GB1099829A - Derivatives of aromatic amines - Google Patents
Derivatives of aromatic aminesInfo
- Publication number
- GB1099829A GB1099829A GB557865A GB557865A GB1099829A GB 1099829 A GB1099829 A GB 1099829A GB 557865 A GB557865 A GB 557865A GB 557865 A GB557865 A GB 557865A GB 1099829 A GB1099829 A GB 1099829A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- oxo
- lower alkyl
- alkadienylene
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of the general formula (A) <FORM:1099829/C2/1> and the acid addition salts, ammonium, alkali metal and alkaline earth metal salts thereof wherein X represents a halogen atom or a lower alkyl, lower alkoxy, hydroxy, lower alkyl thio, lower alkanoyl, trihalomethyl, nitro, amino or dialkylamino group, Z represents -O-, -S-, <FORM:1099829/C2/2> B represents a basic nitrogen containing radical of less than 12 carbon atoms, phenyl X-substituted phenyl or <FORM:1099829/C2/3> Y represents a lower alkenylene, lower alkynylene, lower alkadienylene, lower alkylene, oxolower alkenylene, oxo-lower alkynylene, oxolower alkadienylene or oxo-lower alkylene, R represents a hydrogen atom or a lower alkyl, cycloalkyl, phenyl, (X)m substituted phenyl, furyl, thienyl, pyridyl, piperonyl, alkylamino or dialkylamino group, R1 represents a hydrogen atom or a lower alkyl, aralkyl or acyl group, R2 represents a hydrogen atom or a lower alkyl group which may be the same or different and m = 0, 1, 2, or 3 and (b) <FORM:1099829/C2/4> wherein Z1 is an oxa, SO2 or thia group, R1\t is a hydrogen atom or a lower alkyl, aralkyl or acyl group, X1 is a hydrogen or halogen atom or a lower alkoxy group, Y is a lower alkenylene, lower alkynylene, lower alkadienylene, lower alkylene, oxo-lower alkenylene, oxo-lower alkadienylene or oxo-lower alkylene group, R represents hydrogen, lower alkyl, cycloalkyl, phenyl, (X)m substituted phenyl, furyl, thienyl, pyridyl, piperonyl, alkylamino or dialkylamino and m is 1, 2 or 3. Such compounds are prepared by reacting appropriate aniline derivatives with appropriate compounds of the formula halo-Y-R. Among many specific products described are 21-[N-(2-dimethylaminoethyl) - N - methyl - carbamoyl] cinnamanilide hydrochloride, 21 - (benzylthio) - N - 2 - dimethylamino-ethyl acetanilide hydrochloride, N-acetyl-3-(2-cinnamidophenylthio) - DL - alanine and 21-[2 - (4 - benzyl - 1 - piperazinyl) ethoxy] - p - tri-fluoromethylcinnamanilide hydrochloride.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB557865A GB1099829A (en) | 1965-02-09 | 1965-02-09 | Derivatives of aromatic amines |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB557865A GB1099829A (en) | 1965-02-09 | 1965-02-09 | Derivatives of aromatic amines |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1099829A true GB1099829A (en) | 1968-01-17 |
Family
ID=9798754
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB557865A Expired GB1099829A (en) | 1965-02-09 | 1965-02-09 | Derivatives of aromatic amines |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1099829A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0356152A1 (en) * | 1988-08-18 | 1990-02-28 | HAMARI YAKUHIN KOGYO KABUSHIKI KAISHA also known as HAMARI CHEMICALS, LTD. | Quaternary ammonium salts |
EP1100495A1 (en) * | 1998-07-28 | 2001-05-23 | Smithkline Beecham Corporation | Propenamides as ccr5 modulators |
-
1965
- 1965-02-09 GB GB557865A patent/GB1099829A/en not_active Expired
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0356152A1 (en) * | 1988-08-18 | 1990-02-28 | HAMARI YAKUHIN KOGYO KABUSHIKI KAISHA also known as HAMARI CHEMICALS, LTD. | Quaternary ammonium salts |
EP1100495A1 (en) * | 1998-07-28 | 2001-05-23 | Smithkline Beecham Corporation | Propenamides as ccr5 modulators |
EP1100495A4 (en) * | 1998-07-28 | 2002-09-25 | Smithkline Beecham Corp | Propenamides as ccr5 modulators |
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