ES2543056T3 - Partículas funcionales similares al virus de la gripe (VPL) - Google Patents
Partículas funcionales similares al virus de la gripe (VPL) Download PDFInfo
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- ES2543056T3 ES2543056T3 ES06826264.1T ES06826264T ES2543056T3 ES 2543056 T3 ES2543056 T3 ES 2543056T3 ES 06826264 T ES06826264 T ES 06826264T ES 2543056 T3 ES2543056 T3 ES 2543056T3
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- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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Landscapes
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Applications Claiming Priority (13)
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| US845495P | 2006-09-19 | ||
| PCT/US2006/040862 WO2007047831A2 (en) | 2005-10-18 | 2006-10-18 | Functional influenza virus like particles (vlps) |
Publications (1)
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Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0250488A (ja) * | 1988-08-11 | 1990-02-20 | Nec Corp | 超伝導配線 |
| US8551756B2 (en) | 2003-07-11 | 2013-10-08 | Novavax, Inc. | Avian influenza chimeric VLPS |
| WO2007130327A2 (en) | 2006-05-01 | 2007-11-15 | Technovax, Inc. | Influenza virus-like particle (vlp) compositions |
| US9101578B2 (en) | 2006-05-01 | 2015-08-11 | Technovax, Inc. | Polyvalent influenza virus-like particle (VLP) compositions |
| AU2007345768B2 (en) * | 2006-07-27 | 2013-08-01 | Ligocyte Pharmaceuticals, Inc. | Chimeric influenza virus-like particles |
| US8202967B2 (en) | 2006-10-27 | 2012-06-19 | Boehringer Ingelheim Vetmedica, Inc. | H5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use |
| CA2615372A1 (en) * | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| JP2010533737A (ja) * | 2007-07-19 | 2010-10-28 | ノババックス，インコーポレイテッド | キメラ水痘帯状疱疹ウイルス−ウイルス様粒子 |
| AU2008331673B2 (en) * | 2007-11-12 | 2014-12-11 | The Trustees Of The University Of Pennsylvania | Novel vaccines against multiple subtypes of influenza virus |
| KR20100120157A (ko) | 2007-11-27 | 2010-11-12 | 메디카고 인코포레이티드 | 헤마글루티닌을 발현하는 트랜스제닉 식물에서 생산된 재조합 인플루엔자 바이러스-유사 입자(ＶＬＰｓ) |
| EP2294202B1 (en) | 2008-07-08 | 2015-05-20 | Medicago Inc. | Soluble recombinant influenza antigens |
| DK2318530T3 (en) * | 2008-07-18 | 2016-10-03 | Medicago Inc | Ny epitope to immunization against influenza |
| US8394384B2 (en) * | 2008-11-28 | 2013-03-12 | Merial Limited | Recombinant avian influenza vaccine and uses thereof |
| AU2010243490A1 (en) * | 2009-04-30 | 2011-11-24 | Cytos Biotechnology Ag | Influenza hemagglutinin compositions and uses thereof |
| EP2952581A1 (en) * | 2009-05-01 | 2015-12-09 | Redbiotec AG | Recombinant virus-like particles encoded by multi-gene vector |
| TW201738562A (zh) * | 2009-05-28 | 2017-11-01 | 亞培生物股份有限公司 | 體外病原體檢驗技術 |
| HRP20180706T1 (hr) | 2009-06-24 | 2018-06-01 | Medicago Inc. | Kimerna gripa nalik čestici koja sadrži hemaglutinin |
| CN102549148A (zh) | 2009-09-22 | 2012-07-04 | 麦迪卡格公司 | 制备植物来源的vlp的方法 |
| EP2536428B1 (en) * | 2010-02-18 | 2018-12-05 | Technovax, Inc. | Universal virus-like particle (vlp) influenza vaccines |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| JP2012036154A (ja) * | 2010-08-11 | 2012-02-23 | Goshu Yakuhin Kk | 食品 |
| CN101947317B (zh) * | 2010-09-27 | 2012-05-30 | 武汉大学 | 一种h5n1禽流感病毒样颗粒疫苗的规模化制备方法 |
| CN102676461A (zh) * | 2011-03-17 | 2012-09-19 | 中国科学院上海巴斯德研究所 | 一种利用果蝇细胞生产病毒样颗粒的方法及应用 |
| TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
| EA016866B1 (ru) * | 2011-06-06 | 2012-08-30 | Общество С Ограниченной Ответственностью "Форт" (Ооо "Форт") | Вакцина для специфической профилактики гриппа |
| KR101302245B1 (ko) * | 2011-06-27 | 2013-09-02 | 조지아 스테이트 유니버시티 리서치 파운데이션, 인코포레이티드 | 넓은 범위의 교차 방어능력을 갖는 신규한 보강 인플루엔자 백신 |
| AR088028A1 (es) | 2011-08-15 | 2014-05-07 | Boehringer Ingelheim Vetmed | Proteinas h5, de h5n1 para un uso medicinal |
| JP2014527799A (ja) | 2011-08-26 | 2014-10-23 | ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション | 変異型ｐｂ２遺伝子セグメントを有する弱毒化生ワクチンとしてのインフルエンザウイルス |
| JP5884100B2 (ja) * | 2011-08-31 | 2016-03-15 | 公益財団法人東京都医学総合研究所 | 新型インフルエンザウイルス由来ヘマグルチニンタンパク質遺伝子を有するＤＩｓ株由来組換えワクシニアウイルス |
| US11390878B2 (en) | 2011-09-30 | 2022-07-19 | Medicago Inc. | Increasing protein yield in plants |
| TWI700368B (zh) | 2011-09-30 | 2020-08-01 | 苜蓿股份有限公司 | 增加植物類病毒顆粒產率 |
| CA2863658C (en) * | 2012-02-03 | 2023-03-14 | Emory University | Immunostimulatory compositions, particles, and uses related thereto |
| RU2485973C1 (ru) * | 2012-02-28 | 2013-06-27 | Общество с ограниченной ответственностью "НТфарма" | Рекомбинантная трехвалентная вакцина от гриппа человека |
| EP2958586B1 (en) * | 2013-02-21 | 2018-09-05 | Boehringer Ingelheim Vetmedica GmbH | H5 proteins of h5n1 influenza virus for use as a medicament |
| US9649375B2 (en) * | 2013-03-14 | 2017-05-16 | The Administrators Of The Tulane Educational Fund | Immunogenic peptide conjugate and method for inducing an anti-influenza therapeutic antibody response therewith |
| IL295155A (en) | 2013-03-28 | 2022-09-01 | Medicago Inc | Production of influenza virus-like particles in plants |
| US12467058B2 (en) | 2013-03-28 | 2025-11-11 | Aramis Biotechnologies Inc. | Influenza virus-like particle production in plants |
| TWI714522B (zh) | 2014-01-10 | 2021-01-01 | 加拿大商苜蓿股份有限公司 | Cpmv強化子元件 |
| CN103740655A (zh) * | 2014-01-20 | 2014-04-23 | 瑞鑫百奥生物科技（深圳）有限公司 | H5n1禽流感病毒样颗粒及其应用和制备方法、疫苗 |
| AU2015234595B2 (en) | 2014-03-27 | 2021-03-25 | Medicago Inc. | Modified CPMV enhancer elements |
| US10053671B2 (en) | 2014-06-20 | 2018-08-21 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| CN106559986A (zh) * | 2014-06-20 | 2017-04-05 | 美国政府(由卫生和人类服务部的部长所代表) | 多价流感病毒样颗粒(vlp)及其作为疫苗的用途 |
| JP2018530314A (ja) * | 2015-08-28 | 2018-10-18 | ウィスコンシン アルムニ リサーチ ファンデイション | ウイルス様粒子からの感染性インフルエンザウイルスの生成 |
| RU2639491C2 (ru) * | 2015-08-31 | 2017-12-21 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Вирионы и вирусоподобные частицы вируса мозаики альтернантеры как усилители иммунного ответа |
| EP3344291B1 (en) | 2015-09-03 | 2024-11-27 | Novavax, Inc. | Vaccine compositions having improved stability and immunogenicity |
| CA3014435C (en) | 2016-02-19 | 2023-04-18 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza b virus replication for vaccine development |
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| US12214052B2 (en) | 2017-08-04 | 2025-02-04 | The Hospital For Sick Children | Nanoparticle platform for antibody and vaccine delivery |
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| CN110240634B (zh) * | 2018-03-08 | 2022-09-06 | 普莱柯生物工程股份有限公司 | 一种禽流感病毒样颗粒疫苗、及其制备方法和应用 |
| CN108409842A (zh) * | 2018-03-15 | 2018-08-17 | 山东省农业科学院畜牧兽医研究所 | 一种单克隆抗体及其制备方法 |
| WO2020033527A2 (en) | 2018-08-07 | 2020-02-13 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| JP7655849B2 (ja) | 2018-08-20 | 2025-04-02 | ウィスコンシン アルムニ リサーチ ファンデイション | ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター |
| WO2020163804A1 (en) | 2019-02-08 | 2020-08-13 | Wisconsin Alumni Research Foundation (Warf) | Humanized cell line |
| US11390649B2 (en) | 2019-05-01 | 2022-07-19 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
| US11807872B2 (en) | 2019-08-27 | 2023-11-07 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| US11739303B2 (en) | 2020-01-24 | 2023-08-29 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized NA |
| BR112022018160A2 (pt) * | 2020-03-24 | 2022-10-25 | Byung Chul Ahn | Método de produção de composição de soro para prevenir ou tratar doenças infecciosas relacionadas à mucosa em mamíferos jovens, composição de soro produzida por ele, e uso da mesma |
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| US12290562B2 (en) | 2020-03-25 | 2025-05-06 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| CN113461786B (zh) * | 2020-03-30 | 2022-09-13 | 普莱柯生物工程股份有限公司 | 一种禽流感病毒样颗粒疫苗、及其制备方法和应用 |
| AU2021262999A1 (en) | 2020-05-01 | 2023-01-19 | Sinocelltech Ltd. | Method for improving immunogenicity of protein/peptide antigen |
| CN112342149A (zh) * | 2020-11-12 | 2021-02-09 | 新疆畜牧科学院兽医研究所（新疆畜牧科学院动物临床医学研究中心） | 一种禽流感病毒样颗粒组装表达系统及其应用 |
| CN112979796A (zh) * | 2021-04-27 | 2021-06-18 | 军事科学院军事医学研究院军事兽医研究所 | 马抗甲型h5n1虎源流感病毒免疫球蛋白和特异性免疫球蛋白及其精制方法 |
| CN113862284B (zh) * | 2021-09-13 | 2023-05-26 | 华南农业大学 | 一种编码重组禽流感病毒ha蛋白的基因、病毒样颗粒、疫苗及制备与应用 |
| CN114262720B (zh) * | 2021-12-27 | 2023-07-25 | 河南兴华生物技术有限公司 | 杆状病毒表达系统的信号肽及其应用 |
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| US4866034A (en) | 1982-05-26 | 1989-09-12 | Ribi Immunochem Research Inc. | Refined detoxified endotoxin |
| US4877611A (en) | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
| US4911928A (en) | 1987-03-13 | 1990-03-27 | Micro-Pak, Inc. | Paucilamellar lipid vesicles |
| US6387373B1 (en) | 1993-01-15 | 2002-05-14 | Novavax, Inc. | Vaccines containing paucilsmellar lipid vesicles as immunological adjuvants |
| US5629021A (en) | 1995-01-31 | 1997-05-13 | Novavax, Inc. | Micellar nanoparticles |
| ATE376059T1 (de) * | 2000-06-23 | 2007-11-15 | Wyeth Corp | Assemblierung von wildtyp und chimären influenzavirus-ähnlichen partikeln (vlps) |
| WO2003068804A2 (en) | 2002-02-14 | 2003-08-21 | Novavax, Inc. | Novel insect cell line |
| US8592197B2 (en) * | 2003-07-11 | 2013-11-26 | Novavax, Inc. | Functional influenza virus-like particles (VLPs) |
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