JP2002508361A5 - - Google Patents
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- Publication number
- JP2002508361A5 JP2002508361A5 JP2000539001A JP2000539001A JP2002508361A5 JP 2002508361 A5 JP2002508361 A5 JP 2002508361A5 JP 2000539001 A JP2000539001 A JP 2000539001A JP 2000539001 A JP2000539001 A JP 2000539001A JP 2002508361 A5 JP2002508361 A5 JP 2002508361A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- effective amount
- therapeutically effective
- treatment
- treatment agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 14
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 3
- BIGWXAGEQONZGD-UHFFFAOYSA-N 2h-oxadiazol-5-one Chemical compound O=C1C=NNO1 BIGWXAGEQONZGD-UHFFFAOYSA-N 0.000 description 1
- RKRLQDJTVWZXMM-UHFFFAOYSA-N CC(N1)=NOC1=O Chemical compound CC(N1)=NOC1=O RKRLQDJTVWZXMM-UHFFFAOYSA-N 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 238000001467 acupuncture Methods 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 208000018685 gastrointestinal system disease Diseases 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 208000002551 irritable bowel syndrome Diseases 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6977397P | 1997-12-16 | 1997-12-16 | |
| US60/069,773 | 1997-12-16 | ||
| US10492498P | 1998-10-20 | 1998-10-20 | |
| US60/104,924 | 1998-10-20 | ||
| PCT/US1998/023917 WO1999031074A2 (en) | 1997-12-16 | 1998-11-10 | ((cyclo)alkyl substituted)-.gamma.-aminobutyric acid derivatives (=gaba analogues), their preparation and their use in the treatment of neurological disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002508361A JP2002508361A (ja) | 2002-03-19 |
| JP2002508361A5 true JP2002508361A5 (https=) | 2009-09-10 |
Family
ID=26750408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000539001A Pending JP2002508361A (ja) | 1997-12-16 | 1998-11-10 | （（シクロ）アルキル置換）−γ−アミノ酪酸誘導体（＝ＧＡＢＡ類似体）、それらの製造および神経学的疾患の治療における使用 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US6521650B1 (https=) |
| EP (2) | EP1400526A3 (https=) |
| JP (1) | JP2002508361A (https=) |
| KR (1) | KR20010033154A (https=) |
| CN (1) | CN1210268C (https=) |
| AT (1) | ATE260904T1 (https=) |
| AU (1) | AU759619B2 (https=) |
| BR (1) | BR9813656A (https=) |
| CA (1) | CA2304965C (https=) |
| CU (1) | CU23028A3 (https=) |
| DE (1) | DE69822214T2 (https=) |
| DK (1) | DK1045839T3 (https=) |
| ES (1) | ES2216338T3 (https=) |
| HU (1) | HUP0100472A3 (https=) |
| IL (1) | IL135314A0 (https=) |
| IS (1) | IS5436A (https=) |
| NO (2) | NO317251B1 (https=) |
| NZ (1) | NZ503981A (https=) |
| PL (1) | PL348305A1 (https=) |
| PT (1) | PT1045839E (https=) |
| SI (1) | SI1045839T1 (https=) |
| TR (1) | TR200001794T2 (https=) |
| WO (1) | WO1999031074A2 (https=) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL189872B1 (pl) | 1996-07-24 | 2005-10-31 | Warner Lambert Co | Zastosowanie izobutylogaby i jej pochodnych do wytwarzania leku do leczenia bólu |
| GB2365425A (en) * | 2000-08-01 | 2002-02-20 | Parke Davis & Co Ltd | Alkyl amino acid derivatives useful as pharmaceutical agents |
| AU2002211863A1 (en) | 2000-10-06 | 2002-04-15 | Xenoport, Inc. | Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration |
| AU2002230398A1 (en) | 2000-10-06 | 2002-04-29 | Xenoport, Inc. | Bile-acid conjugates for providing sustained systemic concentrations of drugs |
| US6620829B2 (en) | 2000-10-17 | 2003-09-16 | Warner-Lambert Company | Method of treating noninflammatory cartilage damage |
| GB2368579A (en) * | 2000-10-31 | 2002-05-08 | Parke Davis & Co Ltd | Azole pharmaceutical agents |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| AU2002345638A1 (en) | 2001-06-11 | 2002-12-23 | Xenoport, Inc. | Amino acid conjugates providing for sustained systemic concentrations of gaba analogues |
| CN1753673B (zh) * | 2001-06-11 | 2010-09-29 | 什诺波特有限公司 | Gaba类似物的前药、及其组合物和应用 |
| US7232924B2 (en) | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
| CA2449729C (en) * | 2001-06-11 | 2009-11-03 | Xenoport, Inc. | Prodrugs of gaba analogs, compositions and uses thereof |
| US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| CN1625393A (zh) | 2002-01-31 | 2005-06-08 | 沃纳-兰伯特公司 | 治疗耳鸣的α2δ配体 |
| AU2003222033A1 (en) | 2002-03-20 | 2003-10-08 | Xenoport | Cyclic 1-(acyloxy)-alkyl prodrugs of gaba analogs, compositions and uses thereof |
| WO2004002462A2 (en) * | 2002-06-27 | 2004-01-08 | Warner-Lambert Company Llc | Use of an alpha2delta ligand such as gabapentin or pregabalin for treating ttention deficit hyperactivity disorder |
| US7060727B2 (en) | 2002-12-11 | 2006-06-13 | Xenoport, Inc. | Prodrugs of fused GABA analogs, pharmaceutical compositions and uses thereof |
| AU2003303041B2 (en) | 2002-12-13 | 2008-07-24 | Warner-Lambert Company Llc | Alpha-2-delta ligand to treat lower urinary tract symptoms |
| CA2451267A1 (en) | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
| BRPI0408110A (pt) | 2003-03-07 | 2006-03-01 | Warner Lambert Co | derivados de beta-aminoácido substituìdos com tetrazol e oxadiazolona |
| EP1622613A4 (en) * | 2003-05-14 | 2008-04-02 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
| KR20060119971A (ko) | 2003-09-11 | 2006-11-24 | 제노포트 인코포레이티드 | Ｇａｂａ 유사체의 전구약물을 이용한 요실금의 치료및/또는 예방 |
| AU2004271800A1 (en) | 2003-09-12 | 2005-03-24 | Pfizer Inc. | Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors |
| RU2458049C2 (ru) * | 2003-09-17 | 2012-08-10 | Ксенопорт, Инк. | Лечение или предупреждение синдрома беспокойных ног с использованием пролекарств аналогов гамк |
| NZ579515A (en) | 2003-09-17 | 2011-09-30 | Xenoport Inc | Treating or preventing restless legs syndrome using prodrugs of gaba analogs |
| SG147437A1 (en) | 2003-10-14 | 2008-11-28 | Xenoport Inc | Crystalline form of gamma-aminobutyric acid analog |
| PL1691811T3 (pl) | 2003-12-11 | 2014-12-31 | Sunovion Pharmaceuticals Inc | Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji |
| US20050209319A1 (en) * | 2004-03-18 | 2005-09-22 | Xenoport, Inc. | Treatment of local pain |
| WO2006012603A2 (en) * | 2004-07-22 | 2006-02-02 | Nps Pharmaceuticals, Inc. | Analogs of isovaleramide, a pharmaceutical composition including the same, and a method of treating central nervous system conditions or diseases |
| US7449486B2 (en) | 2004-10-19 | 2008-11-11 | Array Biopharma Inc. | Mitotic kinesin inhibitors and methods of use thereof |
| MX2007005306A (es) | 2004-11-04 | 2007-06-11 | Xenoport Inc | Formas de dosis oral de liberacion sostenida de la prodroga gabapentina. |
| UA95907C2 (en) * | 2005-05-02 | 2011-09-26 | Эррей Биофарма Инк. | Mitotic kinesin inhibitors and methods of use thereof |
| ES2398579T3 (es) * | 2005-09-19 | 2013-03-20 | Teva Pharmaceutical Industries Ltd | Una síntesis asimétrica de ácido (S)-(+)-3-(aminometil)-5-metilhexanoico |
| JP2010505870A (ja) * | 2006-10-03 | 2010-02-25 | アレイ バイオファーマ、インコーポレイテッド | 有糸分裂キネシン阻害剤としてのオキサジアゾール誘導体およびチアジアゾール誘導体、ならびにそれらの使用方法 |
| CA2673545A1 (en) | 2006-12-22 | 2008-07-03 | Recordati Ireland Limited | Combination therapy of lower urinary tract disorders with .alpha.2.delta. ligands and nsaids |
| ES2601852T3 (es) | 2008-01-25 | 2017-02-16 | Xenoport, Inc. | Forma cristalina de sales de calcio de ácidos (3S)-aminometil-5-metil-hexanoicos y métodos de uso |
| EP2250148B1 (en) | 2008-01-25 | 2016-08-17 | XenoPort, Inc. | Crystalline form of calcium-salts of (3s)-aminomethyl-5-methyl-hexanoic acids and methods of use |
| US7868043B2 (en) | 2008-01-25 | 2011-01-11 | Xenoport, Inc. | Mesophasic forms of (3S)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use |
| EP2116539A1 (en) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof |
| SG157299A1 (en) | 2008-05-09 | 2009-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
| EP2297090A1 (en) * | 2008-06-23 | 2011-03-23 | Teva Pharmaceutical Industries Ltd. | Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester |
| ES2589915T3 (es) | 2008-10-08 | 2016-11-17 | Xgene Pharmaceutical Inc | Conjugados de GABA y métodos de utilización de los mismos |
| EP2353591A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof |
| EP2353598A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for use in the prevention and/or treatment of postoperative pain |
| EP2388005A1 (en) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy |
| EP2415471A1 (en) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
| EP2524694A1 (en) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in diabetes type-2 associated pain |
| US9066853B2 (en) | 2013-01-15 | 2015-06-30 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable fiber |
| CA2903000C (en) | 2013-01-28 | 2021-10-12 | Hector L. Lopez | Methods of improving tolerability, pharmacodynamics, and efficacy of .beta.-alanine and use therefor |
| AU2014364644A1 (en) | 2013-12-17 | 2016-06-23 | Laboratorios Del Dr. Esteve, S.A. | Gabapentinoids and Sigma receptor ligands combinations |
| TN2016000228A1 (en) | 2013-12-17 | 2017-10-06 | Esteve Labor Dr | SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITORS (SNRIs) AND SIGMA RECEPTOR LIGANDS COMBINATIONS. |
| CN105481801B (zh) * | 2015-12-11 | 2021-08-13 | 广东莱佛士制药技术有限公司 | 一种普瑞巴林手性中间体的制备方法 |
| CN108358799B (zh) * | 2018-04-24 | 2020-11-10 | 贵州师范大学 | 一种普瑞巴林的制备方法 |
| CN117986143A (zh) * | 2022-11-03 | 2024-05-07 | 中科中山药物创新研究院 | 含有多环结构的γ-氨基丁酸衍生物及其制备方法和用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2465803A (en) * | 1944-02-12 | 1949-03-29 | Ici Ltd | Beta-nitroalkane sulfonic acids |
| CH325458A (de) * | 1953-03-14 | 1957-11-15 | Ruhrchemie Ag | Verfahren zur Herstellung von Sultamen |
| DE2460891C2 (de) | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US4087544A (en) | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
| US4456757A (en) * | 1981-03-20 | 1984-06-26 | Asahi Kasei Kogyo Kabushiki Kaisha | Isoquinolinesulfonyl derivatives and process for the preparation thereof |
| JPS6023360A (ja) * | 1983-07-18 | 1985-02-05 | Mitsui Toatsu Chem Inc | アミノアルキルスルホン酸類の製造法 |
| SE455259B (sv) * | 1984-01-30 | 1988-07-04 | Kenogard Ab | Anvendning av vissa aminoalkanfosfonsyror for bekempning av svampsjukdomar hos vexter |
| AU9137091A (en) * | 1990-11-27 | 1992-06-25 | Northwestern University | Gaba and l-glutamic acid analogs for antiseizure treatment |
| US6197819B1 (en) | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
| FR2674522B1 (fr) * | 1991-03-26 | 1993-07-16 | Lipha | Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant. |
| MY119161A (en) * | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
| WO1996005201A1 (en) * | 1994-08-10 | 1996-02-22 | British Biotech Pharmaceuticals Limited | Imidazopyridine derivatives as dual histamine (h1) and platelet activating factor (paf) antagonists |
| WO1998017627A1 (en) * | 1996-10-23 | 1998-04-30 | Warner-Lambert Company | Substituted gamma aminobutyric acids as pharmaceutical agents |
-
1998
- 1998-11-10 DK DK98962805T patent/DK1045839T3/da active
- 1998-11-10 JP JP2000539001A patent/JP2002508361A/ja active Pending
- 1998-11-10 AU AU17962/99A patent/AU759619B2/en not_active Ceased
- 1998-11-10 NZ NZ503981A patent/NZ503981A/xx unknown
- 1998-11-10 EP EP03027569A patent/EP1400526A3/en not_active Withdrawn
- 1998-11-10 EP EP98962805A patent/EP1045839B1/en not_active Expired - Lifetime
- 1998-11-10 IL IL13531498A patent/IL135314A0/xx unknown
- 1998-11-10 AT AT98962805T patent/ATE260904T1/de not_active IP Right Cessation
- 1998-11-10 CU CU20000139A patent/CU23028A3/es unknown
- 1998-11-10 SI SI9830620T patent/SI1045839T1/xx unknown
- 1998-11-10 DE DE69822214T patent/DE69822214T2/de not_active Expired - Fee Related
- 1998-11-10 TR TR2000/01794T patent/TR200001794T2/xx unknown
- 1998-11-10 US US09/509,917 patent/US6521650B1/en not_active Expired - Fee Related
- 1998-11-10 CA CA002304965A patent/CA2304965C/en not_active Expired - Fee Related
- 1998-11-10 ES ES98962805T patent/ES2216338T3/es not_active Expired - Lifetime
- 1998-11-10 WO PCT/US1998/023917 patent/WO1999031074A2/en not_active Ceased
- 1998-11-10 CN CNB988114747A patent/CN1210268C/zh not_active Expired - Fee Related
- 1998-11-10 BR BR9813656-9A patent/BR9813656A/pt not_active Application Discontinuation
- 1998-11-10 HU HU0100472A patent/HUP0100472A3/hu unknown
- 1998-11-10 PT PT98962805T patent/PT1045839E/pt unknown
- 1998-11-10 KR KR1020007006531A patent/KR20010033154A/ko not_active Ceased
- 1998-11-10 PL PL98348305A patent/PL348305A1/xx unknown
-
2000
- 2000-04-07 IS IS5436A patent/IS5436A/is unknown
- 2000-06-14 NO NO20003037A patent/NO317251B1/no not_active IP Right Cessation
-
2003
- 2003-02-14 US US10/367,349 patent/US20030229054A1/en not_active Abandoned
-
2004
- 2004-02-24 NO NO20040817A patent/NO20040817L/no not_active Application Discontinuation
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