YU81502A - Ciklopostini, postupak za njihovu proizvodnju i njihova primena - Google Patents
Ciklopostini, postupak za njihovu proizvodnju i njihova primenaInfo
- Publication number
- YU81502A YU81502A YU81502A YUP81502A YU81502A YU 81502 A YU81502 A YU 81502A YU 81502 A YU81502 A YU 81502A YU P81502 A YUP81502 A YU P81502A YU 81502 A YU81502 A YU 81502A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- physiologically compatible
- cyclopostins
- production
- compounds
- same
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229930183107 cyclipostin Natural products 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 102000004882 Lipase Human genes 0.000 abstract 1
- 108090001060 Lipase Proteins 0.000 abstract 1
- 239000004367 Lipase Substances 0.000 abstract 1
- 241000187747 Streptomyces Species 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 235000019421 lipase Nutrition 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Pronalazak se odnosi na jedinjenja opšte formule I u kojima R1, R2, E, X1, X2 i X3 imaju u tome značaj, koja mogu da se proizvedu pri gajenju Streptomyces vrsta HAG 004107 (DSM) 13381), na njihove fiziološki prihvatljive soli i hemijske ekvivalente. Pronalazak se dalje odnosi na postupak za proizvodnju ciklipostina, na mikroorganizam HAG 004107 (DSM 13381), na primenu ciklipostina i njihovih fiziološki prihvatljivih soli i hemijskih ekvivalenata kao lekova, naročito u svojstvu inhibitora lipaza, kao i na farmaceutske preparate koji sadrže ciklipostin ili neku njegovu fiziološki prihvatljivu so ili njegov ekvivalent.[The invention relates to compounds of the general formula (I), wherein R1, R2, E, X1, X2 and X3 have the definitions in this application, obtained by the cultivation of the Streptomyces species HAG 004107 (DSM 13381) and to the physiologically compatible salts and chemical equivalents of said compounds. The invention also relates to a method for producing the cyclipostins and their physiologically compatible salts and chemical equivalents as medicaments, in particular as, inhibitors of lipases, and to pharmaceutical preparations containing cyclipostin or a physiologically compatible salt or equivalent thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10021731A DE10021731B4 (de) | 2000-05-04 | 2000-05-04 | Cyclipostine, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitung derselben |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU81502A true YU81502A (sh) | 2006-05-25 |
Family
ID=7640768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU81502A YU81502A (sh) | 2000-05-04 | 2001-04-25 | Ciklopostini, postupak za njihovu proizvodnju i njihova primena |
Country Status (28)
| Country | Link |
|---|---|
| EP (1) | EP1280812B1 (sh) |
| JP (1) | JP5038572B2 (sh) |
| KR (1) | KR100779867B1 (sh) |
| CN (1) | CN1216890C (sh) |
| AR (1) | AR028398A1 (sh) |
| AT (1) | ATE288442T1 (sh) |
| AU (2) | AU2001262229B2 (sh) |
| BR (1) | BR0110459A (sh) |
| CA (1) | CA2407808C (sh) |
| CZ (1) | CZ20023547A3 (sh) |
| DE (2) | DE10021731B4 (sh) |
| DK (1) | DK1280812T3 (sh) |
| EE (1) | EE05090B1 (sh) |
| ES (1) | ES2236234T3 (sh) |
| HK (1) | HK1055745A1 (sh) |
| HR (1) | HRP20020864A2 (sh) |
| HU (1) | HUP0300306A3 (sh) |
| IL (2) | IL152612A0 (sh) |
| MX (1) | MXPA02010297A (sh) |
| NO (1) | NO330438B1 (sh) |
| NZ (1) | NZ522352A (sh) |
| PL (1) | PL358328A1 (sh) |
| PT (1) | PT1280812E (sh) |
| RU (1) | RU2266911C2 (sh) |
| SK (1) | SK15602002A3 (sh) |
| WO (1) | WO2001083497A1 (sh) |
| YU (1) | YU81502A (sh) |
| ZA (1) | ZA200208928B (sh) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2372495T3 (es) | 2003-11-13 | 2012-01-20 | Hanmi Holdings Co., Ltd | Método para la producción en masa de la región constante de inmunoglobulina. |
| US8110665B2 (en) | 2003-11-13 | 2012-02-07 | Hanmi Holdings Co., Ltd. | Pharmaceutical composition comprising an immunoglobulin FC region as a carrier |
| KR100754667B1 (ko) | 2005-04-08 | 2007-09-03 | 한미약품 주식회사 | 비펩타이드성 중합체로 개질된 면역글로불린 Ｆｃ 단편 및이를 포함하는 약제학적 조성물 |
| EP1894601A1 (en) | 2006-08-29 | 2008-03-05 | sanofi-aventis | Treating mycobacterial infections with cyclipostins |
| KR200453850Y1 (ko) * | 2008-04-23 | 2011-05-30 | 주식회사 에이티티알앤디 | 수질 관리 센서 내장형 수도미터기 |
| KR102073748B1 (ko) | 2013-01-31 | 2020-02-05 | 한미약품 주식회사 | 재조합 효모 형질전환체 및 이를 이용하여 면역글로불린 단편을 생산하는 방법 |
| AR096891A1 (es) | 2013-07-12 | 2016-02-03 | Hanmi Pharm Ind Co Ltd | Conjugado de monómero polipéptido biológicamente activo y conjugado de fragmento fc de inmunoglobulina, que muestra aclaramiento mediado por receptor reducido, y el método para la preparación del mismo |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04145089A (ja) * | 1990-10-05 | 1992-05-19 | Nippon Kayaku Co Ltd | 抗生物質ｎｋ９０１０９３、その製造法及びそれを有効成分として含有する殺虫・殺ダニ剤 |
| JPH0656859A (ja) * | 1991-07-25 | 1994-03-01 | Nippon Kayaku Co Ltd | 抗生物質ｎｋ９０１０９３ａ、その製造法及びそれを有効成分として含有する殺虫・殺ダニ剤 |
-
2000
- 2000-05-04 DE DE10021731A patent/DE10021731B4/de not_active Expired - Fee Related
-
2001
- 2001-04-25 EE EEP200200599A patent/EE05090B1/xx not_active IP Right Cessation
- 2001-04-25 ES ES01936275T patent/ES2236234T3/es not_active Expired - Lifetime
- 2001-04-25 HU HU0300306A patent/HUP0300306A3/hu unknown
- 2001-04-25 IL IL15261201A patent/IL152612A0/xx unknown
- 2001-04-25 WO PCT/EP2001/004652 patent/WO2001083497A1/de active IP Right Grant
- 2001-04-25 AU AU2001262229A patent/AU2001262229B2/en not_active Ceased
- 2001-04-25 RU RU2002132558/04A patent/RU2266911C2/ru not_active IP Right Cessation
- 2001-04-25 DE DE50105249T patent/DE50105249D1/de not_active Expired - Lifetime
- 2001-04-25 DK DK01936275T patent/DK1280812T3/da active
- 2001-04-25 JP JP2001580922A patent/JP5038572B2/ja not_active Expired - Fee Related
- 2001-04-25 AU AU6222901A patent/AU6222901A/xx active Pending
- 2001-04-25 PL PL01358328A patent/PL358328A1/xx unknown
- 2001-04-25 SK SK1560-2002A patent/SK15602002A3/sk unknown
- 2001-04-25 MX MXPA02010297A patent/MXPA02010297A/es active IP Right Grant
- 2001-04-25 YU YU81502A patent/YU81502A/sh unknown
- 2001-04-25 CA CA2407808A patent/CA2407808C/en not_active Expired - Fee Related
- 2001-04-25 CZ CZ20023547A patent/CZ20023547A3/cs unknown
- 2001-04-25 EP EP01936275A patent/EP1280812B1/de not_active Expired - Lifetime
- 2001-04-25 KR KR1020027014691A patent/KR100779867B1/ko not_active IP Right Cessation
- 2001-04-25 NZ NZ522352A patent/NZ522352A/en unknown
- 2001-04-25 CN CN018088813A patent/CN1216890C/zh not_active Expired - Fee Related
- 2001-04-25 BR BR0110459-4A patent/BR0110459A/pt not_active IP Right Cessation
- 2001-04-25 AT AT01936275T patent/ATE288442T1/de active
- 2001-04-25 PT PT01936275T patent/PT1280812E/pt unknown
- 2001-05-02 AR ARP010102068A patent/AR028398A1/es not_active Application Discontinuation
-
2002
- 2002-10-30 NO NO20025209A patent/NO330438B1/no not_active IP Right Cessation
- 2002-10-31 HR HRP20020864 patent/HRP20020864A2/xx not_active Application Discontinuation
- 2002-11-03 IL IL152612A patent/IL152612A/en not_active IP Right Cessation
- 2002-11-04 ZA ZA200208928A patent/ZA200208928B/en unknown
-
2003
- 2003-11-06 HK HK03108059A patent/HK1055745A1/xx not_active IP Right Cessation
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