DK1200118T3 - En farmaceutisk sammensætning omfattende megalatran og dens prodrug - Google Patents

En farmaceutisk sammensætning omfattende megalatran og dens prodrug

Info

Publication number
DK1200118T3
DK1200118T3 DK00928047T DK00928047T DK1200118T3 DK 1200118 T3 DK1200118 T3 DK 1200118T3 DK 00928047 T DK00928047 T DK 00928047T DK 00928047 T DK00928047 T DK 00928047T DK 1200118 T3 DK1200118 T3 DK 1200118T3
Authority
DK
Denmark
Prior art keywords
megalatran
prodrug
pharmaceutical composition
pharmaceutical
composition
Prior art date
Application number
DK00928047T
Other languages
English (en)
Inventor
David Gustafsson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9901442A external-priority patent/SE523811C2/sv
Priority claimed from SE9904419A external-priority patent/SE9904419D0/xx
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of DK1200118T3 publication Critical patent/DK1200118T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DK00928047T 1999-04-21 2000-04-19 En farmaceutisk sammensætning omfattende megalatran og dens prodrug DK1200118T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9901442A SE523811C2 (sv) 1999-04-21 1999-04-21 Beredning innehållande en trombininhibitor med låg molekylvikt tillsammans med en prodrog av densamma
SE9904419A SE9904419D0 (sv) 1999-12-03 1999-12-03 New use
PCT/SE2000/000756 WO2000064470A1 (en) 1999-04-21 2000-04-19 A pharmaceutical formulation comprising a low molecular weight thrombin inhibitor and its prodrug

Publications (1)

Publication Number Publication Date
DK1200118T3 true DK1200118T3 (da) 2008-04-21

Family

ID=26663557

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00928047T DK1200118T3 (da) 1999-04-21 2000-04-19 En farmaceutisk sammensætning omfattende megalatran og dens prodrug

Country Status (29)

Country Link
US (3) US6962905B1 (da)
EP (2) EP1200118B1 (da)
JP (1) JP2002542298A (da)
KR (1) KR20010110788A (da)
CN (1) CN100377742C (da)
AR (1) AR023510A1 (da)
AT (1) ATE383868T1 (da)
AU (1) AU754405B2 (da)
BR (1) BR0009847A (da)
CA (1) CA2371008A1 (da)
CZ (1) CZ20013757A3 (da)
DE (1) DE60037816T2 (da)
DK (1) DK1200118T3 (da)
EE (1) EE200100543A (da)
ES (1) ES2298141T3 (da)
HK (1) HK1045465B (da)
HU (1) HUP0200955A3 (da)
IL (1) IL145840A0 (da)
IS (1) IS6111A (da)
MY (1) MY128061A (da)
NO (1) NO20015107D0 (da)
NZ (1) NZ514827A (da)
PL (1) PL201793B1 (da)
PT (1) PT1200118E (da)
RU (1) RU2252783C2 (da)
SA (1) SA00210092B1 (da)
SK (1) SK14962001A3 (da)
TR (1) TR200103017T2 (da)
WO (1) WO2000064470A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9900070D0 (sv) 1999-01-13 1999-01-13 Astra Ab New use
AR023510A1 (es) * 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
US20020116222A1 (en) * 2000-10-22 2002-08-22 Standing Stone, Inc. Method and system for administering anticoagulation therapy
US6462021B1 (en) * 2000-11-06 2002-10-08 Astrazeneca Ab Use of low molecular weight thrombin inhibitor
DE10064797A1 (de) * 2000-12-22 2002-06-27 Knoll Ag Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon
SE0101762D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab New use
SE0101932D0 (sv) * 2001-05-31 2001-05-31 Astrazeneca Ab Pharmaceutical combinations
SE0103590D0 (sv) 2001-10-26 2001-10-26 Astrazeneca Ab New Combination
DE50310038D1 (de) 2002-03-11 2008-08-07 Curacyte Ag Hemmstoffe der urokinase, ihre herstellung und verwendung
SE0203349D0 (sv) * 2002-11-12 2002-11-12 Astrazeneca Ab New use
DE10301300B4 (de) 2003-01-15 2009-07-16 Curacyte Chemistry Gmbh Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein
GB0306615D0 (en) * 2003-03-22 2003-04-30 Astrazeneca Ab New use
DE10342108A1 (de) * 2003-09-11 2005-04-14 Curacyte Chemistry Gmbh Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung
DE102005044319A1 (de) 2005-09-16 2007-03-22 Curacyte Chemistry Gmbh 2-(Aminomethyl)-5-Chlor-Benzylamid-Derivate und ihre Verwendung als Hemmstoffe des Gerinnungsfaktors Xa
DE102006050672A1 (de) 2006-10-24 2008-04-30 Curacyte Discovery Gmbh Hemmstoffe des Plasmins und des Plasmakallikreins
CN110269856A (zh) * 2010-03-30 2019-09-24 维颂公司 多取代芳族化合物作为凝血酶的抑制剂
US9951025B2 (en) 2013-03-15 2018-04-24 Verseon Corporation Halogenopyrazoles as inhibitors of thrombin
CA3051327A1 (en) 2013-03-15 2014-09-18 Verseon Corporation Multisubstituted aromatic compounds as serine protease inhibitors
KR20170048410A (ko) 2014-09-17 2017-05-08 베르선 코포레이션 세린 프로테아제 저해제로서의 피라졸릴-치환된 피리돈 화합물
JP2018506563A (ja) 2015-02-27 2018-03-08 ヴァーセオン コーポレイション セリンプロテアーゼ阻害剤としての置換ピラゾール化合物

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6087380A (en) 1949-11-24 2000-07-11 Boehringer Ingelheim Pharma Kg Disubstituted bicyclic heterocycles, the preparations and the use thereof as pharmaceutical compositions
HU178398B (en) 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
AU600226B2 (en) 1985-02-04 1990-08-09 Merrell Pharmaceuticals Inc. Novel peptidase inhibitors
US5187157A (en) 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
EP0362002B1 (en) 1988-09-01 1995-07-26 Merrell Dow Pharmaceuticals Inc. HIV protease inhibitors
ZA897514B (en) 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
US5518725A (en) 1989-09-25 1996-05-21 University Of Utah Research Foundation Vaccine compositions and method for induction of mucosal immune response via systemic vaccination
CA2075154A1 (en) 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
SE9102462D0 (sv) 1991-08-28 1991-08-28 Astra Ab New isosteric peptides
CZ333492A3 (en) 1991-11-12 1993-09-15 Lilly Co Eli Dipeptide of l-azetidine-2-carboxylic acids and l-argininaldehyde, process of its preparation and pharmaceutical preparation in which said dipeptide is comprised
SE9103612D0 (sv) 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
ATE159030T1 (de) 1992-03-04 1997-10-15 Gyogyszerkutato Intezet Neuartige antikoagulierende peptidderivate und arzneimittel die solche enthalten so wie entsprechendes herstellungsverfahren
AU675981B2 (en) 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
TW257757B (da) 1993-03-03 1995-09-21 Boehringer Mannheim Gmbh
JPH06340619A (ja) 1993-05-03 1994-12-13 Bristol Myers Squibb Co グアニジニルまたはアミジニル置換メチルアミノ複素環トロンビン抑制剤
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
EP0648780A1 (en) 1993-08-26 1995-04-19 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
US5643588A (en) * 1994-11-28 1997-07-01 The Procter & Gamble Company Diaper having a lotioned topsheet
AU1025795A (en) 1994-01-27 1995-08-03 Mitsubishi Chemical Corporation Prolineamide derivatives
US5707966A (en) 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
ZA951617B (en) 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
US5705487A (en) 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
DE4421052A1 (de) 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
US5510369A (en) 1994-07-22 1996-04-23 Merck & Co., Inc. Pyrrolidine thrombin inhibitors
DE4430757A1 (de) 1994-08-30 1996-03-07 Boehringer Mannheim Gmbh Neue 4-Aminopyridazine, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
DE4430755A1 (de) 1994-08-30 1996-03-07 Boehringer Mannheim Gmbh Neue Phosphanoxide, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
SE9404196D0 (sv) * 1994-12-02 1994-12-02 Astra Ab New antithrombotic formulation
PL321759A1 (en) 1995-02-17 1997-12-22 Basf Ag Novel thrombosin inhibitors
US5710130A (en) 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
WO1996031504A1 (en) 1995-04-04 1996-10-10 Merck & Co., Inc. Thrombin inhibitors
US5629324A (en) 1995-04-10 1997-05-13 Merck & Co., Inc. Thrombin inhibitors
CA2224437A1 (en) 1995-06-27 1997-01-16 Merck & Co., Inc. Pyridinone-thrombin inhibitors
SA96170106A (ar) 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
CA2233344A1 (en) 1995-09-29 1997-04-03 3-Dimensional Pharmaceuticals, Inc. Guanidino protease inhibitors
ATE228760T1 (de) 1995-10-24 2002-12-15 Merck & Co Inc Thrombininhibitoren
GB9526273D0 (en) * 1995-12-21 1996-02-21 Astra Ab New prodrugs
TW541316B (en) * 1995-12-21 2003-07-11 Astrazeneca Ab Prodrugs of thrombin inhibitors
DE69631692T2 (de) 1995-12-29 2004-12-02 3-Dimensional Pharmaceuticals, Inc. Amidino proteaseinhibitoren
WO1997030708A1 (en) 1996-02-22 1997-08-28 Merck & Co., Inc. Pyridinone thrombin inhibitors
CA2252964A1 (en) 1996-04-23 1997-10-30 Merck & Co., Inc. Pyrazinone thrombin inhibitors
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
WO1997047299A1 (en) 1996-06-12 1997-12-18 3-Dimensional Pharmaceuticals, Inc. Amidino and guanidino heterocyclic protease inhibitors
US5863929A (en) 1996-06-25 1999-01-26 Eli Lilly And Company Anticoagulant agents
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
DE19632773A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Thrombininhibitoren
DE19632772A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Benzamidine
PE121699A1 (es) 1997-02-18 1999-12-08 Boehringer Ingelheim Pharma Heterociclos biciclicos disustituidos como inhibidores de la trombina
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
DE19727117A1 (de) 1997-06-26 1999-01-07 Boehringer Ingelheim Pharma Phenylalkylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE19753522A1 (de) 1997-12-03 1999-06-10 Boehringer Ingelheim Pharma Substituierte Indole, ihre Herstellung und ihre Verwendung als Arzneimittel
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
DE19754490A1 (de) 1997-12-09 1999-06-10 Boehringer Ingelheim Pharma Durch einen Aminocarbonylrest substituierte Bicyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
AU751111B2 (en) 1998-01-26 2002-08-08 Basf Aktiengesellschaft Thrombin inhibitors
AU2424499A (en) 1998-01-26 1999-08-09 Basf Aktiengesellschaft Heterocyclic amidines as callicrein protease inhibitors
AU2720199A (en) 1998-02-03 1999-08-23 Boehringer Ingelheim Pharma Kg Five-membered, benzo-condensed heterocycles used as antithrombotic agents
DE19816983A1 (de) 1998-04-17 1999-10-21 Boehringer Ingelheim Pharma Bicyclen, deren Herstellung und deren Verwendung als Arzneimittel
TWI248435B (en) 1998-07-04 2006-02-01 Boehringer Ingelheim Pharma Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions
DE19834751A1 (de) 1998-08-01 2000-02-03 Boehringer Ingelheim Pharma Disubstituierte bicyclische Heterocyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
EP1140862A4 (en) * 1998-12-23 2004-07-28 Bristol Myers Squibb Pharma Co THROMBIN OR Xa FACTOR INHIBITORS
AR023510A1 (es) * 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.

Also Published As

Publication number Publication date
AR023510A1 (es) 2002-09-04
CA2371008A1 (en) 2000-11-02
WO2000064470A1 (en) 2000-11-02
IS6111A (is) 2001-10-19
US20080113960A1 (en) 2008-05-15
PL201793B1 (pl) 2009-05-29
IL145840A0 (en) 2002-07-25
AU754405B2 (en) 2002-11-14
JP2002542298A (ja) 2002-12-10
NO20015107L (no) 2001-10-19
ES2298141T3 (es) 2008-05-16
BR0009847A (pt) 2002-01-08
PT1200118E (pt) 2008-03-18
ATE383868T1 (de) 2008-02-15
EE200100543A (et) 2003-02-17
HK1045465A1 (en) 2002-11-29
DE60037816D1 (de) 2008-03-06
SK14962001A3 (sk) 2002-06-04
EP1886691A3 (en) 2008-03-05
HUP0200955A2 (en) 2002-09-28
HK1045465B (zh) 2008-08-01
RU2252783C2 (ru) 2005-05-27
US20060009397A1 (en) 2006-01-12
NO20015107D0 (no) 2001-10-19
US6962905B1 (en) 2005-11-08
PL351917A1 (en) 2003-06-30
MY128061A (en) 2007-01-31
SA00210092B1 (ar) 2006-11-11
HUP0200955A3 (en) 2006-07-28
EP1200118B1 (en) 2008-01-16
AU4633600A (en) 2000-11-10
CZ20013757A3 (cs) 2002-05-15
CN1356908A (zh) 2002-07-03
KR20010110788A (ko) 2001-12-13
EP1886691A2 (en) 2008-02-13
NZ514827A (en) 2005-01-28
EP1200118A1 (en) 2002-05-02
TR200103017T2 (tr) 2002-05-21
DE60037816T2 (de) 2009-01-08
CN100377742C (zh) 2008-04-02

Similar Documents

Publication Publication Date Title
DK1200118T3 (da) En farmaceutisk sammensætning omfattende megalatran og dens prodrug
PT1242087E (pt) Composicoes farmaceuticas
ITMI20001450A0 (it) Nuova composizione farmaceutica
NO992339D0 (no) Farmas°ytiske formuleringer
DE60038698D1 (de) Hydrogel-gesteuerte dosierungsform
DK1524266T3 (da) Farmaceutisk sammensætning
FIU20000164U0 (fi) Uusi farmaseuttinen formulaatio
NO20015670D0 (no) Forbedrede farmasöytiske formuleringer
NO20022606L (no) Farmasöytiske kombinasjoner
ITMI991402A0 (it) Composti amorfi e relative composizioni farmaceutiche
EE05375B1 (et) LevosimendaniÁfarmatseutilineÁlahus
NO20034778D0 (no) Farmasöytiske sammensetninger for oral og topisk anvendelse
PT1239832E (pt) Composicoes farmaceuticas
DE69928344D1 (de) Pharmazeutisches Implantat
NO20014926D0 (no) Farmasöytiske forbindelser
ATE366128T1 (de) Pharmazeutische zusammensetzung
FI4488U1 (fi) Farmaseuttinen koostumus
PT1227817E (pt) Composicao farmaceutica aquosa contendo ciclesonida
AR025867A1 (es) Formulacion portasdora farmaceutica
NO20016430L (no) Farmasöytisk kompleks
PT1189600E (pt) Composicoes farmaceuticas liofilizadas contendo grf
EE200300378A (et) Farmatseutiline kompositsioon
DE60010173D1 (de) Schlichtevorrichtung
SE9904819D0 (sv) A new pharmaceutical composition
IT1308431B1 (it) Elementi per imballaggio