AU2424499A - Heterocyclic amidines as callicrein protease inhibitors - Google Patents

Heterocyclic amidines as callicrein protease inhibitors

Info

Publication number
AU2424499A
AU2424499A AU24244/99A AU2424499A AU2424499A AU 2424499 A AU2424499 A AU 2424499A AU 24244/99 A AU24244/99 A AU 24244/99A AU 2424499 A AU2424499 A AU 2424499A AU 2424499 A AU2424499 A AU 2424499A
Authority
AU
Australia
Prior art keywords
callicrein
protease inhibitors
heterocyclic amidines
amidines
heterocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU24244/99A
Inventor
Dorit Baucke
Hans Wolfgang Hoffken
Wilfried Hornberger
Udo Lange
Helmut Mack
Werner Seitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Publication of AU2424499A publication Critical patent/AU2424499A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
AU24244/99A 1998-01-26 1999-01-23 Heterocyclic amidines as callicrein protease inhibitors Abandoned AU2424499A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19802802 1998-01-26
DE19802802 1998-01-26
PCT/EP1999/000435 WO1999037611A1 (en) 1998-01-26 1999-01-23 Heterocyclic amidines as callicrein protease inhibitors

Publications (1)

Publication Number Publication Date
AU2424499A true AU2424499A (en) 1999-08-09

Family

ID=7855661

Family Applications (1)

Application Number Title Priority Date Filing Date
AU24244/99A Abandoned AU2424499A (en) 1998-01-26 1999-01-23 Heterocyclic amidines as callicrein protease inhibitors

Country Status (4)

Country Link
EP (1) EP1049673A1 (en)
JP (1) JP2002501044A (en)
AU (1) AU2424499A (en)
WO (1) WO1999037611A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU765417B2 (en) * 1998-12-29 2003-09-18 Lg Life Sciences Ltd. Thrombin inhibitors

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002502852A (en) * 1998-02-09 2002-01-29 ３−ディメンショナル ファーマシューティカルズ， インコーポレイテッド Heteroarylamidines, methylamidines and guanidines as protease inhibitors, especially urokinase inhibitors
CA2362390A1 (en) * 1999-02-09 2000-08-17 3-Dimensional Pharmaceuticals, Inc. Heteroaryl amidines, methylamidines and guanidines as protease inhibitors
PL352824A1 (en) * 1999-04-09 2003-09-08 Abbott Gmbh & Co.Kg Prodrugs of thrombin inhibitors
IL145771A0 (en) * 1999-04-09 2002-07-25 Basf Ag Low-molecular inhibitors of complement proteases
AR023510A1 (en) 1999-04-21 2002-09-04 Astrazeneca Ab A TEAM OF PARTS, PHARMACEUTICAL FORMULATION AND USE OF A THROMBIN INHIBITOR.
AU2003210055A1 (en) * 2002-03-22 2003-10-08 Lg Life Sciences Ltd. New crystalline forms of (2S)-N-5-[amino(imino)methyl]-2-thienylmethyl-1-(2R)-2-[(carboxymethyl)amino]-3,3-diphenylpropanoyl-2-pyrrolidinecarboxamide nH20
PL372596A1 (en) * 2002-03-22 2005-07-25 Lg Life Sciences Ltd. Maleic acid salt of (2s)-n-{5-[amino(imino)methyl]-2-thienyl}methyl-1-{(2r)-2-[(carboxymethyl)amino]3,3-diphenylpropanoyl}-2-pyrrolidine carboxamide and a process for
AU2003245060A1 (en) * 2002-06-27 2004-01-19 Lg Life Sciences Ltd. Peptidic thrombin inhibitor compound
EP1736465A4 (en) 2004-03-31 2009-06-17 Ajinomoto Kk Aniline derivatives
DE102005035250A1 (en) * 2005-07-25 2007-02-01 Archimica Gmbh Process for the preparation of nitriles by elimination reactions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9301916D0 (en) * 1993-06-03 1993-06-03 Ab Astra NEW PEPTIDES DERIVATIVES
IL112795A (en) * 1994-03-04 2001-01-28 Astrazeneca Ab Peptide derivatives as antithrombic agents their preparation and pharmaceutical compositions containing them
DE19504504A1 (en) * 1995-02-10 1996-08-14 Basf Ag New orally active thrombin inhibiting peptide cpds.
DE19506610A1 (en) * 1995-02-24 1996-08-29 Basf Ag New orally active thrombin inhibiting peptide cpds.
AU708001B2 (en) * 1995-02-17 1999-07-29 Abbott Gmbh & Co. Kg Novel thrombin inhibitors
DE19632773A1 (en) * 1996-08-14 1998-02-19 Basf Ag New thrombin inhibitors

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU765417B2 (en) * 1998-12-29 2003-09-18 Lg Life Sciences Ltd. Thrombin inhibitors

Also Published As

Publication number Publication date
WO1999037611A1 (en) 1999-07-29
EP1049673A1 (en) 2000-11-08
JP2002501044A (en) 2002-01-15

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase