GB864145A - Novel purines and a process for their manufacture - Google Patents

Novel purines and a process for their manufacture

Info

Publication number
GB864145A
GB864145A GB1885259A GB1885259A GB864145A GB 864145 A GB864145 A GB 864145A GB 1885259 A GB1885259 A GB 1885259A GB 1885259 A GB1885259 A GB 1885259A GB 864145 A GB864145 A GB 864145A
Authority
GB
United Kingdom
Prior art keywords
methyl
substituted
group
unsubstituted
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1885259A
Inventor
Josef Roch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Priority to GB1885259A priority Critical patent/GB864145A/en
Publication of GB864145A publication Critical patent/GB864145A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/22—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Abstract

The invention comprises purine compound of the formula: <FORM:0864145/IV (b)/1> or <FORM:0864145/IV (b)/2> and acid addition salts thereof, wherein at least one of R1, R2 and R3 represents a nitrogen atom forming part of a heterocyclic ring, which may contain a further hetero atom, and may bear halogen, lower alkyl or lower alkoxy substituents, at least one other of R1, R2 and R3 is a substituted amino group, a nitrogen atom forming part of a heterocyclic ring which may contain a further hetero atom and may bear halogen, lower alkyl, lower alkoxy or aryl substituents, or a substituted or unsubstituted hydrazino or guanidino group; the third of the groups R1, R2 and R3 represents a hydrogen or halogen atom, a substituted or unsubstituted hydroxyl, thiol, amino, hydrazino or guanidino group, a nitrogen atom forming part of a heterocyclic ring, which may contain a further hetero atom and which may bear halogen, lower alkyl or lower alkoxy substituents, R3 additionally may be a substituted or unsubstituted alkyl, aralkyl or aryl group and R4 is hydrogen or a substituted or unsubstituted alkyl, aryl or aralkyl group. The compounds are prepared by replacing halogen atoms in the 2-, 6- and/or 8- positions of a purine nucleus (optionally bearing a substituent R4 in the 7- or 9- position) by reaction with a compound R-H, wherein R is one of the groups R1, R2 and R3 or a group which is subsequently converted thereto. Suitably, at least one of R1, R2 and R3 is substituted or unsubstituted piperidino, pyrrolidino, piperazino, n-alkyl or n-aryl piperazino, morpholino or hexamethylene imino group. The products are used pharmaceutically, preferred compounds being the 2-6-dimorpholino-7-methyl-, 2-morpholino-6:8-dipiperidino-7-methyl-, 2-ethylthio-6:8-dimorpholino-7-methyl-, 2;6-dimorpholino-7-methyl-, 2-morpholino-6:8-dipiperidino-7-methyl- and 2:6:8:-tripiperidino-7-methyl-purines.
GB1885259A 1959-06-02 1959-06-02 Novel purines and a process for their manufacture Expired GB864145A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1885259A GB864145A (en) 1959-06-02 1959-06-02 Novel purines and a process for their manufacture

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1885259A GB864145A (en) 1959-06-02 1959-06-02 Novel purines and a process for their manufacture

Publications (1)

Publication Number Publication Date
GB864145A true GB864145A (en) 1961-03-29

Family

ID=10119514

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1885259A Expired GB864145A (en) 1959-06-02 1959-06-02 Novel purines and a process for their manufacture

Country Status (1)

Country Link
GB (1) GB864145A (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5057517A (en) * 1987-07-20 1991-10-15 Merck & Co., Inc. Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents
WO1993020078A1 (en) * 1992-04-03 1993-10-14 The Upjohn Company Pharmaceutically active bicyclic-heterocyclic amines
US5502187A (en) * 1992-04-03 1996-03-26 The Upjohn Company Pharmaceutically active bicyclic-heterocyclic amines
JP2006507273A (en) * 2002-10-15 2006-03-02 シンタ ファーマシューティカルズ コーポレーション New compounds
WO2007034185A1 (en) * 2005-09-20 2007-03-29 Vernalis (R & D) Ltd. Purine compounds as hsp90 protein inhibitors for the treatment of cancer
WO2010044401A1 (en) * 2008-10-14 2010-04-22 第一三共株式会社 Morpholinopurine derivative
EP2307414A2 (en) * 2008-07-07 2011-04-13 Xcovery Holding Company LLC Pi3k isoform selective inhibitors
WO2012104776A1 (en) * 2011-01-31 2012-08-09 Novartis Ag Novel heterocyclic derivatives
WO2014120748A1 (en) 2013-01-30 2014-08-07 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
US9334271B2 (en) 2011-10-28 2016-05-10 Novarits Ag Purine derivatives and their use in the treatment of disease

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5057517A (en) * 1987-07-20 1991-10-15 Merck & Co., Inc. Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents
WO1993020078A1 (en) * 1992-04-03 1993-10-14 The Upjohn Company Pharmaceutically active bicyclic-heterocyclic amines
US5502187A (en) * 1992-04-03 1996-03-26 The Upjohn Company Pharmaceutically active bicyclic-heterocyclic amines
AU675932B2 (en) * 1992-04-03 1997-02-27 Pharmacia & Upjohn Company Pharmaceutically active bicyclic-heterocyclic amines
JP2006507273A (en) * 2002-10-15 2006-03-02 シンタ ファーマシューティカルズ コーポレーション New compounds
JP4768265B2 (en) * 2002-10-15 2011-09-07 シンタ ファーマシューティカルズ コーポレーション New compounds
WO2007034185A1 (en) * 2005-09-20 2007-03-29 Vernalis (R & D) Ltd. Purine compounds as hsp90 protein inhibitors for the treatment of cancer
JP2011527342A (en) * 2008-07-07 2011-10-27 エックスカバリー ホールディング カンパニー エルエルシー PI3K isoform selective inhibitor
US8513221B2 (en) 2008-07-07 2013-08-20 Xcovery Holding, LLC PI3K isoform selective inhibitors
EP2307414A2 (en) * 2008-07-07 2011-04-13 Xcovery Holding Company LLC Pi3k isoform selective inhibitors
CN102089308A (en) * 2008-07-07 2011-06-08 艾科睿控股公司 PI3K isoform selective inhibitors
EP2307414A4 (en) * 2008-07-07 2011-10-26 Xcovery Holding Co Llc Pi3k isoform selective inhibitors
WO2010044401A1 (en) * 2008-10-14 2010-04-22 第一三共株式会社 Morpholinopurine derivative
JP2011001339A (en) * 2008-10-14 2011-01-06 Daiichi Sankyo Co Ltd Morpholinopurine derivative
US8097622B2 (en) 2008-10-14 2012-01-17 Daiichi Sankyo Company, Limited Morpholinopurine derivatives
US8309546B2 (en) 2008-10-14 2012-11-13 Daiichi Sankyo Company, Limited Morpholinopurine derivatives
US8987257B2 (en) 2011-01-31 2015-03-24 Novartis Ag Heterocyclic derivatives
CN103476777A (en) * 2011-01-31 2013-12-25 诺瓦提斯公司 Novel heterocyclic derivatives
WO2012104776A1 (en) * 2011-01-31 2012-08-09 Novartis Ag Novel heterocyclic derivatives
CN103476777B (en) * 2011-01-31 2015-05-27 诺瓦提斯公司 Novel heterocyclic derivatives
US9458163B2 (en) 2011-01-31 2016-10-04 Novartis Ag Heterocyclic derivatives
EA025011B1 (en) * 2011-01-31 2016-11-30 Новартис Аг PURINES USEFUL AS mTOR KINASE INHIBITORS, USE THEREOF AND PHARMACEUTICAL COMPOSITIONS THEREOF
US9334271B2 (en) 2011-10-28 2016-05-10 Novarits Ag Purine derivatives and their use in the treatment of disease
WO2014120748A1 (en) 2013-01-30 2014-08-07 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
EP2951180A4 (en) * 2013-01-30 2016-06-15 Merck Sharp & Dohme 2,6,7,8 substituted purines as hdm2 inhibitors
US9540377B2 (en) 2013-01-30 2017-01-10 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as HDM2 inhibitors

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