GB890471A - New bishydrazinium salts, their production and pharmaceutical compositions containing them - Google Patents

New bishydrazinium salts, their production and pharmaceutical compositions containing them

Info

Publication number
GB890471A
GB890471A GB405060A GB405060A GB890471A GB 890471 A GB890471 A GB 890471A GB 405060 A GB405060 A GB 405060A GB 405060 A GB405060 A GB 405060A GB 890471 A GB890471 A GB 890471A
Authority
GB
United Kingdom
Prior art keywords
formula
bishydrazinium
pharmaceutical compositions
anions
specifications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB405060A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WR Grace and Co
Original Assignee
WR Grace and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WR Grace and Co filed Critical WR Grace and Co
Priority to GB405060A priority Critical patent/GB890471A/en
Publication of GB890471A publication Critical patent/GB890471A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/28Nitrogen atoms
    • C07D295/30Nitrogen atoms non-acylated

Abstract

The invention comprises compounds of the formula <FORM:0890471/IV (b)/1> (wherein n is an integer and X is an anion bearing the charge p). They may be prepared by reacting chloramine or hydroxylamine-O-sulphonic acid acid with the appropriate dimorpholinoalkane of the formula <FORM:0890471/IV (b)/2> which, in turn, may be prepared by the reaction of morpholine with the appropriate alkylene dihalide and subsequent liberation of the free base from the hydrogen halide acid-addition salt first formed. Anions may be exchanged by meta thesis. Examples are given and an extensive list of anions X is provided. A by-product of one example is 4-amino-4-[(4-morpholino)ethyl]-morpholinium chloride. Specification 858,488 and U.S.A. Specifications 2,678,258 and 2,710,248 are referred to.ALSO:Pharmaceutical compositions comprise a bishydrazinium salt of the formula <FORM:0890471/VI/1> (wherein n is an integer and X is an anion bearing the charge p) in admixture with a solid or liquid pharmaceutical carrier. Specific examples of X are those listed in Specification 880,974. Specification 858,488 and U.S.A. Specifications 2,678,258 and 2,710,248 also are referred to.
GB405060A 1960-02-04 1960-02-04 New bishydrazinium salts, their production and pharmaceutical compositions containing them Expired GB890471A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB405060A GB890471A (en) 1960-02-04 1960-02-04 New bishydrazinium salts, their production and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB405060A GB890471A (en) 1960-02-04 1960-02-04 New bishydrazinium salts, their production and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
GB890471A true GB890471A (en) 1962-02-28

Family

ID=9769779

Family Applications (1)

Application Number Title Priority Date Filing Date
GB405060A Expired GB890471A (en) 1960-02-04 1960-02-04 New bishydrazinium salts, their production and pharmaceutical compositions containing them

Country Status (1)

Country Link
GB (1) GB890471A (en)

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