JP2009511084A5 - - Google Patents
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- Publication number
- JP2009511084A5 JP2009511084A5 JP2008536796A JP2008536796A JP2009511084A5 JP 2009511084 A5 JP2009511084 A5 JP 2009511084A5 JP 2008536796 A JP2008536796 A JP 2008536796A JP 2008536796 A JP2008536796 A JP 2008536796A JP 2009511084 A5 JP2009511084 A5 JP 2009511084A5
- Authority
- JP
- Japan
- Prior art keywords
- influenza
- vaccine
- proteins
- influenza virus
- vlp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960005486 vaccine Drugs 0.000 claims 35
- 241000712461 unidentified influenza virus Species 0.000 claims 27
- 108090000623 proteins and genes Proteins 0.000 claims 22
- 102000004169 proteins and genes Human genes 0.000 claims 22
- 206010022000 influenza Diseases 0.000 claims 17
- 230000001932 seasonal effect Effects 0.000 claims 8
- 230000036039 immunity Effects 0.000 claims 6
- 230000009385 viral infection Effects 0.000 claims 5
- 230000001939 inductive effect Effects 0.000 claims 3
- 241000282412 Homo Species 0.000 claims 2
- 241000712431 Influenza A virus Species 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 101710154606 Hemagglutinin Proteins 0.000 claims 1
- 102000005348 Neuraminidase Human genes 0.000 claims 1
- 108010006232 Neuraminidase Proteins 0.000 claims 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 1
- 101710176177 Protein A56 Proteins 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000000185 hemagglutinin Substances 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72751305P | 2005-10-18 | 2005-10-18 | |
| US60/727,513 | 2005-10-18 | ||
| US78084706P | 2006-03-10 | 2006-03-10 | |
| US60/780,847 | 2006-03-10 | ||
| US80000606P | 2006-05-15 | 2006-05-15 | |
| US60/800,006 | 2006-05-15 | ||
| US83119606P | 2006-07-17 | 2006-07-17 | |
| US60/831,196 | 2006-07-17 | ||
| US83211606P | 2006-07-21 | 2006-07-21 | |
| US60/832,116 | 2006-07-21 | ||
| US84549506P | 2006-09-19 | 2006-09-19 | |
| US60/845,495 | 2006-09-19 | ||
| PCT/US2006/040862 WO2007047831A2 (en) | 2005-10-18 | 2006-10-18 | Functional influenza virus like particles (vlps) |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012115616A Division JP5771558B2 (ja) | 2005-10-18 | 2012-05-21 | 機能的インフルエンザウイルス様粒子（ｖｌｐ） |
| JP2015016492A Division JP2015083018A (ja) | 2005-10-18 | 2015-01-30 | 機能的インフルエンザウイルス様粒子（ｖｌｐ） |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009511084A JP2009511084A (ja) | 2009-03-19 |
| JP2009511084A5 true JP2009511084A5 (enExample) | 2009-12-03 |
| JP5714799B2 JP5714799B2 (ja) | 2015-05-07 |
Family
ID=37963272
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008536796A Active JP5714799B2 (ja) | 2005-10-18 | 2006-10-18 | 機能的インフルエンザウイルス様粒子（ｖｌｐ） |
| JP2012115616A Active JP5771558B2 (ja) | 2005-10-18 | 2012-05-21 | 機能的インフルエンザウイルス様粒子（ｖｌｐ） |
| JP2015016492A Withdrawn JP2015083018A (ja) | 2005-10-18 | 2015-01-30 | 機能的インフルエンザウイルス様粒子（ｖｌｐ） |
| JP2016088847A Withdrawn JP2016135142A (ja) | 2005-10-18 | 2016-04-27 | 機能的インフルエンザウイルス様粒子（ｖｌｐ） |
| JP2017144662A Pending JP2017189178A (ja) | 2005-10-18 | 2017-07-26 | 機能的インフルエンザウイルス様粒子（ｖｌｐ） |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012115616A Active JP5771558B2 (ja) | 2005-10-18 | 2012-05-21 | 機能的インフルエンザウイルス様粒子（ｖｌｐ） |
| JP2015016492A Withdrawn JP2015083018A (ja) | 2005-10-18 | 2015-01-30 | 機能的インフルエンザウイルス様粒子（ｖｌｐ） |
| JP2016088847A Withdrawn JP2016135142A (ja) | 2005-10-18 | 2016-04-27 | 機能的インフルエンザウイルス様粒子（ｖｌｐ） |
| JP2017144662A Pending JP2017189178A (ja) | 2005-10-18 | 2017-07-26 | 機能的インフルエンザウイルス様粒子（ｖｌｐ） |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1937301B1 (enExample) |
| JP (5) | JP5714799B2 (enExample) |
| KR (1) | KR101359723B1 (enExample) |
| CN (2) | CN103865892B (enExample) |
| AU (1) | AU2006304640B2 (enExample) |
| BR (1) | BRPI0617486A2 (enExample) |
| CA (1) | CA2625406C (enExample) |
| DK (1) | DK1937301T3 (enExample) |
| ES (1) | ES2543056T3 (enExample) |
| HU (1) | HUE026136T2 (enExample) |
| IL (1) | IL190775A (enExample) |
| NZ (1) | NZ567164A (enExample) |
| PL (1) | PL1937301T3 (enExample) |
| PT (1) | PT1937301E (enExample) |
| RU (1) | RU2483751C2 (enExample) |
| SG (1) | SG2014012868A (enExample) |
| SI (1) | SI1937301T1 (enExample) |
| TW (1) | TWI488968B (enExample) |
| WO (1) | WO2007047831A2 (enExample) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0250488A (ja) * | 1988-08-11 | 1990-02-20 | Nec Corp | 超伝導配線 |
| US8551756B2 (en) | 2003-07-11 | 2013-10-08 | Novavax, Inc. | Avian influenza chimeric VLPS |
| WO2007130327A2 (en) | 2006-05-01 | 2007-11-15 | Technovax, Inc. | Influenza virus-like particle (vlp) compositions |
| US9101578B2 (en) | 2006-05-01 | 2015-08-11 | Technovax, Inc. | Polyvalent influenza virus-like particle (VLP) compositions |
| AU2007345768B2 (en) * | 2006-07-27 | 2013-08-01 | Ligocyte Pharmaceuticals, Inc. | Chimeric influenza virus-like particles |
| US8202967B2 (en) | 2006-10-27 | 2012-06-19 | Boehringer Ingelheim Vetmedica, Inc. | H5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use |
| CA2615372A1 (en) * | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| JP2010533737A (ja) * | 2007-07-19 | 2010-10-28 | ノババックス，インコーポレイテッド | キメラ水痘帯状疱疹ウイルス−ウイルス様粒子 |
| AU2008331673B2 (en) * | 2007-11-12 | 2014-12-11 | The Trustees Of The University Of Pennsylvania | Novel vaccines against multiple subtypes of influenza virus |
| KR20100120157A (ko) | 2007-11-27 | 2010-11-12 | 메디카고 인코포레이티드 | 헤마글루티닌을 발현하는 트랜스제닉 식물에서 생산된 재조합 인플루엔자 바이러스-유사 입자(ＶＬＰｓ) |
| EP2294202B1 (en) | 2008-07-08 | 2015-05-20 | Medicago Inc. | Soluble recombinant influenza antigens |
| DK2318530T3 (en) * | 2008-07-18 | 2016-10-03 | Medicago Inc | Ny epitope to immunization against influenza |
| US8394384B2 (en) * | 2008-11-28 | 2013-03-12 | Merial Limited | Recombinant avian influenza vaccine and uses thereof |
| AU2010243490A1 (en) * | 2009-04-30 | 2011-11-24 | Cytos Biotechnology Ag | Influenza hemagglutinin compositions and uses thereof |
| EP2952581A1 (en) * | 2009-05-01 | 2015-12-09 | Redbiotec AG | Recombinant virus-like particles encoded by multi-gene vector |
| TW201738562A (zh) * | 2009-05-28 | 2017-11-01 | 亞培生物股份有限公司 | 體外病原體檢驗技術 |
| HRP20180706T1 (hr) | 2009-06-24 | 2018-06-01 | Medicago Inc. | Kimerna gripa nalik čestici koja sadrži hemaglutinin |
| CN102549148A (zh) | 2009-09-22 | 2012-07-04 | 麦迪卡格公司 | 制备植物来源的vlp的方法 |
| EP2536428B1 (en) * | 2010-02-18 | 2018-12-05 | Technovax, Inc. | Universal virus-like particle (vlp) influenza vaccines |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| JP2012036154A (ja) * | 2010-08-11 | 2012-02-23 | Goshu Yakuhin Kk | 食品 |
| CN101947317B (zh) * | 2010-09-27 | 2012-05-30 | 武汉大学 | 一种h5n1禽流感病毒样颗粒疫苗的规模化制备方法 |
| CN102676461A (zh) * | 2011-03-17 | 2012-09-19 | 中国科学院上海巴斯德研究所 | 一种利用果蝇细胞生产病毒样颗粒的方法及应用 |
| TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
| EA016866B1 (ru) * | 2011-06-06 | 2012-08-30 | Общество С Ограниченной Ответственностью "Форт" (Ооо "Форт") | Вакцина для специфической профилактики гриппа |
| KR101302245B1 (ko) * | 2011-06-27 | 2013-09-02 | 조지아 스테이트 유니버시티 리서치 파운데이션, 인코포레이티드 | 넓은 범위의 교차 방어능력을 갖는 신규한 보강 인플루엔자 백신 |
| AR088028A1 (es) | 2011-08-15 | 2014-05-07 | Boehringer Ingelheim Vetmed | Proteinas h5, de h5n1 para un uso medicinal |
| JP2014527799A (ja) | 2011-08-26 | 2014-10-23 | ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション | 変異型ｐｂ２遺伝子セグメントを有する弱毒化生ワクチンとしてのインフルエンザウイルス |
| JP5884100B2 (ja) * | 2011-08-31 | 2016-03-15 | 公益財団法人東京都医学総合研究所 | 新型インフルエンザウイルス由来ヘマグルチニンタンパク質遺伝子を有するＤＩｓ株由来組換えワクシニアウイルス |
| US11390878B2 (en) | 2011-09-30 | 2022-07-19 | Medicago Inc. | Increasing protein yield in plants |
| TWI700368B (zh) | 2011-09-30 | 2020-08-01 | 苜蓿股份有限公司 | 增加植物類病毒顆粒產率 |
| CA2863658C (en) * | 2012-02-03 | 2023-03-14 | Emory University | Immunostimulatory compositions, particles, and uses related thereto |
| RU2485973C1 (ru) * | 2012-02-28 | 2013-06-27 | Общество с ограниченной ответственностью "НТфарма" | Рекомбинантная трехвалентная вакцина от гриппа человека |
| EP2958586B1 (en) * | 2013-02-21 | 2018-09-05 | Boehringer Ingelheim Vetmedica GmbH | H5 proteins of h5n1 influenza virus for use as a medicament |
| US9649375B2 (en) * | 2013-03-14 | 2017-05-16 | The Administrators Of The Tulane Educational Fund | Immunogenic peptide conjugate and method for inducing an anti-influenza therapeutic antibody response therewith |
| IL295155A (en) | 2013-03-28 | 2022-09-01 | Medicago Inc | Production of influenza virus-like particles in plants |
| US12467058B2 (en) | 2013-03-28 | 2025-11-11 | Aramis Biotechnologies Inc. | Influenza virus-like particle production in plants |
| TWI714522B (zh) | 2014-01-10 | 2021-01-01 | 加拿大商苜蓿股份有限公司 | Cpmv強化子元件 |
| CN103740655A (zh) * | 2014-01-20 | 2014-04-23 | 瑞鑫百奥生物科技（深圳）有限公司 | H5n1禽流感病毒样颗粒及其应用和制备方法、疫苗 |
| AU2015234595B2 (en) | 2014-03-27 | 2021-03-25 | Medicago Inc. | Modified CPMV enhancer elements |
| US10053671B2 (en) | 2014-06-20 | 2018-08-21 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| CN106559986A (zh) * | 2014-06-20 | 2017-04-05 | 美国政府(由卫生和人类服务部的部长所代表) | 多价流感病毒样颗粒(vlp)及其作为疫苗的用途 |
| JP2018530314A (ja) * | 2015-08-28 | 2018-10-18 | ウィスコンシン アルムニ リサーチ ファンデイション | ウイルス様粒子からの感染性インフルエンザウイルスの生成 |
| RU2639491C2 (ru) * | 2015-08-31 | 2017-12-21 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Вирионы и вирусоподобные частицы вируса мозаики альтернантеры как усилители иммунного ответа |
| EP3344291B1 (en) | 2015-09-03 | 2024-11-27 | Novavax, Inc. | Vaccine compositions having improved stability and immunogenicity |
| CA3014435C (en) | 2016-02-19 | 2023-04-18 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza b virus replication for vaccine development |
| WO2017184626A1 (en) * | 2016-04-18 | 2017-10-26 | Emerging Viral Vaccine Limited | Cold adapted and virulence factor deleted live attenuated vaccine suitable for mucosal delivery |
| US12214052B2 (en) | 2017-08-04 | 2025-02-04 | The Hospital For Sick Children | Nanoparticle platform for antibody and vaccine delivery |
| CN107353328A (zh) * | 2017-08-23 | 2017-11-17 | 上海市动物疫病预防控制中心 | 一种重组的h9n2亚型禽流感病毒样颗粒及其制备方法和用途 |
| CN110240634B (zh) * | 2018-03-08 | 2022-09-06 | 普莱柯生物工程股份有限公司 | 一种禽流感病毒样颗粒疫苗、及其制备方法和应用 |
| CN108409842A (zh) * | 2018-03-15 | 2018-08-17 | 山东省农业科学院畜牧兽医研究所 | 一种单克隆抗体及其制备方法 |
| WO2020033527A2 (en) | 2018-08-07 | 2020-02-13 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| JP7655849B2 (ja) | 2018-08-20 | 2025-04-02 | ウィスコンシン アルムニ リサーチ ファンデイション | ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター |
| WO2020163804A1 (en) | 2019-02-08 | 2020-08-13 | Wisconsin Alumni Research Foundation (Warf) | Humanized cell line |
| US11390649B2 (en) | 2019-05-01 | 2022-07-19 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
| US11807872B2 (en) | 2019-08-27 | 2023-11-07 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| US11739303B2 (en) | 2020-01-24 | 2023-08-29 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized NA |
| BR112022018160A2 (pt) * | 2020-03-24 | 2022-10-25 | Byung Chul Ahn | Método de produção de composição de soro para prevenir ou tratar doenças infecciosas relacionadas à mucosa em mamíferos jovens, composição de soro produzida por ele, e uso da mesma |
| KR102151962B1 (ko) * | 2020-03-24 | 2020-09-04 | 안병철 | 어린 포유동물의 전염성 질병을 예방 또는 치료하기 위한 혈청 조성물의 제조방법, 상기 방법에 의해 제조된 혈청 조성물 및 이의 용도 |
| US12290562B2 (en) | 2020-03-25 | 2025-05-06 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| CN113461786B (zh) * | 2020-03-30 | 2022-09-13 | 普莱柯生物工程股份有限公司 | 一种禽流感病毒样颗粒疫苗、及其制备方法和应用 |
| AU2021262999A1 (en) | 2020-05-01 | 2023-01-19 | Sinocelltech Ltd. | Method for improving immunogenicity of protein/peptide antigen |
| CN112342149A (zh) * | 2020-11-12 | 2021-02-09 | 新疆畜牧科学院兽医研究所（新疆畜牧科学院动物临床医学研究中心） | 一种禽流感病毒样颗粒组装表达系统及其应用 |
| CN112979796A (zh) * | 2021-04-27 | 2021-06-18 | 军事科学院军事医学研究院军事兽医研究所 | 马抗甲型h5n1虎源流感病毒免疫球蛋白和特异性免疫球蛋白及其精制方法 |
| CN113862284B (zh) * | 2021-09-13 | 2023-05-26 | 华南农业大学 | 一种编码重组禽流感病毒ha蛋白的基因、病毒样颗粒、疫苗及制备与应用 |
| CN114262720B (zh) * | 2021-12-27 | 2023-07-25 | 河南兴华生物技术有限公司 | 杆状病毒表达系统的信号肽及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4866034A (en) | 1982-05-26 | 1989-09-12 | Ribi Immunochem Research Inc. | Refined detoxified endotoxin |
| US4877611A (en) | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
| US4911928A (en) | 1987-03-13 | 1990-03-27 | Micro-Pak, Inc. | Paucilamellar lipid vesicles |
| US6387373B1 (en) | 1993-01-15 | 2002-05-14 | Novavax, Inc. | Vaccines containing paucilsmellar lipid vesicles as immunological adjuvants |
| US5629021A (en) | 1995-01-31 | 1997-05-13 | Novavax, Inc. | Micellar nanoparticles |
| ATE376059T1 (de) * | 2000-06-23 | 2007-11-15 | Wyeth Corp | Assemblierung von wildtyp und chimären influenzavirus-ähnlichen partikeln (vlps) |
| WO2003068804A2 (en) | 2002-02-14 | 2003-08-21 | Novavax, Inc. | Novel insect cell line |
| US8592197B2 (en) * | 2003-07-11 | 2013-11-26 | Novavax, Inc. | Functional influenza virus-like particles (VLPs) |
-
2006
- 2006-10-18 JP JP2008536796A patent/JP5714799B2/ja active Active
- 2006-10-18 EP EP20060826264 patent/EP1937301B1/en active Active
- 2006-10-18 SG SG2014012868A patent/SG2014012868A/en unknown
- 2006-10-18 NZ NZ567164A patent/NZ567164A/en unknown
- 2006-10-18 PL PL06826264T patent/PL1937301T3/pl unknown
- 2006-10-18 AU AU2006304640A patent/AU2006304640B2/en active Active
- 2006-10-18 ES ES06826264.1T patent/ES2543056T3/es active Active
- 2006-10-18 CN CN201410085506.7A patent/CN103865892B/zh active Active
- 2006-10-18 KR KR1020087011963A patent/KR101359723B1/ko active Active
- 2006-10-18 BR BRPI0617486-8A patent/BRPI0617486A2/pt not_active Application Discontinuation
- 2006-10-18 CA CA2625406A patent/CA2625406C/en active Active
- 2006-10-18 SI SI200631949T patent/SI1937301T1/sl unknown
- 2006-10-18 WO PCT/US2006/040862 patent/WO2007047831A2/en not_active Ceased
- 2006-10-18 TW TW095138390A patent/TWI488968B/zh active
- 2006-10-18 HU HUE06826264A patent/HUE026136T2/en unknown
- 2006-10-18 RU RU2008119501/15A patent/RU2483751C2/ru active
- 2006-10-18 CN CN200680045850.7A patent/CN101325966B/zh active Active
- 2006-10-18 PT PT68262641T patent/PT1937301E/pt unknown
- 2006-10-18 DK DK06826264.1T patent/DK1937301T3/en active
-
2008
- 2008-04-10 IL IL190775A patent/IL190775A/en active IP Right Grant
-
2012
- 2012-05-21 JP JP2012115616A patent/JP5771558B2/ja active Active
-
2015
- 2015-01-30 JP JP2015016492A patent/JP2015083018A/ja not_active Withdrawn
-
2016
- 2016-04-27 JP JP2016088847A patent/JP2016135142A/ja not_active Withdrawn
-
2017
- 2017-07-26 JP JP2017144662A patent/JP2017189178A/ja active Pending
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