HRP20020864A2 - Cyclipostins, a method for their production and the use of the same - Google Patents

Cyclipostins, a method for their production and the use of the same

Info

Publication number
HRP20020864A2
HRP20020864A2 HRP20020864A HRP20020864A2 HR P20020864 A2 HRP20020864 A2 HR P20020864A2 HR P20020864 A HRP20020864 A HR P20020864A HR P20020864 A2 HRP20020864 A2 HR P20020864A2
Authority
HR
Croatia
Prior art keywords
cyclipostins
physiologically compatible
production
compounds
same
Prior art date
Application number
Inventor
Laszlo Vertesy
Klaus Ehrlich
Michael Kurz
Joachim Wink
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of HRP20020864A2 publication Critical patent/HRP20020864A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Obesity (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention relates to compounds of the general formula (I), wherein R<1>, R<2>, E, X1, X2 and X3 have the definitions in this application, obtained by the cultivation of the Streptomyces species HAG 004107 (DSM 13381) and to the physiologically compatible salts and chemical equivalents of said compounds. The invention also relates to a method for producing the cyclipostins and their physiologically compatible salts and chemical equivalents as medicaments, in particular as inhibitors of lipases, and to pharmaceutical preparations containing cyclipostin or a physiologically compatible salt or equivalent thereof.
HRP20020864 2000-05-04 2002-10-31 Cyclipostins, a method for their production and the use of the same HRP20020864A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10021731A DE10021731B4 (en) 2000-05-04 2000-05-04 Cyclipostins, process for their preparation and pharmaceutical preparation thereof
PCT/EP2001/004652 WO2001083497A1 (en) 2000-05-04 2001-04-25 Cyclipostins, a method for their production and the use of the same

Publications (1)

Publication Number Publication Date
HRP20020864A2 true HRP20020864A2 (en) 2004-12-31

Family

ID=7640768

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20020864 HRP20020864A2 (en) 2000-05-04 2002-10-31 Cyclipostins, a method for their production and the use of the same

Country Status (28)

Country Link
EP (1) EP1280812B1 (en)
JP (1) JP5038572B2 (en)
KR (1) KR100779867B1 (en)
CN (1) CN1216890C (en)
AR (1) AR028398A1 (en)
AT (1) ATE288442T1 (en)
AU (2) AU2001262229B2 (en)
BR (1) BR0110459A (en)
CA (1) CA2407808C (en)
CZ (1) CZ20023547A3 (en)
DE (2) DE10021731B4 (en)
DK (1) DK1280812T3 (en)
EE (1) EE05090B1 (en)
ES (1) ES2236234T3 (en)
HK (1) HK1055745A1 (en)
HR (1) HRP20020864A2 (en)
HU (1) HUP0300306A3 (en)
IL (2) IL152612A0 (en)
MX (1) MXPA02010297A (en)
NO (1) NO330438B1 (en)
NZ (1) NZ522352A (en)
PL (1) PL358328A1 (en)
PT (1) PT1280812E (en)
RU (1) RU2266911C2 (en)
SK (1) SK15602002A3 (en)
WO (1) WO2001083497A1 (en)
YU (1) YU81502A (en)
ZA (1) ZA200208928B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8110665B2 (en) 2003-11-13 2012-02-07 Hanmi Holdings Co., Ltd. Pharmaceutical composition comprising an immunoglobulin FC region as a carrier
DK2256134T3 (en) 2003-11-13 2014-02-24 Hanmi Science Co Ltd IgG Fc fragment to a drug carrier and process for preparation thereof
KR100754667B1 (en) 2005-04-08 2007-09-03 한미약품 주식회사 Immunoglobulin Fc fragment modified by non-peptide polymer and pharmaceutical composition comprising the same
EP1894601A1 (en) 2006-08-29 2008-03-05 sanofi-aventis Treating mycobacterial infections with cyclipostins
KR200453850Y1 (en) * 2008-04-23 2011-05-30 주식회사 에이티티알앤디 Water meter
KR102073748B1 (en) 2013-01-31 2020-02-05 한미약품 주식회사 Recombinant yeast transformant and process for preparing immunoglobulin Fc fragment employing the same
AR096891A1 (en) 2013-07-12 2016-02-03 Hanmi Pharm Ind Co Ltd CONJUGATE OF BIOMOLOGICALLY ACTIVE POLYPEPTIDE MONOMER AND CONJUGATE OF FRAGMENTO FC OF IMMUNOGLOBULINA, THAT SHOWS CLEARING THROUGH REDUCED RECEPTOR, AND THE METHOD FOR PREPARING THE SAME

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04145089A (en) * 1990-10-05 1992-05-19 Nippon Kayaku Co Ltd Antibiotic nk901093, production thereof and insecticide and acaricide comprising the same antibiotic as active ingredient
JPH0656859A (en) * 1991-07-25 1994-03-01 Nippon Kayaku Co Ltd Antibiotic nk901093a, its production and pesticidal and miticidal agent containing the same compound as active component

Also Published As

Publication number Publication date
NO20025209D0 (en) 2002-10-30
KR100779867B1 (en) 2007-11-27
MXPA02010297A (en) 2003-04-25
ES2236234T3 (en) 2005-07-16
PT1280812E (en) 2005-05-31
BR0110459A (en) 2003-03-11
NO330438B1 (en) 2011-04-11
IL152612A (en) 2009-11-18
AU2001262229B2 (en) 2007-01-25
ATE288442T1 (en) 2005-02-15
SK15602002A3 (en) 2003-04-01
CA2407808A1 (en) 2002-10-30
HUP0300306A2 (en) 2003-06-28
EP1280812B1 (en) 2005-02-02
YU81502A (en) 2006-05-25
DE10021731A1 (en) 2001-11-15
JP2003531914A (en) 2003-10-28
ZA200208928B (en) 2003-10-07
AU6222901A (en) 2001-11-12
WO2001083497A1 (en) 2001-11-08
JP5038572B2 (en) 2012-10-03
CA2407808C (en) 2013-06-25
EE200200599A (en) 2004-04-15
HUP0300306A3 (en) 2004-10-28
DE10021731B4 (en) 2005-12-08
CN1216890C (en) 2005-08-31
AR028398A1 (en) 2003-05-07
DE50105249D1 (en) 2005-03-10
DK1280812T3 (en) 2005-05-30
CN1427845A (en) 2003-07-02
PL358328A1 (en) 2004-08-09
RU2266911C2 (en) 2005-12-27
CZ20023547A3 (en) 2003-02-12
HK1055745A1 (en) 2004-01-21
EE05090B1 (en) 2008-10-15
KR20030009464A (en) 2003-01-29
IL152612A0 (en) 2003-06-24
NO20025209L (en) 2002-10-30
NZ522352A (en) 2004-06-25
EP1280812A1 (en) 2003-02-05

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Legal Events

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A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
PNAN Change of the applicant name, address/residence

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, DE

ODRP Renewal fee for the maintenance of a patent

Payment date: 20080423

Year of fee payment: 8

ODBC Application rejected