DK0662972T3 - 3-, 8-substituerede deuteroporphyrinderivater, farmaceutiske midler indeholdende disse og fremgangsmåder til deres fremstilling - Google Patents

3-, 8-substituerede deuteroporphyrinderivater, farmaceutiske midler indeholdende disse og fremgangsmåder til deres fremstilling

Info

Publication number
DK0662972T3
DK0662972T3 DK93921875T DK93921875T DK0662972T3 DK 0662972 T3 DK0662972 T3 DK 0662972T3 DK 93921875 T DK93921875 T DK 93921875T DK 93921875 T DK93921875 T DK 93921875T DK 0662972 T3 DK0662972 T3 DK 0662972T3
Authority
DK
Denmark
Prior art keywords
pct
preparation
methods
pharmaceuticals containing
date
Prior art date
Application number
DK93921875T
Other languages
English (en)
Inventor
Christoph-Stephan Hilger
Franz-Karl Maier
Heinz Gries
Ulrich Niedballa
Johannes Platzek
Mary Lee-Vaupel
Wolfgang Ebert
Juergen Conrad
Josef Gaida
Original Assignee
Diagnostikforschung Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diagnostikforschung Inst filed Critical Diagnostikforschung Inst
Application granted granted Critical
Publication of DK0662972T3 publication Critical patent/DK0662972T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0485—Porphyrins, texaphyrins wherein the nitrogen atoms forming the central ring system complex the radioactive metal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK93921875T 1992-09-28 1993-09-28 3-, 8-substituerede deuteroporphyrinderivater, farmaceutiske midler indeholdende disse og fremgangsmåder til deres fremstilling DK0662972T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4232925A DE4232925A1 (de) 1992-09-28 1992-09-28 3-,8-substituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel und Verfahren zu ihrer Herstellung
PCT/EP1993/002645 WO1994007894A1 (de) 1992-09-28 1993-09-28 3-,8-substituierte deuteroporphyrinderivate, diese enthaltende pharmazeutische mittel und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
DK0662972T3 true DK0662972T3 (da) 2003-03-03

Family

ID=6469326

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93921875T DK0662972T3 (da) 1992-09-28 1993-09-28 3-, 8-substituerede deuteroporphyrinderivater, farmaceutiske midler indeholdende disse og fremgangsmåder til deres fremstilling

Country Status (11)

Country Link
US (1) US5849259A (da)
EP (1) EP0662972B1 (da)
JP (1) JPH08504399A (da)
AT (1) ATE226953T1 (da)
CA (1) CA2145509C (da)
DE (2) DE4232925A1 (da)
DK (1) DK0662972T3 (da)
ES (1) ES2186677T3 (da)
NO (1) NO303732B1 (da)
WO (1) WO1994007894A1 (da)
ZA (1) ZA937194B (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0758907A1 (en) * 1994-05-11 1997-02-26 Schering Aktiengesellschaft The use of porphyrin-complex or expanded porphyrin-complex compounds as localization diagnosticum for infarction or necrosis
DE19719033C1 (de) * 1997-04-29 1999-01-28 Schering Ag Ionenpaare, Verfahren zu ihrer Herstellung und ihre Verwendung als Kontrastmittel
EP0885616A1 (de) * 1997-06-20 1998-12-23 Schering Aktiengesellschaft Verwendung von intravenösen Kontrastmitteln sowie Vorrichtungen für die Projektionsmammographie
DE19845782C1 (de) * 1998-09-22 2000-04-13 Schering Ag Verfahren zur Herstellung von Metallporphyrin-Metallkomplex-Konjugaten
US6194566B1 (en) 1997-12-02 2001-02-27 Schering Aktiengesellschaft Process for the production of metalloporphyrin-metal complex conjugates
US6136841A (en) * 1998-06-02 2000-10-24 Schering Aktiengesellschaft 3-, 8-substituted deuteroporphyrin derivatives, pharmaceutical agents that contain the latter, process for their production and their use in photodynamic therapy and MRI diagnosis
DE19825512A1 (de) * 1998-06-02 1999-12-09 Schering Ag 3-,8-subsituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung in der photodynamischen Therapie und MRI-Diagnostik
US6251367B1 (en) 1998-07-24 2001-06-26 Schering Aktiengesellschaft Paramagnetic 3-,8-substituted deuteroporphyrin derivatives, pharmaceutical agents that contain the latter, process for their production, and their use for MR imaging of necrosis and infarction
DE19835082A1 (de) * 1998-07-24 2000-02-03 Schering Ag Paramagnetische 3-,8-substituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung für das Nekrose- und Infarkt-MR-Imaging
US6482943B1 (en) 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
EP1698629A3 (en) 1999-04-30 2006-11-29 Cellgate, Inc. Polyamines and their use in therapy
US6649587B1 (en) 1999-04-30 2003-11-18 Slil Biomedical Corporation Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
CA2368801A1 (en) * 1999-04-30 2000-11-09 Slil Biomedical Corporation Conjugates as therapies for cancer and prostate diseases
US6548045B2 (en) * 1999-11-30 2003-04-15 Photochemical Co., Ltd. Nitroimidazole substituted porphyrin complex
DE19961533A1 (de) * 1999-12-20 2002-03-28 Steag Micro Tech Gmbh Vorrichtung und Verfahren zum Behandeln von Substraten
US7097826B2 (en) * 1999-12-23 2006-08-29 Health Research, Inc. Chlorin and bacteriochlorin-based difunctional aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
US20030072715A1 (en) * 2000-08-02 2003-04-17 Benjamin Frydman Cyclic polyamine compounds for cancer therapy
EP1337504A4 (en) 2000-11-08 2005-10-05 Cellgate Inc NOVEL AMINO ACID CONJUGATES AND POLYAMINE ANALOGUES USEFUL AS ANTICANCING AGENTS
WO2002096366A2 (en) * 2001-05-31 2002-12-05 Miravant Pharmaceuticals, Inc. Metallotetrapyrrolic photosensitizing agents for use in photodynamic therapy
EP1401430A4 (en) * 2001-05-31 2005-10-19 Miravant Pharm Inc SUBSTITUTED PORPHYRIN AND AZAPORPHYRIN DERIVATIVES AND USE IN PHOTODYNAMIC THERAPY, RADIOIMAGING, AND MRI DIAGNOSIS
JP5000050B2 (ja) * 2001-08-31 2012-08-15 浩 前田 抗腫瘍剤及びその製造方法
DE10240343A1 (de) * 2002-08-27 2004-03-11 Schering Ag Peroxynitrit-Umlagerungskatalysatoren
GB2397067B (en) 2002-12-23 2005-05-11 Destiny Pharma Ltd Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation
JP5823988B2 (ja) * 2011-01-31 2015-11-25 国立大学法人宇都宮大学 ポルフィリン型骨格を有する化合物の金属錯体の製造方法
CN102363619A (zh) * 2011-11-18 2012-02-29 中国医学科学院生物医学工程研究所 水溶性原卟啉化合物及制备方法及用途
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
KR102464647B1 (ko) 2016-11-28 2022-11-08 바이엘 파마 악티엔게젤샤프트 자기 공명 영상화에 사용하기 위한 높은 이완도 가돌리늄 킬레이트 화합물
CN113164628A (zh) 2018-11-23 2021-07-23 拜耳股份有限公司 造影介质制剂及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485086A (en) * 1983-04-11 1984-11-27 Wong Dennis W Radiolabeled tumor imaging agent and method of preparation
US5283255A (en) * 1987-01-20 1994-02-01 The University Of British Columbia Wavelength-specific cytotoxic agents
DE3827940A1 (de) * 1988-08-13 1990-03-01 Schering Ag 13,17-propionsaeure- und propionsaeurederivat- substituierte porphyrin-komplexverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US4935498A (en) * 1989-03-06 1990-06-19 Board Of Regents, The University Of Texas System Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles
US5371199B1 (en) * 1992-08-14 1995-12-26 Univ Pennsylvania Substituted porphyrins porphyrin-containing polymers and synthetic methods therefor

Also Published As

Publication number Publication date
NO303732B1 (no) 1998-08-24
DE59310310D1 (de) 2002-12-05
US5849259A (en) 1998-12-15
DE4232925A1 (de) 1994-03-31
EP0662972A1 (de) 1995-07-19
NO951166L (no) 1995-03-27
CA2145509A1 (en) 1994-04-14
CA2145509C (en) 2005-04-05
ATE226953T1 (de) 2002-11-15
EP0662972B1 (de) 2002-10-30
WO1994007894A1 (de) 1994-04-14
ZA937194B (en) 1994-04-21
JPH08504399A (ja) 1996-05-14
ES2186677T3 (es) 2003-05-16
NO951166D0 (no) 1995-03-27

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