KR100252551B1 - 신규의 4-아미노피리딘, 이것의 제조방법 및 이것을 함유하는 약제 - Google Patents
신규의 4-아미노피리딘, 이것의 제조방법 및 이것을 함유하는 약제Info
- Publication number
- KR100252551B1 KR100252551B1 KR1019950703694A KR19950703694A KR100252551B1 KR 100252551 B1 KR100252551 B1 KR 100252551B1 KR 1019950703694 A KR1019950703694 A KR 1019950703694A KR 19950703694 A KR19950703694 A KR 19950703694A KR 100252551 B1 KR100252551 B1 KR 100252551B1
- Authority
- KR
- South Korea
- Prior art keywords
- group
- phenyl
- methyl
- compound
- pyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4306506A DE4306506A1 (de) | 1993-03-03 | 1993-03-03 | Neue 4-Alkylaminopyridine - Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel |
| DEP4306506.6 | 1993-03-03 | ||
| DE19934312966 DE4312966A1 (de) | 1993-04-21 | 1993-04-21 | Neue 4-Aminopyridine - Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel |
| DEP4312966.8 | 1993-04-21 | ||
| PCT/EP1994/000608 WO1994020467A1 (de) | 1993-03-03 | 1994-03-02 | Neue 4-aminopyridine, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR960701019A KR960701019A (ko) | 1996-02-24 |
| KR100252551B1 true KR100252551B1 (ko) | 2000-05-01 |
Family
ID=25923593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019950703694A Expired - Fee Related KR100252551B1 (ko) | 1993-03-03 | 1994-03-02 | 신규의 4-아미노피리딘, 이것의 제조방법 및 이것을 함유하는 약제 |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0687253B1 (enExample) |
| JP (1) | JPH08507503A (enExample) |
| KR (1) | KR100252551B1 (enExample) |
| CN (1) | CN1046710C (enExample) |
| AT (1) | ATE174590T1 (enExample) |
| AU (1) | AU682026B2 (enExample) |
| CA (1) | CA2156729A1 (enExample) |
| CZ (1) | CZ225495A3 (enExample) |
| DE (1) | DE59407494D1 (enExample) |
| DK (1) | DK0687253T3 (enExample) |
| ES (1) | ES2127919T3 (enExample) |
| FI (1) | FI954105A7 (enExample) |
| GR (1) | GR3029691T3 (enExample) |
| HU (1) | HUT72898A (enExample) |
| IL (1) | IL108786A (enExample) |
| NO (1) | NO953447D0 (enExample) |
| NZ (1) | NZ262725A (enExample) |
| PL (1) | PL176455B1 (enExample) |
| RU (1) | RU2126388C1 (enExample) |
| SK (1) | SK108295A3 (enExample) |
| TW (1) | TW257757B (enExample) |
| WO (1) | WO1994020467A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4430755A1 (de) * | 1994-08-30 | 1996-03-07 | Boehringer Mannheim Gmbh | Neue Phosphanoxide, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel |
| IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| US5792769A (en) * | 1995-09-29 | 1998-08-11 | 3-Dimensional Pharmaceuticals, Inc. | Guanidino protease inhibitors |
| GB9525620D0 (en) * | 1995-12-15 | 1996-02-14 | Glaxo Group Ltd | Chemical compounds |
| IL124883A0 (en) | 1995-12-29 | 1999-01-26 | Dimensional Pharm Inc | Amidino protease inhibitors and pharmaceutical compositions containing the same |
| AU1608397A (en) | 1996-02-02 | 1997-08-22 | Zeneca Limited | Heterocyclic compounds useful as pharmaceutical agents |
| GB9602166D0 (en) | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
| SE9602646D0 (sv) * | 1996-07-04 | 1996-07-04 | Astra Ab | Pharmaceutically-useful compounds |
| PL331599A1 (en) * | 1996-08-14 | 1999-08-02 | Zeneca Ltd | Substituted derivatives of pyrimidine and their pharmaceutical application |
| JP2001500864A (ja) * | 1996-09-13 | 2001-01-23 | メルク エンド カンパニー インコーポレーテッド | トロンビン阻害物質 |
| GB9821483D0 (en) | 1998-10-03 | 1998-11-25 | Glaxo Group Ltd | Chemical compounds |
| UA56197C2 (uk) | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
| TW499412B (en) | 1996-11-26 | 2002-08-21 | Dimensional Pharm Inc | Aminoguanidines and alkoxyguanidines as protease inhibitors |
| AU7624298A (en) * | 1996-12-03 | 1998-06-29 | Graybill, Todd L. | Aminobenzenedicarboxylic acid-based combinatorial libraries |
| ATE242774T1 (de) | 1997-02-13 | 2003-06-15 | Astrazeneca Ab | Heterozyklische verbindungen die als oxido- squalen-zyklase-inhibitoren anwendung finden |
| AU5999698A (en) | 1997-02-13 | 1998-09-08 | Zeneca Limited | Heterocyclic compounds useful as oxido-squalene cyclase inhibitors |
| GB9715895D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic compounds |
| JP4327915B2 (ja) * | 1998-03-30 | 2009-09-09 | 株式会社デ・ウエスタン・セラピテクス研究所 | スルフォンアミド誘導体 |
| CN1173950C (zh) | 1998-10-06 | 2004-11-03 | 大日本制药株式会社 | 2,3-二取代的吡啶衍生物、其制备方法、含有其的药物组合物和用于制备中的中间体 |
| GB9902989D0 (en) | 1999-02-11 | 1999-03-31 | Zeneca Ltd | Heterocyclic derivatives |
| AR023510A1 (es) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
| WO2002012207A1 (en) | 2000-08-04 | 2002-02-14 | 3-Dimensional Pharmaceuticals, Inc. | Cyclic oxyguanidine protease inhibitors |
| AU2001292331B2 (en) * | 2000-10-04 | 2007-01-18 | Kissei Pharmaceutical Co., Ltd. | 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation |
| EP1399137A4 (en) * | 2001-05-07 | 2005-12-14 | Smithkline Beecham Corp | SULPHONAMIDES |
| AU2002256497A1 (en) * | 2001-05-07 | 2002-11-18 | Smithkline Beecham Corporation | Sulfonamides |
| US7476683B2 (en) | 2002-08-27 | 2009-01-13 | Merck Patent Gmbh | Glycinamide derivatives as raf-kinase inhibitors |
| JP2006508061A (ja) * | 2002-09-20 | 2006-03-09 | ファイザー・プロダクツ・インク | エストロゲン受容体に対するアミドおよびスルホンアミドリガンド |
| BRPI0416283A (pt) | 2003-11-05 | 2007-01-23 | Hoffmann La Roche | compostos, processo para a fabricação de compostos, composição farmacêutica, método para o tratamento e/ou prevenção de doenças que são moduladas por agonistas de ppar(delta) e/ou ppar(alfa) e uso destes compostos |
| US8940900B2 (en) * | 2007-02-28 | 2015-01-27 | Advinus Therapeutics Private Limited | 2,2,2-tri-substituted acetamide derivatives as glucokinase activators, their process and pharmaceutical application |
| RU2354647C2 (ru) * | 2007-06-28 | 2009-05-10 | Общество С Ограниченной Ответственностью "Бионика" | Новые соединения, обладающие функцией ингибиторов тромбина, и фармацевтические композиции на их основе |
| RU2353619C2 (ru) * | 2007-06-28 | 2009-04-27 | Общество С Ограниченной Ответственностью "Бионика" | Новые соединения, обладающие функцией антикоагулянтов, фармацевтические композиции на их основе для лечения тромботических состояний и плазмозамещающий раствор для коррекции гиперкоагуляционных нарушений при гемодилюции |
| GB0815781D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815782D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815784D0 (en) * | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| US8265575B2 (en) * | 2009-06-16 | 2012-09-11 | Mediatek Inc. | Methods for handling a transmitting process and communication apparatuses utilizing the same |
| US8207639B2 (en) | 2009-10-23 | 2012-06-26 | Sunonwealth Electric Machine Industry Co., Ltd. | Motor and heating dissipating fan including motor having an annular balancing member |
| RU2685261C1 (ru) * | 2018-04-05 | 2019-04-17 | Общество с ограниченной ответственностью "ФК ЛАБОРАТОРИЗ" | Вещество 4-амино-1-{ 2-[3-метил-5-(бензолсульфонилокси)фенокси] этил} -пиридиний хлорид, обладающее свойствами биологически активного агента, влияющими на естественно текущие процессы свертываемости крови млекопитающих, антикоагулянт на его основе и способ его получения путем химического синтеза |
| CN109172573B (zh) * | 2018-09-12 | 2021-01-26 | 黑龙江中桂制药有限公司 | 一种口服抗血栓药物及其用途 |
| CN110669337B (zh) * | 2019-07-08 | 2020-09-25 | 中国科学院长春应用化学研究所 | 一种芳香型二胺单体及其制备方法 |
| WO2024243343A2 (en) * | 2023-05-23 | 2024-11-28 | John Karanicolas | Compounds that re-activate mutant p53 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1097620A1 (ru) * | 1983-02-16 | 1984-06-15 | Новокузнецкий научно-исследовательский химико-фармацевтический институт | Способ получени диэтил-N-(6-метилпиридил-2)-аминометиленмалоната |
| SU1318599A1 (ru) * | 1985-06-26 | 1987-06-23 | МГУ им.М.В.Ломоносова | Способ получени 1-алкил-2-хлор-2-алкоксиэтенилалкил(арил)хлорфосфинов |
| DE3529529A1 (de) * | 1985-08-17 | 1987-02-19 | Boehringer Mannheim Gmbh | Verfahren zur herstellung einer stabilen modifikation von torasemid |
| GB8819307D0 (en) * | 1988-08-13 | 1988-09-14 | Pfizer Ltd | Antiarrhythmic agents |
| JPH0256465A (ja) * | 1988-08-22 | 1990-02-26 | Hamari Yakuhin Kogyo Kk | アセトアミド化合物 |
| US4885927A (en) * | 1988-09-12 | 1989-12-12 | General Motors Corporation | Method and apparatus for press forming intricate metallic shapes such as spool valve elements |
| US5539104A (en) * | 1991-10-31 | 1996-07-23 | Smithkline Beecham Corp. | 1,4 Diazocines as fibrinogen antagonists |
| WO1993010091A2 (en) * | 1991-11-14 | 1993-05-27 | Glaxo Group Limited | Piperidine acetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation |
| DE4212304A1 (de) * | 1992-04-13 | 1993-10-14 | Cassella Ag | Asparaginsäurederivate, ihre Herstellung und Verwendung |
-
1994
- 1994-02-22 TW TW083101504A patent/TW257757B/zh active
- 1994-02-28 IL IL10878694A patent/IL108786A/en not_active IP Right Cessation
- 1994-03-02 CZ CZ952254A patent/CZ225495A3/cs unknown
- 1994-03-02 SK SK1082-95A patent/SK108295A3/sk unknown
- 1994-03-02 AT AT94909909T patent/ATE174590T1/de not_active IP Right Cessation
- 1994-03-02 AU AU62574/94A patent/AU682026B2/en not_active Ceased
- 1994-03-02 DE DE59407494T patent/DE59407494D1/de not_active Expired - Fee Related
- 1994-03-02 ES ES94909909T patent/ES2127919T3/es not_active Expired - Lifetime
- 1994-03-02 HU HU9502568A patent/HUT72898A/hu unknown
- 1994-03-02 KR KR1019950703694A patent/KR100252551B1/ko not_active Expired - Fee Related
- 1994-03-02 DK DK94909909T patent/DK0687253T3/da active
- 1994-03-02 PL PL94310520A patent/PL176455B1/pl unknown
- 1994-03-02 FI FI954105A patent/FI954105A7/fi unknown
- 1994-03-02 CA CA002156729A patent/CA2156729A1/en not_active Abandoned
- 1994-03-02 EP EP94909909A patent/EP0687253B1/de not_active Expired - Lifetime
- 1994-03-02 JP JP6519556A patent/JPH08507503A/ja active Pending
- 1994-03-02 RU RU95122612A patent/RU2126388C1/ru active
- 1994-03-02 CN CN94191554A patent/CN1046710C/zh not_active Expired - Fee Related
- 1994-03-02 NZ NZ262725A patent/NZ262725A/en unknown
- 1994-03-02 WO PCT/EP1994/000608 patent/WO1994020467A1/de not_active Ceased
-
1995
- 1995-09-01 NO NO953447A patent/NO953447D0/no unknown
-
1999
- 1999-03-16 GR GR990400775T patent/GR3029691T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2156729A1 (en) | 1994-09-15 |
| PL176455B1 (pl) | 1999-05-31 |
| CZ225495A3 (en) | 1996-01-17 |
| ES2127919T3 (es) | 1999-05-01 |
| RU2126388C1 (ru) | 1999-02-20 |
| FI954105A0 (fi) | 1995-09-01 |
| FI954105A7 (fi) | 1995-09-01 |
| CN1119858A (zh) | 1996-04-03 |
| KR960701019A (ko) | 1996-02-24 |
| EP0687253B1 (de) | 1998-12-16 |
| GR3029691T3 (en) | 1999-06-30 |
| AU6257494A (en) | 1994-09-26 |
| PL310520A1 (en) | 1995-12-27 |
| DE59407494D1 (de) | 1999-01-28 |
| AU682026B2 (en) | 1997-09-18 |
| WO1994020467A1 (de) | 1994-09-15 |
| IL108786A (en) | 1999-04-11 |
| NO953447L (no) | 1995-09-01 |
| NZ262725A (en) | 1997-05-26 |
| CN1046710C (zh) | 1999-11-24 |
| NO953447D0 (no) | 1995-09-01 |
| DK0687253T3 (da) | 1999-08-23 |
| HU9502568D0 (en) | 1995-11-28 |
| IL108786A0 (en) | 1994-06-24 |
| TW257757B (enExample) | 1995-09-21 |
| SK108295A3 (en) | 1996-06-05 |
| HUT72898A (en) | 1996-06-28 |
| EP0687253A1 (de) | 1995-12-20 |
| JPH08507503A (ja) | 1996-08-13 |
| ATE174590T1 (de) | 1999-01-15 |
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