JP2004526699A5 - - Google Patents
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- Publication number
- JP2004526699A5 JP2004526699A5 JP2002561022A JP2002561022A JP2004526699A5 JP 2004526699 A5 JP2004526699 A5 JP 2004526699A5 JP 2002561022 A JP2002561022 A JP 2002561022A JP 2002561022 A JP2002561022 A JP 2002561022A JP 2004526699 A5 JP2004526699 A5 JP 2004526699A5
- Authority
- JP
- Japan
- Prior art keywords
- indol
- ester
- methylpiperidin
- acid
- benzenesulfonic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26499601P | 2001-01-30 | 2001-01-30 | |
| PCT/US2002/000502 WO2002060871A2 (en) | 2001-01-30 | 2002-01-17 | Benzenesulfonic acid indol-5-yl esters as antagonists of the 5-ht6 receptor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004526699A JP2004526699A (ja) | 2004-09-02 |
| JP2004526699A5 true JP2004526699A5 (enExample) | 2005-12-22 |
Family
ID=23008516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002561022A Pending JP2004526699A (ja) | 2001-01-30 | 2002-01-17 | ５−ｈｔ６受容体の拮抗薬としてのベンゼンスルホン酸インドール−５−イルエステル類 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7230011B2 (enExample) |
| EP (1) | EP1377580B1 (enExample) |
| JP (1) | JP2004526699A (enExample) |
| CN (1) | CN1275967C (enExample) |
| AT (1) | ATE340795T1 (enExample) |
| AU (1) | AU2002236730B2 (enExample) |
| BR (1) | BR0206595A (enExample) |
| CA (1) | CA2433351A1 (enExample) |
| DE (1) | DE60214990T2 (enExample) |
| ES (1) | ES2272667T3 (enExample) |
| MX (1) | MXPA03006605A (enExample) |
| WO (1) | WO2002060871A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2222828B1 (es) * | 2003-07-30 | 2006-04-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de 1-sulfonilindoles, su preparacion y su aplicacion como medicamentos. |
| ES2222829B1 (es) * | 2003-07-30 | 2006-03-01 | Laboratorios Del Dr. Esteve, S.A. | Derivados de 4-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos. |
| ES2222832B1 (es) * | 2003-07-30 | 2006-02-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de 6-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos. |
| ES2222830B1 (es) | 2003-07-30 | 2006-02-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de 7-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos. |
| ES2222827B1 (es) * | 2003-07-30 | 2006-03-01 | Laboratorios Del Dr. Esteve, S.A. | Derivados de 5-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos. |
| MXPA06007415A (es) * | 2004-01-02 | 2007-01-26 | Suven Life Sciences Ltd | Inden [2, 1a] indenos e isoindol [2,1-a] indoles novedosos. |
| JP2009501705A (ja) * | 2005-07-05 | 2009-01-22 | アストラゼネカ・アクチエボラーグ | 新規化合物、その製造方法、中間体、医薬組成物、並びにアルツハイマー病、認知障害、統合失調症に伴う認識機能障害、肥満及びパーキンソン病のような５−ｈｔ６介在疾患の治療におけるそれらの使用 |
| JP2009515833A (ja) * | 2005-10-24 | 2009-04-16 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ３−ピペリジン−４−イル−インドールｏｒｌ−１受容体モジュレーター |
| AU2007217040A1 (en) | 2006-02-17 | 2007-08-30 | Memory Pharmaceuticals Corporation | Compounds having 5-HT6 receptor affinity |
| AR061637A1 (es) * | 2006-06-26 | 2008-09-10 | Epix Delaware Inc | Composiciones y metodos de tratamiento de trastornos del snc |
| ATE537166T1 (de) * | 2006-10-27 | 2011-12-15 | Boehringer Ingelheim Int | Piperidylpropanthiole als ccr3-modulatoren |
| WO2008049875A1 (en) * | 2006-10-27 | 2008-05-02 | Boehringer Ingelheim International Gmbh | Novel substituted piperidyl-propane-thiols |
| JP2010515674A (ja) | 2007-01-08 | 2010-05-13 | スベン ライフ サイエンシズ リミティド | ５−（ヘテロシクリル）アルキル−ｎ−（アリールスルホニル）インドール化合物および５−ｈｔ６リガンドとしてのそれらの使用 |
| CA2683124C (en) | 2007-05-03 | 2012-09-25 | Suven Life Sciences Limited | Aminoalkoxy aryl sulfonamide compounds and their use as 5-ht6 ligands |
| AU2008315309B2 (en) | 2007-10-26 | 2011-06-09 | Suven Life Sciences Limited | Amino arylsulfonamide compounds and their use as 5-HT6 ligands |
| US8318725B2 (en) | 2008-09-17 | 2012-11-27 | Suven Life Sciences Limited | Aryl indolyl sulfonamide compounds and their use as 5-HT6 ligands |
| ES2424036T3 (es) | 2008-09-17 | 2013-09-26 | Suven Life Sciences Limited | Compuestos de amina de arilsulfonamida y su uso como ligandos de 5-HT6 |
| US8563567B2 (en) | 2009-12-30 | 2013-10-22 | Arqule, Inc. | Substituted heterocyclic compounds |
| MX2012007783A (es) | 2010-01-05 | 2012-10-03 | Suven Life Sciences Ltd | Compuestos sulfona que actuan como ligandos del receptor 5-ht6. |
| KR101250606B1 (ko) * | 2011-01-24 | 2013-04-03 | 이화여자대학교 산학협력단 | 5-ｈｔ６ 수용체 억제 작용을 갖는 신규한 벤조티아졸 및 벤즈이소티아졸유도체, 이의 제조 방법 및 이를 포함하는 약학적 조성물 |
| AU2012321345B2 (en) * | 2011-10-03 | 2016-03-17 | The University Of Utah Research Foundation | Application of 5-HT6 receptor antagonists for the alleviation of cognitive deficits of down syndrome |
| WO2015082499A2 (en) * | 2013-12-03 | 2015-06-11 | Iomet Pharma Ltd | Pharmaceutical compound |
| EP3166924B1 (en) | 2014-07-08 | 2019-02-20 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
| EP3250561A1 (en) * | 2015-01-30 | 2017-12-06 | Pfizer Inc | Sulfonamide-subsituted indole modulators of rorc2 and methods of use thereof |
| EP3331530A4 (en) * | 2015-08-03 | 2018-12-19 | Raze Therapeutics Inc. | Mthfd2 inhibitors and uses thereof |
| CN115521307B (zh) * | 2022-09-30 | 2023-09-22 | 甘肃皓天医药科技有限责任公司 | 一种5-卤代-7-氮杂吲哚的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2126399C1 (ru) * | 1991-11-25 | 1999-02-20 | Пфайзер Инк. | Производные индола, замещенные индолы и способ ингибирования 5ht1 рецептора серотонина |
| US5521196A (en) | 1994-10-05 | 1996-05-28 | Eli Lilly And Company | 5-HT1F agonists for the treatment of migraine |
| US5521197A (en) | 1994-12-01 | 1996-05-28 | Eli Lilly And Company | 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists |
| DE4444864A1 (de) * | 1994-12-16 | 1996-06-20 | Bayer Ag | Verwendung von 5-Acyl-1,4-dihydropyridinen |
| PL322843A1 (en) | 1995-03-20 | 1998-02-16 | Lilly Co Eli | 5-substituted 3-91,2,3,6-tetrahydropyridin-4-yl)- and 3-9piperydin-4-4-yl0-1h-indoles nevel 5-htif natagonists |
| AU7261196A (en) | 1995-10-10 | 1997-04-30 | Eli Lilly And Company | N-{2-substituted-3-(2-aminoethyl)-1h-indol-5-yl}-amides: new 5-ht1f agonists |
| CA2268164A1 (en) | 1996-10-08 | 1998-04-16 | Yao-Chang Xu | New serotonin 5-ht1f agonists |
| US6133287A (en) | 1998-03-24 | 2000-10-17 | Allelix Biopharmaceuticals Inc. | Piperidine-indole compounds having 5-HT6 affinity |
| WO2000063203A1 (en) | 1999-04-21 | 2000-10-26 | Allelix Biopharmaceuticals Inc. | Piperidine-indole compounds having 5-ht6 affinity |
| ATE321751T1 (de) | 1999-07-28 | 2006-04-15 | Kirin Brewery | Harnstoffderivate als ccr-3 rezeptor-inhibitoren |
-
2002
- 2002-01-17 AU AU2002236730A patent/AU2002236730B2/en not_active Ceased
- 2002-01-17 WO PCT/US2002/000502 patent/WO2002060871A2/en not_active Ceased
- 2002-01-17 DE DE60214990T patent/DE60214990T2/de not_active Expired - Fee Related
- 2002-01-17 BR BR0206595-9A patent/BR0206595A/pt not_active IP Right Cessation
- 2002-01-17 CN CNB028043480A patent/CN1275967C/zh not_active Expired - Fee Related
- 2002-01-17 AT AT02703087T patent/ATE340795T1/de not_active IP Right Cessation
- 2002-01-17 JP JP2002561022A patent/JP2004526699A/ja active Pending
- 2002-01-17 CA CA002433351A patent/CA2433351A1/en not_active Abandoned
- 2002-01-17 EP EP02703087A patent/EP1377580B1/en not_active Expired - Lifetime
- 2002-01-17 US US10/466,969 patent/US7230011B2/en not_active Expired - Fee Related
- 2002-01-17 MX MXPA03006605A patent/MXPA03006605A/es active IP Right Grant
- 2002-01-17 ES ES02703087T patent/ES2272667T3/es not_active Expired - Lifetime
-
2007
- 2007-01-18 US US11/624,389 patent/US20070135484A1/en not_active Abandoned
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