MX2023000935A - Un metodo de deteccion para diagnosticar la deficiencia de la hormona del crecimiento en pacientes pediatricos utilizando macimorelina. - Google Patents
Un metodo de deteccion para diagnosticar la deficiencia de la hormona del crecimiento en pacientes pediatricos utilizando macimorelina.Info
- Publication number
- MX2023000935A MX2023000935A MX2023000935A MX2023000935A MX2023000935A MX 2023000935 A MX2023000935 A MX 2023000935A MX 2023000935 A MX2023000935 A MX 2023000935A MX 2023000935 A MX2023000935 A MX 2023000935A MX 2023000935 A MX2023000935 A MX 2023000935A
- Authority
- MX
- Mexico
- Prior art keywords
- growth hormone
- macimorelin
- pediatric patients
- diagnosing
- hormone deficiency
- Prior art date
Links
- UJVDJAPJQWZRFR-DHIUTWEWSA-N 2-amino-n-[(2r)-1-[[(1r)-1-formamido-2-(1h-indol-3-yl)ethyl]amino]-3-(1h-indol-3-yl)-1-oxopropan-2-yl]-2-methylpropanamide Chemical compound C1=CC=C2C(C[C@@H](NC(=O)[C@@H](CC=3C4=CC=CC=C4NC=3)NC(=O)C(C)(N)C)NC=O)=CNC2=C1 UJVDJAPJQWZRFR-DHIUTWEWSA-N 0.000 title abstract 4
- 206010056438 Growth hormone deficiency Diseases 0.000 title abstract 4
- 229960000298 macimorelin Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 238000012216 screening Methods 0.000 title abstract 2
- 102000018997 Growth Hormone Human genes 0.000 abstract 5
- 108010051696 Growth Hormone Proteins 0.000 abstract 5
- 239000000122 growth hormone Substances 0.000 abstract 5
- 239000008280 blood Substances 0.000 abstract 3
- 210000004369 blood Anatomy 0.000 abstract 3
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/61—Growth hormones [GH] (Somatotropin)
Abstract
La presente invención se relaciona con un método de detección para diagnosticar una deficiencia en la hormona del crecimiento en pacientes pediátricos utilizando macimorelina. La presente invención proporciona además la sustancia macimorelina para su utilización en el diagnóstico de la deficiencia de la hormona del crecimiento en pacientes pediátricos. El método comprende proporcionar al menos una muestra de sangre, tomada de un sujeto dentro de un intervalo de aproximadamente 15 a aproximadamente 100 minutos después de una administración de una cantidad de macimorelina eficaz para inducir la secreción de la hormona del crecimiento, medir el nivel de la hormona del crecimiento de cada muestra de sangre, comparar el nivel medido de la hormona del crecimiento con un valor umbral único, diagnosticar si el sujeto sufre de deficiencia de la hormona del crecimiento o no en función de la comparación del nivel de la hormona del crecimiento con dicho valor umbral único en dicha al menos una muestra de sangre. El método de la invención es una prueba independiente y no necesita ser repetida y no se requiere ninguna prueba alternativa de estimulación de la hormona del crecimiento para realizar un diagnóstico confiable en pacientes pediátricos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2020/070691 WO2022017599A1 (en) | 2020-07-22 | 2020-07-22 | A screening method for diagnosing growth hormone deficiency in pediatric patients by using macimorelin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023000935A true MX2023000935A (es) | 2023-02-22 |
Family
ID=71784051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023000935A MX2023000935A (es) | 2020-07-22 | 2020-07-22 | Un metodo de deteccion para diagnosticar la deficiencia de la hormona del crecimiento en pacientes pediatricos utilizando macimorelina. |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP4185866A1 (es) |
| JP (1) | JP2023535000A (es) |
| KR (1) | KR102635025B1 (es) |
| CN (1) | CN114258492A (es) |
| AR (1) | AR124626A1 (es) |
| AU (1) | AU2020460118A1 (es) |
| CA (1) | CA3185680A1 (es) |
| IL (1) | IL299918A (es) |
| MX (1) | MX2023000935A (es) |
| TW (1) | TW202219511A (es) |
| WO (1) | WO2022017599A1 (es) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK287169B6 (sk) | 2000-06-13 | 2010-02-08 | Zentaris Ag | Zlúčeniny zvyšujúce sekréciu rastového hormónu, farmaceutický prostriedok s ich obsahom a ich použitie |
| GB0603295D0 (en) | 2006-02-18 | 2006-03-29 | Ardana Bioscience Ltd | Methods and kits |
| CN105209055A (zh) * | 2013-03-11 | 2015-12-30 | 阿穆尼克斯运营公司 | 用人生长激素类似物治疗小儿生长激素缺乏症 |
| CN106310229A (zh) * | 2015-06-30 | 2017-01-11 | 深圳翰宇药业股份有限公司 | 一种马昔瑞林薄膜衣片及其制备方法 |
| US10288629B1 (en) | 2017-12-19 | 2019-05-14 | Aeterna Zentaris, Inc. | Method of assessing growth hormone deficiency in humans by a macimorelin containing composition |
-
2020
- 2020-07-22 JP JP2023504173A patent/JP2023535000A/ja active Pending
- 2020-07-22 CN CN202080006891.5A patent/CN114258492A/zh active Pending
- 2020-07-22 AU AU2020460118A patent/AU2020460118A1/en active Pending
- 2020-07-22 IL IL299918A patent/IL299918A/en unknown
- 2020-07-22 MX MX2023000935A patent/MX2023000935A/es unknown
- 2020-07-22 CA CA3185680A patent/CA3185680A1/en active Pending
- 2020-07-22 EP EP20745175.8A patent/EP4185866A1/en active Pending
- 2020-07-22 KR KR1020217043189A patent/KR102635025B1/ko active IP Right Grant
- 2020-07-22 WO PCT/EP2020/070691 patent/WO2022017599A1/en unknown
-
2021
- 2021-06-23 TW TW110122905A patent/TW202219511A/zh unknown
- 2021-07-20 AR ARP210102035A patent/AR124626A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN114258492A (zh) | 2022-03-29 |
| AU2020460118A1 (en) | 2023-02-02 |
| WO2022017599A1 (en) | 2022-01-27 |
| KR102635025B1 (ko) | 2024-02-07 |
| KR20220015466A (ko) | 2022-02-08 |
| TW202219511A (zh) | 2022-05-16 |
| JP2023535000A (ja) | 2023-08-15 |
| EP4185866A1 (en) | 2023-05-31 |
| CA3185680A1 (en) | 2022-01-27 |
| AR124626A1 (es) | 2023-04-19 |
| IL299918A (en) | 2023-03-01 |
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