ES436109A1 - Procedure for the preparation of new derivatives of pyridine. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of new derivatives of pyridine. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES436109A1
ES436109A1 ES436109A ES436109A ES436109A1 ES 436109 A1 ES436109 A1 ES 436109A1 ES 436109 A ES436109 A ES 436109A ES 436109 A ES436109 A ES 436109A ES 436109 A1 ES436109 A1 ES 436109A1
Authority
ES
Spain
Prior art keywords
formula
group
translation
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES436109A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
A Christiaens SA
Original Assignee
A Christiaens SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by A Christiaens SA filed Critical A Christiaens SA
Publication of ES436109A1 publication Critical patent/ES436109A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C07D213/71—Sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Procedure for the preparation of new pyridine derivatives, of the following formula: **(See formula)** in which R1, which can be in position 3 or in position 5, represents a group chosen from among the formulas **(See formula)** in which y R3 and R4, which may be identical or different, each represent hydrogen, a C1-C3 alkyl group which may be substituted by a C1-C2 alkoxy group or a methylpiperazinyl group 6 and together form the nitrogen atom to which a pyrrolidinyl, piperidyl, methylpiperidyl, morpholinyl, methylpiperazinyl or homopiperidyl ring is attached, and R2, which may be in the 2, 4 or 6 position, represents an alkylpiperazinyl or hydroxyethylpiperazinyl group with C1-C3, characterized in that comprises reacting a compound of the formula **(See formula)** in which R1 has the aforementioned meanings and X, which may be in the 2, 4 or 6 position, represents a halogen, with methylpiperazine or hydroxyethylpiperazine, the compound obtained from formula (I) being converted, if desired, into a acid addition salt. (Machine-translation by Google Translate, not legally binding)
ES436109A 1974-04-04 1975-03-27 Procedure for the preparation of new derivatives of pyridine. (Machine-translation by Google Translate, not legally binding) Expired ES436109A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1509474 1974-04-04

Publications (1)

Publication Number Publication Date
ES436109A1 true ES436109A1 (en) 1977-01-01

Family

ID=10052924

Family Applications (1)

Application Number Title Priority Date Filing Date
ES436109A Expired ES436109A1 (en) 1974-04-04 1975-03-27 Procedure for the preparation of new derivatives of pyridine. (Machine-translation by Google Translate, not legally binding)

Country Status (8)

Country Link
JP (1) JPS50140469A (en)
BE (1) BE827326A (en)
CA (1) CA1051888A (en)
DE (1) DE2514334A1 (en)
ES (1) ES436109A1 (en)
FR (1) FR2266506A1 (en)
LU (1) LU72195A1 (en)
NL (1) NL7503975A (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4994456A (en) * 1989-03-01 1991-02-19 Nisshin Flour Milling Co., Ltd. Pyridinecarboxylic acid amide derivatives and pharmaceutical compositions comprising same
DE19918021C1 (en) * 1999-04-21 2000-06-29 Ruetgers Organics Gmbh Preparation of chlorinated pyridine sulfonic acid chloride derivatives from hydroxypyridine sulfonic acids and phosphorus trichloride/chlorine gas; useful as intermediates for drugs, e.g. torasemide
PL370039A1 (en) 2000-03-20 2005-05-16 Teva Pharmaceutical Industries Ltd. Novel processes for preparing torsemide intermediate
MXPA06011414A (en) 2004-03-31 2007-04-20 Johnson & Johnson Non-imidazole heterocyclic compounds.
WO2005118543A1 (en) * 2004-06-03 2005-12-15 Ono Pharmaceutical Co., Ltd. Kinase inhibitor and use thereof
JP2007031391A (en) * 2005-07-29 2007-02-08 Koei Chem Co Ltd Method for producing alkylaminopyridine carbonitrile
AU2007256931B2 (en) 2006-05-30 2013-01-24 Janssen Pharmaceutica N.V. Substituted pyridyl amide compounds as modulators of the histamine H3 receptor
NZ584998A (en) 2007-11-20 2012-08-31 Janssen Pharmaceutica Nv Cycloalkyloxy-and heterocycloalkyloxypyridine compounds as modulators of the histamine h3 receptor

Also Published As

Publication number Publication date
DE2514334A1 (en) 1975-10-09
LU72195A1 (en) 1975-08-20
CA1051888A (en) 1979-04-03
NL7503975A (en) 1975-10-07
JPS50140469A (en) 1975-11-11
BE827326A (en) 1975-09-29
FR2266506A1 (en) 1975-10-31

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