JP2003335752A5 - - Google Patents
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- Publication number
- JP2003335752A5 JP2003335752A5 JP2003156884A JP2003156884A JP2003335752A5 JP 2003335752 A5 JP2003335752 A5 JP 2003335752A5 JP 2003156884 A JP2003156884 A JP 2003156884A JP 2003156884 A JP2003156884 A JP 2003156884A JP 2003335752 A5 JP2003335752 A5 JP 2003335752A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound
- embedded image
- branched
- carbon atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 description 14
- 229910052799 carbon Inorganic materials 0.000 description 8
- 125000004432 carbon atom Chemical group C* 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 125000000217 alkyl group Chemical group 0.000 description 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 6
- 125000000623 heterocyclic group Chemical group 0.000 description 4
- 102000018997 Growth Hormone Human genes 0.000 description 3
- 108010051696 Growth Hormone Proteins 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 3
- 125000000753 cycloalkyl group Chemical group 0.000 description 3
- 239000000122 growth hormone Substances 0.000 description 3
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 2
- -1 α-aminoisobutyryl Chemical group 0.000 description 2
- NAWXUBYGYWOOIX-SFHVURJKSA-N (2s)-2-[[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]amino]-4-methylidenepentanedioic acid Chemical compound C1=CC2=NC(N)=NC(N)=C2C=C1CCC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 NAWXUBYGYWOOIX-SFHVURJKSA-N 0.000 description 1
- 125000001397 3-pyrrolyl group Chemical group [H]N1C([H])=C([*])C([H])=C1[H] 0.000 description 1
- 102100033367 Appetite-regulating hormone Human genes 0.000 description 1
- 101710111255 Appetite-regulating hormone Proteins 0.000 description 1
- 206010053759 Growth retardation Diseases 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000003324 growth hormone secretagogue Substances 0.000 description 1
- 231100000001 growth retardation Toxicity 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 description 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21132600P | 2000-06-13 | 2000-06-13 | |
| US60/211,326 | 2000-06-13 | ||
| US23492800P | 2000-09-26 | 2000-09-26 | |
| US60/234,928 | 2000-09-26 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002510444A Division JP3522265B2 (ja) | 2000-06-13 | 2001-06-13 | 成長ホルモン分泌促進薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003335752A JP2003335752A (ja) | 2003-11-28 |
| JP2003335752A5 true JP2003335752A5 (https=) | 2008-07-10 |
| JP4932132B2 JP4932132B2 (ja) | 2012-05-16 |
Family
ID=26906052
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002510444A Expired - Lifetime JP3522265B2 (ja) | 2000-06-13 | 2001-06-13 | 成長ホルモン分泌促進薬 |
| JP2003156884A Expired - Lifetime JP4932132B2 (ja) | 2000-06-13 | 2003-06-02 | 成長ホルモン分泌促進薬 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002510444A Expired - Lifetime JP3522265B2 (ja) | 2000-06-13 | 2001-06-13 | 成長ホルモン分泌促進薬 |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US6861409B2 (https=) |
| EP (1) | EP1289951B1 (https=) |
| JP (2) | JP3522265B2 (https=) |
| KR (1) | KR100825109B1 (https=) |
| CN (1) | CN1232507C (https=) |
| AR (1) | AR029941A1 (https=) |
| AT (3) | ATE370119T1 (https=) |
| AU (2) | AU6606601A (https=) |
| BG (3) | BG66130B1 (https=) |
| BR (1) | BRPI0111591B8 (https=) |
| CA (1) | CA2407659C (https=) |
| CY (2) | CY1107710T1 (https=) |
| CZ (2) | CZ303173B6 (https=) |
| DE (3) | DE60112753T2 (https=) |
| DK (3) | DK1289951T3 (https=) |
| ES (3) | ES2250416T3 (https=) |
| FR (1) | FR19C1044I2 (https=) |
| HU (1) | HU229233B1 (https=) |
| IL (2) | IL153067A0 (https=) |
| MX (1) | MXPA02011899A (https=) |
| NL (1) | NL300999I2 (https=) |
| NO (1) | NO323873B1 (https=) |
| NZ (1) | NZ522280A (https=) |
| PL (1) | PL216676B1 (https=) |
| PT (2) | PT1344773E (https=) |
| RU (1) | RU2270198C2 (https=) |
| SK (1) | SK287169B6 (https=) |
| TW (2) | TW200831076A (https=) |
| WO (1) | WO2001096300A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE370119T1 (de) * | 2000-06-13 | 2007-09-15 | Zentaris Gmbh | Wachstumhormonsekretionsförderer |
| CU23157A1 (es) * | 2001-01-03 | 2006-07-18 | Ct Ingenieria Genetica Biotech | COMPOSICION FARMACéUTICA PARA EL TRATAMIENTO DEL DANO TISULAR DEBIDO A FALTA DE IRRIGACION SANGUINEA ARTERIAL |
| US7476653B2 (en) | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
| US7034050B2 (en) * | 2004-04-28 | 2006-04-25 | Romano Deghenghi | Pseudopeptides growth hormone secretagogues |
| RU2416612C9 (ru) * | 2005-07-22 | 2012-03-27 | Ипсен Фарма С.А.С. | Стимуляторы секреции гормона роста |
| EP1757290A1 (en) | 2005-08-16 | 2007-02-28 | Zentaris GmbH | Novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors |
| GB0603295D0 (en) | 2006-02-18 | 2006-03-29 | Ardana Bioscience Ltd | Methods and kits |
| CU23558A1 (es) | 2006-02-28 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento |
| US7763707B2 (en) * | 2006-03-13 | 2010-07-27 | Liat Mintz | Use of ghrelin splice variant for treating cachexia and/or anorexia and/or anorexia-cachexia and/or malnutrition and/or lipodystrophy and/or muscle wasting and/or appetite-stimulation |
| CN101657436A (zh) | 2007-02-09 | 2010-02-24 | 特兰齐姆制药公司 | 大环生长素释放肽受体调节剂及其使用方法 |
| EP2103602A1 (en) | 2008-03-17 | 2009-09-23 | AEterna Zentaris GmbH | Novel 1,2,4-triazole derivatives and process of manufacturing thereof |
| US8431642B2 (en) * | 2008-06-09 | 2013-04-30 | Exxonmobil Chemical Patents Inc. | Polyolefin adhesive compositions and articles made therefrom |
| EP2431035A1 (en) | 2010-09-16 | 2012-03-21 | Æterna Zentaris GmbH | Novel Triazole Derivatives with Improved Receptor Activity and Bioavailability Properties as Ghrelin Antagonists of Growth Hormone Secretagogue Receptors |
| US9198889B2 (en) | 2012-09-19 | 2015-12-01 | Quality IP Holdings, LLC | Methods for treating post-traumatic stress disorder |
| US10300101B2 (en) | 2012-09-19 | 2019-05-28 | Quality IP Holdings, LLC | Methods and compositions for enhancing or maintaining fertility |
| US8747922B2 (en) | 2012-09-19 | 2014-06-10 | Quality Ip Holdings, Inc. | Methods and compositions for increasing sex steroids and growth hormones |
| US8747921B2 (en) | 2012-09-19 | 2014-06-10 | Quality Ip Holdings, Inc. | Methods for improving health in humans |
| US8747923B2 (en) | 2012-09-20 | 2014-06-10 | Quality Ip Holdings, Inc. | Methods for improving health in canines |
| US8715752B2 (en) | 2012-09-20 | 2014-05-06 | Quality Ip Holdings, Inc. | Compositions for increasing human growth hormone levels |
| US9066953B2 (en) | 2012-09-20 | 2015-06-30 | Quality IP Holdings, LLC | Methods for increasing endurance and fat metabolism in humans |
| US10292957B2 (en) | 2012-09-20 | 2019-05-21 | Quality IP Holdings, LLC | Compositions and methods for treating fibromyalgia |
| CA2889499C (en) | 2012-10-24 | 2019-09-10 | Daiichi Sankyo Company, Limited | Growth hormone secretagogue receptor agonists for treating amyotrophic lateral sclerosis |
| CN105330720A (zh) * | 2014-06-06 | 2016-02-17 | 深圳翰宇药业股份有限公司 | 一种制备马昔瑞林的方法 |
| AU2016328969B2 (en) | 2015-09-21 | 2020-10-08 | Lumos Pharma, Inc. | Detecting and treating growth hormone deficiency |
| US10894072B2 (en) | 2017-02-13 | 2021-01-19 | IP Quality Holdings, LLC | Compositions and methods for treating fibromyalgia |
| US10288629B1 (en) | 2017-12-19 | 2019-05-14 | Aeterna Zentaris, Inc. | Method of assessing growth hormone deficiency in humans by a macimorelin containing composition |
| MX2023000935A (es) | 2020-07-22 | 2023-02-22 | Aeterna Zentaris Gmbh | Un metodo de deteccion para diagnosticar la deficiencia de la hormona del crecimiento en pacientes pediatricos utilizando macimorelina. |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4880778A (en) * | 1986-05-12 | 1989-11-14 | Eastman Kodak Company | Combinations having synergistic growth hormone releasing activity and methods for use thereof |
| AU637316B2 (en) * | 1988-01-28 | 1993-05-27 | Eastman Kodak Company | Polypeptide compounds having growth hormone releasing activity |
| US5536814A (en) * | 1993-09-27 | 1996-07-16 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
| WO1995014666A1 (en) * | 1993-11-24 | 1995-06-01 | Merck & Co., Inc. | Indolyl group containing compounds and the use thereof to promote the release of growth hormone(s) |
| US5798337A (en) * | 1994-11-16 | 1998-08-25 | Genentech, Inc. | Low molecular weight peptidomimetic growth hormone secretagogues |
| US6025471A (en) * | 1998-06-03 | 2000-02-15 | Deghenghi; Romano | Diazaspiro, azepino and azabicyclo therapeutic peptides |
| ATE370119T1 (de) * | 2000-06-13 | 2007-09-15 | Zentaris Gmbh | Wachstumhormonsekretionsförderer |
-
2001
- 2001-06-13 AT AT03075950T patent/ATE370119T1/de active
- 2001-06-13 SK SK1756-2002A patent/SK287169B6/sk not_active IP Right Cessation
- 2001-06-13 KR KR1020027016614A patent/KR100825109B1/ko not_active Expired - Lifetime
- 2001-06-13 PT PT03075950T patent/PT1344773E/pt unknown
- 2001-06-13 BR BRPI0111591A patent/BRPI0111591B8/pt not_active IP Right Cessation
- 2001-06-13 DE DE60112753T patent/DE60112753T2/de not_active Expired - Lifetime
- 2001-06-13 DK DK01943504T patent/DK1289951T3/da active
- 2001-06-13 DE DE60128494T patent/DE60128494T2/de not_active Expired - Lifetime
- 2001-06-13 EP EP01943504A patent/EP1289951B1/en not_active Expired - Lifetime
- 2001-06-13 DK DK05075086T patent/DK1524272T3/da active
- 2001-06-13 IL IL15306701A patent/IL153067A0/xx unknown
- 2001-06-13 CZ CZ20024095A patent/CZ303173B6/cs not_active IP Right Cessation
- 2001-06-13 AR ARP010102827A patent/AR029941A1/es active IP Right Grant
- 2001-06-13 MX MXPA02011899A patent/MXPA02011899A/es active IP Right Grant
- 2001-06-13 CZ CZ2011-585A patent/CZ305279B6/cs not_active IP Right Cessation
- 2001-06-13 PL PL363081A patent/PL216676B1/pl unknown
- 2001-06-13 RU RU2002135312/04A patent/RU2270198C2/ru not_active IP Right Cessation
- 2001-06-13 ES ES01943504T patent/ES2250416T3/es not_active Expired - Lifetime
- 2001-06-13 DK DK03075950T patent/DK1344773T3/da active
- 2001-06-13 WO PCT/EP2001/006717 patent/WO2001096300A1/en not_active Ceased
- 2001-06-13 PT PT05075086T patent/PT1524272E/pt unknown
- 2001-06-13 JP JP2002510444A patent/JP3522265B2/ja not_active Expired - Lifetime
- 2001-06-13 HU HU0302026A patent/HU229233B1/hu active IP Right Revival
- 2001-06-13 CN CNB018104916A patent/CN1232507C/zh not_active Expired - Lifetime
- 2001-06-13 ES ES03075950T patent/ES2292900T3/es not_active Expired - Lifetime
- 2001-06-13 US US09/880,498 patent/US6861409B2/en not_active Expired - Lifetime
- 2001-06-13 DE DE60130025T patent/DE60130025T2/de not_active Expired - Lifetime
- 2001-06-13 CA CA2407659A patent/CA2407659C/en not_active Expired - Lifetime
- 2001-06-13 ES ES05075086T patent/ES2288724T3/es not_active Expired - Lifetime
- 2001-06-13 AT AT01943504T patent/ATE302181T1/de active
- 2001-06-13 AT AT05075086T patent/ATE362472T1/de active
- 2001-06-13 NZ NZ522280A patent/NZ522280A/en not_active IP Right Cessation
- 2001-06-13 AU AU6606601A patent/AU6606601A/xx active Pending
- 2001-06-13 AU AU2001266066A patent/AU2001266066B2/en not_active Expired
- 2001-08-01 TW TW097111056A patent/TW200831076A/zh unknown
- 2001-08-01 TW TW090114317A patent/TWI305529B/zh not_active IP Right Cessation
-
2002
- 2002-11-24 IL IL153067A patent/IL153067A/en active IP Right Grant
- 2002-12-09 NO NO20025893A patent/NO323873B1/no not_active IP Right Cessation
- 2002-12-12 BG BG107379A patent/BG66130B1/bg unknown
-
2003
- 2003-06-02 JP JP2003156884A patent/JP4932132B2/ja not_active Expired - Lifetime
-
2004
- 2004-05-04 US US10/837,620 patent/US7297681B2/en not_active Expired - Lifetime
-
2007
- 2007-08-07 CY CY20071101051T patent/CY1107710T1/el unknown
- 2007-11-08 CY CY20071101443T patent/CY1107793T1/el unknown
-
2010
- 2010-07-21 BG BG10110708A patent/BG66216B1/bg unknown
- 2010-10-18 BG BG10110771A patent/BG66217B1/bg unknown
-
2019
- 2019-07-05 NL NL300999C patent/NL300999I2/nl unknown
- 2019-07-08 FR FR19C1044C patent/FR19C1044I2/fr active Active
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