU2015132962A (ru) | 2013-01-10 | 2017-02-14 | Новартис Аг | Иммуногенные композиции на основе вируса гриппа и их применение |
| JP6525469B2 (ja) | 2013-03-13 | 2019-06-05 | ノバルティス アーゲー | インフルエンザｂ型ウイルス再集合 |
| CA2911296A1 (en) | 2013-05-10 | 2014-11-13 | Wayne Volkmuth | Avoiding narcolepsy risk in influenza vaccines |
| DE202013005130U1 (de) | 2013-06-05 | 2013-09-10 | Novartis Ag | Influenza Virus Reassortierung |
| DE202013005100U1 (de) | 2013-06-05 | 2013-08-26 | Novartis Ag | Influenza Virus Reassortierung |
| US10329537B2 (en) | 2013-06-06 | 2019-06-25 | Seqirus UK Limited | Influenza virus reassortment |
| CN104436157A (zh) | 2013-09-23 | 2015-03-25 | 恩金生物有限公司 | 流感疫苗和治疗 |
| CN105792843B (zh) * | 2013-11-29 | 2020-02-28 | 泰尔茂株式会社 | 佐剂组合物及包含其的疫苗组合物、以及它们的制造方法 |
| WO2016087479A1 (en) | 2014-12-02 | 2016-06-09 | Novartis Ag | Manufacture of surfactant-containing compositions |
| EP3294448A4 (en) | 2015-05-14 | 2018-12-12 | Longhorn Vaccines and Diagnostics, LLC | Rapid methods for the extraction of nucleic acids from biological samples |
| WO2016207853A2 (en) | 2015-06-26 | 2016-12-29 | Seqirus UK Limited | Antigenically matched influenza vaccines |
| KR102790570B1 (ko) | 2015-07-07 | 2025-04-04 | 세퀴러스 유케이 리미티드 | 인플루엔자 효능 검정 |
| WO2017167768A1 (en) | 2016-03-28 | 2017-10-05 | Glaxosmithkline Biologicals S.A. | Novel vaccine composition |
| GB201614799D0 (en) * | 2016-09-01 | 2016-10-19 | Glaxosmithkline Biologicals Sa | Compositions |
| CA3069542A1 (en) | 2017-08-04 | 2019-02-07 | Syngenta Participations Ag | Methods and compositions for targeted genomic insertion |
| ES2991988T3 (es) | 2017-10-30 | 2024-12-05 | Takeda Pharmaceuticals Co | Detergentes compatibles con el medio ambiente para la inactivación de virus con envoltura lipídica |
| CN113993542A (zh) | 2019-01-30 | 2022-01-28 | 葛兰素史密丝克莱恩生物有限公司 | 用于自乳化的油/表面活性剂混合物 |
| AU2020389047A1 (en) | 2019-11-18 | 2022-06-02 | Seqirus Pty Ltd. | Method for producing reassortant influenza viruses |
| US12485166B2 (en) | 2020-02-06 | 2025-12-02 | Longhorn Vaccines And Diagnostics, Llc | Vaccines for the treatment and prevention of zoonotic infections |
| RU2754398C1 (ru) * | 2020-06-25 | 2021-09-01 | Общество с ограниченной ответственностью «ФОРТ» | Способ получения четырехвалентной вакцины для профилактики гриппа |
| US20230218526A1 (en) | 2020-06-30 | 2023-07-13 | Seqirus UK Limited | Cold filtration of oil-in-water emulsion adjuvants |
| US12409214B2 (en) | 2020-10-20 | 2025-09-09 | Longhorn Vaccines And Diagnostics, Llc | Immunogenic antigens |
| WO2025019631A1 (en) | 2023-07-19 | 2025-01-23 | Icahn School Of Medicine At Mount Sinai | Immunogenic compositions containing inactivated influenza a virus and cpg oligonucleotide adjuvant and uses thereof |
Family Cites Families (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US639A (en) | 1838-03-17 | of boston | ||
| US5520A (en) | 1848-04-18 | Oegan-pipb | ||
| US4270537A (en) | 1979-11-19 | 1981-06-02 | Romaine Richard A | Automatic hypodermic syringe |
| DD155875A1 (de) | 1980-12-31 | 1982-07-14 | Willy Nordheim | Verfahren zur herstellung eines ballaststoffarmen inaktivierten influenzaimpfstoffes |
| US4436727A (en) | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
| DD211444A3 (de) | 1982-08-19 | 1984-07-11 | Saechsisches Serumwerk | Verfahren zur herstellung von influenza-impfstoffen |
| SE8205892D0 (sv) | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| DD300833A7 (de) | 1985-10-28 | 1992-08-13 | Saechsische Landesgewerbefoerd | Verfahren zur herstellung von inaktivierten influenza-vollvirusimpfstoffen |
| US4886499A (en) | 1986-12-18 | 1989-12-12 | Hoffmann-La Roche Inc. | Portable injection appliance |
| GB8704027D0 (en) | 1987-02-20 | 1987-03-25 | Owen Mumford Ltd | Syringe needle combination |
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| CA1331443C (en) | 1987-05-29 | 1994-08-16 | Charlotte A. Kensil | Saponin adjuvant |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
| US5339163A (en) | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| FR2638359A1 (fr) | 1988-11-03 | 1990-05-04 | Tino Dalto | Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau |
| AU626049B2 (en) * | 1989-05-29 | 1992-07-23 | Lion Corporation | Method for preparing vaccine for dental caries and vaccinal compositions for dental caries used as nasal drop |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5190521A (en) | 1990-08-22 | 1993-03-02 | Tecnol Medical Products, Inc. | Apparatus and method for raising a skin wheal and anesthetizing skin |
| US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
| GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
| SE9102652D0 (sv) | 1991-09-13 | 1991-09-13 | Kabi Pharmacia Ab | Injection needle arrangement |
| JP3723231B2 (ja) | 1991-12-23 | 2005-12-07 | ディミナコ アクチェンゲゼルシャフト | アジュバント |
| IL101007A (en) * | 1992-02-18 | 1997-08-14 | Pharmos Ltd | Dry stable compositions prepared by lyophilization |
| US5328483A (en) | 1992-02-27 | 1994-07-12 | Jacoby Richard M | Intradermal injection device with medication and needle guard |
| ATE156710T1 (de) | 1992-06-25 | 1997-08-15 | Smithkline Beecham Biolog | Adjuvantien enthaltende impfstoffzusammensetzung |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
| US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
| NZ263538A (en) | 1993-03-23 | 1996-10-28 | Smithkline Beecham Biolog | Vaccine compositions of 3-o-deacylated monophosphoryl lipid a |
| WO1995011700A1 (en) * | 1993-10-29 | 1995-05-04 | Pharmos Corp. | Submicron emulsions as vaccine adjuvants |
| GB9326253D0 (en) * | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| WO1995024176A1 (en) | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
| US5466220A (en) | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
| US5616487A (en) * | 1994-09-15 | 1997-04-01 | Aastrom Biosciences, Inc. | Stabilized retrovirus compositions |
| AUPM873294A0 (en) | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
| US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
| DE69619894T2 (de) | 1995-06-30 | 2002-11-14 | American Cyanamid Co., Madison | Stabile Makrolide und Makrolide Imptstoff-Zusammensetzungen |
| US20020165168A1 (en) * | 1995-12-16 | 2002-11-07 | Joachim Bunger | Use of sugar derivatives as antimicrobial, antimycotic and/or antiviral active substances |
| US5893397A (en) | 1996-01-12 | 1999-04-13 | Bioject Inc. | Medication vial/syringe liquid-transfer apparatus |
| GB9607549D0 (en) | 1996-04-11 | 1996-06-12 | Weston Medical Ltd | Spring-powered dispensing device |
| US5919480A (en) | 1996-06-24 | 1999-07-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Liposomal influenza vaccine composition and method |
| US6403098B1 (en) * | 1996-09-26 | 2002-06-11 | Merck & Co., Inc. | Rotavirus vaccine formulations |
| DE19649895A1 (de) * | 1996-12-02 | 1998-06-04 | Henkel Kgaa | Schäumende Körperreinigungsmittel |
| ATE444760T1 (de) * | 1997-01-13 | 2009-10-15 | Univ Emory | Glutathion zur behandlung von influenzainfektionen |
| GB9705740D0 (en) * | 1997-03-20 | 1997-05-07 | Medeva Europ Ltd | A method of preservation |
| PL190237B1 (pl) | 1997-04-01 | 2005-11-30 | Corixa Corp | Kompozycja adiuwantowa, szczepionka, sposób wytwarzania kompozycji adiuwantowej oraz zastosowanie |
| US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
| GB9711990D0 (en) * | 1997-06-11 | 1997-08-06 | Smithkline Beecham Biolog | Vaccine |
| CA2302554C (en) * | 1997-09-05 | 2007-04-10 | Smithkline Beecham Biologicals S.A. | Oil in water emulsions containing saponins |
| IT1298087B1 (it) | 1998-01-08 | 1999-12-20 | Fiderm S R L | Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni |
| AU746163B2 (en) * | 1998-04-09 | 2002-04-18 | Smithkline Beecham Biologicals (Sa) | Adjuvant compositions |
| FR2780278B1 (fr) * | 1998-06-24 | 2001-01-19 | Oreal | Composition conditionnante et detergente et utilisation |
| DE19841796A1 (de) * | 1998-09-12 | 2000-03-16 | Beiersdorf Ag | Kombinationen von Antiadhäsiva (Kohlenhydrate) und Mikrobiziden |
| EP1187629B1 (en) * | 1999-04-19 | 2004-09-22 | GlaxoSmithKline Biologicals S.A. | Adjuvant composition comprising saponin and an immunostimulatory oligonucleotide |
| AUPQ233799A0 (en) * | 1999-08-19 | 1999-09-09 | Minister For Agriculture, Minister For Land And Water Conservation For And On Behalf Of The State Of New South Wales | Recombinant sub-unit vaccine |
| AR025749A1 (es) * | 1999-09-24 | 2002-12-11 | Smithkline Beecham Biolog | Vacunas |
| JP2003509473A (ja) * | 1999-09-24 | 2003-03-11 | スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム | ワクチン |
| DE60036952T2 (de) * | 1999-09-24 | 2008-08-07 | Glaxosmithkline Biologicals S.A. | Influenzavirus-impfstoffzusammensetzung zur nasalen anwendung |
| US6494865B1 (en) | 1999-10-14 | 2002-12-17 | Becton Dickinson And Company | Intradermal delivery device including a needle assembly |
| DE60014163T2 (de) | 1999-10-19 | 2005-10-06 | The Procter & Gamble Company, Cincinnati | Zusammensetzungen zur vorbeugung und behandlung der erkältung und grippe-artiger symptome und ihre verwendung |
| MXPA03002890A (es) * | 2000-10-02 | 2004-12-03 | Glaxosmithkline Biolog Sa | Preparacion de virus con envolvente dividido. |
| WO2002067983A1 (en) * | 2001-02-23 | 2002-09-06 | Glaxosmithkline Biologicals S.A. | Novel vaccine |
| TWI228420B (en) * | 2001-05-30 | 2005-03-01 | Smithkline Beecham Pharma Gmbh | Novel vaccine composition |
| US9856414B2 (en) | 2013-06-10 | 2018-01-02 | Dober Chemical Corp. | Compositions, systems and methods of making coated additive components |
-
2002
- 2002-05-28 TW TW091111304A patent/TWI228420B/zh not_active IP Right Cessation
- 2002-05-28 MY MYPI20021956A patent/MY134424A/en unknown
- 2002-05-29 JP JP2003500240A patent/JP4074582B2/ja not_active Expired - Lifetime
- 2002-05-29 CZ CZ20033253A patent/CZ298697B6/cs unknown
- 2002-05-29 EP EP02743125A patent/EP1407008B1/en not_active Expired - Lifetime
- 2002-05-29 PT PT02743125T patent/PT1407008E/pt unknown
- 2002-05-29 NZ NZ529755A patent/NZ529755A/en not_active IP Right Cessation
- 2002-05-29 BR BRPI0210076-2 patent/BRPI0210076B8/pt not_active IP Right Cessation
- 2002-05-29 PL PL366990A patent/PL206435B1/pl unknown
- 2002-05-29 CA CA2448208A patent/CA2448208C/en not_active Expired - Lifetime
- 2002-05-29 KR KR1020037015649A patent/KR100871021B1/ko not_active Expired - Lifetime
- 2002-05-29 HU HU0400445A patent/HU229368B1/hu unknown
- 2002-05-29 US US10/480,952 patent/US7316813B2/en not_active Expired - Lifetime
- 2002-05-29 AU AU2002344182A patent/AU2002344182C1/en not_active Expired
- 2002-05-29 WO PCT/EP2002/005883 patent/WO2002097072A2/en not_active Ceased
- 2002-05-29 SI SI200230806T patent/SI1407008T1/sl unknown
- 2002-05-29 DE DE60230760T patent/DE60230760D1/de not_active Expired - Lifetime
- 2002-05-29 ES ES02743125T patent/ES2318020T3/es not_active Expired - Lifetime
- 2002-05-29 DK DK02743125T patent/DK1407008T3/da active
- 2002-05-29 AU AU2006200742A patent/AU2006200742C9/en active Active
- 2002-05-29 CN CNB028146557A patent/CN1279165C/zh not_active Expired - Lifetime
- 2002-05-29 MX MXPA03010944A patent/MXPA03010944A/es active IP Right Grant
- 2002-05-29 EP EP09100013A patent/EP2039761A1/en not_active Ceased
- 2002-05-29 EP EP12170561A patent/EP2495314A1/en not_active Withdrawn
- 2002-05-29 CN CN2006101156101A patent/CN101069744B/zh not_active Expired - Lifetime
- 2002-05-29 AT AT02743125T patent/ATE420159T1/de active
- 2002-05-30 AR ARP020102018A patent/AR036039A1/es not_active Application Discontinuation
-
2003
- 2003-11-18 IL IL158931A patent/IL158931A/en active IP Right Grant
- 2003-11-24 NO NO20035208A patent/NO335212B1/no not_active IP Right Cessation
- 2003-11-27 ZA ZA2003/09250A patent/ZA200309250B/en unknown
- 2003-11-27 CO CO03104769A patent/CO5540349A2/es active IP Right Grant
-
2007
- 2007-10-18 US US11/874,647 patent/US20080181914A1/en not_active Abandoned
-
2008
- 2008-01-17 IL IL188834A patent/IL188834A/en active IP Right Grant
-
2009
- 2009-03-26 CY CY20091100357T patent/CY1108930T1/el unknown
-
2013
- 2013-12-18 FR FR13C0072C patent/FR13C0072I1/fr active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004527264A5 (enExample) | ||
| Tregoning et al. | Adjuvanted influenza vaccines | |
| US20230210965A1 (en) | PRIME-BOOST REGIMENS INVOLVING ADMINISTRATION OF AT LEAST ONE mRNA CONSTRUCT | |
| Shah et al. | Overview of vaccine adjuvants: introduction, history, and current status | |
| CA2448208A1 (en) | Influenza vaccine composition | |
| AU646257B2 (en) | Oral vaccine comprising antigen surface-associated with red blood cells | |
| ES2257072T3 (es) | Composicion de vacuna antigripal. | |
| US20090208523A1 (en) | Adjuvant for vaccines | |
| MY126588A (en) | Intranasal influenza virus vaccine | |
| JP2009539965A5 (enExample) | ||
| Egli et al. | Vaccine adjuvants–understanding molecular mechanisms to improve vaccines | |
| JP2009511084A5 (enExample) | ||
| JP2009514839A5 (enExample) | ||
| Jones et al. | A nasal Proteosome™ influenza vaccine containing baculovirus-derived hemagglutinin induces protective mucosal and systemic immunity | |
| Peeters et al. | Pulmonary immunization of chickens using non-adjuvanted spray-freeze dried whole inactivated virus vaccine completely protects against highly pathogenic H5N1 avian influenza virus | |
| US9198965B2 (en) | Peptide adjuvant for influenza vaccination | |
| CA2632516C (en) | Dsrnas as influenza virus vaccine adjuvants or immuno-stimulants | |
| EP1796720B1 (en) | Bivalent avian influenza vaccines | |
| Faulkner et al. | Influenza hemagglutinin peptides fused to interferon gamma and encapsulated in liposomes protects mice against influenza infection | |
| Katz et al. | A nonionic block co-polymer adjuvant (CRL1005) enhances the immunogenicity and protective efficacy of inactivated influenza vaccine in young and aged mice | |
| Potter et al. | Effect of priming on subsequent response to inactivated influenza vaccine | |
| Wareing et al. | Influenza update: vaccine development and clinical trials | |
| CN101405027B (zh) | 基于病毒颗粒的鼻内流感疫苗 | |
| Park et al. | Immune responses of mice to influenza subunit vaccine in combination with CIA07 as an adjuvant | |
| Geeraedts et al. | Influenza vaccines: what do we want and how can we get it? |