GB898068A - Amino compounds - Google Patents

Amino compounds

Info

Publication number
GB898068A
GB898068A GB2396060A GB2396060A GB898068A GB 898068 A GB898068 A GB 898068A GB 2396060 A GB2396060 A GB 2396060A GB 2396060 A GB2396060 A GB 2396060A GB 898068 A GB898068 A GB 898068A
Authority
GB
United Kingdom
Prior art keywords
general formula
alkyl
products
quaternary ammonium
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2396060A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of GB898068A publication Critical patent/GB898068A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises compounds of the general formula <FORM:0898068/IV (b)/1> (wherein Y represents an alkyl or aralkyl group, or an aryl group optionally substituted by one or more C1-5 alkyl and/or alkoxy groups, and R1 and R2, which may be the same or different, represent alkyl groups or jointly form a heterocyclic ring with the nitrogen atom) and their non-toxic acid addition and quaternary ammonium salts, and the preparation thereof by (a) interaction of compounds of the general formulae <FORM:0898068/IV (b)/2> and X2MgHal (wherein one of X1 and X2 is identical with Y and the other is a 3,4-dimethylphenyl group), or (b) reductive amination of ketones of the general formula <FORM:0898068/IV (b)/3> with amines of the general formula H.N.R1R2, or (c) reaction of the corresponding primary amines with alkylating agents or with a 1,4-dihalobutane or a 1,5-dihalopentane, the products of (a) or (c) being, if desired, isolated as acid addition or quaternary ammonium salts. The products have oxytocic properties. Specification 802,723 is referred to.
GB2396060A 1959-07-09 1960-07-08 Amino compounds Expired GB898068A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DET16915A DE1116227B (en) 1959-07-09 1959-07-09 Process for the preparation of tertiary amines

Publications (1)

Publication Number Publication Date
GB898068A true GB898068A (en) 1962-06-06

Family

ID=7548390

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2396060A Expired GB898068A (en) 1959-07-09 1960-07-08 Amino compounds

Country Status (2)

Country Link
DE (1) DE1116227B (en)
GB (1) GB898068A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2233558A (en) * 1989-06-02 1991-01-16 Wyeth John & Brother Ltd Psychotropic composition comprising aromatic tertiary amines

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2233558A (en) * 1989-06-02 1991-01-16 Wyeth John & Brother Ltd Psychotropic composition comprising aromatic tertiary amines
GB2233558B (en) * 1989-06-02 1993-12-15 Wyeth John & Brother Ltd Psychotropic use of aromatic amines

Also Published As

Publication number Publication date
DE1116227B (en) 1961-11-02

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