SE8302345D0 - PLEUROMUTILIN DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS PHARMACEUTICALS - Google Patents
PLEUROMUTILIN DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS PHARMACEUTICALSInfo
- Publication number
- SE8302345D0 SE8302345D0 SE8302345A SE8302345A SE8302345D0 SE 8302345 D0 SE8302345 D0 SE 8302345D0 SE 8302345 A SE8302345 A SE 8302345A SE 8302345 A SE8302345 A SE 8302345A SE 8302345 D0 SE8302345 D0 SE 8302345D0
- Authority
- SE
- Sweden
- Prior art keywords
- alkylamino
- pharmaceuticals
- processes
- production
- unsubstituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compounds of formula I <IMAGE> wherein R1 represents ethyl or vinyl, R2 represents lower alkoxy, amino, lower alkylamino which may be unsubstituted or substituted by amino, lower alkylamino, di-(lower)-alkylamino or hydroxy, di-(lower)-alkylamino or a five or six membered, saturated heterocycle which contains one or two nitrogens as heteroatoms and which may be unsubstituted or substituted by lower alkyl and R3 and R4 represent, independently, hydrogen or lower alkyl, in free base o; acid addition or quaternary salt form, exhibit pharmacological activity, particularly against bacteria and obligatory anaerobes, and can be incorporated into chemotherapeutic compositions.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT165182 | 1982-04-28 | ||
| AT427082 | 1982-11-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8302345D0 true SE8302345D0 (en) | 1983-04-26 |
| SE8302345L SE8302345L (en) | 1983-10-29 |
Family
ID=25596422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8302345A SE8302345L (en) | 1982-04-28 | 1983-04-26 | PLEUROMUTILIN DERIVATIVES, THE PROCEDURES FOR THEIR PREPARATION AND THEIR USE AS A MEDICINAL PRODUCT |
Country Status (12)
| Country | Link |
|---|---|
| AU (1) | AU1393783A (en) |
| DE (1) | DE3314479A1 (en) |
| DK (1) | DK185683A (en) |
| ES (1) | ES521847A0 (en) |
| FI (1) | FI831367L (en) |
| FR (1) | FR2526019A1 (en) |
| GB (1) | GB2121035A (en) |
| IL (1) | IL68508A0 (en) |
| IT (1) | IT1197634B (en) |
| NL (1) | NL8301448A (en) |
| PT (1) | PT76598B (en) |
| SE (1) | SE8302345L (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0153277B1 (en) * | 1984-02-17 | 1987-08-26 | Sandoz Ag | Pleuromutilin derivatives, process for their preparation and their use |
| HU208115B (en) * | 1989-10-03 | 1993-08-30 | Biochemie Gmbh | New process for producting pleuromutilin derivatives |
| GB0017031D0 (en) * | 2000-07-11 | 2000-08-30 | Biochemie Gmbh | Antimicrobials |
| GB0218578D0 (en) | 2002-08-09 | 2002-09-18 | Glaxo Group Ltd | Novel method |
| CN104447450B (en) * | 2014-07-08 | 2016-09-28 | 南通大学 | Cysteine amide-type pleuromutilin derivative and preparation method and medical usage |
| CN104961666B (en) * | 2014-07-08 | 2017-04-12 | 南通大学 | 2-mercaptoacetamide pleuromutilin derivatives, and preparation method and medical application thereof |
| CN109384698B (en) * | 2017-08-04 | 2022-07-08 | 保定加合精细化工有限公司 | Preparation method of diterpene antibiotic for livestock and poultry |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT301752B (en) * | 1969-07-21 | 1972-09-25 | Biochemie Gmbh | Process for the preparation of new pleuromutilin derivatives |
| US3919290A (en) * | 1972-10-03 | 1975-11-11 | Sandoz Ltd | Substituted 14-desoxy-mutilins |
| IE44428B1 (en) * | 1975-09-30 | 1981-12-02 | Squibb & Sons Inc | New derivatives of pleuromutilin and compositions containig same |
| DE2823712C2 (en) * | 1978-05-31 | 1987-04-09 | Sandoz-Patent-GmbH, 7850 Lörrach | Process for the preparation of pleuromutilin derivatives |
-
1983
- 1983-04-19 FR FR8306523A patent/FR2526019A1/en active Granted
- 1983-04-21 DE DE19833314479 patent/DE3314479A1/en not_active Withdrawn
- 1983-04-21 FI FI831367A patent/FI831367L/en not_active Application Discontinuation
- 1983-04-25 GB GB08311194A patent/GB2121035A/en not_active Withdrawn
- 1983-04-25 NL NL8301448A patent/NL8301448A/en not_active Application Discontinuation
- 1983-04-26 SE SE8302345A patent/SE8302345L/en not_active Application Discontinuation
- 1983-04-26 PT PT76598A patent/PT76598B/en unknown
- 1983-04-26 DK DK185683A patent/DK185683A/en not_active Application Discontinuation
- 1983-04-26 ES ES521847A patent/ES521847A0/en active Granted
- 1983-04-26 AU AU13937/83A patent/AU1393783A/en not_active Abandoned
- 1983-04-27 IT IT48162/83A patent/IT1197634B/en active
- 1983-04-27 IL IL68508A patent/IL68508A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE8302345L (en) | 1983-10-29 |
| FR2526019B1 (en) | 1985-04-26 |
| IT1197634B (en) | 1988-12-06 |
| IL68508A0 (en) | 1983-07-31 |
| NL8301448A (en) | 1983-11-16 |
| DK185683A (en) | 1983-10-29 |
| ES8406431A1 (en) | 1984-08-01 |
| PT76598A (en) | 1983-05-01 |
| DK185683D0 (en) | 1983-04-26 |
| AU1393783A (en) | 1983-11-03 |
| FI831367A0 (en) | 1983-04-21 |
| DE3314479A1 (en) | 1983-11-03 |
| ES521847A0 (en) | 1984-08-01 |
| FR2526019A1 (en) | 1983-11-04 |
| GB2121035A (en) | 1983-12-14 |
| IT8348162A0 (en) | 1983-04-27 |
| FI831367L (en) | 1983-10-29 |
| GB8311194D0 (en) | 1983-06-02 |
| PT76598B (en) | 1986-01-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
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