GB702067A - Improvements relating to compounds of the benzhydryl ether type - Google Patents

Improvements relating to compounds of the benzhydryl ether type

Info

Publication number
GB702067A
GB702067A GB4451/51A GB445151A GB702067A GB 702067 A GB702067 A GB 702067A GB 4451/51 A GB4451/51 A GB 4451/51A GB 445151 A GB445151 A GB 445151A GB 702067 A GB702067 A GB 702067A
Authority
GB
United Kingdom
Prior art keywords
piperidinol
group
benzhydryl
reacting
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4451/51A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nopco Chemical Co
Original Assignee
Nopco Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nopco Chemical Co filed Critical Nopco Chemical Co
Publication of GB702067A publication Critical patent/GB702067A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises benzhydryl ethers of the formula <FORM:0702067/IV(b)/1> where R1 and R2 are hydrogen, a halogen, an alkyl group or an alkoxy group but are not both hydrogen and R3 is an alkyl group, a cycloalkyl group, a heterocyclic ring, an aryl group or an aralkyl group and acid addition salts and quaternary ammonium salts thereof. They are prepared by reacting a corresponding benzhydryl halide with an N-substituted piperidinol or a sodium or potassium derivative thereof, or by reacting the alkali metal derivative of the benzhydrol with an N-subsituted-4-halo piperidine, the reaction in either case being preferably carried out in the presence of a tertiary amine. Specified acid addition salts are the hydrochlorides, hydrobromides, citrates, maleates, tartrates, succinates, sulphates and photphates. In examples 1-methyl-4-piperidinol is treated with the corresponding benzhydryl chloride to give the p : p1-dimethoxybenzhydryl-, p-chloro-p1-methoxybenzhydryl-, p-chlorobenzhydryl-, p-bromobenzhydryl-, p : p1-dichlorobenzhydryl-, p : p1-dibromobenzhydryl-andp-methoxybenzhydrylethers of 1-methyl-4-piperidinol. The general formulae of many other compounds according to the invention are given.
GB4451/51A 1950-04-07 1951-02-23 Improvements relating to compounds of the benzhydryl ether type Expired GB702067A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US702067XA 1950-04-07 1950-04-07

Publications (1)

Publication Number Publication Date
GB702067A true GB702067A (en) 1954-01-06

Family

ID=22093831

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4451/51A Expired GB702067A (en) 1950-04-07 1951-02-23 Improvements relating to compounds of the benzhydryl ether type

Country Status (1)

Country Link
GB (1) GB702067A (en)

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