JP5714799B2 - 機能的インフルエンザウイルス様粒子(vlp) - Google Patents

機能的インフルエンザウイルス様粒子(vlp) Download PDF

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JP5714799B2
JP5714799B2 JP2008536796A JP2008536796A JP5714799B2 JP 5714799 B2 JP5714799 B2 JP 5714799B2 JP 2008536796 A JP2008536796 A JP 2008536796A JP 2008536796 A JP2008536796 A JP 2008536796A JP 5714799 B2 JP5714799 B2 JP 5714799B2
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influenza
vlp
protein
virus
proteins
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JP2009511084A5 (enExample
JP2009511084A (ja
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ゲイル スミス,
ゲイル スミス,
リック ブライト,
リック ブライト,
ピーター プッシュコ,
ピーター プッシュコ,
チンユー チャン,
チンユー チャン,
クトゥブ マハムッド,
クトゥブ マハムッド,
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ノババックス インコーポレイテッド
ノババックス インコーポレイテッド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/145Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08RNA viruses
    • C07K14/11Orthomyxoviridae, e.g. influenza virus
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5258Virus-like particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16123Virus like particles [VLP]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
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  • Engineering & Computer Science (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Zoology (AREA)
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  • Wood Science & Technology (AREA)
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  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2008536796A 2005-10-18 2006-10-18 機能的インフルエンザウイルス様粒子(vlp) Active JP5714799B2 (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US72751305P 2005-10-18 2005-10-18
US60/727,513 2005-10-18
US78084706P 2006-03-10 2006-03-10
US60/780,847 2006-03-10
US80000606P 2006-05-15 2006-05-15
US60/800,006 2006-05-15
US83119606P 2006-07-17 2006-07-17
US60/831,196 2006-07-17
US83211606P 2006-07-21 2006-07-21
US60/832,116 2006-07-21
US84549506P 2006-09-19 2006-09-19
US60/845,495 2006-09-19
PCT/US2006/040862 WO2007047831A2 (en) 2005-10-18 2006-10-18 Functional influenza virus like particles (vlps)

Related Child Applications (2)

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JP2012115616A Division JP5771558B2 (ja) 2005-10-18 2012-05-21 機能的インフルエンザウイルス様粒子(vlp)
JP2015016492A Division JP2015083018A (ja) 2005-10-18 2015-01-30 機能的インフルエンザウイルス様粒子(vlp)

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JP2009511084A JP2009511084A (ja) 2009-03-19
JP2009511084A5 JP2009511084A5 (enExample) 2009-12-03
JP5714799B2 true JP5714799B2 (ja) 2015-05-07

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JP2008536796A Active JP5714799B2 (ja) 2005-10-18 2006-10-18 機能的インフルエンザウイルス様粒子(vlp)
JP2012115616A Active JP5771558B2 (ja) 2005-10-18 2012-05-21 機能的インフルエンザウイルス様粒子(vlp)
JP2015016492A Withdrawn JP2015083018A (ja) 2005-10-18 2015-01-30 機能的インフルエンザウイルス様粒子(vlp)
JP2016088847A Withdrawn JP2016135142A (ja) 2005-10-18 2016-04-27 機能的インフルエンザウイルス様粒子(vlp)
JP2017144662A Pending JP2017189178A (ja) 2005-10-18 2017-07-26 機能的インフルエンザウイルス様粒子(vlp)

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JP2012115616A Active JP5771558B2 (ja) 2005-10-18 2012-05-21 機能的インフルエンザウイルス様粒子(vlp)
JP2015016492A Withdrawn JP2015083018A (ja) 2005-10-18 2015-01-30 機能的インフルエンザウイルス様粒子(vlp)
JP2016088847A Withdrawn JP2016135142A (ja) 2005-10-18 2016-04-27 機能的インフルエンザウイルス様粒子(vlp)
JP2017144662A Pending JP2017189178A (ja) 2005-10-18 2017-07-26 機能的インフルエンザウイルス様粒子(vlp)

Country Status (19)

Country Link
EP (1) EP1937301B1 (enExample)
JP (5) JP5714799B2 (enExample)
KR (1) KR101359723B1 (enExample)
CN (2) CN103865892B (enExample)
AU (1) AU2006304640B2 (enExample)
BR (1) BRPI0617486A2 (enExample)
CA (1) CA2625406C (enExample)
DK (1) DK1937301T3 (enExample)
ES (1) ES2543056T3 (enExample)
HU (1) HUE026136T2 (enExample)
IL (1) IL190775A (enExample)
NZ (1) NZ567164A (enExample)
PL (1) PL1937301T3 (enExample)
PT (1) PT1937301E (enExample)
RU (1) RU2483751C2 (enExample)
SG (1) SG2014012868A (enExample)
SI (1) SI1937301T1 (enExample)
TW (1) TWI488968B (enExample)
WO (1) WO2007047831A2 (enExample)

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