GB1037655A - Di(aralkyl)amines - Google Patents

Di(aralkyl)amines

Info

Publication number
GB1037655A
GB1037655A GB2088564A GB2088564A GB1037655A GB 1037655 A GB1037655 A GB 1037655A GB 2088564 A GB2088564 A GB 2088564A GB 2088564 A GB2088564 A GB 2088564A GB 1037655 A GB1037655 A GB 1037655A
Authority
GB
United Kingdom
Prior art keywords
alkyl
compound
halogen
formula
reduced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2088564A
Inventor
Johan Gootjes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Pharmaceutische Fabrieken NV
Original Assignee
Koninklijke Pharmaceutische Fabrieken NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Pharmaceutische Fabrieken NV filed Critical Koninklijke Pharmaceutische Fabrieken NV
Priority to GB2088564A priority Critical patent/GB1037655A/en
Priority to NL6505765A priority patent/NL6505765A/xx
Priority to BE663997D priority patent/BE663997A/xx
Publication of GB1037655A publication Critical patent/GB1037655A/en
Expired legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

New compounds of formula <FORM:1037655/C2/1> where R1 is lower (1-6 C) alkyl, R2 is halogen, R3 is hydrogen or lower alkyl, and m and n are each 1-4, and non-toxic acid addition salts thereof, are prepared by reacting a dialkoxyphenalkylamine and a compound X.CO.(CH2)n- 1PhR2, X being halogen, to form an amide of formula <FORM:1037655/C2/2> and reducing the carbonyl group, optionally followed by reaction with an alkanoyl halide to form an N,N-disubstituted amide which is reduced. Processes also mentioned are (I) performing the second acylation-reduction above as a first step to yield a compound (R1O)2-Ph-(CH2)m.NH.alkyl which can then either by acylated and reduced or reacted with a compound X(CH2)nPhR2, and (II) reacting compounds (R1O)2-Ph-(CH2)m-X and alkyl.NH.(CH1)n-Ph-R2. Pharmaceutical compositions comprise the new compounds with carriers. Oral and parenteral preparations having analgesic, sedative and anaesthetic-potentiating activity are mentioned.
GB2088564A 1964-05-20 1964-05-20 Di(aralkyl)amines Expired GB1037655A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB2088564A GB1037655A (en) 1964-05-20 1964-05-20 Di(aralkyl)amines
NL6505765A NL6505765A (en) 1964-05-20 1965-05-06
BE663997D BE663997A (en) 1964-05-20 1965-05-17

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2088564A GB1037655A (en) 1964-05-20 1964-05-20 Di(aralkyl)amines

Publications (1)

Publication Number Publication Date
GB1037655A true GB1037655A (en) 1966-08-03

Family

ID=10153410

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2088564A Expired GB1037655A (en) 1964-05-20 1964-05-20 Di(aralkyl)amines

Country Status (3)

Country Link
BE (1) BE663997A (en)
GB (1) GB1037655A (en)
NL (1) NL6505765A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5141962A (en) * 1989-04-28 1992-08-25 Roussel Uclaf Amine compounds
JP2011513377A (en) * 2008-03-06 2011-04-28 ノヴァレメッド リミテッド Method for treating or preventing pain

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5141962A (en) * 1989-04-28 1992-08-25 Roussel Uclaf Amine compounds
JP2011513377A (en) * 2008-03-06 2011-04-28 ノヴァレメッド リミテッド Method for treating or preventing pain

Also Published As

Publication number Publication date
NL6505765A (en) 1965-11-22
BE663997A (en) 1965-11-17

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