NO20025209D0 - Cyclipostins, their preparation and use - Google Patents
Cyclipostins, their preparation and useInfo
- Publication number
- NO20025209D0 NO20025209D0 NO20025209A NO20025209A NO20025209D0 NO 20025209 D0 NO20025209 D0 NO 20025209D0 NO 20025209 A NO20025209 A NO 20025209A NO 20025209 A NO20025209 A NO 20025209A NO 20025209 D0 NO20025209 D0 NO 20025209D0
- Authority
- NO
- Norway
- Prior art keywords
- physiologically compatible
- cyclipostins
- compounds
- relates
- chemical equivalents
- Prior art date
Links
- 229930183107 cyclipostin Natural products 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 102000004882 Lipase Human genes 0.000 abstract 1
- 108090001060 Lipase Proteins 0.000 abstract 1
- 239000004367 Lipase Substances 0.000 abstract 1
- 241000187747 Streptomyces Species 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 235000019421 lipase Nutrition 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
The invention relates to compounds of the general formula (I), wherein R<1>, R<2>, E, X1, X2 and X3 have the definitions in this application, obtained by the cultivation of the Streptomyces species HAG 004107 (DSM 13381) and to the physiologically compatible salts and chemical equivalents of said compounds. The invention also relates to a method for producing the cyclipostins and their physiologically compatible salts and chemical equivalents as medicaments, in particular as inhibitors of lipases, and to pharmaceutical preparations containing cyclipostin or a physiologically compatible salt or equivalent thereof.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10021731A DE10021731B4 (en) | 2000-05-04 | 2000-05-04 | Cyclipostins, process for their preparation and pharmaceutical preparation thereof |
PCT/EP2001/004652 WO2001083497A1 (en) | 2000-05-04 | 2001-04-25 | Cyclipostins, a method for their production and the use of the same |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20025209L NO20025209L (en) | 2002-10-30 |
NO20025209D0 true NO20025209D0 (en) | 2002-10-30 |
NO330438B1 NO330438B1 (en) | 2011-04-11 |
Family
ID=7640768
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20025209A NO330438B1 (en) | 2000-05-04 | 2002-10-30 | Cyclipostins, their preparation and use as well as pharmaceutical preparation and microorganism |
Country Status (28)
Country | Link |
---|---|
EP (1) | EP1280812B1 (en) |
JP (1) | JP5038572B2 (en) |
KR (1) | KR100779867B1 (en) |
CN (1) | CN1216890C (en) |
AR (1) | AR028398A1 (en) |
AT (1) | ATE288442T1 (en) |
AU (2) | AU2001262229B2 (en) |
BR (1) | BR0110459A (en) |
CA (1) | CA2407808C (en) |
CZ (1) | CZ20023547A3 (en) |
DE (2) | DE10021731B4 (en) |
DK (1) | DK1280812T3 (en) |
EE (1) | EE05090B1 (en) |
ES (1) | ES2236234T3 (en) |
HK (1) | HK1055745A1 (en) |
HR (1) | HRP20020864A2 (en) |
HU (1) | HUP0300306A3 (en) |
IL (2) | IL152612A0 (en) |
MX (1) | MXPA02010297A (en) |
NO (1) | NO330438B1 (en) |
NZ (1) | NZ522352A (en) |
PL (1) | PL358328A1 (en) |
PT (1) | PT1280812E (en) |
RU (1) | RU2266911C2 (en) |
SK (1) | SK15602002A3 (en) |
WO (1) | WO2001083497A1 (en) |
YU (1) | YU81502A (en) |
ZA (1) | ZA200208928B (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8110665B2 (en) | 2003-11-13 | 2012-02-07 | Hanmi Holdings Co., Ltd. | Pharmaceutical composition comprising an immunoglobulin FC region as a carrier |
EP1682582B1 (en) | 2003-11-13 | 2011-08-31 | Hanmi Holdings Co., Ltd | Method for the mass production of immunoglobulin constant region |
KR100754667B1 (en) | 2005-04-08 | 2007-09-03 | 한미약품 주식회사 | Immunoglobulin Fc fragment modified by non-peptide polymer and pharmaceutical composition comprising the same |
EP1894601A1 (en) | 2006-08-29 | 2008-03-05 | sanofi-aventis | Treating mycobacterial infections with cyclipostins |
KR200453850Y1 (en) * | 2008-04-23 | 2011-05-30 | 주식회사 에이티티알앤디 | Water meter |
KR102073748B1 (en) | 2013-01-31 | 2020-02-05 | 한미약품 주식회사 | Recombinant yeast transformant and process for preparing immunoglobulin Fc fragment employing the same |
AR096891A1 (en) | 2013-07-12 | 2016-02-03 | Hanmi Pharm Ind Co Ltd | CONJUGATE OF BIOMOLOGICALLY ACTIVE POLYPEPTIDE MONOMER AND CONJUGATE OF FRAGMENTO FC OF IMMUNOGLOBULINA, THAT SHOWS CLEARING THROUGH REDUCED RECEPTOR, AND THE METHOD FOR PREPARING THE SAME |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04145089A (en) * | 1990-10-05 | 1992-05-19 | Nippon Kayaku Co Ltd | Antibiotic nk901093, production thereof and insecticide and acaricide comprising the same antibiotic as active ingredient |
JPH0656859A (en) * | 1991-07-25 | 1994-03-01 | Nippon Kayaku Co Ltd | Antibiotic nk901093a, its production and pesticidal and miticidal agent containing the same compound as active component |
-
2000
- 2000-05-04 DE DE10021731A patent/DE10021731B4/en not_active Expired - Fee Related
-
2001
- 2001-04-25 PL PL01358328A patent/PL358328A1/en unknown
- 2001-04-25 NZ NZ522352A patent/NZ522352A/en unknown
- 2001-04-25 DE DE50105249T patent/DE50105249D1/en not_active Expired - Lifetime
- 2001-04-25 YU YU81502A patent/YU81502A/en unknown
- 2001-04-25 EP EP01936275A patent/EP1280812B1/en not_active Expired - Lifetime
- 2001-04-25 EE EEP200200599A patent/EE05090B1/en not_active IP Right Cessation
- 2001-04-25 AU AU2001262229A patent/AU2001262229B2/en not_active Ceased
- 2001-04-25 CN CN018088813A patent/CN1216890C/en not_active Expired - Fee Related
- 2001-04-25 SK SK1560-2002A patent/SK15602002A3/en unknown
- 2001-04-25 HU HU0300306A patent/HUP0300306A3/en unknown
- 2001-04-25 JP JP2001580922A patent/JP5038572B2/en not_active Expired - Fee Related
- 2001-04-25 BR BR0110459-4A patent/BR0110459A/en not_active IP Right Cessation
- 2001-04-25 IL IL15261201A patent/IL152612A0/en unknown
- 2001-04-25 AT AT01936275T patent/ATE288442T1/en active
- 2001-04-25 WO PCT/EP2001/004652 patent/WO2001083497A1/en active IP Right Grant
- 2001-04-25 PT PT01936275T patent/PT1280812E/en unknown
- 2001-04-25 CA CA2407808A patent/CA2407808C/en not_active Expired - Fee Related
- 2001-04-25 DK DK01936275T patent/DK1280812T3/en active
- 2001-04-25 RU RU2002132558/04A patent/RU2266911C2/en not_active IP Right Cessation
- 2001-04-25 AU AU6222901A patent/AU6222901A/en active Pending
- 2001-04-25 ES ES01936275T patent/ES2236234T3/en not_active Expired - Lifetime
- 2001-04-25 KR KR1020027014691A patent/KR100779867B1/en not_active IP Right Cessation
- 2001-04-25 CZ CZ20023547A patent/CZ20023547A3/en unknown
- 2001-04-25 MX MXPA02010297A patent/MXPA02010297A/en active IP Right Grant
- 2001-05-02 AR ARP010102068A patent/AR028398A1/en not_active Application Discontinuation
-
2002
- 2002-10-30 NO NO20025209A patent/NO330438B1/en not_active IP Right Cessation
- 2002-10-31 HR HRP20020864 patent/HRP20020864A2/en not_active Application Discontinuation
- 2002-11-03 IL IL152612A patent/IL152612A/en not_active IP Right Cessation
- 2002-11-04 ZA ZA200208928A patent/ZA200208928B/en unknown
-
2003
- 2003-11-06 HK HK03108059A patent/HK1055745A1/en not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM1K | Lapsed by not paying the annual fees |