JP2003534257A5 - - Google Patents
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- Publication number
- JP2003534257A5 JP2003534257A5 JP2001585703A JP2001585703A JP2003534257A5 JP 2003534257 A5 JP2003534257 A5 JP 2003534257A5 JP 2001585703 A JP2001585703 A JP 2001585703A JP 2001585703 A JP2001585703 A JP 2001585703A JP 2003534257 A5 JP2003534257 A5 JP 2003534257A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- aryl
- oxo
- pharmaceutically acceptable
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- -1 -S (O)nRFour Chemical group 0.000 description 12
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 10
- 125000003118 aryl group Chemical group 0.000 description 9
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 description 9
- 125000000753 cycloalkyl group Chemical group 0.000 description 8
- 239000003937 drug carrier Substances 0.000 description 8
- 239000008194 pharmaceutical composition Substances 0.000 description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 7
- 125000000217 alkyl group Chemical group 0.000 description 7
- 150000002148 esters Chemical class 0.000 description 6
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- 239000001257 hydrogen Substances 0.000 description 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 239000012453 solvate Substances 0.000 description 6
- 125000000547 substituted alkyl group Chemical group 0.000 description 6
- 125000005346 substituted cycloalkyl group Chemical group 0.000 description 6
- 235000010290 biphenyl Nutrition 0.000 description 5
- 239000004305 biphenyl Substances 0.000 description 5
- XNLWJFYYOIRPIO-UHFFFAOYSA-N 3-phenylbenzoic acid Chemical compound OC(=O)C1=CC=CC(C=2C=CC=CC=2)=C1 XNLWJFYYOIRPIO-UHFFFAOYSA-N 0.000 description 4
- 125000005842 heteroatom Chemical group 0.000 description 4
- 229910052757 nitrogen Chemical group 0.000 description 4
- 125000003107 substituted aryl group Chemical group 0.000 description 4
- 206010043554 thrombocytopenia Diseases 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 125000004093 cyano group Chemical group *C#N 0.000 description 3
- 229910052736 halogen Inorganic materials 0.000 description 3
- 150000002367 halogens Chemical class 0.000 description 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 125000004423 acyloxy group Chemical group 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 125000004104 aryloxy group Chemical group 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- XDXWLKQMMKQXPV-UHFFFAOYSA-N chembl3186485 Chemical compound CC1=NN(C=2C=C(C)C(C)=CC=2)C(=O)C1=NNC(C=1O)=CC=CC=1C1=CC=CC(C(O)=O)=C1 XDXWLKQMMKQXPV-UHFFFAOYSA-N 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 125000004043 oxo group Chemical group O=* 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- IIBBJCNVTRCTDV-UHFFFAOYSA-N CC1=NN(C=2C=C(C)C(C)=CC=2)C(=O)C1=NNC(C=1O)=CC=CC=1C(C=1)=CC=CC=1C1=NN=NN1 Chemical group CC1=NN(C=2C=C(C)C(C)=CC=2)C(=O)C1=NNC(C=1O)=CC=CC=1C(C=1)=CC=CC=1C1=NN=NN1 IIBBJCNVTRCTDV-UHFFFAOYSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 125000002950 monocyclic group Chemical group 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- ACVYVLVWPXVTIT-UHFFFAOYSA-N phosphinic acid Chemical compound O[PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-N 0.000 description 1
- 125000003367 polycyclic group Chemical group 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20708400P | 2000-05-25 | 2000-05-25 | |
| US60/207,084 | 2000-05-25 | ||
| US22892900P | 2000-08-30 | 2000-08-30 | |
| US60/228,929 | 2000-08-30 | ||
| PCT/US2001/016863 WO2001089457A2 (en) | 2000-05-25 | 2001-05-24 | Thrombopoietin mimetics |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005353686A Division JP4546919B2 (ja) | 2000-05-25 | 2005-12-07 | トロンボポエチン摸倣物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003534257A JP2003534257A (ja) | 2003-11-18 |
| JP2003534257A5 true JP2003534257A5 (enExample) | 2006-02-02 |
| JP3813875B2 JP3813875B2 (ja) | 2006-08-23 |
Family
ID=26901947
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001585703A Expired - Lifetime JP3813875B2 (ja) | 2000-05-25 | 2001-05-24 | トロンボポエチン摸倣物 |
| JP2005353686A Expired - Fee Related JP4546919B2 (ja) | 2000-05-25 | 2005-12-07 | トロンボポエチン摸倣物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005353686A Expired - Fee Related JP4546919B2 (ja) | 2000-05-25 | 2005-12-07 | トロンボポエチン摸倣物 |
Country Status (30)
| Country | Link |
|---|---|
| US (9) | US7160870B2 (enExample) |
| EP (3) | EP1864981B8 (enExample) |
| JP (2) | JP3813875B2 (enExample) |
| KR (2) | KR100847172B1 (enExample) |
| CN (4) | CN101342169A (enExample) |
| AR (2) | AR030696A1 (enExample) |
| AT (2) | ATE445606T1 (enExample) |
| AU (2) | AU7493801A (enExample) |
| BE (1) | BE2010C018I2 (enExample) |
| BR (1) | BRPI0111116B8 (enExample) |
| CA (1) | CA2411468C (enExample) |
| CY (4) | CY2010012I2 (enExample) |
| CZ (1) | CZ303176B6 (enExample) |
| DE (4) | DE60130760T2 (enExample) |
| DK (3) | DK1294378T3 (enExample) |
| ES (3) | ES2328179T3 (enExample) |
| FR (1) | FR10C0034I2 (enExample) |
| HK (1) | HK1056114A1 (enExample) |
| HU (3) | HU230387B1 (enExample) |
| IL (5) | IL152988A0 (enExample) |
| LU (1) | LU91681I2 (enExample) |
| MX (1) | MXPA02011621A (enExample) |
| MY (1) | MY136707A (enExample) |
| NO (3) | NO324246B1 (enExample) |
| NZ (2) | NZ522474A (enExample) |
| PL (2) | PL216528B1 (enExample) |
| PT (3) | PT1294378E (enExample) |
| SI (3) | SI1294378T1 (enExample) |
| TW (1) | TWI305207B (enExample) |
| WO (1) | WO2001089457A2 (enExample) |
Families Citing this family (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL151248A0 (en) | 2000-03-08 | 2003-04-10 | Metabasis Therapeutics Inc | Novel aryl fructose-1,6-bisphosphatase inhibitors |
| US20110212054A1 (en) * | 2000-05-25 | 2011-09-01 | Glaxosmithkline Llc. | Thrombopoietin mimetics |
| CY2010012I2 (el) * | 2000-05-25 | 2020-05-29 | Novartis Ag | Μιμητικα θρομβοποιητινης |
| EP1370252A4 (en) * | 2001-03-01 | 2006-04-05 | Smithkline Beecham Corp | Thrombopoietin mimetics |
| US7659409B2 (en) | 2002-03-19 | 2010-02-09 | Mitsubishi Chemical Corporation | 3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same |
| TWI280128B (en) * | 2002-05-22 | 2007-05-01 | Smithkline Beecham Corp | 3'-[(2Z)-[1-(3,4- dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine) |
| AU2003248630A1 (en) * | 2002-06-06 | 2003-12-22 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
| CA2495184A1 (en) | 2002-08-14 | 2004-02-26 | Nissan Chemical Industries, Ltd. | Thrombopoietin receptor activators and process for their production |
| TWI324593B (en) | 2002-10-09 | 2010-05-11 | Nissan Chemical Ind Ltd | Pyrazolone compounds and thrombopoietin receptor activator |
| US20090298179A1 (en) * | 2003-04-29 | 2009-12-03 | Connie Erickson-Miller | Methods For Treating Degenerative Diseases/Injuries |
| JP4895807B2 (ja) * | 2003-04-29 | 2012-03-14 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 変性疾患／損傷の治療方法 |
| US20100004302A1 (en) * | 2003-04-29 | 2010-01-07 | Connie Erickson-Miller | Methods for Treating Degenerative Diseases/Injuries |
| US20090048318A1 (en) * | 2003-04-29 | 2009-02-19 | Connie Erickson-Miller | Methods for treating degenerative diseases/injuries |
| US20090143453A1 (en) * | 2003-04-29 | 2009-06-04 | Connie Erickson-Miller | Methods for treating degenerative diseases/injuries |
| US7753958B2 (en) * | 2003-08-05 | 2010-07-13 | Gordon Charles R | Expandable intervertebral implant |
| SE0302486D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| TW200526638A (en) * | 2003-10-22 | 2005-08-16 | Smithkline Beecham Corp | 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline |
| WO2005118551A2 (en) | 2004-05-28 | 2005-12-15 | Ligand Pharmaceuticals Inc. | Thrombopoietin activity modulating compounds and methods |
| EP1805142A4 (en) * | 2004-09-23 | 2009-06-10 | Reddy Us Therapeutics Inc | PYRIDINE-BASED COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING SAME |
| KR100958337B1 (ko) * | 2004-10-25 | 2010-05-17 | 리간드 파마슈티칼스 인코포레이티드 | 트롬보포이에틴 활성 조절 화합물 및 방법 |
| TWI351954B (en) | 2004-12-08 | 2011-11-11 | Nissan Chemical Ind Ltd | Heterocyclic compounds and thrombopoietin receptor |
| JP4973192B2 (ja) | 2004-12-14 | 2012-07-11 | 日産化学工業株式会社 | アミド化合物及びトロンボポエチンレセプター活性化剤 |
| TW200716580A (en) | 2005-06-08 | 2007-05-01 | Smithkline Beecham Corp | (5Z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5H)-one |
| CA2609319C (en) | 2005-07-15 | 2014-02-04 | Nissan Chemical Industries, Ltd. | Thiophene compounds and thrombopoietin receptor activators |
| US7960425B2 (en) | 2005-07-20 | 2011-06-14 | Nissan Chemical Industries, Ltd. | Pyrazole compounds and thrombopoietin receptor activators |
| JP2009511603A (ja) * | 2005-10-13 | 2009-03-19 | スミスクライン・ビーチャム・コーポレイション | 貯蔵中の血小板の有効性を維持する方法 |
| WO2007052808A1 (ja) | 2005-11-07 | 2007-05-10 | Nissan Chemical Industries, Ltd. | ヒドラジド化合物及びトロンボポエチンレセプター活性化剤 |
| EP2025671A4 (en) | 2006-06-07 | 2011-04-06 | Nissan Chemical Ind Ltd | NITROGENIC HETEROCYCLIC COMPOUND AND THROMBOPOIETIN RECEPTOR ACTIVATOR |
| EP2086551A4 (en) * | 2006-12-01 | 2011-06-08 | Stategics Inc | Thrombopoietin mimetics |
| US20110160130A1 (en) * | 2007-02-16 | 2011-06-30 | Connie Erickson-Miller | Cancer treatment method |
| US20110129550A1 (en) * | 2007-02-16 | 2011-06-02 | Connie Erickson-Miller | Cancer treatment method |
| UY30915A1 (es) | 2007-02-16 | 2008-09-02 | Smithkline Beecham Corp | Método de tratamiento de canceres |
| WO2008134338A1 (en) * | 2007-04-24 | 2008-11-06 | Smithkline Beecham Corporation | Novel processes of making hydroxy-1-azo-derivatives as tpo mimetics |
| ECSP077628A (es) | 2007-05-03 | 2008-12-30 | Smithkline Beechman Corp | Nueva composición farmacéutica |
| BRPI0818346A2 (pt) | 2007-10-09 | 2015-04-07 | Univ Pennsylvania | Morte de células de leucemia mielóide aguda humana pelo agonista de receptor de trombopoietina(tpora) |
| CN101481352A (zh) * | 2008-01-10 | 2009-07-15 | 上海恒瑞医药有限公司 | 双环取代吡唑酮偶氮类衍生物、其制备方法及其在医药上的应用 |
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| EP3134409B1 (en) | 2014-04-22 | 2020-02-12 | Université de Montréal | Compounds and use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells |
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| TR202014694A1 (tr) | 2020-09-16 | 2022-03-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Eltrombopag olami̇n i̇çeren bi̇r kati oral farmasöri̇k formülasyon |
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| CN113336704B (zh) * | 2021-06-11 | 2022-10-11 | 上海大学 | 丹参素衍生物及其制备方法和医药用途 |
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