DK1200118T3 - En farmaceutisk sammensætning omfattende megalatran og dens prodrug - Google Patents

En farmaceutisk sammensætning omfattende megalatran og dens prodrug

Info

Publication number
DK1200118T3
DK1200118T3 DK00928047T DK00928047T DK1200118T3 DK 1200118 T3 DK1200118 T3 DK 1200118T3 DK 00928047 T DK00928047 T DK 00928047T DK 00928047 T DK00928047 T DK 00928047T DK 1200118 T3 DK1200118 T3 DK 1200118T3
Authority
DK
Denmark
Prior art keywords
megalatran
prodrug
pharmaceutical composition
pharmaceutical
composition
Prior art date
Application number
DK00928047T
Other languages
English (en)
Inventor
David Gustafsson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9901442A external-priority patent/SE523811C2/sv
Priority claimed from SE9904419A external-priority patent/SE9904419D0/xx
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of DK1200118T3 publication Critical patent/DK1200118T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DK00928047T 1999-04-21 2000-04-19 En farmaceutisk sammensætning omfattende megalatran og dens prodrug DK1200118T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9901442A SE523811C2 (sv) 1999-04-21 1999-04-21 Beredning innehållande en trombininhibitor med låg molekylvikt tillsammans med en prodrog av densamma
SE9904419A SE9904419D0 (sv) 1999-12-03 1999-12-03 New use
PCT/SE2000/000756 WO2000064470A1 (en) 1999-04-21 2000-04-19 A pharmaceutical formulation comprising a low molecular weight thrombin inhibitor and its prodrug

Publications (1)

Publication Number Publication Date
DK1200118T3 true DK1200118T3 (da) 2008-04-21

Family

ID=26663557

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00928047T DK1200118T3 (da) 1999-04-21 2000-04-19 En farmaceutisk sammensætning omfattende megalatran og dens prodrug

Country Status (29)

Country Link
US (3) US6962905B1 (da)
EP (2) EP1886691A3 (da)
JP (1) JP2002542298A (da)
KR (1) KR20010110788A (da)
CN (1) CN100377742C (da)
AR (1) AR023510A1 (da)
AT (1) ATE383868T1 (da)
AU (1) AU754405B2 (da)
BR (1) BR0009847A (da)
CA (1) CA2371008A1 (da)
CZ (1) CZ20013757A3 (da)
DE (1) DE60037816T2 (da)
DK (1) DK1200118T3 (da)
EE (1) EE200100543A (da)
ES (1) ES2298141T3 (da)
HK (1) HK1045465B (da)
HU (1) HUP0200955A3 (da)
IL (1) IL145840A0 (da)
IS (1) IS6111A (da)
MY (1) MY128061A (da)
NO (1) NO20015107D0 (da)
NZ (1) NZ514827A (da)
PL (1) PL201793B1 (da)
PT (1) PT1200118E (da)
RU (1) RU2252783C2 (da)
SA (1) SA00210092B1 (da)
SK (1) SK14962001A3 (da)
TR (1) TR200103017T2 (da)
WO (1) WO2000064470A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9900070D0 (sv) 1999-01-13 1999-01-13 Astra Ab New use
AR023510A1 (es) * 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
US20020116222A1 (en) * 2000-10-22 2002-08-22 Standing Stone, Inc. Method and system for administering anticoagulation therapy
US6462021B1 (en) * 2000-11-06 2002-10-08 Astrazeneca Ab Use of low molecular weight thrombin inhibitor
DE10064797A1 (de) * 2000-12-22 2002-06-27 Knoll Ag Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon
SE0101762D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab New use
SE0101932D0 (sv) * 2001-05-31 2001-05-31 Astrazeneca Ab Pharmaceutical combinations
SE0103590D0 (sv) 2001-10-26 2001-10-26 Astrazeneca Ab New Combination
AU2003219039A1 (en) 2002-03-11 2003-09-22 Curacyte Ag Urokinase inhibitors, production and use thereof
SE0203349D0 (sv) * 2002-11-12 2002-11-12 Astrazeneca Ab New use
DE10301300B4 (de) 2003-01-15 2009-07-16 Curacyte Chemistry Gmbh Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein
GB0306615D0 (en) * 2003-03-22 2003-04-30 Astrazeneca Ab New use
DE10342108A1 (de) 2003-09-11 2005-04-14 Curacyte Chemistry Gmbh Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung
DE102005044319A1 (de) 2005-09-16 2007-03-22 Curacyte Chemistry Gmbh 2-(Aminomethyl)-5-Chlor-Benzylamid-Derivate und ihre Verwendung als Hemmstoffe des Gerinnungsfaktors Xa
DE102006050672A1 (de) 2006-10-24 2008-04-30 Curacyte Discovery Gmbh Hemmstoffe des Plasmins und des Plasmakallikreins
EP2560966B1 (en) 2010-03-30 2021-01-06 Verseon International Corporation Multisubstituted aromatic compounds as inhibitors of thrombin
EP2970141B1 (en) 2013-03-15 2020-02-26 Verseon Corporation Halogenopyrazoles as inhibitors of thrombin
LT2968297T (lt) 2013-03-15 2019-01-10 Verseon Corporation Multipakeistieji aromatiniai junginiai kaip serino proteazės inhibitoriai
CA2960790A1 (en) 2014-09-17 2016-03-24 Verseon Corporation Pyrazolyl-substituted pyridone compounds as serine protease inhibitors
EP3261639B1 (en) 2015-02-27 2022-08-24 Verseon International Corporation Substituted pyrazole compounds as serine protease inhibitors

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6087380A (en) 1949-11-24 2000-07-11 Boehringer Ingelheim Pharma Kg Disubstituted bicyclic heterocycles, the preparations and the use thereof as pharmaceutical compositions
HU178398B (en) 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
CA1341029C (en) 1985-02-04 2000-06-20 Michael Kolb Peptidase inhibitors
US5187157A (en) 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
EP0362002B1 (en) 1988-09-01 1995-07-26 Merrell Dow Pharmaceuticals Inc. HIV protease inhibitors
ZA897515B (en) 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
US5518725A (en) 1989-09-25 1996-05-21 University Of Utah Research Foundation Vaccine compositions and method for induction of mucosal immune response via systemic vaccination
CA2075154A1 (en) 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
SE9102462D0 (sv) 1991-08-28 1991-08-28 Astra Ab New isosteric peptides
ZA928581B (en) 1991-11-12 1994-05-06 Lilly Co Eli Antithrombotic agents
SE9103612D0 (sv) 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
ES2110599T3 (es) 1992-03-04 1998-02-16 Gyogyszerkutato Intezet Nuevos derivados de peptidos anticoagulantes y composiciones farmaceuticas que contienen los mismos, asi como un proceso para su preparacion.
AU675981B2 (en) 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
TW257757B (da) 1993-03-03 1995-09-21 Boehringer Mannheim Gmbh
JPH06340619A (ja) 1993-05-03 1994-12-13 Bristol Myers Squibb Co グアニジニルまたはアミジニル置換メチルアミノ複素環トロンビン抑制剤
SE9301916D0 (sv) 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
EP0648780A1 (en) 1993-08-26 1995-04-19 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
US5643588A (en) * 1994-11-28 1997-07-01 The Procter & Gamble Company Diaper having a lotioned topsheet
AU1025795A (en) 1994-01-27 1995-08-03 Mitsubishi Chemical Corporation Prolineamide derivatives
US5705487A (en) 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
ZA951617B (en) 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
US5707966A (en) 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
DE4421052A1 (de) 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
US5510369A (en) 1994-07-22 1996-04-23 Merck & Co., Inc. Pyrrolidine thrombin inhibitors
DE4430757A1 (de) 1994-08-30 1996-03-07 Boehringer Mannheim Gmbh Neue 4-Aminopyridazine, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
DE4430755A1 (de) 1994-08-30 1996-03-07 Boehringer Mannheim Gmbh Neue Phosphanoxide, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
SE9404196D0 (sv) * 1994-12-02 1994-12-02 Astra Ab New antithrombotic formulation
CN1198839C (zh) 1995-02-17 2005-04-27 艾伯特有限及两合公司 作为凝血酶抑制剂的新的二肽脒类
US5710130A (en) 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
JPH11503161A (ja) 1995-04-04 1999-03-23 メルク エンド カンパニー インコーポレーテッド トロンビン阻害剤
US5629324A (en) 1995-04-10 1997-05-13 Merck & Co., Inc. Thrombin inhibitors
CA2224437A1 (en) 1995-06-27 1997-01-16 Merck & Co., Inc. Pyridinone-thrombin inhibitors
SA96170106A (ar) 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
CA2233344A1 (en) 1995-09-29 1997-04-03 3-Dimensional Pharmaceuticals, Inc. Guanidino protease inhibitors
ATE228760T1 (de) 1995-10-24 2002-12-15 Merck & Co Inc Thrombininhibitoren
GB9526273D0 (en) * 1995-12-21 1996-02-21 Astra Ab New prodrugs
TW541316B (en) 1995-12-21 2003-07-11 Astrazeneca Ab Prodrugs of thrombin inhibitors
PT883405E (pt) 1995-12-29 2004-06-30 Dimensional Pharm Inc Inibidores de amidino-protease
CA2245811A1 (en) 1996-02-22 1997-08-28 Merck & Co., Inc. Pyridinone thrombin inhibitors
JP3140790B2 (ja) 1996-04-23 2001-03-05 メルク エンド カンパニー インコーポレーテッド ピラジノン系トロンビン阻害薬
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
WO1997047299A1 (en) 1996-06-12 1997-12-18 3-Dimensional Pharmaceuticals, Inc. Amidino and guanidino heterocyclic protease inhibitors
US5863929A (en) 1996-06-25 1999-01-26 Eli Lilly And Company Anticoagulant agents
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
DE19632772A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Benzamidine
DE19632773A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Thrombininhibitoren
PE121699A1 (es) 1997-02-18 1999-12-08 Boehringer Ingelheim Pharma Heterociclos biciclicos disustituidos como inhibidores de la trombina
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
DE19727117A1 (de) 1997-06-26 1999-01-07 Boehringer Ingelheim Pharma Phenylalkylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE19753522A1 (de) 1997-12-03 1999-06-10 Boehringer Ingelheim Pharma Substituierte Indole, ihre Herstellung und ihre Verwendung als Arzneimittel
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
DE19754490A1 (de) 1997-12-09 1999-06-10 Boehringer Ingelheim Pharma Durch einen Aminocarbonylrest substituierte Bicyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
BR9907112A (pt) 1998-01-26 2000-10-24 Basf Ag Composto, medicamento, e, uso de um composto
WO1999037611A1 (de) 1998-01-26 1999-07-29 Basf Aktiengesellschaft Heterocyclische amidine als kallikrein protease inhibitoren
JP2002502844A (ja) 1998-02-03 2002-01-29 ベーリンガー インゲルハイム ファルマ コマンディトゲゼルシャフト ５員複素環縮合ベンゾ誘導体、その調製及び医薬品としてのそれらの使用
DE19816983A1 (de) 1998-04-17 1999-10-21 Boehringer Ingelheim Pharma Bicyclen, deren Herstellung und deren Verwendung als Arzneimittel
TWI248435B (en) 1998-07-04 2006-02-01 Boehringer Ingelheim Pharma Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions
DE19834751A1 (de) 1998-08-01 2000-02-03 Boehringer Ingelheim Pharma Disubstituierte bicyclische Heterocyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
AU3127900A (en) * 1998-12-23 2000-07-31 Du Pont Pharmaceuticals Company Thrombin or factor xa inhibitors
AR023510A1 (es) * 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.

Also Published As

Publication number Publication date
AU4633600A (en) 2000-11-10
RU2252783C2 (ru) 2005-05-27
AU754405B2 (en) 2002-11-14
EP1200118A1 (en) 2002-05-02
IL145840A0 (en) 2002-07-25
CA2371008A1 (en) 2000-11-02
ATE383868T1 (de) 2008-02-15
EP1886691A2 (en) 2008-02-13
SA00210092B1 (ar) 2006-11-11
DE60037816D1 (de) 2008-03-06
SK14962001A3 (sk) 2002-06-04
PL201793B1 (pl) 2009-05-29
PL351917A1 (en) 2003-06-30
WO2000064470A1 (en) 2000-11-02
CN100377742C (zh) 2008-04-02
NZ514827A (en) 2005-01-28
EE200100543A (et) 2003-02-17
TR200103017T2 (tr) 2002-05-21
HK1045465A1 (en) 2002-11-29
HK1045465B (zh) 2008-08-01
BR0009847A (pt) 2002-01-08
US20080113960A1 (en) 2008-05-15
US20060009397A1 (en) 2006-01-12
HUP0200955A2 (en) 2002-09-28
AR023510A1 (es) 2002-09-04
CZ20013757A3 (cs) 2002-05-15
DE60037816T2 (de) 2009-01-08
NO20015107L (no) 2001-10-19
CN1356908A (zh) 2002-07-03
EP1200118B1 (en) 2008-01-16
NO20015107D0 (no) 2001-10-19
JP2002542298A (ja) 2002-12-10
US6962905B1 (en) 2005-11-08
PT1200118E (pt) 2008-03-18
EP1886691A3 (en) 2008-03-05
KR20010110788A (ko) 2001-12-13
MY128061A (en) 2007-01-31
HUP0200955A3 (en) 2006-07-28
IS6111A (is) 2001-10-19
ES2298141T3 (es) 2008-05-16

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