TW257757B - - Google Patents

Info

Publication number
TW257757B
TW257757B TW083101504A TW83101504A TW257757B TW 257757 B TW257757 B TW 257757B TW 083101504 A TW083101504 A TW 083101504A TW 83101504 A TW83101504 A TW 83101504A TW 257757 B TW257757 B TW 257757B
Authority
TW
Taiwan
Prior art keywords
stands
atom
compounds
hydrogen
halogen
Prior art date
Application number
TW083101504A
Other languages
English (en)
Chinese (zh)
Inventor
Helmut Michel
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4306506A external-priority patent/DE4306506A1/de
Priority claimed from DE19934312966 external-priority patent/DE4312966A1/de
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Application granted granted Critical
Publication of TW257757B publication Critical patent/TW257757B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW083101504A 1993-03-03 1994-02-22 TW257757B (enExample)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4306506A DE4306506A1 (de) 1993-03-03 1993-03-03 Neue 4-Alkylaminopyridine - Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
DE19934312966 DE4312966A1 (de) 1993-04-21 1993-04-21 Neue 4-Aminopyridine - Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
TW257757B true TW257757B (enExample) 1995-09-21

Family

ID=25923593

Family Applications (1)

Application Number Title Priority Date Filing Date
TW083101504A TW257757B (enExample) 1993-03-03 1994-02-22

Country Status (22)

Country Link
EP (1) EP0687253B1 (enExample)
JP (1) JPH08507503A (enExample)
KR (1) KR100252551B1 (enExample)
CN (1) CN1046710C (enExample)
AT (1) ATE174590T1 (enExample)
AU (1) AU682026B2 (enExample)
CA (1) CA2156729A1 (enExample)
CZ (1) CZ225495A3 (enExample)
DE (1) DE59407494D1 (enExample)
DK (1) DK0687253T3 (enExample)
ES (1) ES2127919T3 (enExample)
FI (1) FI954105A0 (enExample)
GR (1) GR3029691T3 (enExample)
HU (1) HUT72898A (enExample)
IL (1) IL108786A (enExample)
NO (1) NO953447L (enExample)
NZ (1) NZ262725A (enExample)
PL (1) PL176455B1 (enExample)
RU (1) RU2126388C1 (enExample)
SK (1) SK108295A3 (enExample)
TW (1) TW257757B (enExample)
WO (1) WO1994020467A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8207639B2 (en) 2009-10-23 2012-06-26 Sunonwealth Electric Machine Industry Co., Ltd. Motor and heating dissipating fan including motor having an annular balancing member

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4430755A1 (de) * 1994-08-30 1996-03-07 Boehringer Mannheim Gmbh Neue Phosphanoxide, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
IL115420A0 (en) * 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
US5792769A (en) * 1995-09-29 1998-08-11 3-Dimensional Pharmaceuticals, Inc. Guanidino protease inhibitors
GB9525620D0 (en) * 1995-12-15 1996-02-14 Glaxo Group Ltd Chemical compounds
CA2256309C (en) * 1995-12-29 2006-08-15 3-Dimensional Pharmaceuticals, Inc. Amidino protease inhibitors
US6313127B1 (en) 1996-02-02 2001-11-06 Zeneca Limited Heterocyclic compounds useful as pharmaceutical agents
GB9602166D0 (en) 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
WO1998006705A1 (en) * 1996-08-14 1998-02-19 Zeneca Limited Substituted pyrimidine derivatives and their pharmaceutical use
AU725403B2 (en) * 1996-09-13 2000-10-12 Merck & Co., Inc. Thrombin inhibitors
GB9821483D0 (en) 1998-10-03 1998-11-25 Glaxo Group Ltd Chemical compounds
UA56197C2 (uk) 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
TW499412B (en) 1996-11-26 2002-08-21 Dimensional Pharm Inc Aminoguanidines and alkoxyguanidines as protease inhibitors
WO1998024760A1 (en) * 1996-12-03 1998-06-11 Graybill Todd L Aminobenzenedicarboxylic acid-based combinatorial libraries
WO1998035956A1 (en) 1997-02-13 1998-08-20 Zeneca Limited Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
JP2001511799A (ja) 1997-02-13 2001-08-14 ゼネカ・リミテッド オキシド−スクアレンシクラーゼ阻害剤として有用なヘテロ環式化合物
GB9715895D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
JP4327915B2 (ja) * 1998-03-30 2009-09-09 株式会社デ・ウエスタン・セラピテクス研究所 スルフォンアミド誘導体
BR9914091A (pt) 1998-10-06 2001-11-27 Dainippon Pharmaceutical Co Derivados de piridina 2,3-di-substituìda, processopara preparação dos mesmos, composições dedroga contendo os mesmos e intermediários paraa preparação
GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
JP2004505956A (ja) 2000-08-04 2004-02-26 3−ディメンショナル ファーマシューティカルズ, インコーポレイテッド 環式オキシグアニジンプロテアーゼインヒビター
AU9233101A (en) * 2000-10-04 2002-04-15 Kissei Pharmaceutical 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation
WO2002089740A2 (en) * 2001-05-07 2002-11-14 Smithkline Beecham Corporation Sulfonamides
US6849635B2 (en) * 2001-05-07 2005-02-01 Smithkline Beecham Corporation Sulfonamides
ATE402700T1 (de) 2002-08-27 2008-08-15 Merck Patent Gmbh Glycinamid-derivate als raf-kinase-hemmer
MXPA05003054A (es) * 2002-09-20 2005-05-27 Pfizer Prod Inc Ligandos de amida y sulfonamida para el receptor de estrogenos.
RU2374230C2 (ru) 2003-11-05 2009-11-27 Ф.Хоффманн-Ля Рош Аг Фенильные производные в качестве ppar агонистов
WO2008104994A2 (en) * 2007-02-28 2008-09-04 Advinus Therapeutics Private Limited 2,2,2-tri-substituted acetamide derivatives as glucokinase activators, their process and pharmaceutical application
RU2353619C2 (ru) * 2007-06-28 2009-04-27 Общество С Ограниченной Ответственностью "Бионика" Новые соединения, обладающие функцией антикоагулянтов, фармацевтические композиции на их основе для лечения тромботических состояний и плазмозамещающий раствор для коррекции гиперкоагуляционных нарушений при гемодилюции
RU2354647C2 (ru) * 2007-06-28 2009-05-10 Общество С Ограниченной Ответственностью "Бионика" Новые соединения, обладающие функцией ингибиторов тромбина, и фармацевтические композиции на их основе
GB0815784D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815782D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815781D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
US8265575B2 (en) * 2009-06-16 2012-09-11 Mediatek Inc. Methods for handling a transmitting process and communication apparatuses utilizing the same
RU2685261C1 (ru) * 2018-04-05 2019-04-17 Общество с ограниченной ответственностью "ФК ЛАБОРАТОРИЗ" Вещество 4-амино-1-{ 2-[3-метил-5-(бензолсульфонилокси)фенокси] этил} -пиридиний хлорид, обладающее свойствами биологически активного агента, влияющими на естественно текущие процессы свертываемости крови млекопитающих, антикоагулянт на его основе и способ его получения путем химического синтеза
CN109172573B (zh) * 2018-09-12 2021-01-26 黑龙江中桂制药有限公司 一种口服抗血栓药物及其用途
CN110669337B (zh) * 2019-07-08 2020-09-25 中国科学院长春应用化学研究所 一种芳香型二胺单体及其制备方法
EP4716529A2 (en) * 2023-05-23 2026-04-01 Institute For Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center Compounds that re-activate mutant p53

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1097620A1 (ru) * 1983-02-16 1984-06-15 Новокузнецкий научно-исследовательский химико-фармацевтический институт Способ получени диэтил-N-(6-метилпиридил-2)-аминометиленмалоната
SU1318599A1 (ru) * 1985-06-26 1987-06-23 МГУ им.М.В.Ломоносова Способ получени 1-алкил-2-хлор-2-алкоксиэтенилалкил(арил)хлорфосфинов
DE3529529A1 (de) * 1985-08-17 1987-02-19 Boehringer Mannheim Gmbh Verfahren zur herstellung einer stabilen modifikation von torasemid
GB8819307D0 (en) * 1988-08-13 1988-09-14 Pfizer Ltd Antiarrhythmic agents
JPH0256465A (ja) * 1988-08-22 1990-02-26 Hamari Yakuhin Kogyo Kk アセトアミド化合物
US4885927A (en) * 1988-09-12 1989-12-12 General Motors Corporation Method and apparatus for press forming intricate metallic shapes such as spool valve elements
EP0610432A1 (en) * 1991-10-31 1994-08-17 Smithkline Beecham Corporation C8-cyclic peptidomimetics as fibrinogen antagonists
JPH07501063A (ja) * 1991-11-14 1995-02-02 グラクソ、グループ、リミテッド フィブリノーゲン依存性血小板凝集阻害剤としてのピペリジン酢酸誘導体
DE4212304A1 (de) * 1992-04-13 1993-10-14 Cassella Ag Asparaginsäurederivate, ihre Herstellung und Verwendung

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8207639B2 (en) 2009-10-23 2012-06-26 Sunonwealth Electric Machine Industry Co., Ltd. Motor and heating dissipating fan including motor having an annular balancing member

Also Published As

Publication number Publication date
HU9502568D0 (en) 1995-11-28
JPH08507503A (ja) 1996-08-13
IL108786A0 (en) 1994-06-24
EP0687253B1 (de) 1998-12-16
NO953447D0 (no) 1995-09-01
SK108295A3 (en) 1996-06-05
CN1046710C (zh) 1999-11-24
DE59407494D1 (de) 1999-01-28
RU2126388C1 (ru) 1999-02-20
EP0687253A1 (de) 1995-12-20
NO953447L (no) 1995-09-01
FI954105A7 (fi) 1995-09-01
CZ225495A3 (en) 1996-01-17
KR960701019A (ko) 1996-02-24
ATE174590T1 (de) 1999-01-15
IL108786A (en) 1999-04-11
FI954105A0 (fi) 1995-09-01
KR100252551B1 (ko) 2000-05-01
WO1994020467A1 (de) 1994-09-15
PL176455B1 (pl) 1999-05-31
AU6257494A (en) 1994-09-26
AU682026B2 (en) 1997-09-18
PL310520A1 (en) 1995-12-27
DK0687253T3 (da) 1999-08-23
CA2156729A1 (en) 1994-09-15
HUT72898A (en) 1996-06-28
CN1119858A (zh) 1996-04-03
ES2127919T3 (es) 1999-05-01
GR3029691T3 (en) 1999-06-30
NZ262725A (en) 1997-05-26

Similar Documents

Publication Publication Date Title
HU9502568D0 (en) New 4-aminopyridines, process for preparing the same and medicaments containing the same
ZA919181B (en) Oxazolopyridine derivatives,processes for preparing these and pharmaceutical compositions containing them
PL317604A1 (en) Derivatives of amides, method of obtaining them and pharmaceutic compositions containing such derivatives
FI865037A7 (fi) Mikrobicida kompositioner.
HU9401943D0 (en) Process for producing amide and urea derivatives and compositions containing them
MY109737A (en) Treatment and compounds.
ZA932168B (en) Naphthylalkylamines, process for preparing them and pharmaceutical compositions containing them
MX9707053A (es) Nuevos derivados de arilglicinamida, procedimiento para su preparacion, y composiciones farmaceuticas que contienen estos compuestos.
HUT74182A (en) Novel imidazole derivatives, process for producing the same and pharmaceutical compositions containing the compounds
WO1998009953A3 (de) Azinyloxy- und phenoxy-diaryl-carbonsäure derivate, deren herstellung und deren verwendung als gemischte eta/etb endothelin-rezeptorantagonist
IL102093A0 (en) 1-methylcarbapenem derivatives,processes for the preparation thereof,and pharmaceutical compositions containing the same
MY100115A (en) Nitrogen containing heterocyclic compounds, and their production and use.
HUT50164A (en) Process for production of derivatives of 6-phenil /piperazinil-alkyl/-1h, 3h-pirimidin-2,4-dion and medical compositions containing them
PL326554A1 (en) Derivatives of amine and thiourea and inhibitors of nitrogen oxide synthase
MY131762A (en) Pharmaceutical compounds
GR900100035A (el) Παράγωγα υδροξυαλκανοκαρβονικού οξέος, η παρασευή και η χρησιμοπποίηση τους.
TW238304B (en) A process for the preparation of 1-substituted-5(4H)-tetrazolinones
ATE116647T1 (de) Thiophenderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen.
AU639154B2 (en) New imidazole compounds, a process for the preparation thereof, and pharmaceutical compositions containing them
TW259785B (en) Chemical compounds
MY109714A (en) Process for preparing 8-chloroquinolone derivatives
DE68905363D1 (de) Heterotetracyclische laktamderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten.
PL322069A1 (en) Arginin analoques exhibiting inhibiting activity in respect to synthase no
MX9702089A (es) Carboxamidas biciclicas como antagonistas de 5-ht1a.
HUT58273A (en) Process for producing aminoketon compounds and pharmaceutical compositions containing them