ES355189A1 - N-(tertiary amino-alkyl)-2-alkenyl (or alkynyl) oxy-benzamides and a process for the preparation thereof - Google Patents
N-(tertiary amino-alkyl)-2-alkenyl (or alkynyl) oxy-benzamides and a process for the preparation thereofInfo
- Publication number
- ES355189A1 ES355189A1 ES355189A ES355189A ES355189A1 ES 355189 A1 ES355189 A1 ES 355189A1 ES 355189 A ES355189 A ES 355189A ES 355189 A ES355189 A ES 355189A ES 355189 A1 ES355189 A1 ES 355189A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- alkynyl
- alkenyl
- benzamides
- oxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
Abstract
Novel compounds of formula in which A is C 1-5 alkenyl or C 1-5 alkynyl X, Y are H, halo, amino, C 1-5 alkylamino or di-(C 1 _ 5 alkyl)-amino R 1 , R 2 are C 1-5 alkyl or together with N they form a heterocyclo which may also contain O and n is 1-3 are prepared by reacting a compound II with an amine III H 2 N-(CH 2 ) n -NR 1 (R 2 ) followed by acid addition or quaternary ammonium salt formation if desired. Intermediates isolated are those of Formula II prepared from the acid by reaction with thionyl chloride. Pharmaceutical compositions for enteral, parenteral or topical application contain a compound I together with a suitable excipient and are used as local anaesthetics.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR111225A FR6557M (en) | 1967-06-20 | 1967-06-20 | |
| FR120062A FR1542708A (en) | 1967-06-20 | 1967-09-05 | New n- (tertiary-aminoalkyl) -2-alkylene (or alkinyl) oxybenzamides and their preparation process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES355189A1 true ES355189A1 (en) | 1970-03-16 |
Family
ID=26177493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES355189A Expired ES355189A1 (en) | 1967-06-20 | 1968-06-19 | N-(tertiary amino-alkyl)-2-alkenyl (or alkynyl) oxy-benzamides and a process for the preparation thereof |
Country Status (20)
| Country | Link |
|---|---|
| AT (1) | AT284821B (en) |
| BE (1) | BE716315A (en) |
| BG (1) | BG15553A3 (en) |
| CA (1) | CA935161A (en) |
| CH (1) | CH489472A (en) |
| CS (1) | CS172300B2 (en) |
| DE (1) | DE1768671C3 (en) |
| DK (1) | DK144063C (en) |
| ES (1) | ES355189A1 (en) |
| FI (1) | FI49710C (en) |
| FR (2) | FR6557M (en) |
| GB (1) | GB1201221A (en) |
| IE (1) | IE32154B1 (en) |
| IL (1) | IL30185A (en) |
| MC (1) | MC720A1 (en) |
| NL (1) | NL160806C (en) |
| NO (1) | NO120190B (en) |
| OA (1) | OA03878A (en) |
| SE (2) | SE372261B (en) |
| YU (1) | YU32928B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH653670A5 (en) * | 1983-03-03 | 1986-01-15 | Hoffmann La Roche | BENZAMIDE DERIVATIVES. |
| JP3933244B2 (en) * | 1997-04-04 | 2007-06-20 | 株式会社資生堂 | Alkylenediamine derivatives and anti-ulcer agents, antibacterial agents |
-
1967
- 1967-06-20 FR FR111225A patent/FR6557M/fr not_active Expired
- 1967-09-05 FR FR120062A patent/FR1542708A/en not_active Expired
-
1968
- 1968-06-10 NO NO2254/68A patent/NO120190B/no unknown
- 1968-06-10 BE BE716315D patent/BE716315A/xx not_active IP Right Cessation
- 1968-06-14 DE DE1768671A patent/DE1768671C3/en not_active Expired
- 1968-06-16 IL IL30185A patent/IL30185A/en unknown
- 1968-06-17 CH CH898068A patent/CH489472A/en not_active IP Right Cessation
- 1968-06-18 SE SE6808239A patent/SE372261B/xx unknown
- 1968-06-18 SE SE7410567A patent/SE391333B/en unknown
- 1968-06-19 ES ES355189A patent/ES355189A1/en not_active Expired
- 1968-06-19 CA CA022982A patent/CA935161A/en not_active Expired
- 1968-06-19 YU YU1408/68A patent/YU32928B/en unknown
- 1968-06-19 FI FI681715A patent/FI49710C/en active
- 1968-06-19 AT AT589168A patent/AT284821B/en not_active IP Right Cessation
- 1968-06-19 CS CS4532A patent/CS172300B2/cs unknown
- 1968-06-19 DK DK288968A patent/DK144063C/en not_active IP Right Cessation
- 1968-06-19 MC MC762A patent/MC720A1/en unknown
- 1968-06-20 NL NL6808703.A patent/NL160806C/en not_active IP Right Cessation
- 1968-06-20 IE IE736/68A patent/IE32154B1/en unknown
- 1968-06-20 GB GB29497/68A patent/GB1201221A/en not_active Expired
- 1968-06-20 OA OA53299A patent/OA03878A/en unknown
- 1968-07-18 BG BG010153A patent/BG15553A3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MC720A1 (en) | 1969-04-01 |
| AT284821B (en) | 1970-09-25 |
| NL160806B (en) | 1979-07-16 |
| DK144063C (en) | 1982-04-19 |
| OA03878A (en) | 1975-08-14 |
| FR6557M (en) | 1968-12-23 |
| IL30185A0 (en) | 1968-08-22 |
| FR1542708A (en) | 1968-10-18 |
| IE32154L (en) | 1968-12-20 |
| IE32154B1 (en) | 1973-05-02 |
| CS172300B2 (en) | 1976-12-29 |
| GB1201221A (en) | 1970-08-05 |
| NL160806C (en) | 1979-12-17 |
| YU32928B (en) | 1975-12-31 |
| DK144063B (en) | 1981-11-30 |
| SE7410567L (en) | 1974-08-20 |
| NL6808703A (en) | 1968-12-23 |
| CH489472A (en) | 1970-04-30 |
| CA935161A (en) | 1973-10-09 |
| FI49710B (en) | 1975-06-02 |
| SE372261B (en) | 1974-12-16 |
| BE716315A (en) | 1968-12-10 |
| NO120190B (en) | 1970-09-14 |
| IL30185A (en) | 1972-11-28 |
| DE1768671B2 (en) | 1973-08-02 |
| FI49710C (en) | 1975-09-10 |
| YU140868A (en) | 1975-06-30 |
| DE1768671A1 (en) | 1972-08-10 |
| SE391333B (en) | 1977-02-14 |
| BG15553A3 (en) | 1972-05-20 |
| DE1768671C3 (en) | 1974-03-14 |
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