JP2003525207A5 - - Google Patents
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- Publication number
- JP2003525207A5 JP2003525207A5 JP2000621366A JP2000621366A JP2003525207A5 JP 2003525207 A5 JP2003525207 A5 JP 2003525207A5 JP 2000621366 A JP2000621366 A JP 2000621366A JP 2000621366 A JP2000621366 A JP 2000621366A JP 2003525207 A5 JP2003525207 A5 JP 2003525207A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- compound according
- medicament
- treating
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 19
- 239000003814 drug Substances 0.000 description 9
- 125000004432 carbon atom Chemical group C* 0.000 description 7
- BIGWXAGEQONZGD-UHFFFAOYSA-N 2h-oxadiazol-5-one Chemical compound O=C1C=NNO1 BIGWXAGEQONZGD-UHFFFAOYSA-N 0.000 description 3
- -1 4-isobutyl-pyrrolidin-3-yl Chemical group 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 125000002837 carbocyclic group Chemical group 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- UKTMYUZOEFEYNX-UHFFFAOYSA-N 4-(2h-tetrazol-5-yl)-2-azaspiro[4.5]decane Chemical compound N=1N=NNC=1C1CNCC21CCCCC2 UKTMYUZOEFEYNX-UHFFFAOYSA-N 0.000 description 1
- DQYXECHFBDDSEZ-HTQZYQBOSA-N 5-[(3s,4s)-4-(2-methylpropyl)pyrrolidin-3-yl]-2h-tetrazole Chemical compound CC(C)C[C@@H]1CNC[C@H]1C1=NN=NN1 DQYXECHFBDDSEZ-HTQZYQBOSA-N 0.000 description 1
- DQYXECHFBDDSEZ-UHFFFAOYSA-N 5-[4-(2-methylpropyl)pyrrolidin-3-yl]-2h-tetrazole Chemical compound CC(C)CC1CNCC1C1=NN=NN1 DQYXECHFBDDSEZ-UHFFFAOYSA-N 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 208000014644 Brain disease Diseases 0.000 description 1
- 0 CC1(*)C(*)CNC1 Chemical compound CC1(*)C(*)CNC1 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 208000032274 Encephalopathy Diseases 0.000 description 1
- STCPSJQRNFVLNL-UHFFFAOYSA-N OC1ON=CN1 Chemical compound OC1ON=CN1 STCPSJQRNFVLNL-UHFFFAOYSA-N 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 230000007659 motor function Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 230000002981 neuropathic effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 208000020685 sleep-wake disease Diseases 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13709699P | 1999-06-02 | 1999-06-02 | |
| US60/137,096 | 1999-06-02 | ||
| PCT/US2000/011399 WO2000073300A1 (en) | 1999-06-02 | 2000-04-28 | Amino heterocycles useful as pharmaceutical agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003525207A JP2003525207A (ja) | 2003-08-26 |
| JP2003525207A5 true JP2003525207A5 (https=) | 2007-06-28 |
Family
ID=22475823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000621366A Pending JP2003525207A (ja) | 1999-06-02 | 2000-04-28 | 薬剤として有用なアミノ複素環 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6436974B1 (https=) |
| EP (1) | EP1187832B1 (https=) |
| JP (1) | JP2003525207A (https=) |
| AT (1) | ATE228128T1 (https=) |
| AU (1) | AU4673300A (https=) |
| BR (1) | BR0011236A (https=) |
| CA (1) | CA2371395A1 (https=) |
| DE (1) | DE60000833T2 (https=) |
| DK (1) | DK1187832T3 (https=) |
| ES (1) | ES2185591T3 (https=) |
| PT (1) | PT1187832E (https=) |
| WO (1) | WO2000073300A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL126999A (en) | 1996-07-24 | 2002-03-10 | Warner Lambert Co | Pharmaceutical preparations containing isobutylgaba and its history for use in the treatment of pain |
| IL152770A0 (en) * | 2000-06-26 | 2003-06-24 | Warner Lambert Co | Gabapentin analogues for sleep disorders |
| US6855735B2 (en) * | 2002-03-20 | 2005-02-15 | Temple University Of The Commonwealth System Of Higher Education | Ketamine treatment of restless legs syndrome |
| US20050209319A1 (en) * | 2004-03-18 | 2005-09-22 | Xenoport, Inc. | Treatment of local pain |
| JP2008513482A (ja) | 2004-09-20 | 2008-05-01 | ターガセプト，インコーポレイテッド | ニコチン性コリン作動性受容体活性を有するアザスピロアルケンおよびアザピロアルカン |
| GB0514686D0 (en) * | 2005-07-18 | 2005-08-24 | Novartis Ag | Organic compounds |
| EP1820502A1 (en) | 2006-02-10 | 2007-08-22 | Laboratorios Del Dr. Esteve, S.A. | Active substance combination comprising azolylcarbinol compounds |
| EP2116539A1 (en) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof |
| JP2010043063A (ja) | 2008-05-09 | 2010-02-25 | Agency For Science Technology & Research | 川崎病の診断及び治療 |
| EP2353598A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for use in the prevention and/or treatment of postoperative pain |
| EP2353591A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof |
| EP2388005A1 (en) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy |
| EP2415471A1 (en) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
| EP2524694A1 (en) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in diabetes type-2 associated pain |
| TW201607538A (zh) | 2013-12-17 | 2016-03-01 | 以斯提夫博士實驗室股份有限公司 | 血清素－去甲腎上腺素再攝取抑制劑（ＳＮＲＩＳ）和σ受體配體組合物 |
| WO2015091505A1 (en) | 2013-12-17 | 2015-06-25 | Laboratorios Del Dr. Esteve, S.A. | Gabapentinoids and sigma receptor ligands combinations |
| TW201607923A (zh) * | 2014-07-15 | 2016-03-01 | 歌林達有限公司 | 被取代之氮螺環（４．５）癸烷衍生物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1354554A (en) * | 1970-08-31 | 1974-06-05 | Robins Co Inc A H | 2-substituted benzimidazoles |
| EP0402056A3 (en) * | 1989-06-06 | 1991-09-04 | Beecham Group p.l.c. | Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them |
| US5066662A (en) * | 1990-05-21 | 1991-11-19 | Warner-Lambert Company | Substituted oxazolidin-2-ones and 1,2,4-oxadiazolin-5-ones and derivatives thereof acting at muscarinic receptors |
| US5342846A (en) * | 1990-12-05 | 1994-08-30 | Synphar Laboratories, Inc. | 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid compounds and 7-(substituted triazolyl pyrrolidin-1-yl) 4-oxoquinoline-3-carboxylic acid derivatives useful as antibacterial agents |
| WO1992010492A1 (en) * | 1990-12-05 | 1992-06-25 | Synphar Laboratories, Inc. | 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid compounds useful as antibacterial agents |
| US5356902A (en) | 1992-11-06 | 1994-10-18 | Eli Lilly And Company | Decahydroisoquinoline compounds as excitatory amino acid receptor antagonists |
| US5446051A (en) | 1994-05-31 | 1995-08-29 | Eli Lilly And Company | Aryl-spaced decahydroisoquinoline-3-carboxylic acids as excitatory amino acid receptor antagonists |
| US5510381A (en) * | 1995-05-15 | 1996-04-23 | Warner-Lambert Company | Method of treatment of mania and bipolar disorder |
-
2000
- 2000-04-28 PT PT00928499T patent/PT1187832E/pt unknown
- 2000-04-28 WO PCT/US2000/011399 patent/WO2000073300A1/en not_active Ceased
- 2000-04-28 ES ES00928499T patent/ES2185591T3/es not_active Expired - Lifetime
- 2000-04-28 CA CA002371395A patent/CA2371395A1/en not_active Abandoned
- 2000-04-28 AT AT00928499T patent/ATE228128T1/de not_active IP Right Cessation
- 2000-04-28 EP EP00928499A patent/EP1187832B1/en not_active Expired - Lifetime
- 2000-04-28 BR BR0011236-4A patent/BR0011236A/pt not_active IP Right Cessation
- 2000-04-28 US US09/980,187 patent/US6436974B1/en not_active Expired - Fee Related
- 2000-04-28 DK DK00928499T patent/DK1187832T3/da active
- 2000-04-28 DE DE60000833T patent/DE60000833T2/de not_active Expired - Fee Related
- 2000-04-28 AU AU46733/00A patent/AU4673300A/en not_active Abandoned
- 2000-04-28 JP JP2000621366A patent/JP2003525207A/ja active Pending
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