DK0629212T3 - Antikoagulerende peptidderivater og farmaceutiske præparater indeholdende disse samt fremgangsmåde til fremstilling deraf. - Google Patents
Antikoagulerende peptidderivater og farmaceutiske præparater indeholdende disse samt fremgangsmåde til fremstilling deraf.Info
- Publication number
- DK0629212T3 DK0629212T3 DK93905589.3T DK93905589T DK0629212T3 DK 0629212 T3 DK0629212 T3 DK 0629212T3 DK 93905589 T DK93905589 T DK 93905589T DK 0629212 T3 DK0629212 T3 DK 0629212T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- pyridyl
- pharmaceutical compositions
- compositions containing
- peptide derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9200725A HU211088B (en) | 1992-03-04 | 1992-03-04 | Process for producing peptide derivates inhibiting coagulation of blood and pharmaceutical compositions containing them |
HU9201657A HU9201657D0 (en) | 1992-05-19 | 1992-05-19 | Process for the production of anti-coagulant new peptid derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0629212T3 true DK0629212T3 (da) | 1998-05-25 |
Family
ID=26318068
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93905589.3T DK0629212T3 (da) | 1992-03-04 | 1993-03-04 | Antikoagulerende peptidderivater og farmaceutiske præparater indeholdende disse samt fremgangsmåde til fremstilling deraf. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5760235A (da) |
EP (1) | EP0629212B1 (da) |
JP (1) | JPH08501057A (da) |
KR (1) | KR950700324A (da) |
AT (1) | ATE159030T1 (da) |
AU (1) | AU663169B2 (da) |
CA (1) | CA2131367A1 (da) |
DE (1) | DE69314478T2 (da) |
DK (1) | DK0629212T3 (da) |
ES (1) | ES2110599T3 (da) |
WO (1) | WO1993018060A1 (da) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6984627B1 (en) | 1993-06-03 | 2006-01-10 | Astrazeneca Ab | Peptide derivatives |
DE4421052A1 (de) | 1994-06-17 | 1995-12-21 | Basf Ag | Neue Thrombininhibitoren, ihre Herstellung und Verwendung |
MX9706069A (es) * | 1995-02-17 | 1997-10-31 | Basf Ag | Nuevos inhibidores de la trombina. |
SA96170106A (ar) | 1995-07-06 | 2005-12-03 | أسترا أكتيبولاج | مشتقات حامض أميني جديدة |
TWI238827B (en) * | 1995-12-21 | 2005-09-01 | Astrazeneca Ab | Prodrugs of thrombin inhibitors |
DE19549118C2 (de) * | 1995-12-29 | 2000-07-13 | Thomas W Stief | Hämostaseaktivierungs-Inhibitor und Verfahren zum Hemmen der Hämostaseaktivierung in Blut oder anderen biologischen Flüssigkeiten |
SE9602263D0 (sv) | 1996-06-07 | 1996-06-07 | Astra Ab | New amino acid derivatives |
SE9602646D0 (sv) | 1996-07-04 | 1996-07-04 | Astra Ab | Pharmaceutically-useful compounds |
AR013084A1 (es) | 1997-06-19 | 2000-12-13 | Astrazeneca Ab | Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados |
SE9704543D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Ab | New compounds |
IL136139A0 (en) | 1998-01-26 | 2001-05-20 | Basf Ag | Thrombin inhibitors |
SE9804313D0 (sv) | 1998-12-14 | 1998-12-14 | Astra Ab | New compounds |
NZ512714A (en) | 1999-01-13 | 2003-10-31 | Astrazeneca Ab | Amidinobenzylamine derivatives useful as thrombin inhibitors |
AR023510A1 (es) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
SE0001803D0 (sv) | 2000-05-16 | 2000-05-16 | Astrazeneca Ab | New compounds i |
US6433186B1 (en) | 2000-08-16 | 2002-08-13 | Astrazeneca Ab | Amidino derivatives and their use as thormbin inhibitors |
AR035216A1 (es) | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
US7129233B2 (en) | 2000-12-01 | 2006-10-31 | Astrazeneca Ab | Mandelic acid derivatives and their use as thrombin inhibitors |
AR034517A1 (es) | 2001-06-21 | 2004-02-25 | Astrazeneca Ab | Formulacion farmaceutica |
SE0201661D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | New salts |
SE0201659D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Modified release pharmaceutical formulation |
US7795205B2 (en) | 2004-04-12 | 2010-09-14 | Canyon Pharmaceuticals, Inc. | Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor |
US20060084887A1 (en) * | 2004-10-18 | 2006-04-20 | Golde William T | Rapid, simple and humane method of bleeding mice |
TW200827336A (en) | 2006-12-06 | 2008-07-01 | Astrazeneca Ab | New crystalline forms |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU169870B (da) * | 1974-06-14 | 1977-02-28 | ||
HU177098B (en) * | 1979-01-04 | 1981-07-28 | Gyogyszerkutato Intezet | Process for producing new peptidyl-n-carboxy-l-arginin-a |
HU184368B (en) * | 1981-01-13 | 1984-08-28 | Gyogyszerkutato Intezet | Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate |
HU192646B (en) * | 1984-12-21 | 1987-06-29 | Gyogyszerkutato Intezet | Process for preparing new n-alkyl-peptide aldehydes |
CA1311583C (en) * | 1986-12-15 | 1992-12-15 | Gerard Armand Marguerie De Rotrou | Peptide derivatives and their application, in particular in therapy |
US5430023A (en) * | 1990-09-28 | 1995-07-04 | Eli Lilly And Company | Tripeptide antithrombotic agents |
IL99527A (en) * | 1990-09-28 | 1997-08-14 | Lilly Co Eli | Tripeptide antithrombotic agents |
CA2075154A1 (en) * | 1991-08-06 | 1993-02-07 | Neelakantan Balasubramanian | Peptide aldehydes as antithrombotic agents |
US5416093A (en) * | 1991-11-12 | 1995-05-16 | Eli Lilly And Company | Antithrombotic agents |
-
1993
- 1993-03-04 AU AU36469/93A patent/AU663169B2/en not_active Ceased
- 1993-03-04 EP EP93905589A patent/EP0629212B1/en not_active Expired - Lifetime
- 1993-03-04 AT AT93905589T patent/ATE159030T1/de not_active IP Right Cessation
- 1993-03-04 US US08/740,009 patent/US5760235A/en not_active Expired - Fee Related
- 1993-03-04 WO PCT/HU1993/000013 patent/WO1993018060A1/en active IP Right Grant
- 1993-03-04 CA CA002131367A patent/CA2131367A1/en not_active Abandoned
- 1993-03-04 ES ES93905589T patent/ES2110599T3/es not_active Expired - Lifetime
- 1993-03-04 DE DE69314478T patent/DE69314478T2/de not_active Expired - Fee Related
- 1993-03-04 JP JP5515508A patent/JPH08501057A/ja active Pending
- 1993-03-04 DK DK93905589.3T patent/DK0629212T3/da active
-
1994
- 1994-09-05 KR KR1019940703090A patent/KR950700324A/ko active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ATE159030T1 (de) | 1997-10-15 |
DE69314478T2 (de) | 1999-02-11 |
AU3646993A (en) | 1993-10-05 |
KR950700324A (ko) | 1995-01-16 |
DE69314478D1 (de) | 1997-11-13 |
ES2110599T3 (es) | 1998-02-16 |
EP0629212B1 (en) | 1997-10-08 |
AU663169B2 (en) | 1995-09-28 |
EP0629212A1 (en) | 1994-12-21 |
WO1993018060A1 (en) | 1993-09-16 |
US5760235A (en) | 1998-06-02 |
CA2131367A1 (en) | 1993-09-16 |
JPH08501057A (ja) | 1996-02-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0629212T3 (da) | Antikoagulerende peptidderivater og farmaceutiske præparater indeholdende disse samt fremgangsmåde til fremstilling deraf. | |
IL127352A (en) | Pyridyl alkene- and pyridyl alkine-acid amides and pharmaceutical compositions containing them | |
NO934501L (no) | Karboksylsyrederivater, legemidler inneholdende disse forbindelser, og fremgangsmåte for deres fremstilling | |
NO940261L (no) | 5-leddete heterocykler, fremgangsmåte ved fremstilling derav og legemidler som inneholder disse forbindelser | |
AU560757B2 (en) | Pharmaceutical compositions containing 3-hydroxybutanoic acid or a salt derived from this acid, and compounds derived from 3-hydroxybutanoic acid which can be used as medicaments | |
YU69991A (sh) | Derivati piridina | |
MY129425A (en) | Indole derivatives useful a.o. for the treatment of osteoporosis | |
NO932120L (no) | Bifenylderivater, legemidler inneholdende disse, og fremgangsmaate for deres fremstilling | |
HUT75123A (en) | 5-pyrrolyl-2-pyridylmethylsulfinyl benzimidazole derivatives | |
DK0662972T3 (da) | 3-, 8-substituerede deuteroporphyrinderivater, farmaceutiske midler indeholdende disse og fremgangsmåder til deres fremstilling | |
RU94028888A (ru) | Производные 1,3-замещенного циклоалкана и циклоалкена, смесь их изомеров или индивидуальные изомеры, их гидраты и соли, способ их получения и фармацевтическая композиция | |
HUT40403A (en) | Process for preparing derivatives of amino acids | |
PL328712A1 (en) | Anionic salts of non-narcotic analgetic agents of carboxylic acid type combined with morphine and diamorphine, method of obtaining them, their application and pharmaceutic agents containing such salts | |
HUT55034A (en) | Process for producing peptides with hemoregulating effect and pharmaceutical compositions comprising such compounds as active ingredient | |
UA70986C2 (uk) | Похідні (1-арацил-3-арил-3-піперидилетил)піперидину, спосіб їх отримання та фармацевтична композиція, що має у своєму складі такі похідні | |
UA27242C2 (uk) | Комплекс включення 3-морфоліносидноніміну, або його солей, або його таутомірного ізомеру, що має антиішемічний ефект, спосіб їх отримання, фармацевтична композиція, спосіб її одержання та спосіб лікування ішемічної хвороби серця | |
HU9601527D0 (en) | New peptid-andehyde derivatives of anticoagulant activity | |
YU81502A (sh) | Ciklopostini, postupak za njihovu proizvodnju i njihova primena | |
AU5500896A (en) | Substituted phenylamidines, pharmaceutical compositions containing these compounds and processes for preparing them | |
DK0722460T3 (da) | Peptidderivater der er terapeutisk aktive i blodkoaguleringskaskaden, fremgangsmåde til fremstilling heraf og farmaceutiske | |
HUT63633A (en) | Process for producing new anticoagulant peptide derivatives | |
AU1466592A (en) | Gem-diphosphonic acid nitrosocarbamoyl derivatives, a process for the preparation thereof and pharmaceutical compositions containing them | |
TH52870A (th) | อนุพันธ์อินโดลใหม่, กรรมวิธีสำหรับการเตรียมอนุพันธ์นั้น, การใช้อนุพันธ์นั้น และองค์ประกอบทางเภสัชกรรมซึ่งมีอนุพันธ์นั้น | |
RU94022252A (ru) | Производные акриловой кислоты, амины, используемые для получения данных производных, способ предотвращения или лечения заболевания |