WO2002102743A3 - Deuterierte n- und alpha-substituierte diphenylalkoyxessigsäureaminoalkylester sowie diese verbindungen enthaltende arzneimittel - Google Patents

Deuterierte n- und alpha-substituierte diphenylalkoyxessigsäureaminoalkylester sowie diese verbindungen enthaltende arzneimittel Download PDF

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Publication number
WO2002102743A3
WO2002102743A3 PCT/DE2002/002260 DE0202260W WO02102743A3 WO 2002102743 A3 WO2002102743 A3 WO 2002102743A3 DE 0202260 W DE0202260 W DE 0202260W WO 02102743 A3 WO02102743 A3 WO 02102743A3
Authority
WO
WIPO (PCT)
Prior art keywords
substituted
acetic acid
alkyl esters
amino alkyl
acid amino
Prior art date
Application number
PCT/DE2002/002260
Other languages
English (en)
French (fr)
Other versions
WO2002102743A9 (de
WO2002102743A2 (de
Inventor
Rudolf-Giesbert Alken
Johann Roither
Wolf-Dietrich Huebner
Werner Hrachowina
Thomas Stabingis
Original Assignee
Berolina Drug Dev Ab
Rudolf-Giesbert Alken
Johann Roither
Wolf-Dietrich Huebner
Werner Hrachowina
Thomas Stabingis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NZ53035202A priority Critical patent/NZ530352A/xx
Application filed by Berolina Drug Dev Ab, Rudolf-Giesbert Alken, Johann Roither, Wolf-Dietrich Huebner, Werner Hrachowina, Thomas Stabingis filed Critical Berolina Drug Dev Ab
Priority to HU0400213A priority patent/HUP0400213A3/hu
Priority to IL15941002A priority patent/IL159410A0/xx
Priority to JP2003505289A priority patent/JP2004534802A/ja
Priority to US10/481,153 priority patent/US20040242887A1/en
Priority to CA002451638A priority patent/CA2451638A1/en
Priority to KR10-2003-7016441A priority patent/KR20040020926A/ko
Priority to EP02752970A priority patent/EP1397327A2/de
Publication of WO2002102743A2 publication Critical patent/WO2002102743A2/de
Publication of WO2002102743A3 publication Critical patent/WO2002102743A3/de
Priority to IS7061A priority patent/IS7061A/is
Priority to NO20035599A priority patent/NO20035599D0/no
Publication of WO2002102743A9 publication Critical patent/WO2002102743A9/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Die Erfindung offenbart deuterierte N-substituierte α, α-Diphenyl-α-alkoxyessigsäureaminoalkylester sowie deren physiologisch verträgliche Salze. Weiterhin betrifft die Erfindung die Verwendung deuterierter N-substituierter α, α-Diphenyl-α-alkoxyessigsäureaminoalkylester, zur Behandlung hypertoner Funktionszustände im Bereich der Harnblase sowie zur Herstellung von Arzneimitteln zur Behandlung hypertoner Funktionszustände im Bereich der Harnblase. Außerdem offenbart die Erfindung pharmazeutische Zusammensetzungen enthaltend deuterierte N-substituierte α, α-Diphenyl-α-alkoxyessigsäureaminoalkylester sowie deren physiologisch verträgliche Salze zur Behandlung hypertoner Funktionszustände im Bereich der Harnblase neben pharmazeutisch verträglichen Hilfs- und/oder Zusatzstoffen.
PCT/DE2002/002260 2001-06-17 2002-06-17 Deuterierte n- und alpha-substituierte diphenylalkoyxessigsäureaminoalkylester sowie diese verbindungen enthaltende arzneimittel WO2002102743A2 (de)

Priority Applications (10)

Application Number Priority Date Filing Date Title
CA002451638A CA2451638A1 (en) 2001-06-17 2002-06-17 Deuterated n-substituted and .alpha.-substituted diphenylalkoxy acetic acid amino alkyl esters and medicaments containing these compounds
HU0400213A HUP0400213A3 (en) 2001-06-17 2002-06-17 Deuterated n-substituted and alpha-substituted diphenylalkoxy acetic acid amino alkyl esters and medicaments containing these compounds
IL15941002A IL159410A0 (en) 2001-06-17 2002-06-17 DEUTERATED N-SUBSTITUTED AND alpha-SUBSTITUTED DIPHENYLALKOXY ACETIC ACID AMINO ALKYL ESTERS AND MEDICAMENTS CONTAINING THESE COMPOUNDS
JP2003505289A JP2004534802A (ja) 2001-06-17 2002-06-17 重水素化Ｎ−及びα−置換ジフェニルアルコキシ酢酸アミノアルキルエステル並びにこれを含有する医薬品
US10/481,153 US20040242887A1 (en) 2001-06-17 2002-06-17 Deuterated n-substituted and alpha-substituted diphenylalkoxy acetic acid amino alkyl esters and medicaments containing these compounds
NZ53035202A NZ530352A (en) 2001-06-17 2002-06-17 Deuterated N-substituted and alpha-substituted diphenylalkoxy acetic acid amino alkyl esters and medicaments containing these compounds
KR10-2003-7016441A KR20040020926A (ko) 2001-06-17 2002-06-17 중수소화된 엔-치환 및 α-치환 디페닐알콕시 아세트산아미노 알킬 에스테르 및 이 화합물을 포함한 의약품
EP02752970A EP1397327A2 (de) 2001-06-17 2002-06-17 Deuterierte n- und alpha-substituierte diphenylalkoyxessigsäureaminoalkylester sowie diese verbindungen enthaltende arzneimittel
IS7061A IS7061A (is) 2001-06-17 2003-11-28 Tvívetnis N-setnir og a-setnir dífenýlalkoxý ediksýru amínó alkýl esterar og lyf sem innihalda téð efnasambönd
NO20035599A NO20035599D0 (no) 2001-06-17 2003-12-16 Deutererte N-substituerte og <alfa>-substituerte difenylalkoksyeddiksyreaminoalkylestere og medikamenter inneholdende disse

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10129832.3 2001-06-17
DE10129832A DE10129832A1 (de) 2001-06-17 2001-06-17 Deuterierte N- und alpha-substituierte Diphenylalkoxyessigsäureaminoalkylester sowie diese Verbindungen enthaltende Arzneimittel

Publications (3)

Publication Number Publication Date
WO2002102743A2 WO2002102743A2 (de) 2002-12-27
WO2002102743A3 true WO2002102743A3 (de) 2003-03-13
WO2002102743A9 WO2002102743A9 (de) 2004-03-11

Family

ID=7688891

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2002/002260 WO2002102743A2 (de) 2001-06-17 2002-06-17 Deuterierte n- und alpha-substituierte diphenylalkoyxessigsäureaminoalkylester sowie diese verbindungen enthaltende arzneimittel

Country Status (16)

Country Link
US (1) US20040242887A1 (de)
EP (1) EP1397327A2 (de)
JP (1) JP2004534802A (de)
KR (1) KR20040020926A (de)
CN (1) CN1516684A (de)
CA (1) CA2451638A1 (de)
CZ (1) CZ20033365A3 (de)
DE (1) DE10129832A1 (de)
HU (1) HUP0400213A3 (de)
IL (1) IL159410A0 (de)
IS (1) IS7061A (de)
NO (1) NO20035599D0 (de)
NZ (1) NZ530352A (de)
PL (1) PL367218A1 (de)
RU (1) RU2004101229A (de)
WO (1) WO2002102743A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080146573A1 (en) * 2006-12-04 2008-06-19 Auspex Pharmaceuticals, Inc. Preparation and utility of substituted oxzolidinones
US20090209608A1 (en) * 2007-08-29 2009-08-20 Protia, Llc Deuterium-enriched asenapine
US20090062185A1 (en) * 2007-08-29 2009-03-05 Protia, Llc Deuterium-enriched anidulafungin
US20090069219A1 (en) * 2007-09-09 2009-03-12 Protia, Llc Deuterium-enriched telavancin
US20090076158A1 (en) * 2007-09-13 2009-03-19 Protia, Llc Deuterium-enriched bicalutamide
US20090075870A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched caspofungin
US20090082419A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched tegaserod
AR075584A1 (es) 2009-02-27 2011-04-20 Intermune Inc COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO.
WO2010138889A1 (en) * 2009-05-28 2010-12-02 Concert Pharmaceuticals, Inc. Peptides for the treatment of hcv infections
KR20120110090A (ko) * 2009-09-28 2012-10-09 에프. 호프만-라 로슈 리미티드 Ｃ형 간염 바이러스 복제의 신규한 마크로시클릭 저해제
CN102584592B (zh) * 2011-12-28 2014-10-15 李进 一种氘代的拟除虫菊酯化合物及其制备方法和应用
EP2810936B1 (de) * 2012-01-30 2017-11-22 Taiho Pharmaceutical Co., Ltd. Neuartige essigsäureesterverbindung oder salz davon
CA2881182C (en) * 2012-08-09 2021-01-26 Chase Pharmaceuticals Corporation Piperidinium quaternary salts
CN105283444B (zh) * 2013-05-30 2017-06-16 大鹏药品工业株式会社 氟代二苯乙醇酸酯化合物及其盐
CN107445798B (zh) * 2016-06-01 2020-11-03 中国农业大学 一种α,α‐二氘代醇类化合物的合成方法
CN116078377B (zh) * 2023-03-06 2023-06-27 泽升科技(广州)有限公司 一种负载催化剂催化制备氘代苯的生产工艺

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD106642A1 (de) * 1973-03-02 1974-06-20
DE2937489A1 (de) * 1978-10-09 1980-04-17 Apogepha Veb Arzneimittel zur behandlung hypertoner funktionszustaende der harnblase

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6439873A (en) * 1987-08-05 1989-02-10 Sharp Kk Synchronizing signal generating circuit
EP0682649B1 (de) * 1993-01-28 1998-09-02 University Of Iowa Research Foundation Deuteriertes sevofluran als inhalationsbetäubungsmittel
DE4343838C2 (de) * 1993-12-22 1998-07-09 Lohmann Therapie Syst Lts Deuteriertes Arzneimittel in transdermaler Applikation und Verfahren zu seiner Herstellung

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD106642A1 (de) * 1973-03-02 1974-06-20
DE2937489A1 (de) * 1978-10-09 1980-04-17 Apogepha Veb Arzneimittel zur behandlung hypertoner funktionszustaende der harnblase

Also Published As

Publication number Publication date
CA2451638A1 (en) 2002-12-27
CN1516684A (zh) 2004-07-28
CZ20033365A3 (cs) 2004-09-15
IL159410A0 (en) 2004-06-01
PL367218A1 (en) 2005-02-21
WO2002102743A9 (de) 2004-03-11
NO20035599D0 (no) 2003-12-16
RU2004101229A (ru) 2005-06-27
KR20040020926A (ko) 2004-03-09
HUP0400213A3 (en) 2005-08-29
WO2002102743A2 (de) 2002-12-27
EP1397327A2 (de) 2004-03-17
IS7061A (is) 2003-11-28
US20040242887A1 (en) 2004-12-02
NZ530352A (en) 2004-12-24
JP2004534802A (ja) 2004-11-18
HUP0400213A2 (hu) 2004-07-28
DE10129832A1 (de) 2003-07-10

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