ES355189A1 - N-(tertiary amino-alkyl)-2-alkenyl (or alkynyl) oxy-benzamides and a process for the preparation thereof - Google Patents

N-(tertiary amino-alkyl)-2-alkenyl (or alkynyl) oxy-benzamides and a process for the preparation thereof

Info

Publication number
ES355189A1
ES355189A1 ES355189A ES355189A ES355189A1 ES 355189 A1 ES355189 A1 ES 355189A1 ES 355189 A ES355189 A ES 355189A ES 355189 A ES355189 A ES 355189A ES 355189 A1 ES355189 A1 ES 355189A1
Authority
ES
Spain
Prior art keywords
alkyl
alkynyl
alkenyl
benzamides
oxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES355189A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe dEtudes Scientifiques et Industrielles de lIle de France SA
Original Assignee
Societe dEtudes Scientifiques et Industrielles de lIle de France SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe dEtudes Scientifiques et Industrielles de lIle de France SA filed Critical Societe dEtudes Scientifiques et Industrielles de lIle de France SA
Publication of ES355189A1 publication Critical patent/ES355189A1/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Novel compounds of formula in which A is C 1-5 alkenyl or C 1-5 alkynyl X, Y are H, halo, amino, C 1-5 alkylamino or di-(C 1 _ 5 alkyl)-amino R 1 , R 2 are C 1-5 alkyl or together with N they form a heterocyclo which may also contain O and n is 1-3 are prepared by reacting a compound II with an amine III H 2 N-(CH 2 ) n -NR 1 (R 2 ) followed by acid addition or quaternary ammonium salt formation if desired. Intermediates isolated are those of Formula II prepared from the acid by reaction with thionyl chloride. Pharmaceutical compositions for enteral, parenteral or topical application contain a compound I together with a suitable excipient and are used as local anaesthetics.
ES355189A 1967-06-20 1968-06-19 N-(tertiary amino-alkyl)-2-alkenyl (or alkynyl) oxy-benzamides and a process for the preparation thereof Expired ES355189A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR111225A FR6557M (en) 1967-06-20 1967-06-20
FR120062A FR1542708A (en) 1967-06-20 1967-09-05 New n- (tertiary-aminoalkyl) -2-alkylene (or alkinyl) oxybenzamides and their preparation process

Publications (1)

Publication Number Publication Date
ES355189A1 true ES355189A1 (en) 1970-03-16

Family

ID=26177493

Family Applications (1)

Application Number Title Priority Date Filing Date
ES355189A Expired ES355189A1 (en) 1967-06-20 1968-06-19 N-(tertiary amino-alkyl)-2-alkenyl (or alkynyl) oxy-benzamides and a process for the preparation thereof

Country Status (20)

Country Link
AT (1) AT284821B (en)
BE (1) BE716315A (en)
BG (1) BG15553A3 (en)
CA (1) CA935161A (en)
CH (1) CH489472A (en)
CS (1) CS172300B2 (en)
DE (1) DE1768671C3 (en)
DK (1) DK144063C (en)
ES (1) ES355189A1 (en)
FI (1) FI49710C (en)
FR (2) FR6557M (en)
GB (1) GB1201221A (en)
IE (1) IE32154B1 (en)
IL (1) IL30185A (en)
MC (1) MC720A1 (en)
NL (1) NL160806C (en)
NO (1) NO120190B (en)
OA (1) OA03878A (en)
SE (2) SE372261B (en)
YU (1) YU32928B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH653670A5 (en) * 1983-03-03 1986-01-15 Hoffmann La Roche BENZAMIDE DERIVATIVES.
JP3933244B2 (en) * 1997-04-04 2007-06-20 株式会社資生堂 Alkylenediamine derivatives and anti-ulcer agents, antibacterial agents

Also Published As

Publication number Publication date
MC720A1 (en) 1969-04-01
AT284821B (en) 1970-09-25
NL160806B (en) 1979-07-16
DK144063C (en) 1982-04-19
OA03878A (en) 1975-08-14
FR6557M (en) 1968-12-23
IL30185A0 (en) 1968-08-22
FR1542708A (en) 1968-10-18
IE32154L (en) 1968-12-20
IE32154B1 (en) 1973-05-02
CS172300B2 (en) 1976-12-29
GB1201221A (en) 1970-08-05
NL160806C (en) 1979-12-17
YU32928B (en) 1975-12-31
DK144063B (en) 1981-11-30
SE7410567L (en) 1974-08-20
NL6808703A (en) 1968-12-23
CH489472A (en) 1970-04-30
CA935161A (en) 1973-10-09
FI49710B (en) 1975-06-02
SE372261B (en) 1974-12-16
BE716315A (en) 1968-12-10
NO120190B (en) 1970-09-14
IL30185A (en) 1972-11-28
DE1768671B2 (en) 1973-08-02
FI49710C (en) 1975-09-10
YU140868A (en) 1975-06-30
DE1768671A1 (en) 1972-08-10
SE391333B (en) 1977-02-14
BG15553A3 (en) 1972-05-20
DE1768671C3 (en) 1974-03-14

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