GB1371969A - Triazene derivatives their production and their medicinal use - Google Patents
Triazene derivatives their production and their medicinal useInfo
- Publication number
- GB1371969A GB1371969A GB43991/72*2A GB4399172A GB1371969A GB 1371969 A GB1371969 A GB 1371969A GB 4399172 A GB4399172 A GB 4399172A GB 1371969 A GB1371969 A GB 1371969A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- halogen
- compounds
- production
- sept
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
- C07C245/22—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond containing chains of three or more nitrogen atoms with one or more nitrogen-to-nitrogen double bonds
- C07C245/24—Chains of only three nitrogen atoms, e.g. diazoamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C205/60—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms in ortho-position to the carboxyl group, e.g. nitro-salicylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/61—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
- C07C309/49—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
- C07C309/52—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton the carbon skeleton being further substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/66—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfo, esterified sulfo or halosulfonyl groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B43/00—Preparation of azo dyes from other azo compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
1371969 Triazenes BAYER AG 22 Sept 1972 [24 Sept 1971 7 March 1972] 43991/72 Heading C2 The invention comprises compounds of formula wherein R is H or a cation, R<SP>1</SP>, R<SP>2</SP> are each H, C 1-4 alkyl, CO 4 H, SO 3 H or halogen; R<SP>3</SP>, R<SP>4</SP> are each H, CN, C 1-4 alkyl or alkoxy, CO 2 H, SO 3 H, halogen, SO 2 NH 2 or SO 2 N (C 1-4 alkyl) 2 ; X is a direct bond, N=N, O, CO, S(=O) 0-2 CH 2 or CH 2 CH 2 (either of which may be halogen-, OH- or C 1-4 alkyl-substituted), or CH=CH (optionally halogen- or C 1-4 alkyl-substituted); R<SP>5</SP>, R<SP>6</SP> are Me and/or Et; and the salts of such compounds which contain a CO 2 H or SO 3 H group. These compounds are prepared by reacting with HNR<SP>5</SP>R<SP>6</SP>, the corresponding amine (after diazotization); the latter is generally made by reducing the corresponding nitro-compound. Therapeutic compositions for oral, parenteral, rectal, topical or aerosol administration, comprise compounds of the above formula, which have concerostatic activity.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2147781A DE2147781A1 (en) | 1971-09-24 | 1971-09-24 | TRIAZENE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND THEIR USE AS A MEDICINAL PRODUCT |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1371969A true GB1371969A (en) | 1974-10-30 |
Family
ID=5820498
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB43991/72*2A Expired GB1371969A (en) | 1971-09-24 | 1972-09-22 | Triazene derivatives their production and their medicinal use |
Country Status (12)
Country | Link |
---|---|
JP (2) | JPS4839614A (en) |
AT (1) | AT317177B (en) |
AU (1) | AU456553B2 (en) |
BE (1) | BE789138A (en) |
DD (1) | DD103891A5 (en) |
DE (1) | DE2147781A1 (en) |
FR (1) | FR2154568B1 (en) |
GB (1) | GB1371969A (en) |
HU (1) | HU165298B (en) |
IL (1) | IL40406A0 (en) |
NL (1) | NL7212793A (en) |
ZA (1) | ZA726484B (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012122969A1 (en) | 2011-03-16 | 2012-09-20 | Creative Therapeutics Gmbh | Substituted diphenyl derivatives |
WO2012130850A1 (en) | 2011-03-31 | 2012-10-04 | Bayer Pharma Aktiengesellschaft | Tissue targeting by means of oncocidal bridged diphenyl derivatives for the selective treatment of sexual organ tumors |
EP2557075A1 (en) * | 2011-08-09 | 2013-02-13 | Trin Therapeutics GmbH | New triazene compounds for treating cancer |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3010104A1 (en) | 1980-03-15 | 1981-10-01 | Basf Ag, 6700 Ludwigshafen | AMINOAZO CONNECTIONS |
US5189266A (en) * | 1989-06-09 | 1993-02-23 | Nissan Motor Co., Ltd. | Vehicular exhaust resonance suppression system and sensing means therefore |
MY122278A (en) * | 1999-07-19 | 2006-04-29 | Upjohn Co | 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position |
US7030109B2 (en) | 1999-07-19 | 2006-04-18 | Pharmacia & Upjohn Company | 1,2,3,4,5,6-Hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position |
US8034797B2 (en) * | 2007-07-04 | 2011-10-11 | Trin Therapeutics Gmbh | Triazene compounds for the treatment of cancer |
-
0
- BE BE789138D patent/BE789138A/en unknown
-
1971
- 1971-09-24 DE DE2147781A patent/DE2147781A1/en active Pending
-
1972
- 1972-09-21 NL NL7212793A patent/NL7212793A/xx unknown
- 1972-09-21 AU AU46957/72A patent/AU456553B2/en not_active Expired
- 1972-09-21 IL IL7240406A patent/IL40406A0/en unknown
- 1972-09-22 DD DD165817A patent/DD103891A5/xx unknown
- 1972-09-22 JP JP47094713A patent/JPS4839614A/ja active Pending
- 1972-09-22 HU HUBA2807A patent/HU165298B/hu unknown
- 1972-09-22 AT AT818572A patent/AT317177B/en active
- 1972-09-22 GB GB43991/72*2A patent/GB1371969A/en not_active Expired
- 1972-09-22 ZA ZA726484A patent/ZA726484B/en unknown
- 1972-09-22 JP JP47094714A patent/JPS4839453A/ja active Pending
- 1972-09-25 FR FR7233863A patent/FR2154568B1/fr not_active Expired
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012122969A1 (en) | 2011-03-16 | 2012-09-20 | Creative Therapeutics Gmbh | Substituted diphenyl derivatives |
CN103492365A (en) * | 2011-03-16 | 2014-01-01 | 创新治疗有限公司 | Substituted diphenyl derivatives |
US9409859B2 (en) * | 2011-03-16 | 2016-08-09 | Creative Therapeutics Gmbh | Substituted diphenyl derivatives |
AU2012228755B2 (en) * | 2011-03-16 | 2017-03-23 | Creative Therapeutics Gmbh | Substituted diphenyl derivatives |
WO2012130850A1 (en) | 2011-03-31 | 2012-10-04 | Bayer Pharma Aktiengesellschaft | Tissue targeting by means of oncocidal bridged diphenyl derivatives for the selective treatment of sexual organ tumors |
EP2557075A1 (en) * | 2011-08-09 | 2013-02-13 | Trin Therapeutics GmbH | New triazene compounds for treating cancer |
Also Published As
Publication number | Publication date |
---|---|
HU165298B (en) | 1974-08-28 |
AT317177B (en) | 1974-08-12 |
AU4695772A (en) | 1974-03-28 |
JPS4839614A (en) | 1973-06-11 |
DE2147781A1 (en) | 1973-03-29 |
NL7212793A (en) | 1973-03-27 |
BE789138A (en) | 1973-03-22 |
DD103891A5 (en) | 1974-02-12 |
JPS4839453A (en) | 1973-06-09 |
IL40406A0 (en) | 1972-11-28 |
ZA726484B (en) | 1973-06-27 |
FR2154568A1 (en) | 1973-05-11 |
FR2154568B1 (en) | 1976-03-05 |
AU456553B2 (en) | 1974-12-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PLNP | Patent lapsed through nonpayment of renewal fees |