JP2004513168A5 - - Google Patents

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Publication number
JP2004513168A5
JP2004513168A5 JP2002541095A JP2002541095A JP2004513168A5 JP 2004513168 A5 JP2004513168 A5 JP 2004513168A5 JP 2002541095 A JP2002541095 A JP 2002541095A JP 2002541095 A JP2002541095 A JP 2002541095A JP 2004513168 A5 JP2004513168 A5 JP 2004513168A5
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JP
Japan
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alkyl
formula
methyl
ring
compound
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JP2002541095A
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Japanese (ja)
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JP2004513168A (ja
JP4234426B2 (ja
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Priority claimed from PCT/EP2001/012785 external-priority patent/WO2002038561A1/en
Publication of JP2004513168A publication Critical patent/JP2004513168A/ja
Publication of JP2004513168A5 publication Critical patent/JP2004513168A5/ja
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Publication of JP4234426B2 publication Critical patent/JP4234426B2/ja
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JP2002541095A 2000-11-07 2001-11-05 プロテインキナーゼcインヒビターとしてのインドリルマレイミド誘導体 Expired - Fee Related JP4234426B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24640000P 2000-11-07 2000-11-07
US28370501P 2001-04-13 2001-04-13
PCT/EP2001/012785 WO2002038561A1 (en) 2000-11-07 2001-11-05 Indolylmaleimide derivatives as protein kinase c inhibitors

Publications (3)

Publication Number Publication Date
JP2004513168A JP2004513168A (ja) 2004-04-30
JP2004513168A5 true JP2004513168A5 (enExample) 2005-04-21
JP4234426B2 JP4234426B2 (ja) 2009-03-04

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JP2002541095A Expired - Fee Related JP4234426B2 (ja) 2000-11-07 2001-11-05 プロテインキナーゼcインヒビターとしてのインドリルマレイミド誘導体

Country Status (30)

Country Link
EP (2) EP1337527B1 (enExample)
JP (1) JP4234426B2 (enExample)
KR (3) KR20080014934A (enExample)
CN (1) CN1253449C (enExample)
AR (1) AR035211A1 (enExample)
AT (1) ATE445613T1 (enExample)
AU (3) AU2181002A (enExample)
BR (1) BRPI0115193B1 (enExample)
CA (1) CA2428133C (enExample)
CY (1) CY1110564T1 (enExample)
CZ (1) CZ307144B6 (enExample)
DE (1) DE60140201D1 (enExample)
DK (1) DK1337527T3 (enExample)
EC (1) ECSP104578A (enExample)
ES (1) ES2332770T3 (enExample)
HU (1) HU228999B1 (enExample)
IL (3) IL155618A0 (enExample)
MX (1) MXPA03004037A (enExample)
MY (2) MY127157A (enExample)
NO (1) NO327427B1 (enExample)
NZ (2) NZ525656A (enExample)
PE (1) PE20020544A1 (enExample)
PL (1) PL208794B1 (enExample)
PT (1) PT1337527E (enExample)
RU (2) RU2329263C2 (enExample)
SG (1) SG159378A1 (enExample)
SI (1) SI1337527T1 (enExample)
SK (1) SK287919B6 (enExample)
TW (2) TW200738687A (enExample)
WO (1) WO2002038561A1 (enExample)

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JP2005531609A (ja) 2002-06-05 2005-10-20 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ キナーゼ阻害剤としてのシスインドリル−マレイミド誘導体
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GB0303319D0 (en) * 2003-02-13 2003-03-19 Novartis Ag Organic compounds
US8598146B2 (en) 2003-09-16 2013-12-03 Garvan Institute Of Medical Research Methods for identifying modulators of protein kinase C-epsilon (PKCε) and method of treatment of aberrant glucose metabolism associated therewith
WO2005039549A1 (en) * 2003-10-27 2005-05-06 Novartis Ag Indolyl-pyrroledione derivatives for the treatment of neurological and vascular disorders related to beta-amyloid generation and/or aggregation
EP1687002A4 (en) * 2003-11-10 2008-07-23 Synta Pharmaceuticals Corp CONDENSED HETEROCYCLIC COMPOUNDS
EP1745037B1 (en) * 2004-01-19 2013-01-02 Novartis AG Indolylmaleimide derivatives as inhibitors for the treatment of graft rejection or autoimmune diseases
GB0401089D0 (en) * 2004-01-19 2004-02-18 Novartis Ag Organic compounds
US20070232658A1 (en) * 2004-04-08 2007-10-04 Jurgen Wagner Protein Kinase C Inhibitors for the Treatment of Autoimmune Diseases and of Transplant Rejiction
GB0410713D0 (en) * 2004-05-13 2004-06-16 Novartis Ag Organic compounds
AU2005313485B2 (en) 2004-12-08 2011-02-03 Johannes Gutenberg-Universitat Mainz 3-(indolyl)-4-arylmaleimide derivatives and their use as angiogenesis inhibitors
GB0504203D0 (en) * 2005-03-01 2005-04-06 Novartis Ag Organic compounds
GB0507918D0 (en) 2005-04-19 2005-05-25 Novartis Ag Organic compounds
EP1885454A2 (en) 2005-05-04 2008-02-13 DeveloGen Aktiengesellschaft Use of gsk-3 inhibitors for preventing and treating pancreatic autoimmune disorders
GB0511060D0 (en) 2005-05-31 2005-07-06 Novartis Ag Organic compounds
EP2246346B1 (en) 2005-07-11 2012-10-24 Novartis AG Indolylmaleimide derivatives as protein kinase inhibitors
PL2848258T3 (pl) 2005-10-26 2018-06-29 Novartis Ag Leczenie rodzinnej gorączki śródziemnomorskiej przeciwciałami przeciwko IL-1beta
NO20220050A1 (no) 2005-11-21 2008-08-12 Novartis Ag Neuroendokrin tumorbehandling
GB0601744D0 (en) 2006-01-27 2006-03-08 Novartis Ag Organic compounds
GB0605691D0 (en) * 2006-03-21 2006-05-03 Novartis Ag Organic Compounds
GB0613162D0 (en) * 2006-06-30 2006-08-09 Novartis Ag Organic compounds
JP2010501586A (ja) * 2006-08-23 2010-01-21 ノバルティス アクチエンゲゼルシャフト 眼疾患におけるpkc阻害剤、特にインドリルマレイミド誘導体の使用
WO2008051440A1 (en) * 2006-10-20 2008-05-02 Novartis Ag Crystal modifications -3- (1h-ind0l-3-yl) -4- [2- (4-methyl-piperazin-1-yl) -quinazolin-4-yl] -pyrrole-2, 5-d ione
CA2671040A1 (en) * 2006-12-07 2008-06-19 Novartis Ag Use of pkc inhibitors in transplantation
KR20090100363A (ko) 2006-12-19 2009-09-23 노파르티스 아게 키나제 억제제로서의 인돌릴말레이미드 유도체
CA2679484A1 (en) * 2007-03-09 2008-09-18 Novartis Ag Salts of 3-(1h-ind0l-3-yl)-4-[2-(4-methyl-piperazin-i-yl)-quinazolin-4-yl]-pyrrole-2,5-dione
KR101591533B1 (ko) 2007-05-29 2016-02-03 노파르티스 아게 항-il-1-베타 치료법에 대한 신규 적응증
MX2010003259A (es) * 2007-09-27 2010-04-12 Novartis Ag Ensayo de monitoreo de farmacos.
EP2209916B1 (en) 2007-11-08 2011-12-21 Novartis AG Gene expression signatures for chronic/sclerosing allograft nephropathy
AU2008333215B2 (en) 2007-12-05 2013-06-13 Johannes Gutenberg-Universitat Mainz Use of 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide derivatives in leukemia management
US8268834B2 (en) 2008-03-19 2012-09-18 Novartis Ag Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
US9752191B2 (en) 2009-07-09 2017-09-05 The Scripps Research Institute Gene expression profiles associated with chronic allograft nephropathy
RU2441000C2 (ru) * 2009-11-27 2012-01-27 Общество с ограниченной ответственностью "Молекулярные Технологии" 4-(1-(4-(4-метоксифенилтио)-2,5-диоксо-2,5-дигидро-1н-пирро-3-ил)-1н-индол-3-ил)бутилкарбамимидотиоат и способ его применения
EP2338486A1 (en) 2009-12-18 2011-06-29 Johannes Gutenberg-Universität Mainz 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide derivatives for use in the treatment of colon and gastric adenocarcinoma
EP2343291A1 (en) 2009-12-18 2011-07-13 Johannes Gutenberg-Universität Mainz 3-(Indolyl)- or 3-(Azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment
US8791100B2 (en) 2010-02-02 2014-07-29 Novartis Ag Aryl benzylamine compounds
BR112012024585A2 (pt) * 2010-03-30 2016-05-31 Novartis Ag inibidores de pkc para o tratamento de linfomade células b tendo sinalização do receptor de células b ativas crônicas
UA112517C2 (uk) 2010-07-06 2016-09-26 Новартіс Аг Тетрагідропіридопіримідинові похідні
EP2474541A1 (en) 2010-12-23 2012-07-11 Johannes- Gutenberg-Universität Mainz Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment
CN102153605B (zh) * 2011-03-02 2014-02-19 福建省微生物研究所 一种咪唑立宾的提纯方法
UY34072A (es) 2011-05-17 2013-01-03 Novartis Ag Derivados sustituidos de indol
AU2012277391A1 (en) 2011-06-27 2013-12-19 Novartis Ag Solid forms and salts of tetrahydro-pyrido-pyrimidine derivatives
GB201111427D0 (en) * 2011-07-05 2011-08-17 Amakem Nv Novel bisindolylmaleimides, pan-pkc inhibitors
WO2013008095A1 (en) 2011-07-08 2013-01-17 Novartis Ag Novel pyrrolo pyrimidine derivatives
US8846712B2 (en) 2011-09-12 2014-09-30 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013057711A1 (en) 2011-10-21 2013-04-25 Novartis Ag Quinazoline derivatives as pi3k modulators
AP2014007680A0 (en) 2011-12-02 2014-06-30 Novartis Ag Anti-1L-beta (interleukin-1beta) antibody-based prophylactic therapy to prevent complications leading to vaso-occlusion in sickle cell disease
CA2857302C (en) 2011-12-15 2020-08-25 Novartis Ag Use of inhibitors of the activity or function of pi3k
US20150148377A1 (en) 2011-12-22 2015-05-28 Novartis Ag Quinoline Derivatives
IN2014CN04174A (enExample) 2011-12-22 2015-09-04 Novartis Ag
EP2847191B1 (en) 2012-05-09 2016-06-15 Sanofi Substituted 6-(4-hydroxy-phenyl)-1h-pyrazolo[3,4-b]pyridine derivatives as kinase inhibitors
AU2013343059A1 (en) 2012-11-07 2015-04-09 Novartis Ag Substituted indole derivatives
TW201422625A (zh) 2012-11-26 2014-06-16 Novartis Ag 二氫-吡啶并-□衍生物之固體形式
PL2925366T3 (pl) * 2012-11-29 2018-08-31 Novartis Ag Kombinacje farmaceutyczne
US9993463B2 (en) 2012-12-10 2018-06-12 Centogene Ag Use of maleimide derivatives for preventing and treating cancer
WO2014090398A1 (en) * 2012-12-10 2014-06-19 Centogene Ag Use of maleimide derivatives for preventing and treating leukemia
WO2014128612A1 (en) 2013-02-20 2014-08-28 Novartis Ag Quinazolin-4-one derivatives
WO2014174478A1 (en) 2013-04-26 2014-10-30 Novartis Ag Pharmaceutical combinations of a pkc inhibitor and a c-met receptor tyrosine kinase inhibitor
WO2015179773A1 (en) 2014-05-22 2015-11-26 The Scripps Research Institute Tissue molecular signatures of kidney transplant rejections
KR20160060100A (ko) 2013-09-22 2016-05-27 칼리토르 사이언시즈, 엘엘씨 치환된 아미노피리미딘 화합물 및 이용 방법
US9512084B2 (en) 2013-11-29 2016-12-06 Novartis Ag Amino pyrimidine derivatives
WO2015148868A1 (en) 2014-03-28 2015-10-01 Calitor Sciences, Llc Substituted heteroaryl compounds and methods of use
BR112016024533A8 (pt) 2014-04-24 2021-03-30 Novartis Ag derivados de amino pirazina como inibidores de fosfatidilinositol 3-cinase ou sal, seu uso, e composição e combinação farmacêuticas
KR20160141856A (ko) 2014-04-24 2016-12-09 노파르티스 아게 포스파티딜이노시톨 3-키나제 억제제로서의 피라진 유도체
CN106458980A (zh) 2014-04-24 2017-02-22 诺华股份有限公司 作为磷脂酰肌醇3‑激酶抑制剂的氨基吡啶衍生物
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
JO3589B1 (ar) 2014-08-06 2020-07-05 Novartis Ag مثبطات كيناز البروتين c وطرق استخداماتها
MX2018001903A (es) 2015-08-14 2018-06-20 Novartis Ag Inhibidores de mdm2 para el tratamiento de melanoma uveal.
US9938257B2 (en) 2015-09-11 2018-04-10 Calitor Sciences, Llc Substituted heteroaryl compounds and methods of use
EP3187495A1 (en) 2015-12-30 2017-07-05 Johannes Gutenberg-Universität Mainz 3-(5-fluoroindolyl)-4-arylmaleimide compounds and their use in tumor treatment
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