JP2003521888A5 - - Google Patents
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- Publication number
- JP2003521888A5 JP2003521888A5 JP2001512892A JP2001512892A JP2003521888A5 JP 2003521888 A5 JP2003521888 A5 JP 2003521888A5 JP 2001512892 A JP2001512892 A JP 2001512892A JP 2001512892 A JP2001512892 A JP 2001512892A JP 2003521888 A5 JP2003521888 A5 JP 2003521888A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- polynucleotide
- bacterial cell
- amino acid
- modified bacterial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000001580 bacterial effect Effects 0.000 description 29
- 229920001184 polypeptide Polymers 0.000 description 29
- 108090000765 processed proteins & peptides Proteins 0.000 description 29
- 102000004196 processed proteins & peptides Human genes 0.000 description 29
- 238000000034 method Methods 0.000 description 25
- 102000040430 polynucleotide Human genes 0.000 description 19
- 108091033319 polynucleotide Proteins 0.000 description 19
- 239000002157 polynucleotide Substances 0.000 description 19
- 150000001413 amino acids Chemical class 0.000 description 12
- 239000002773 nucleotide Substances 0.000 description 12
- 125000003729 nucleotide group Chemical group 0.000 description 12
- 238000012217 deletion Methods 0.000 description 11
- 230000037430 deletion Effects 0.000 description 11
- 101150053253 pgi gene Proteins 0.000 description 11
- 102000039446 nucleic acids Human genes 0.000 description 9
- 108020004707 nucleic acids Proteins 0.000 description 9
- 150000007523 nucleic acids Chemical class 0.000 description 9
- 150000008575 L-amino acids Chemical class 0.000 description 8
- 235000001014 amino acid Nutrition 0.000 description 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 6
- 230000004075 alteration Effects 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 238000003780 insertion Methods 0.000 description 5
- 230000037431 insertion Effects 0.000 description 5
- 238000006467 substitution reaction Methods 0.000 description 5
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 4
- 241000186226 Corynebacterium glutamicum Species 0.000 description 3
- 238000012258 culturing Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 102000004195 Isomerases Human genes 0.000 description 2
- 108090000769 Isomerases Proteins 0.000 description 2
- 235000019766 L-Lysine Nutrition 0.000 description 2
- 239000004472 Lysine Substances 0.000 description 2
- VFRROHXSMXFLSN-SLPGGIOYSA-N aldehydo-D-glucose 6-phosphate Chemical compound OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O VFRROHXSMXFLSN-SLPGGIOYSA-N 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 230000004907 flux Effects 0.000 description 2
- 230000006801 homologous recombination Effects 0.000 description 2
- 238000002744 homologous recombination Methods 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 108020001657 6-phosphogluconate dehydrogenase Proteins 0.000 description 1
- 102000004567 6-phosphogluconate dehydrogenase Human genes 0.000 description 1
- 102100031126 6-phosphogluconolactonase Human genes 0.000 description 1
- 108010029731 6-phosphogluconolactonase Proteins 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 description 1
- 102000012011 Isocitrate Dehydrogenase Human genes 0.000 description 1
- 108010075869 Isocitrate Dehydrogenase Proteins 0.000 description 1
- ACFIXJIJDZMPPO-NNYOXOHSSA-N NADPH Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-N 0.000 description 1
- 101710104378 Putative malate oxidoreductase [NAD] Proteins 0.000 description 1
- 101000693619 Starmerella bombicola Lactone esterase Proteins 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000002414 glycolytic effect Effects 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000004108 pentose phosphate pathway Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14521799P | 1999-07-23 | 1999-07-23 | |
| US60/145,217 | 1999-07-23 | ||
| US15001799P | 1999-08-20 | 1999-08-20 | |
| US60/150,017 | 1999-08-20 | ||
| PCT/US2000/019914 WO2001007626A2 (en) | 1999-07-23 | 2000-07-21 | Methods for producing l-amino acids by increasing cellular nadph |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010268851A Division JP2011041582A (ja) | 1999-07-23 | 2010-12-01 | 細胞性ｎａｄｐｈの増加によるｌ−アミノ酸の生成方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003521888A JP2003521888A (ja) | 2003-07-22 |
| JP2003521888A5 true JP2003521888A5 (enExample) | 2007-09-20 |
| JP4841093B2 JP4841093B2 (ja) | 2011-12-21 |
Family
ID=26842765
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001512892A Expired - Lifetime JP4841093B2 (ja) | 1999-07-23 | 2000-07-21 | 細胞性ｎａｄｐｈの増加によるｌ−アミノ酸の生成方法 |
| JP2010268851A Withdrawn JP2011041582A (ja) | 1999-07-23 | 2010-12-01 | 細胞性ｎａｄｐｈの増加によるｌ−アミノ酸の生成方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010268851A Withdrawn JP2011041582A (ja) | 1999-07-23 | 2010-12-01 | 細胞性ｎａｄｐｈの増加によるｌ−アミノ酸の生成方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6465238B1 (enExample) |
| EP (1) | EP1208205B1 (enExample) |
| JP (2) | JP4841093B2 (enExample) |
| KR (1) | KR100575403B1 (enExample) |
| CN (1) | CN1372597A (enExample) |
| AT (1) | ATE340857T1 (enExample) |
| AU (1) | AU6362200A (enExample) |
| BR (1) | BR0012712B1 (enExample) |
| CA (1) | CA2377693C (enExample) |
| DE (1) | DE60030988T2 (enExample) |
| DK (1) | DK1208205T3 (enExample) |
| ES (1) | ES2272303T3 (enExample) |
| MX (1) | MXPA02000729A (enExample) |
| NZ (1) | NZ517295A (enExample) |
| PT (1) | PT1208205E (enExample) |
| WO (1) | WO2001007626A2 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6830903B1 (en) | 1999-07-23 | 2004-12-14 | Archer-Daniels-Midland Company | Methods for producing L-amino acids using a corynebacterium glutamicum with a disrupted pgi gene |
| DK1208205T3 (da) * | 1999-07-23 | 2007-02-05 | Archer Daniels Midland Co | Fremgangsmåder til frembringelse af L-aminosyrer ved hjælp af en forögelse af cellulært NADPH |
| US6586214B1 (en) * | 1999-09-15 | 2003-07-01 | Degussa Ag | Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene) |
| CN1350586A (zh) * | 2000-03-20 | 2002-05-22 | 德古萨股份公司 | 经扩增gnd基因发酵制备L－氨基酸的方法 |
| DE10112992A1 (de) * | 2001-03-17 | 2002-09-26 | Degussa | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien |
| US7160711B2 (en) * | 2001-08-06 | 2007-01-09 | Degussa Ag | Coryneform bacteria which produce chemical compounds I |
| DE10220574A1 (de) * | 2002-05-08 | 2003-11-20 | Degussa | Verfahren zur Herstellung von Aminosäuren mit coryneformen Bakterien unter Verwendung von Phosphoglucose-Isomerasen aus coryneformen Bakterien |
| JP2007514436A (ja) * | 2003-12-18 | 2007-06-07 | ビーエーエスエフ アクチェンゲゼルシャフト | 発酵による精密化学物質の製造方法 |
| MXPA06006759A (es) | 2003-12-18 | 2006-09-04 | Basf Ag | Metodos para la preparacion de lisina por fermentacion de corynebacterium glutamicum. |
| BRPI0417706A (pt) * | 2003-12-18 | 2007-03-20 | Basf Ag | métodos para aumentar o fluxo metabólico através da via pentose fosfato em um microorganismo, e para produzir um produto quimico fino, e microorganismo recombinante |
| RU2288264C2 (ru) * | 2004-02-12 | 2006-11-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Бактерия, принадлежащая к роду escherichia - продуцент l-треонина и способ получения l-треонина |
| US20050191684A1 (en) * | 2004-02-25 | 2005-09-01 | Zimenkov Danila V. | Method for producing L-amino acids |
| EP1718731B2 (en) * | 2004-02-25 | 2016-10-19 | Ajinomoto Co., Inc. | Microorganism expressing 6-phosphogluconolactonase and its use in the production of L-amino acids. |
| RU2004105179A (ru) * | 2004-02-25 | 2005-08-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | 6-фосфоглюконолактоназа из escherichia coli, фрагмент днк, бактерия, принадлежащая к роду escherichia, -продуцент l-аминокислоты, и способ получения l-аминокислоты |
| ATE499441T1 (de) * | 2004-02-27 | 2011-03-15 | Kyowa Hakko Bio Co Ltd | Verfahren zur herstellung von aminosäuren |
| RU2004124226A (ru) | 2004-08-10 | 2006-01-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Использование фосфокетолазы для продукции полезных метаболитов |
| KR100563226B1 (ko) * | 2004-08-10 | 2006-03-21 | 한국생산기술연구원 | 연료전지용 분리판 |
| EP1838837B1 (en) | 2004-12-22 | 2015-04-15 | The Michigan Biotechnology Institute | Recombinant microorganisms for increased production of organic acids |
| DE102005013676A1 (de) | 2005-03-24 | 2006-09-28 | Degussa Ag | Allele des zwf-Gens aus coryneformen Bakterien |
| DE102005023829A1 (de) | 2005-05-24 | 2006-11-30 | Degussa Ag | Allele des opcA-Gens aus coryneformen Bakterien |
| DE102005048818A1 (de) | 2005-10-10 | 2007-04-12 | Degussa Ag | Mikrobiologische Herstellung von 3-Hydroxypropionsäure |
| KR100873168B1 (ko) * | 2007-03-07 | 2008-12-10 | 전북대학교산학협력단 | ｌｏｎ 유전자 및／또는 ｃｐｘＲ 유전자가 결실된살모넬라 변이균주 및 이를 함유하는 살모넬라 생백신 |
| CA2704227A1 (en) | 2007-11-10 | 2009-05-14 | Joule Biotechnologies, Inc. | Hyperphotosynthetic organisms |
| CA2790053A1 (en) * | 2010-03-31 | 2011-10-06 | E.I. Du Pont De Nemours And Company | Pentose phosphate pathway upregulation to increase production of non-native products of interest in transgenic microorganisms |
| US9181568B2 (en) | 2012-04-23 | 2015-11-10 | Exxonmobil Research And Engineering Company | Cell systems and methods for improving fatty acid synthesis by expression of dehydrogenases |
| KR101429814B1 (ko) * | 2012-10-05 | 2014-08-12 | 상지대학교산학협력단 | Ｇｄｈ 활성 조절을 통해 ｌ-쓰레오닌 생산능이 향상된 코리네박테리움 속 미생물 및 이를 이용한 ｌ-쓰레오닌 생산 방법 |
| US10689671B2 (en) | 2014-05-12 | 2020-06-23 | Metabolic Explorer | Microorganism and method for the production of 1.2-propanediol based on NADPH dependent acetol reductase and improved NADPH supply |
| KR102384227B1 (ko) | 2015-05-18 | 2022-04-07 | 삼성전자주식회사 | Nadph 생성이 증가된 유전적으로 조작된 효모 세포, 효모 세포 중 nadph 수준을 증가시키는 방법, 상기 효모 세포를 제조하는 방법 및 상기 효모 세포를 이용하여 락테이트를 생산하는 방법 |
| CN112725253B (zh) * | 2020-12-30 | 2023-01-06 | 宁夏伊品生物科技股份有限公司 | 一种改造基因bbd29_14900的重组菌株及其构建方法与应用 |
| CN113930465A (zh) * | 2021-10-21 | 2022-01-14 | 呼伦贝尔东北阜丰生物科技有限公司 | 一种苏氨酸发酵代谢调控工艺 |
| CN113774096A (zh) * | 2021-10-21 | 2021-12-10 | 呼伦贝尔东北阜丰生物科技有限公司 | 一种苏氨酸生产提取工艺的优化方法 |
| CN114181288B (zh) * | 2022-02-17 | 2022-05-03 | 北京中科伊品生物科技有限公司 | 制备l-缬氨酸的方法及其所用的基因与该基因编码的蛋白质 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS594988B2 (ja) * | 1976-02-03 | 1984-02-02 | 日石三菱株式会社 | グリコ−スイソメラ−ゼの製法 |
| KR950704503A (ko) | 1992-11-05 | 1995-11-20 | 필립 프랑켄호이저, 주하 쿠르키넨 | 크실리톨을 제조하기 위한 재조합 방법 및 숙주(Recombinant method and host for manufacture of xylitol) |
| EP0672161B1 (en) | 1992-11-05 | 1999-09-22 | Xyrofin Oy | Recombinant method and host for manufacture of xylitol |
| DK0733712T3 (da) | 1993-10-28 | 2002-03-18 | Ajinomoto Kk | Fremgangsmåde til fremstilling af et stof |
| US5846790A (en) * | 1994-08-19 | 1998-12-08 | Ajinomoto Co., Inc. | Methods of producing L-lysine and L-glutamic acid by fermentation |
| JPH09224661A (ja) * | 1996-02-23 | 1997-09-02 | Mitsubishi Chem Corp | グルコース−６−リン酸デヒドロゲナーゼおよびそれをコードするｄｎａ |
| JPH09224662A (ja) * | 1996-02-23 | 1997-09-02 | Mitsubishi Chem Corp | ６−ホスホグルコン酸デヒドロゲナーゼおよびそれをコードするｄｎａ |
| JP3944916B2 (ja) * | 1997-07-18 | 2007-07-18 | 味の素株式会社 | 発酵法によるプリンヌクレオシドの製造法 |
| FR2772788B1 (fr) * | 1997-12-19 | 2000-11-17 | Roquette Freres | Procede pour accroitre la production de certains polyols par une souche osmotolerante |
| DK1208205T3 (da) * | 1999-07-23 | 2007-02-05 | Archer Daniels Midland Co | Fremgangsmåder til frembringelse af L-aminosyrer ved hjælp af en forögelse af cellulært NADPH |
| US6586214B1 (en) * | 1999-09-15 | 2003-07-01 | Degussa Ag | Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene) |
-
2000
- 2000-07-21 DK DK00950529T patent/DK1208205T3/da active
- 2000-07-21 CA CA2377693A patent/CA2377693C/en not_active Expired - Fee Related
- 2000-07-21 US US09/621,451 patent/US6465238B1/en not_active Expired - Lifetime
- 2000-07-21 WO PCT/US2000/019914 patent/WO2001007626A2/en not_active Ceased
- 2000-07-21 KR KR1020027000925A patent/KR100575403B1/ko not_active Expired - Lifetime
- 2000-07-21 PT PT00950529T patent/PT1208205E/pt unknown
- 2000-07-21 AU AU63622/00A patent/AU6362200A/en not_active Abandoned
- 2000-07-21 MX MXPA02000729A patent/MXPA02000729A/es active IP Right Grant
- 2000-07-21 EP EP00950529A patent/EP1208205B1/en not_active Expired - Lifetime
- 2000-07-21 DE DE60030988T patent/DE60030988T2/de not_active Expired - Lifetime
- 2000-07-21 BR BRPI0012712-4A patent/BR0012712B1/pt not_active IP Right Cessation
- 2000-07-21 CN CN00810748A patent/CN1372597A/zh active Pending
- 2000-07-21 AT AT00950529T patent/ATE340857T1/de not_active IP Right Cessation
- 2000-07-21 ES ES00950529T patent/ES2272303T3/es not_active Expired - Lifetime
- 2000-07-21 NZ NZ517295A patent/NZ517295A/en not_active IP Right Cessation
- 2000-07-21 JP JP2001512892A patent/JP4841093B2/ja not_active Expired - Lifetime
-
2002
- 2002-08-20 US US10/223,355 patent/US6680190B2/en not_active Expired - Lifetime
-
2010
- 2010-12-01 JP JP2010268851A patent/JP2011041582A/ja not_active Withdrawn
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