NO953447L - Nye 4-aminopyridiner, fremgangsmåte for deres fremstilling samt legemidler inneholdende disse - Google Patents

Nye 4-aminopyridiner, fremgangsmåte for deres fremstilling samt legemidler inneholdende disse

Info

Publication number
NO953447L
NO953447L NO953447A NO953447A NO953447L NO 953447 L NO953447 L NO 953447L NO 953447 A NO953447 A NO 953447A NO 953447 A NO953447 A NO 953447A NO 953447 L NO953447 L NO 953447L
Authority
NO
Norway
Prior art keywords
stands
atom
compounds
hydrogen
halogen
Prior art date
Application number
NO953447A
Other languages
English (en)
Other versions
NO953447D0 (no
Inventor
Wolfgang Von Der Saal
Reinhard Heck
Herbert Leinert
Thomas Poll
Karlheinz Stegmeier
Helmut Michel
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4306506A external-priority patent/DE4306506A1/de
Priority claimed from DE19934312966 external-priority patent/DE4312966A1/de
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of NO953447L publication Critical patent/NO953447L/no
Publication of NO953447D0 publication Critical patent/NO953447D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Nye 4-aminopyridiner med generell formel I (I) hvori R1 betegner gruppen R6-SO-NR7-, R6- S02-NR7-, R'-NR7-SO-, R6-NR7-S02-, R6-SO-0-, R6-SO,-0-, R6-0-SO- eller R6-O-SO,, R2 betegner et hydrogen- eller halogenatom, en cyano-, alkyl-, alkoksy- eller halogenalkyl- gruppe, X betegner et oksygenatom, et svovelatom eller NH-gruppen, RJ og R4 er like eller forskjellige og betegner hydrogenatomer eller alkylgrupper, R5 betegner et hydrogenatom, en alkylgruppe eller en aralkyl- gruppe. R6 betegner en alifatisk eller syklisk, eventuelt substituert rest, R7 betegner et hydrogenatom eller en alifatisk eller syklisk, eventuelt substituert rest, Y betegner en lineær eller for- grenet alkylenkjede, R8 og R9 er like eller forskjellige og betegner hydrogenatomer, aralkyl-, sykloalkyl- eller alkylgrupper som kan være en- eller flersubstituert med halogen, hydroksy, alkoksy, alkylkarbonyloksy, amin eller karboksy, eller R8 og R* danner sammen med N-atomet de er bundet til, en mettet ring som kan inneholde et ytterligere oksygen-, svovel- eller nitrogenatom, så vel som hydrater, solvater og fysio- logisk forenlige salter derav, og også optisk aktive former, racemater og dia- stereomerblandinger av disse forbind- elser. Fremgangsmåter for fremstilling av de ovennevnte forbindelser, lege- midler som inneholder slike forbindelser samt anvendelse av disse forbind- elser ved fremstilling av legemidler er også beskrevet.
NO953447A 1993-03-03 1995-09-01 Nye 4-aminopyridiner, fremgangsmåte for deres fremstilling samt legemidler inneholdende disse NO953447D0 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4306506A DE4306506A1 (de) 1993-03-03 1993-03-03 Neue 4-Alkylaminopyridine - Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
DE19934312966 DE4312966A1 (de) 1993-04-21 1993-04-21 Neue 4-Aminopyridine - Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
PCT/EP1994/000608 WO1994020467A1 (de) 1993-03-03 1994-03-02 Neue 4-aminopyridine, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
NO953447L true NO953447L (no) 1995-09-01
NO953447D0 NO953447D0 (no) 1995-09-01

Family

ID=25923593

Family Applications (1)

Application Number Title Priority Date Filing Date
NO953447A NO953447D0 (no) 1993-03-03 1995-09-01 Nye 4-aminopyridiner, fremgangsmåte for deres fremstilling samt legemidler inneholdende disse

Country Status (22)

Country Link
EP (1) EP0687253B1 (no)
JP (1) JPH08507503A (no)
KR (1) KR100252551B1 (no)
CN (1) CN1046710C (no)
AT (1) ATE174590T1 (no)
AU (1) AU682026B2 (no)
CA (1) CA2156729A1 (no)
CZ (1) CZ225495A3 (no)
DE (1) DE59407494D1 (no)
DK (1) DK0687253T3 (no)
ES (1) ES2127919T3 (no)
FI (1) FI954105A0 (no)
GR (1) GR3029691T3 (no)
HU (1) HUT72898A (no)
IL (1) IL108786A (no)
NO (1) NO953447D0 (no)
NZ (1) NZ262725A (no)
PL (1) PL176455B1 (no)
RU (1) RU2126388C1 (no)
SK (1) SK108295A3 (no)
TW (1) TW257757B (no)
WO (1) WO1994020467A1 (no)

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DE4430755A1 (de) * 1994-08-30 1996-03-07 Boehringer Mannheim Gmbh Neue Phosphanoxide, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
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US5792769A (en) * 1995-09-29 1998-08-11 3-Dimensional Pharmaceuticals, Inc. Guanidino protease inhibitors
GB9525620D0 (en) 1995-12-15 1996-02-14 Glaxo Group Ltd Chemical compounds
IL124883A0 (en) * 1995-12-29 1999-01-26 Dimensional Pharm Inc Amidino protease inhibitors and pharmaceutical compositions containing the same
GB9602166D0 (en) 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
US6313127B1 (en) 1996-02-02 2001-11-06 Zeneca Limited Heterocyclic compounds useful as pharmaceutical agents
SE9602646D0 (sv) * 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
CZ45699A3 (cs) * 1996-08-14 1999-05-12 Zeneca Limited Substituované deriváty pyrimidinu, způsob jejich přípravy a farmaceutický prostředek, který je obsahuje
WO1998010763A1 (en) * 1996-09-13 1998-03-19 Merck & Co., Inc. Thrombin inhibitors
GB9821483D0 (en) 1998-10-03 1998-11-25 Glaxo Group Ltd Chemical compounds
UA56197C2 (uk) 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
TW499412B (en) 1996-11-26 2002-08-21 Dimensional Pharm Inc Aminoguanidines and alkoxyguanidines as protease inhibitors
WO1998024760A1 (en) * 1996-12-03 1998-06-11 Graybill Todd L Aminobenzenedicarboxylic acid-based combinatorial libraries
US6440972B1 (en) 1997-02-13 2002-08-27 Zeneca Limited Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
DE69815509T2 (de) 1997-02-13 2004-05-13 Astrazeneca Ab Heterozyklische verbindungen die als oxido-squalen-zyklase-inhibitoren anwendung finden
GB9715895D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
JP4327915B2 (ja) * 1998-03-30 2009-09-09 株式会社デ・ウエスタン・セラピテクス研究所 スルフォンアミド誘導体
CA2345577A1 (en) 1998-10-06 2000-04-13 Mari Itoh 2,3-disubstituted pyridine derivatives, process for the preparation thereof, drug compositions containing the same and intermediates for the preparation
GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
WO2002012207A1 (en) 2000-08-04 2002-02-14 3-Dimensional Pharmaceuticals, Inc. Cyclic oxyguanidine protease inhibitors
US20050043536A1 (en) * 2001-05-07 2005-02-24 Dashyant Dhanak Sulfonamides
WO2002089785A1 (en) * 2001-05-07 2002-11-14 Smithkline Beecham Corporation Sulfonamides
CN1678314A (zh) * 2002-08-27 2005-10-05 默克专利有限公司 作为raf－激酶抑制剂的甘氨酸酰胺衍生物
WO2004026823A1 (en) 2002-09-20 2004-04-01 Pfizer Products Inc. Amide and sulfonamide ligands for the estrogen receptor
KR100847976B1 (ko) 2003-11-05 2008-07-22 에프. 호프만-라 로슈 아게 Ｐｐａｒ 작용제로서 페닐 유도체
WO2008104994A2 (en) * 2007-02-28 2008-09-04 Advinus Therapeutics Private Limited 2,2,2-tri-substituted acetamide derivatives as glucokinase activators, their process and pharmaceutical application
RU2354647C2 (ru) * 2007-06-28 2009-05-10 Общество С Ограниченной Ответственностью "Бионика" Новые соединения, обладающие функцией ингибиторов тромбина, и фармацевтические композиции на их основе
RU2353619C2 (ru) * 2007-06-28 2009-04-27 Общество С Ограниченной Ответственностью "Бионика" Новые соединения, обладающие функцией антикоагулянтов, фармацевтические композиции на их основе для лечения тромботических состояний и плазмозамещающий раствор для коррекции гиперкоагуляционных нарушений при гемодилюции
GB0815781D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815784D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815782D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
US8265575B2 (en) * 2009-06-16 2012-09-11 Mediatek Inc. Methods for handling a transmitting process and communication apparatuses utilizing the same
US8207639B2 (en) 2009-10-23 2012-06-26 Sunonwealth Electric Machine Industry Co., Ltd. Motor and heating dissipating fan including motor having an annular balancing member
RU2685261C1 (ru) * 2018-04-05 2019-04-17 Общество с ограниченной ответственностью "ФК ЛАБОРАТОРИЗ" Вещество 4-амино-1-{ 2-[3-метил-5-(бензолсульфонилокси)фенокси] этил} -пиридиний хлорид, обладающее свойствами биологически активного агента, влияющими на естественно текущие процессы свертываемости крови млекопитающих, антикоагулянт на его основе и способ его получения путем химического синтеза
CN109172573B (zh) * 2018-09-12 2021-01-26 黑龙江中桂制药有限公司 一种口服抗血栓药物及其用途
CN110669337B (zh) * 2019-07-08 2020-09-25 中国科学院长春应用化学研究所 一种芳香型二胺单体及其制备方法

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DE4212304A1 (de) * 1992-04-13 1993-10-14 Cassella Ag Asparaginsäurederivate, ihre Herstellung und Verwendung

Also Published As

Publication number Publication date
DK0687253T3 (da) 1999-08-23
TW257757B (no) 1995-09-21
CN1119858A (zh) 1996-04-03
KR100252551B1 (ko) 2000-05-01
CA2156729A1 (en) 1994-09-15
JPH08507503A (ja) 1996-08-13
AU6257494A (en) 1994-09-26
HUT72898A (en) 1996-06-28
KR960701019A (ko) 1996-02-24
NZ262725A (en) 1997-05-26
EP0687253A1 (de) 1995-12-20
PL310520A1 (en) 1995-12-27
IL108786A (en) 1999-04-11
ES2127919T3 (es) 1999-05-01
EP0687253B1 (de) 1998-12-16
SK108295A3 (en) 1996-06-05
HU9502568D0 (en) 1995-11-28
GR3029691T3 (en) 1999-06-30
PL176455B1 (pl) 1999-05-31
CN1046710C (zh) 1999-11-24
FI954105A (fi) 1995-09-01
FI954105A0 (fi) 1995-09-01
IL108786A0 (en) 1994-06-24
DE59407494D1 (de) 1999-01-28
NO953447D0 (no) 1995-09-01
CZ225495A3 (en) 1996-01-17
AU682026B2 (en) 1997-09-18
ATE174590T1 (de) 1999-01-15
RU2126388C1 (ru) 1999-02-20
WO1994020467A1 (de) 1994-09-15

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