JP2002533472A5 - - Google Patents
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- Publication number
- JP2002533472A5 JP2002533472A5 JP2000591067A JP2000591067A JP2002533472A5 JP 2002533472 A5 JP2002533472 A5 JP 2002533472A5 JP 2000591067 A JP2000591067 A JP 2000591067A JP 2000591067 A JP2000591067 A JP 2000591067A JP 2002533472 A5 JP2002533472 A5 JP 2002533472A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- methyl
- compound
- compound according
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 9
- 229910052739 hydrogen Inorganic materials 0.000 description 9
- 239000001257 hydrogen Substances 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 8
- -1 ethylene, propylene Chemical group 0.000 description 7
- 208000035143 Bacterial infection Diseases 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 125000000837 carbohydrate group Chemical group 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Chemical group 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11372898P | 1998-12-23 | 1998-12-23 | |
| US60/113,728 | 1998-12-23 | ||
| US12931399P | 1999-04-14 | 1999-04-14 | |
| US60/129,313 | 1999-04-14 | ||
| US16402499P | 1999-11-04 | 1999-11-04 | |
| US60/164,024 | 1999-11-04 | ||
| US16997899P | 1999-12-10 | 1999-12-10 | |
| US60/169,978 | 1999-12-10 | ||
| PCT/US1999/030543 WO2000039156A1 (en) | 1998-12-23 | 1999-12-22 | Glycopeptide derivatives and pharmaceutical compositions containing the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002533472A JP2002533472A (ja) | 2002-10-08 |
| JP2002533472A5 true JP2002533472A5 (https=) | 2006-12-21 |
| JP4362017B2 JP4362017B2 (ja) | 2009-11-11 |
Family
ID=27493926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000591067A Expired - Fee Related JP4362017B2 (ja) | 1998-12-23 | 1999-12-22 | グリコペプチド誘導体およびそれを含有する薬学的組成物 |
Country Status (23)
| Country | Link |
|---|---|
| US (9) | US6392012B1 (https=) |
| EP (1) | EP1140993B1 (https=) |
| JP (1) | JP4362017B2 (https=) |
| KR (1) | KR100665204B1 (https=) |
| CN (1) | CN1249081C (https=) |
| AT (1) | ATE242783T1 (https=) |
| AU (1) | AU768204B2 (https=) |
| BR (1) | BRPI9914221B8 (https=) |
| CA (1) | CA2336445C (https=) |
| CZ (1) | CZ301184B6 (https=) |
| DE (1) | DE69908819T2 (https=) |
| DK (1) | DK1140993T3 (https=) |
| ES (1) | ES2201825T3 (https=) |
| HK (1) | HK1040721B (https=) |
| HU (1) | HU230190B1 (https=) |
| IL (2) | IL140093A0 (https=) |
| NO (1) | NO326066B1 (https=) |
| NZ (1) | NZ508594A (https=) |
| PL (1) | PL198311B1 (https=) |
| PT (1) | PT1140993E (https=) |
| SI (1) | SI1140993T1 (https=) |
| WO (1) | WO2000039156A1 (https=) |
| ZA (1) | ZA200007222B (https=) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1140993E (pt) * | 1998-12-23 | 2003-10-31 | Theravance Inc | Derivados de glicopeptidos e composicoes farmaceuticas contendo os mesmos |
| US6518243B1 (en) * | 1999-04-02 | 2003-02-11 | Trustees Of Princeton University | Desleucyl glycopeptide antibiotics and methods of making same |
| US6699836B2 (en) * | 1999-04-02 | 2004-03-02 | The Trustees Of Princeton University | Vancomycin analogs |
| AU2001238020A1 (en) * | 2000-02-04 | 2001-08-14 | Advanced Medicine, Inc. | Glycopeptide derivatives having antibiotic activity |
| CA2726789A1 (en) | 2000-02-05 | 2001-11-08 | Theravance, Inc. | Cyclodextrin containing glycopeptide antibiotic compositions |
| AU2001259298A1 (en) | 2000-05-02 | 2001-11-12 | Advanced Medicine, Inc. | Polyacid glycopeptide derivatives |
| JP4713810B2 (ja) | 2000-05-02 | 2011-06-29 | セラヴァンス， インコーポレーテッド | グリコペプチドに対する還元的アルキル化プロセス |
| ES2302733T3 (es) * | 2000-06-22 | 2008-08-01 | Theravance, Inc. | Derivados carboxi-sacaridos de glucopeptido. |
| WO2001098329A1 (en) * | 2000-06-22 | 2001-12-27 | Theravance, Inc. | Polyhydroxy glycopeptide derivatives |
| UA75083C2 (uk) | 2000-06-22 | 2006-03-15 | Тераванс, Інк. | Похідні глікопептидфосфонатів |
| US6872804B2 (en) | 2000-06-22 | 2005-03-29 | Theravance, Inc. | Glycopeptide disulfide and thioester derivatives |
| US6905669B2 (en) * | 2001-04-24 | 2005-06-14 | Supergen, Inc. | Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase |
| TWI275594B (en) * | 2001-08-24 | 2007-03-11 | Theravance Inc | Process for preparing vancomycin phosphonate derivatives |
| TWI312785B (en) * | 2001-08-24 | 2009-08-01 | Theravance Inc | Process for preparing vancomycin derivatives |
| ATE322975T1 (de) | 2001-09-19 | 2006-04-15 | Procter & Gamble | Farbbedruckte mehrschichtstruktur, ein damit hergestellter absorbierender artikel und verfahren zu deren herstellung |
| TWI335332B (en) | 2001-10-12 | 2011-01-01 | Theravance Inc | Cross-linked vancomycin-cephalosporin antibiotics |
| CN101404986B (zh) | 2002-05-17 | 2011-09-28 | 赛奎拉公司 | 用于诊断和治疗感染性疾病的组合物和制药方法 |
| US20040033986A1 (en) | 2002-05-17 | 2004-02-19 | Protopopova Marina Nikolaevna | Anti tubercular drug: compositions and methods |
| TWI325323B (en) * | 2002-05-24 | 2010-06-01 | Theravance Inc | Cross-linked glycopeptide-cephalosporin antibiotics |
| AU2003243574A1 (en) | 2002-06-17 | 2003-12-31 | Theravance, Inc. | PROCESS FOR PREPARING N-PROTECTED Beta-AMINO ALDEHYDE COMPOUNDS |
| BRPI0312654A2 (pt) * | 2002-07-09 | 2017-05-02 | Fasgen Llc | métodos de tratar infecções microbianas em seres humanos e animais |
| MXPA05005338A (es) * | 2002-11-18 | 2005-12-14 | Vicuron Pharm Inc | Metodos para administrar dalbavancin para el tratamiento de infecciones bacterianas. |
| US20060074014A1 (en) * | 2002-11-18 | 2006-04-06 | Vicuron Pharmaceuticals Inc. | Dalbavancin compositions for treatment of bacterial infections |
| JP2007500222A (ja) | 2003-05-23 | 2007-01-11 | セラヴァンス インコーポレーテッド | 架橋グリコペプチド−セファロスポリン抗生物質 |
| DE602004012269T2 (de) * | 2003-07-11 | 2009-04-30 | Theravance, Inc., South San Francisco | Quervernetzte glycopeptid-cephalosporin-antibiotika |
| DE102004055582A1 (de) | 2004-11-18 | 2006-05-24 | Bayer Cropscience Ag | N-Heterocyclyl-phthalsäurediamide |
| US8778874B2 (en) | 2004-11-29 | 2014-07-15 | National University Corporation Nagoya University | Glycopeptide antibiotic monomer derivatives |
| US8304597B2 (en) | 2004-12-15 | 2012-11-06 | The Procter And Gamble Company | Method of using an absorbent article having a functional enhancement indicator |
| US7632918B2 (en) * | 2005-02-28 | 2009-12-15 | Novartis Vaccines And Diagnostics, Inc. | Semi-synthetic glycopeptides with antibiotic activity |
| US7368422B2 (en) * | 2005-02-28 | 2008-05-06 | Novartis Vaccines And Diagnostics Inc. | Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity |
| US20070185015A1 (en) * | 2005-02-28 | 2007-08-09 | Chiron Corporation and North China Pharmaceutical Corporation | Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity |
| JP5178520B2 (ja) | 2005-09-22 | 2013-04-10 | メディバス エルエルシー | 固体ポリマー送達組成物およびその使用法 |
| CA2623198C (en) | 2005-09-22 | 2014-08-05 | Medivas, Llc | Bis-(a-amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use |
| WO2007084507A2 (en) * | 2006-01-13 | 2007-07-26 | The Scripps Research Institute | [ψ[CH2NH]PG4] GLYCOPEPTIDE ANTIBIOTIC ANALOGS |
| TW200808818A (en) * | 2006-05-26 | 2008-02-16 | Shionogi & Co | Glycopeptide antibiotic derivatives |
| CA2710602A1 (en) * | 2007-12-26 | 2009-07-09 | Lead Therapeutics, Inc. | Novel semi-synthetic glycopeptides as antibacterial agents |
| CN101959900A (zh) | 2007-12-26 | 2011-01-26 | 盐野义制药株式会社 | 糖肽类抗生素糖基化衍生物 |
| EP2260060A4 (en) | 2008-04-01 | 2013-01-16 | Univ Cornell | ORGANIC SOLUBLE CHITOSA SALT AND CHITOSAN DERIVED BIOMATERIALS MANUFACTURED THEREFROM |
| GB2465863A (en) * | 2008-12-05 | 2010-06-09 | Lead Therapeutics Inc | Semi-synthetic heptapeptidic glycopeptides for the treatment of bacterial infections |
| CN101928330B (zh) * | 2009-06-26 | 2013-10-16 | 上海来益生物药物研究开发中心有限责任公司 | 一种新的化合物及其应用 |
| WO2012129493A1 (en) * | 2011-03-24 | 2012-09-27 | Seachaid Pharmaceuticals, Inc. | Vancomycin derivatives |
| KR102237887B1 (ko) | 2013-03-15 | 2021-04-07 | 멜린타 서브시디어리 코프. | 항생제를 사용하여 과체중 및 비만 환자에서 감염을 치료하는 방법 |
| AU2014322817A1 (en) * | 2013-09-23 | 2016-04-21 | Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) | Vancomycin-sugar conjugates and uses thereof |
| WO2016103284A1 (en) * | 2014-12-25 | 2016-06-30 | Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) | Glycopeptides and uses thereof |
| CA3011208A1 (en) * | 2016-01-15 | 2017-07-20 | Universitat Hamburg | Methods for the production of rhamnosylated flavonoids |
| US10696698B2 (en) * | 2016-01-28 | 2020-06-30 | ACatechol, Inc. | Surface primer compositions and methods of use |
| CN107325159A (zh) * | 2016-04-29 | 2017-11-07 | 中国科学院上海药物研究所 | 一类万古霉素衍生物、其制备方法、药物组合物和用途 |
| IL270685B (en) * | 2017-05-22 | 2022-09-01 | Insmed Inc | Cleavable derivatives of lipoglycopeptide and their uses |
| CN107987131B (zh) * | 2017-11-16 | 2021-03-09 | 上海来益生物药物研究开发中心有限责任公司 | 一组具有抗耐药性细菌活性的化合物、其制备方法和应用 |
| CN108409837B (zh) | 2018-03-06 | 2021-09-24 | 上海来益生物药物研究开发中心有限责任公司 | 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用 |
| NL2023883B1 (en) * | 2019-09-24 | 2021-04-26 | Univ Leiden | Antibiotic compounds |
| CN111620931B (zh) * | 2020-06-12 | 2021-12-17 | 苏州博源医疗科技有限公司 | 万古霉素衍生物及其制备方法和应用 |
| CN114213284B (zh) * | 2022-01-04 | 2023-08-01 | 丽珠集团福州福兴医药有限公司 | (9h-芴-9-基)-癸基(2-氧代乙基)氨基甲酸甲酯及其合成方法 |
| CN121270649A (zh) * | 2024-07-03 | 2026-01-06 | 烟台新药创制山东省实验室 | 一类万古霉素衍生物、其制备方法、药物组合物和用途 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4497802A (en) | 1983-10-21 | 1985-02-05 | Eli Lilly And Company | N-Acyl glycopeptide derivatives |
| US4914187A (en) | 1984-11-13 | 1990-04-03 | Gruppo Lepetit S.P.A | Ester derivatives of antibiotic L 17046 |
| GB8428619D0 (en) | 1984-11-13 | 1984-12-19 | Lepetit Spa | Derivatives of antibiotic l 17046 |
| US4698327A (en) | 1985-04-25 | 1987-10-06 | Eli Lilly And Company | Novel glycopeptide derivatives |
| US4643987A (en) | 1985-08-14 | 1987-02-17 | Eli Lilly And Company | Modified glycopeptides |
| US4639433A (en) | 1985-08-14 | 1987-01-27 | Eli Lilly And Company | Glycopeptide derivatives |
| GB8704847D0 (en) * | 1987-03-02 | 1987-04-08 | Lepetit Spa | Substituted alkylamides of teicoplanin compounds |
| FR2632185B1 (fr) * | 1988-06-01 | 1992-05-22 | Rhone Poulenc Chimie | Silice pour compositions dentifrices compatible notamment avec le zinc |
| GB8817397D0 (en) | 1988-07-21 | 1988-08-24 | Lepetit Spa | N15-alkyl & n15 n15-di-alkyl derivatives of teicoplanin antibiotics carrying functional groups on alkyl side chain |
| US5534420A (en) | 1988-07-28 | 1996-07-09 | Eli Lilly And Company | Biotransformation of glycopeptide antibiotics |
| EP0376041B1 (en) | 1988-12-27 | 1996-02-28 | GRUPPO LEPETIT S.p.A. | C63-Amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-teicoplanins |
| IE64155B1 (en) | 1989-03-29 | 1995-07-12 | Lepetit Spa | New substituted alkylamide derivatives of teicoplanin |
| ZA909847B (en) | 1989-12-13 | 1992-08-26 | Lilly Co Eli | Glycopeptide derivatives |
| AU647122B2 (en) | 1990-05-28 | 1994-03-17 | Gruppo Lepetit S.P.A. | C63-amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy- teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics |
| WO1992017456A1 (fr) | 1991-03-26 | 1992-10-15 | Fujisawa Pharmaceutical Co., Ltd. | Derive d'acide amine et sel dudit derive |
| EP0596929B1 (en) | 1991-07-29 | 1995-07-26 | GRUPPO LEPETIT S.p.A. | Amide derivatives of antibiotic a 40926 |
| US5750509A (en) | 1991-07-29 | 1998-05-12 | Gruppo Lepetit S.P.A. | Amide derivatives of antibiotic A 40926 |
| US5840684A (en) | 1994-01-28 | 1998-11-24 | Eli Lilly And Company | Glycopeptide antibiotic derivatives |
| TW457248B (en) | 1994-01-28 | 2001-10-01 | Lilly Co Eli | Glycopeptide antibiotic derivatives |
| IT1282586B1 (it) | 1996-02-08 | 1998-03-31 | Chemical And Biolog Ind | Composizioni farmaceutiche per il trattamento biologico delle infezioni dovute a ceppi di enterococcus faecium resistenti agli |
| WO1997034623A1 (en) | 1996-03-21 | 1997-09-25 | Transcell Technologies, Inc. | Solid phase lipoglycopeptide library, compositions and methods |
| AU2441697A (en) | 1996-04-12 | 1997-11-07 | Eli Lilly And Company | Covalently-linked glycopeptide dimers |
| CA2251086C (en) | 1996-04-12 | 2007-02-20 | Eli Lilly And Company | Glycopeptide compounds |
| EP0912604B1 (en) | 1996-04-23 | 2001-11-14 | Biosearch Italia S.p.A. | Improved chemical process for preparing amide derivatives of antibiotic A 40926 |
| US5919756A (en) | 1996-06-28 | 1999-07-06 | Eli Lilly And Company | Amides |
| US5939382A (en) | 1996-11-21 | 1999-08-17 | Eli Lilly And Company | Reducing agent for reductive alkylation of glycopeptide antibiotics |
| US5952466A (en) | 1997-11-12 | 1999-09-14 | Eli Lilly And Company | Reductive alkylation of glycopeptide antibiotics |
| US5916873A (en) | 1997-04-17 | 1999-06-29 | Eli Lilly And Company | Teicoplanin derivatives |
| US5919771A (en) | 1997-05-20 | 1999-07-06 | Eli Lilly And Company | Urea and thiourea derivatives of glycopeptides |
| US5952310A (en) | 1997-05-20 | 1999-09-14 | Eli Lilly And Company | Glycopeptide hexapeptides |
| US5977063A (en) | 1997-05-20 | 1999-11-02 | Eli Lilly And Company | Alkylated hexapeptides |
| US6518242B1 (en) | 1998-02-20 | 2003-02-11 | Theravance, Inc. | Derivatives of glycopeptide antibacterial agents |
| CA2318394A1 (en) | 1998-02-20 | 1999-08-26 | Advanced Medicine, Inc. | Novel antibacterial agents |
| WO1999056760A1 (en) | 1998-05-01 | 1999-11-11 | Eli Lilly And Company | N1-modified glycopeptides |
| CA2337103A1 (en) | 1998-07-14 | 2000-01-27 | Robert Kerns | Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same |
| PT1140993E (pt) * | 1998-12-23 | 2003-10-31 | Theravance Inc | Derivados de glicopeptidos e composicoes farmaceuticas contendo os mesmos |
| UA75083C2 (uk) | 2000-06-22 | 2006-03-15 | Тераванс, Інк. | Похідні глікопептидфосфонатів |
| TWI325323B (en) | 2002-05-24 | 2010-06-01 | Theravance Inc | Cross-linked glycopeptide-cephalosporin antibiotics |
| DE602004012269T2 (de) | 2003-07-11 | 2009-04-30 | Theravance, Inc., South San Francisco | Quervernetzte glycopeptid-cephalosporin-antibiotika |
-
1999
- 1999-12-22 PT PT99965331T patent/PT1140993E/pt unknown
- 1999-12-22 WO PCT/US1999/030543 patent/WO2000039156A1/en not_active Ceased
- 1999-12-22 DE DE69908819T patent/DE69908819T2/de not_active Expired - Lifetime
- 1999-12-22 CA CA2336445A patent/CA2336445C/en not_active Expired - Lifetime
- 1999-12-22 US US09/470,209 patent/US6392012B1/en not_active Expired - Lifetime
- 1999-12-22 HK HK02102171.5A patent/HK1040721B/en unknown
- 1999-12-22 KR KR1020017003918A patent/KR100665204B1/ko not_active Expired - Lifetime
- 1999-12-22 BR BRPI9914221A patent/BRPI9914221B8/pt not_active IP Right Cessation
- 1999-12-22 HU HU0400887A patent/HU230190B1/hu unknown
- 1999-12-22 CZ CZ20010022A patent/CZ301184B6/cs not_active IP Right Cessation
- 1999-12-22 JP JP2000591067A patent/JP4362017B2/ja not_active Expired - Fee Related
- 1999-12-22 DK DK99965331T patent/DK1140993T3/da active
- 1999-12-22 EP EP99965331A patent/EP1140993B1/en not_active Expired - Lifetime
- 1999-12-22 CN CNB99809434XA patent/CN1249081C/zh not_active Expired - Lifetime
- 1999-12-22 SI SI9930389T patent/SI1140993T1/xx unknown
- 1999-12-22 PL PL348451A patent/PL198311B1/pl unknown
- 1999-12-22 ES ES99965331T patent/ES2201825T3/es not_active Expired - Lifetime
- 1999-12-22 AT AT99965331T patent/ATE242783T1/de active
- 1999-12-22 AU AU31273/00A patent/AU768204B2/en not_active Expired
- 1999-12-22 IL IL14009399A patent/IL140093A0/xx active IP Right Grant
- 1999-12-22 NZ NZ508594A patent/NZ508594A/en not_active IP Right Cessation
-
2000
- 2000-09-06 US US09/656,473 patent/US6444786B1/en not_active Expired - Lifetime
- 2000-11-01 US US09/674,456 patent/US6455669B1/en not_active Expired - Lifetime
- 2000-12-05 IL IL140093A patent/IL140093A/en not_active IP Right Cessation
- 2000-12-06 ZA ZA200007222A patent/ZA200007222B/xx unknown
- 2000-12-12 NO NO20006323A patent/NO326066B1/no not_active IP Right Cessation
-
2002
- 2002-03-06 US US10/092,088 patent/US6962970B2/en not_active Expired - Lifetime
-
2004
- 2004-04-15 US US10/825,038 patent/US6949681B2/en not_active Expired - Lifetime
-
2005
- 2005-05-13 US US11/128,901 patent/US7101964B2/en not_active Expired - Lifetime
-
2006
- 2006-04-17 US US11/405,234 patent/US7351791B2/en not_active Expired - Fee Related
-
2007
- 2007-10-24 US US11/977,377 patent/US7723470B2/en not_active Expired - Fee Related
-
2009
- 2009-05-08 US US12/437,778 patent/US8030445B2/en not_active Expired - Fee Related
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