GB1071815A - Phenothiazine derivatives - Google Patents
Phenothiazine derivativesInfo
- Publication number
- GB1071815A GB1071815A GB42571/64A GB4257164A GB1071815A GB 1071815 A GB1071815 A GB 1071815A GB 42571/64 A GB42571/64 A GB 42571/64A GB 4257164 A GB4257164 A GB 4257164A GB 1071815 A GB1071815 A GB 1071815A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl group
- tertiary
- mono
- atoms
- quaternary ammonium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compounds of the formula <FORM:1071815/C2/1> <FORM:1071815/C2/2> and their mono- and di-quaternary ammonium salts formed by reaction with one or two moles of R5X where A is a C1- 2-alkylene residue B is straight or branched chain alkylene residue containing a straight chain of 3-5 C between the two N atoms, R1 is a C1- 4 alkyl group, R2 and R3 each represents a C1- 4 alkyl group or they may be joined to represent with the common N atom, a heterocyclic ring of 5-8 atoms and optionally containing a second hetero atom, R4 is H, C1- 4 alkyl, CF3, halogen or acetyl, R5 is a C1- 4 alkyl group and X is Cl, Br or I o R5SO4 are prepared either by reacting the tertiary base with R5X or by first forming the base by condensing a phenothiazine with an aminoalkylaminoalkanoyl halide, a haloalkanoylan aminoalkanoyl- or a haloalkylaminoalkanoylphenothiazine with an aminoalkylamine, a haloalkylamine or an amine respectively and optionally quaternating the tertiary base or by replacing the tertiary bases in the forgoing reaction by the corresponding quarternary bases. N - Methyl - N - 3 - methylaminopropylpiperidinium chloride is prepared from N-3-chloropropyl-N-methyl piperidinium chloride and methylamine. Pharmaceutical compositions comprise the mono- and di-quaternary ammonium salts of the invention and a carrier therefor. The compositions, which are useful in the treatment of bronchospasm and spasm of smooth muscle, are formulated for oral and parenteral administration and also in the form of an aerosol.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB42571/64A GB1071815A (en) | 1964-10-19 | 1964-10-19 | Phenothiazine derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB42571/64A GB1071815A (en) | 1964-10-19 | 1964-10-19 | Phenothiazine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1071815A true GB1071815A (en) | 1967-06-14 |
Family
ID=10425012
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB42571/64A Expired GB1071815A (en) | 1964-10-19 | 1964-10-19 | Phenothiazine derivatives |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1071815A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0126366A2 (en) * | 1983-05-17 | 1984-11-28 | DOMPE' FARMACEUTICI S.p.A. | Quaternary salts of dibenzo(1,4)diazepinone, pyrido-(1,4)benzodiazepinone, pyrido(1,5)benzodiazepinone derivatives and pharmacological activity thereof |
WO2001092240A1 (en) * | 2000-05-29 | 2001-12-06 | Dalhousie University | Novel n-substituted phenothiazines and their use as modulators of serine hydrolase enzymes |
-
1964
- 1964-10-19 GB GB42571/64A patent/GB1071815A/en not_active Expired
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0126366A2 (en) * | 1983-05-17 | 1984-11-28 | DOMPE' FARMACEUTICI S.p.A. | Quaternary salts of dibenzo(1,4)diazepinone, pyrido-(1,4)benzodiazepinone, pyrido(1,5)benzodiazepinone derivatives and pharmacological activity thereof |
EP0126366A3 (en) * | 1983-05-17 | 1985-07-24 | Dompe' Farmaceutici S.P.A. | Quaternary salts of dibenzo(1,4)diazepinone, pyrido-(1,4)benzodiazepinone, pyrido(1,5)benzodiazepinone derivatives and pharmacological activity thereof |
WO2001092240A1 (en) * | 2000-05-29 | 2001-12-06 | Dalhousie University | Novel n-substituted phenothiazines and their use as modulators of serine hydrolase enzymes |
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