GB880334A - New hydrazinium compounds, their production and pharmaceutical compositions containing them - Google Patents

Abstract

The invention comprises hydrazinium salts of the formula <FORM:0880334/IV (b)/1> (wherein R is a hydrogen or halogen atom, R1 and R11 are alkyl radicals each containing less than 8 carbon atoms or together with the nitrogen atom to which they are attached form a morpholino, piperidino, piperazino or 4-alkyl-piperazino radical, the 4-alkyl radical containing less than 8 carbon atoms, A is an alkylene radical of 2 to 4 carbon atoms and X is an anion bearing the charge n). They may be prepared by reacting chloramine or hydroxylamine-O-sulphonic acid with the appropriate tertiary amine or by reaction of the hydrazine R1R11NNH2 with the appropriate N-(A-X)-substituted phenothiazine. Anions may be exchanged by metathesis. Examples are given and an extensive list of suitable anions derived from organic and inorganic acids is provided. Specification 858,488 and U.S.A. Specification 2,678,258, 2,710,248 are referred to.ALSO:Pharmaceutical compositions having sedative and anti-emetic properties comprise a hydrazinium salt of the formula <FORM:0880334/VI/1> (wherein R is a hydrogen or halogen atom, R1 and R1 are alkyl radicals each containing less than 8 carbon atoms or together with the nitrogen atom to which they are attached form a morpholino, piperidino, piperazino or 4-alkyl-piperazino radical, the 4-alkyl radical containing less than 8 carbon atoms, A is an alkylene radical of 2 to 4 carbon atoms and X is an organic or inorganic anion bearing the charge n) and a carrier therefor. Specification 858,488 and U.S.A. Specifications 2,678,258, 2,710,248 are referred to.