NZ240481A - Aminosulphonyl urea derivatives and pharmaceutical compositions - Google Patents

Aminosulphonyl urea derivatives and pharmaceutical compositions

Info

Publication number
NZ240481A
NZ240481A NZ240481A NZ24048191A NZ240481A NZ 240481 A NZ240481 A NZ 240481A NZ 240481 A NZ240481 A NZ 240481A NZ 24048191 A NZ24048191 A NZ 24048191A NZ 240481 A NZ240481 A NZ 240481A
Authority
NZ
New Zealand
Prior art keywords
pharmaceutical compositions
aminosulphonyl
urea derivatives
compounds
acat inhibitors
Prior art date
Application number
NZ240481A
Inventor
Joseph Armand Picard
Drago Robert Sliskovic
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NZ240481A publication Critical patent/NZ240481A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04—Diamides of sulfuric acids
    • C07C307/06—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04—Diamides of sulfuric acids
    • C07C307/08—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04—Diamides of sulfuric acids
    • C07C307/10—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides pharmaceutically useful compounds which are aminosulfonyl urea compounds which are ACAT inhibitors rendering them useful in controlling blood cholesterol levels, pharmaceutical compositions and methods of using the ACAT inhibitors and closely related compounds which are also aminosulfonyl urea compounds.
NZ240481A 1990-11-07 1991-11-05 Aminosulphonyl urea derivatives and pharmaceutical compositions NZ240481A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61028790A 1990-11-07 1990-11-07
US07/747,040 US5214206A (en) 1990-11-07 1991-08-19 Aminosulfonyl urea acat inhibitors

Publications (1)

Publication Number Publication Date
NZ240481A true NZ240481A (en) 1994-06-27

Family

ID=27086230

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ240481A NZ240481A (en) 1990-11-07 1991-11-05 Aminosulphonyl urea derivatives and pharmaceutical compositions

Country Status (16)

Country Link
US (2) US5214206A (en)
EP (1) EP0556322B1 (en)
JP (2) JP3256541B2 (en)
AT (1) ATE139226T1 (en)
AU (1) AU657928B2 (en)
CA (1) CA2094806C (en)
DE (1) DE69120287T2 (en)
DK (1) DK0556322T3 (en)
ES (1) ES2088128T3 (en)
GR (1) GR3020355T3 (en)
IE (1) IE75379B1 (en)
MX (1) MX9101958A (en)
NZ (1) NZ240481A (en)
PH (1) PH30665A (en)
PT (1) PT99435B (en)
WO (1) WO1992008694A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2145743T3 (en) * 1990-12-28 2000-07-16 Teijin Ltd COMPOSITE OF CONDENSED RING BENZOXA, ITS PRODUCTION AND PHARMACEUTICAL COMPOSITION THAT CONTAINS IT.
US5576335A (en) * 1994-02-01 1996-11-19 Nisshin Flour Milling Co., Ltd. Urea derivatives and their use as ACAT inhibitors
US5491170A (en) * 1994-12-19 1996-02-13 Warner-Lambert Company β-carboxy sulfonamide ACAT inhibitors
US6103733A (en) * 1998-09-09 2000-08-15 Bachmann; Kenneth A. Method for increasing HDL cholesterol levels using heteroaromatic phenylmethanes
CA2369967A1 (en) * 2001-02-12 2002-08-12 Joseph Anthony Cornicelli Methods of treating nuclear factor-kappa b mediated diseases and disorders
EP1281399A3 (en) * 2001-08-01 2004-02-11 Warner-Lambert Company Dual inhibitors of wax ester and cholesteryl ester synthesis for inhibiting sebum production
EP2640721B1 (en) 2010-11-16 2018-06-06 Texas Heart Institute Agonists that enhance binding of integrin-expressing cells to integrin receptors
CN103288749A (en) * 2013-03-04 2013-09-11 盐城工学院 Amino sulfonylurea compounds capable of being used as herbicides
EP3733209A1 (en) * 2014-10-03 2020-11-04 Synaffix B.V. Sulfamide linker, conjugates thereof, and methods of preparation
MD3259253T2 (en) * 2015-02-16 2020-06-30 Univ Queensland Sulfonylureas and related compounds and use of same
US11858922B2 (en) * 2016-02-16 2024-01-02 The University Of Queensland Sulfonylureas and related compounds and use of same
TWI789401B (en) 2017-07-07 2023-01-11 愛爾蘭商英弗雷佐姆有限公司 Novel compounds
GB201721185D0 (en) 2017-12-18 2018-01-31 Nodthera Ltd Sulphonyl urea derivatives
BR112021002770A2 (en) * 2018-08-15 2021-05-04 Inflazome Limited innovative sulfonamideurea compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2312404A (en) * 1939-11-22 1943-03-02 Haack Erich Method of preparing n-sulphonylureas
CH396872A (en) * 1959-08-13 1965-08-15 Ciba Geigy Process for the production of new ureas
US3242174A (en) * 1962-02-06 1966-03-22 Pfizer & Co C 1-(tertiary aminosulfonyl)-3-(hydrocarbon) ureas
GB990860A (en) * 1962-02-08 1965-05-05 Pfizer & Co C N,n-disubstituted sulfamylureas and compositions thereof
US3245982A (en) * 1962-03-27 1966-04-12 Pfizer & Co C Sulfamylsemicarbazides
DE1518541A1 (en) * 1965-03-16 1969-09-11 Boehringer Mannheim Gmbh Process for the preparation of sulfonylureas and sulfonyl semicarbazides
CH649081A5 (en) * 1982-01-12 1985-04-30 Ciba Geigy Ag TRIAZA CONNECTIONS.

Also Published As

Publication number Publication date
IE75379B1 (en) 1997-09-10
JP3256541B2 (en) 2002-02-12
WO1992008694A1 (en) 1992-05-29
DE69120287T2 (en) 1996-10-10
CA2094806A1 (en) 1992-05-08
PT99435A (en) 1992-12-31
JPH06501707A (en) 1994-02-24
DE69120287D1 (en) 1996-07-18
PH30665A (en) 1997-09-16
EP0556322A1 (en) 1993-08-25
DK0556322T3 (en) 1996-10-14
EP0556322B1 (en) 1996-06-12
JP2001026574A (en) 2001-01-30
US5214206A (en) 1993-05-25
US5288757A (en) 1994-02-22
IE913874A1 (en) 1992-05-20
CA2094806C (en) 2004-11-02
AU657928B2 (en) 1995-03-30
PT99435B (en) 1999-04-30
AU8959791A (en) 1992-06-11
MX9101958A (en) 1992-07-08
ATE139226T1 (en) 1996-06-15
ES2088128T3 (en) 1996-08-01
GR3020355T3 (en) 1996-09-30

Similar Documents

Publication Publication Date Title
TR199901172T2 (en) Newly substituted pyrazole derivatives.
NO931635D0 (en) PROCEDURE FOR THE PREPARATION OF CHINAZOLINE DERIVATIVES
NO971889D0 (en) Compounds and compositions for delivery of active agents
EE9800223A (en) Phenanthridines, medicinal products containing them and their use
GEP20063885B (en) Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
ATE185548T1 (en) USE OF N-ARYLMETHYLENE ETHYLENEDIAMINE DIACETATE, N-ARYLMETHYLENE IMINODIACETATE OR N,N'-DIARYLMETHYLENE ETHYLENEDIAMINE DIACETATE AGAINST OXIDATIVE STRESS
PT804252E (en) METALLIC CHELTER AGENTS THAT CONTAINS DIAMOND MONOAMINES AND THIOIS
CY1108610T1 (en) IL-2 Peptides and their derivatives and their use as therapeutic agents
MX9704030A (en) 2-heterocyclyloxy and thiomethyl-1,2,5-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof.
BG103399A (en) New heterocycle-substituted benzamides and their application for the treatment of diseases
DE69401204T2 (en) GONADOTROPINE CONTAINING FREEZER DRIED DROPS
ATE231872T1 (en) THIAZOLOPYRIMIDE DERIVATIVES
MX9702382A (en) New pyrimidone derivatives with antifungal activity.
MX9702170A (en) Use of aromatase inhibitors in the preparation of a drug for treating a relative androgen deficiency in men.
NZ240481A (en) Aminosulphonyl urea derivatives and pharmaceutical compositions
NO972391D0 (en) 2-Substituted 1,2,5-thiadiazolidin-3-one 1,1-dioxides and their preparations and methods
IL127918A0 (en) Novel amino sugar and related sugar derivatives of indolylopyrrolocarbazoles their use as antitumor agents and pharmaceutical formulations
MX9403088A (en) Indole derivatives.
SE9802937D0 (en) Novel compounds
AU8332791A (en) Oral pharmaceutical compositions containing melatonin
MX9704034A (en) Substituted 2-arylcarbonyloxymethyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives and compositions and method of use thereof.
AU6415994A (en) Substituted caprolactams and derivatives thereof useful for treatment of hiv disease
NO991734L (en) Pyrazolinones for the treatment of potency disorders
HUT41002A (en) Process for preparing anticonvulsives
DK0720597T3 (en) Triarylethylene derivatives for therapeutic use

Legal Events

Date Code Title Description
RENW Renewal (renewal fees accepted)
RENW Renewal (renewal fees accepted)
EXPY Patent expired