GB990860A - N,n-disubstituted sulfamylureas and compositions thereof - Google Patents

Abstract

The invention comprises (a) compounds of the general formulae <FORM:0990860/C2/1> and <FORM:0990860/C2/2> (wherein R is a C1-3 alkyl group, R1 is a phenylalkyl, chlorobenzyl, naphthylalkyl or thienylalkyl group, in which each alkyl group contains 1-3 carbon atoms, Z represents the atoms completing a tetrahydropyridino, C- (lower alkyl) piperidino, 4,4-di (lower alkyl) piperidino, 4,4 - tetramethylenepiperidino, 4,4-pentamethylenepiperidino, piperazino, N1-methylpiperazino, C - (lower alkyl) morpholino, di (lower alkyl) morpholino, thiamorpholino, C-(lower alkyl) thiamorpholino or di (lower alkyl) thiamorpholino group, in which the lower alkyl groups contain 1-3 carbon atoms, and R11 is a C2-8 alkyl, C4-9 cycloalkylalkyl, C3-8 cycloalkyl, C7-13 aralkyl, trifluoromethyl, p - tolyl, p-chlorophenyl, p - di (lower alkyl) aminophenyl or S - (lower alkyl) mercaptophenyl group, in which the lower alkyl groups contain 1-3 carbon atoms), non-toxic alkali metal, alkaline earth metal, ammonium and amine salts thereof, and acid addition salts of those compounds wherein R11 is a p-di (lower alkyl) aminophenyl group and/or Z represents the atoms completing a piperazino or N1-methylpiperazino group; and (b) pharmaceutical preparations containing them. The sulphamyl ureas are prepared by (a) reacting the sodium salt of the appropriate N,N-disubstituted aminosulphonamide with the appropriate N,N-diphenylurea derivative; or (b) reacting the appropriate N,N-disubstituted aminosulphonamide with the appropriate isocyanate in the presence of triethylamine, optionally followed in either case by salt formation. Other standard methods of preparation are outlined. The compounds of the invention are hypoglycaemic agents and may be administered orally in the form of pharmaceutical preparations (e.g. capsules, tablets, lozenges, troches, hard candies, aqueous suspensions and elixirs) containing them together with a carrier.