JP2002542298A5 - - Google Patents
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- Publication number
- JP2002542298A5 JP2002542298A5 JP2000613460A JP2000613460A JP2002542298A5 JP 2002542298 A5 JP2002542298 A5 JP 2002542298A5 JP 2000613460 A JP2000613460 A JP 2000613460A JP 2000613460 A JP2000613460 A JP 2000613460A JP 2002542298 A5 JP2002542298 A5 JP 2002542298A5
- Authority
- JP
- Japan
- Prior art keywords
- kit product
- prodrug
- pharmaceutical formulation
- kit
- component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000651 prodrug Substances 0.000 description 9
- 229940002612 prodrug Drugs 0.000 description 9
- 239000008194 pharmaceutical composition Substances 0.000 description 8
- 101000712605 Theromyzon tessulatum Theromin Proteins 0.000 description 7
- 229940122388 Thrombin inhibitor Drugs 0.000 description 7
- 239000003868 thrombin inhibitor Substances 0.000 description 7
- 238000001356 surgical procedure Methods 0.000 description 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 206010051055 Deep vein thrombosis Diseases 0.000 description 2
- 108090000190 Thrombin Proteins 0.000 description 2
- 206010047249 Venous thrombosis Diseases 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 229960004072 thrombin Drugs 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000011902 gastrointestinal surgery Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- DKWNMCUOEDMMIN-PKOBYXMFSA-N melagatran Chemical group C1=CC(C(=N)N)=CC=C1CNC(=O)[C@H]1N(C(=O)[C@H](NCC(O)=O)C2CCCCC2)CC1 DKWNMCUOEDMMIN-PKOBYXMFSA-N 0.000 description 1
- 229960002137 melagatran Drugs 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9901442A SE523811C2 (sv) | 1999-04-21 | 1999-04-21 | Beredning innehållande en trombininhibitor med låg molekylvikt tillsammans med en prodrog av densamma |
| SE9901442-5 | 1999-04-21 | ||
| SE9904419-0 | 1999-12-03 | ||
| SE9904419A SE9904419D0 (sv) | 1999-12-03 | 1999-12-03 | New use |
| PCT/SE2000/000756 WO2000064470A1 (en) | 1999-04-21 | 2000-04-19 | A pharmaceutical formulation comprising a low molecular weight thrombin inhibitor and its prodrug |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002542298A JP2002542298A (ja) | 2002-12-10 |
| JP2002542298A5 true JP2002542298A5 (enExample) | 2007-06-14 |
Family
ID=26663557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000613460A Pending JP2002542298A (ja) | 1999-04-21 | 2000-04-19 | 低分子量トロンビン阻害物質およびそのプロドラッグを含む医薬製剤 |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US6962905B1 (enExample) |
| EP (2) | EP1200118B1 (enExample) |
| JP (1) | JP2002542298A (enExample) |
| KR (1) | KR20010110788A (enExample) |
| CN (1) | CN100377742C (enExample) |
| AR (1) | AR023510A1 (enExample) |
| AT (1) | ATE383868T1 (enExample) |
| AU (1) | AU754405B2 (enExample) |
| BR (1) | BR0009847A (enExample) |
| CA (1) | CA2371008A1 (enExample) |
| CZ (1) | CZ20013757A3 (enExample) |
| DE (1) | DE60037816T2 (enExample) |
| DK (1) | DK1200118T3 (enExample) |
| EE (1) | EE200100543A (enExample) |
| ES (1) | ES2298141T3 (enExample) |
| HK (1) | HK1045465B (enExample) |
| HU (1) | HUP0200955A3 (enExample) |
| IL (1) | IL145840A0 (enExample) |
| IS (1) | IS6111A (enExample) |
| MY (1) | MY128061A (enExample) |
| NO (1) | NO20015107D0 (enExample) |
| NZ (1) | NZ514827A (enExample) |
| PL (1) | PL201793B1 (enExample) |
| PT (1) | PT1200118E (enExample) |
| RU (1) | RU2252783C2 (enExample) |
| SA (1) | SA00210092B1 (enExample) |
| SK (1) | SK14962001A3 (enExample) |
| TR (1) | TR200103017T2 (enExample) |
| WO (1) | WO2000064470A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9900070D0 (sv) | 1999-01-13 | 1999-01-13 | Astra Ab | New use |
| AR023510A1 (es) * | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
| US20020116222A1 (en) * | 2000-10-22 | 2002-08-22 | Standing Stone, Inc. | Method and system for administering anticoagulation therapy |
| US6462021B1 (en) * | 2000-11-06 | 2002-10-08 | Astrazeneca Ab | Use of low molecular weight thrombin inhibitor |
| DE10064797A1 (de) * | 2000-12-22 | 2002-06-27 | Knoll Ag | Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon |
| SE0101762D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | New use |
| SE0101932D0 (sv) * | 2001-05-31 | 2001-05-31 | Astrazeneca Ab | Pharmaceutical combinations |
| SE0103590D0 (sv) | 2001-10-26 | 2001-10-26 | Astrazeneca Ab | New Combination |
| ATE399175T1 (de) | 2002-03-11 | 2008-07-15 | Curacyte Ag | Hemmstoffe der urokinase, ihre herstellung und verwendung |
| SE0203349D0 (sv) * | 2002-11-12 | 2002-11-12 | Astrazeneca Ab | New use |
| DE10301300B4 (de) | 2003-01-15 | 2009-07-16 | Curacyte Chemistry Gmbh | Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein |
| GB0306615D0 (en) * | 2003-03-22 | 2003-04-30 | Astrazeneca Ab | New use |
| DE10342108A1 (de) * | 2003-09-11 | 2005-04-14 | Curacyte Chemistry Gmbh | Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung |
| DE102005044319A1 (de) | 2005-09-16 | 2007-03-22 | Curacyte Chemistry Gmbh | 2-(Aminomethyl)-5-Chlor-Benzylamid-Derivate und ihre Verwendung als Hemmstoffe des Gerinnungsfaktors Xa |
| DE102006050672A1 (de) | 2006-10-24 | 2008-04-30 | Curacyte Discovery Gmbh | Hemmstoffe des Plasmins und des Plasmakallikreins |
| CA2829790C (en) | 2010-03-30 | 2018-06-05 | Verseon Corporation | Multisubstituted aromatic compounds as inhibitors of thrombin |
| CA2902431A1 (en) | 2013-03-15 | 2014-09-25 | Kevin Michael Short | Halogenopyrazoles as inhibitors of thrombin |
| EP3421036B8 (en) | 2013-03-15 | 2020-12-30 | Verseon International Corporation | Multisubstituted aromatic compounds as serine protease inhibitors |
| RU2017112739A (ru) | 2014-09-17 | 2018-10-17 | Версеон Корпорейшн | Пиразолил-замещенные пиридоновые соединения как ингибиторы сериновых протеаз |
| SG11201706411YA (en) | 2015-02-27 | 2017-09-28 | Verseon Corp | Substituted pyrazole compounds as serine protease inhibitors |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6087380A (en) | 1949-11-24 | 2000-07-11 | Boehringer Ingelheim Pharma Kg | Disubstituted bicyclic heterocycles, the preparations and the use thereof as pharmaceutical compositions |
| HU178398B (en) | 1979-06-12 | 1982-04-28 | Gyogyszerkutato Intezet | Process for producing new agmatine derivatives of activity against haemagglutination |
| AU600226B2 (en) | 1985-02-04 | 1990-08-09 | Merrell Pharmaceuticals Inc. | Novel peptidase inhibitors |
| US5187157A (en) | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
| ZA883953B (en) * | 1987-06-05 | 1990-02-28 | Du Pont | Peptide boronic acid inhibitors of trypsin-like proteases |
| EP0362002B1 (en) | 1988-09-01 | 1995-07-26 | Merrell Dow Pharmaceuticals Inc. | HIV protease inhibitors |
| ZA897515B (en) | 1988-10-07 | 1990-06-27 | Merrell Dow Pharma | Novel peptidase inhibitors |
| US5518725A (en) | 1989-09-25 | 1996-05-21 | University Of Utah Research Foundation | Vaccine compositions and method for induction of mucosal immune response via systemic vaccination |
| DE4115468A1 (de) * | 1991-05-11 | 1992-11-12 | Behringwerke Ag | Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien |
| CA2075154A1 (en) | 1991-08-06 | 1993-02-07 | Neelakantan Balasubramanian | Peptide aldehydes as antithrombotic agents |
| SE9102462D0 (sv) | 1991-08-28 | 1991-08-28 | Astra Ab | New isosteric peptides |
| CZ333492A3 (en) | 1991-11-12 | 1993-09-15 | Lilly Co Eli | Dipeptide of l-azetidine-2-carboxylic acids and l-argininaldehyde, process of its preparation and pharmaceutical preparation in which said dipeptide is comprised |
| SE9103612D0 (sv) | 1991-12-04 | 1991-12-04 | Astra Ab | New peptide derivatives |
| DE69314478T2 (de) | 1992-03-04 | 1999-02-11 | Gyogyszerkutato Intezet Kft., Budapest | Neuartige antikoagulierende peptidderivate und arzneimittel die solche enthalten so wie entsprechendes herstellungsverfahren |
| AU675981B2 (en) | 1992-12-02 | 1997-02-27 | Bristol-Myers Squibb Company | Guanidinyl-substituted heterocyclic thrombin inhibitors |
| TW257757B (enExample) | 1993-03-03 | 1995-09-21 | Boehringer Mannheim Gmbh | |
| JPH06340619A (ja) | 1993-05-03 | 1994-12-13 | Bristol Myers Squibb Co | グアニジニルまたはアミジニル置換メチルアミノ複素環トロンビン抑制剤 |
| SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
| EP0648780A1 (en) | 1993-08-26 | 1995-04-19 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
| US5643588A (en) * | 1994-11-28 | 1997-07-01 | The Procter & Gamble Company | Diaper having a lotioned topsheet |
| AU1025795A (en) | 1994-01-27 | 1995-08-03 | Mitsubishi Chemical Corporation | Prolineamide derivatives |
| US5705487A (en) | 1994-03-04 | 1998-01-06 | Eli Lilly And Company | Antithrombotic agents |
| US5707966A (en) | 1994-03-04 | 1998-01-13 | Eli Lilly And Company | Antithrombotic agents |
| IL112795A (en) | 1994-03-04 | 2001-01-28 | Astrazeneca Ab | Peptide derivatives as antithrombic agents their preparation and pharmaceutical compositions containing them |
| DE4421052A1 (de) | 1994-06-17 | 1995-12-21 | Basf Ag | Neue Thrombininhibitoren, ihre Herstellung und Verwendung |
| US5510369A (en) | 1994-07-22 | 1996-04-23 | Merck & Co., Inc. | Pyrrolidine thrombin inhibitors |
| DE4430757A1 (de) | 1994-08-30 | 1996-03-07 | Boehringer Mannheim Gmbh | Neue 4-Aminopyridazine, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel |
| DE4430755A1 (de) | 1994-08-30 | 1996-03-07 | Boehringer Mannheim Gmbh | Neue Phosphanoxide, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel |
| SE9404196D0 (sv) * | 1994-12-02 | 1994-12-02 | Astra Ab | New antithrombotic formulation |
| CA2211109A1 (en) | 1995-02-17 | 1996-08-22 | Basf Aktiengesellschaft | Novel thrombin inhibitors |
| US5710130A (en) | 1995-02-27 | 1998-01-20 | Eli Lilly And Company | Antithrombotic agents |
| AU698911B2 (en) | 1995-04-04 | 1998-11-12 | Merck & Co., Inc. | Thrombin inhibitors |
| US5629324A (en) | 1995-04-10 | 1997-05-13 | Merck & Co., Inc. | Thrombin inhibitors |
| CA2224437A1 (en) | 1995-06-27 | 1997-01-16 | Merck & Co., Inc. | Pyridinone-thrombin inhibitors |
| SA96170106A (ar) | 1995-07-06 | 2005-12-03 | أسترا أكتيبولاج | مشتقات حامض أميني جديدة |
| BR9610876A (pt) | 1995-09-29 | 1999-07-13 | Dimensional Pharm Inc | Inibidores de protease de guanidino |
| ATE228760T1 (de) | 1995-10-24 | 2002-12-15 | Merck & Co Inc | Thrombininhibitoren |
| GB9526273D0 (en) * | 1995-12-21 | 1996-02-21 | Astra Ab | New prodrugs |
| TWI238827B (en) * | 1995-12-21 | 2005-09-01 | Astrazeneca Ab | Prodrugs of thrombin inhibitors |
| WO1997024135A1 (en) | 1995-12-29 | 1997-07-10 | 3-Dimensional Pharmaceuticals, Inc. | Amidino protease inhibitors |
| WO1997030708A1 (en) | 1996-02-22 | 1997-08-28 | Merck & Co., Inc. | Pyridinone thrombin inhibitors |
| BR9708859A (pt) | 1996-04-23 | 1999-08-03 | Merck & Co Inc | Composto uso do mesmo composição para inibir formação de trombo em sangue e processos para inibir trombina e formação de agregados de plaquetas sanguíneas e de trombo no sangue para tratar ou evitar tromboemolismo venoso e embolismo pulmonar trombose tromboembolismo cardiogênico acidente vascular cerebral trombose angina instável infartação miocárdica aterosclerose distúrbio cardaco isquêmico reoclus o restenose oclus o de enxertos de derivação de artéria coronária e doença cerebrovascular oclus |
| SE9602263D0 (sv) | 1996-06-07 | 1996-06-07 | Astra Ab | New amino acid derivatives |
| WO1997047299A1 (en) | 1996-06-12 | 1997-12-18 | 3-Dimensional Pharmaceuticals, Inc. | Amidino and guanidino heterocyclic protease inhibitors |
| WO1997049404A1 (en) | 1996-06-25 | 1997-12-31 | Eli Lilly And Company | Anticoagulant agents |
| SE9602646D0 (sv) | 1996-07-04 | 1996-07-04 | Astra Ab | Pharmaceutically-useful compounds |
| DE19632772A1 (de) | 1996-08-14 | 1998-02-19 | Basf Ag | Neue Benzamidine |
| DE19632773A1 (de) | 1996-08-14 | 1998-02-19 | Basf Ag | Neue Thrombininhibitoren |
| PE121699A1 (es) | 1997-02-18 | 1999-12-08 | Boehringer Ingelheim Pharma | Heterociclos biciclicos disustituidos como inhibidores de la trombina |
| AR013084A1 (es) | 1997-06-19 | 2000-12-13 | Astrazeneca Ab | Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados |
| DE19727117A1 (de) | 1997-06-26 | 1999-01-07 | Boehringer Ingelheim Pharma | Phenylalkylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| DE19753522A1 (de) | 1997-12-03 | 1999-06-10 | Boehringer Ingelheim Pharma | Substituierte Indole, ihre Herstellung und ihre Verwendung als Arzneimittel |
| SE9704543D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Ab | New compounds |
| DE19754490A1 (de) | 1997-12-09 | 1999-06-10 | Boehringer Ingelheim Pharma | Durch einen Aminocarbonylrest substituierte Bicyclen, ihre Herstellung und ihre Verwendung als Arzneimittel |
| AU2424499A (en) | 1998-01-26 | 1999-08-09 | Basf Aktiengesellschaft | Heterocyclic amidines as callicrein protease inhibitors |
| WO1999037668A1 (de) | 1998-01-26 | 1999-07-29 | Basf Aktiengesellschaft | Thrombininhibitoren |
| CA2319494A1 (en) | 1998-02-03 | 1999-08-12 | Boehringer Ingelheim Pharma Kg | 5-membered heterocyclic condensed benzoderivatives, the preparation thereof and their use as pharmaceuticals |
| DE19816983A1 (de) | 1998-04-17 | 1999-10-21 | Boehringer Ingelheim Pharma | Bicyclen, deren Herstellung und deren Verwendung als Arzneimittel |
| TWI248435B (en) | 1998-07-04 | 2006-02-01 | Boehringer Ingelheim Pharma | Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions |
| DE19834751A1 (de) | 1998-08-01 | 2000-02-03 | Boehringer Ingelheim Pharma | Disubstituierte bicyclische Heterocyclen, ihre Herstellung und ihre Verwendung als Arzneimittel |
| EP1058549A4 (en) * | 1998-12-23 | 2003-11-12 | Bristol Myers Squibb Pharma Co | FACTOR Xa OR THROMBIN INHIBITORS |
| AR023510A1 (es) * | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
-
2000
- 2000-04-14 AR ARP000101756A patent/AR023510A1/es not_active Application Discontinuation
- 2000-04-19 MY MYPI20001656A patent/MY128061A/en unknown
- 2000-04-19 ES ES00928047T patent/ES2298141T3/es not_active Expired - Lifetime
- 2000-04-19 HU HU0200955A patent/HUP0200955A3/hu unknown
- 2000-04-19 US US09/582,863 patent/US6962905B1/en not_active Expired - Fee Related
- 2000-04-19 DE DE60037816T patent/DE60037816T2/de not_active Expired - Fee Related
- 2000-04-19 EP EP00928047A patent/EP1200118B1/en not_active Expired - Lifetime
- 2000-04-19 CN CNB008091447A patent/CN100377742C/zh not_active Expired - Fee Related
- 2000-04-19 CZ CZ20013757A patent/CZ20013757A3/cs unknown
- 2000-04-19 PT PT00928047T patent/PT1200118E/pt unknown
- 2000-04-19 TR TR2001/03017T patent/TR200103017T2/xx unknown
- 2000-04-19 AT AT00928047T patent/ATE383868T1/de not_active IP Right Cessation
- 2000-04-19 DK DK00928047T patent/DK1200118T3/da active
- 2000-04-19 RU RU2001128157/15A patent/RU2252783C2/ru active
- 2000-04-19 PL PL351917A patent/PL201793B1/pl unknown
- 2000-04-19 NZ NZ514827A patent/NZ514827A/en unknown
- 2000-04-19 JP JP2000613460A patent/JP2002542298A/ja active Pending
- 2000-04-19 EP EP07120002A patent/EP1886691A3/en not_active Withdrawn
- 2000-04-19 IL IL14584000A patent/IL145840A0/xx unknown
- 2000-04-19 BR BR0009847-7A patent/BR0009847A/pt not_active Application Discontinuation
- 2000-04-19 WO PCT/SE2000/000756 patent/WO2000064470A1/en not_active Ceased
- 2000-04-19 AU AU46336/00A patent/AU754405B2/en not_active Ceased
- 2000-04-19 SK SK1496-2001A patent/SK14962001A3/sk unknown
- 2000-04-19 KR KR1020017013403A patent/KR20010110788A/ko not_active Abandoned
- 2000-04-19 HK HK02107166.1A patent/HK1045465B/en not_active IP Right Cessation
- 2000-04-19 EE EEP200100543A patent/EE200100543A/xx unknown
- 2000-04-19 CA CA002371008A patent/CA2371008A1/en not_active Abandoned
- 2000-05-15 SA SA00210092A patent/SA00210092B1/ar unknown
-
2001
- 2001-10-19 IS IS6111A patent/IS6111A/is unknown
- 2001-10-19 NO NO20015107A patent/NO20015107D0/no not_active Application Discontinuation
-
2005
- 2005-08-18 US US11/206,006 patent/US20060009397A1/en not_active Abandoned
-
2007
- 2007-11-09 US US11/979,882 patent/US20080113960A1/en not_active Abandoned
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