JP2005517677A5 - - Google Patents
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- Publication number
- JP2005517677A5 JP2005517677A5 JP2003556413A JP2003556413A JP2005517677A5 JP 2005517677 A5 JP2005517677 A5 JP 2005517677A5 JP 2003556413 A JP2003556413 A JP 2003556413A JP 2003556413 A JP2003556413 A JP 2003556413A JP 2005517677 A5 JP2005517677 A5 JP 2005517677A5
- Authority
- JP
- Japan
- Prior art keywords
- aryl
- lower alkyl
- lower alkoxy
- cycloalkyl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34393701P | 2001-12-27 | 2001-12-27 | |
| US39911002P | 2002-07-26 | 2002-07-26 | |
| PCT/EP2002/014771 WO2003055883A1 (en) | 2001-12-27 | 2002-12-27 | Pyrimidotriazines as phosphatase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005517677A JP2005517677A (ja) | 2005-06-16 |
| JP2005517677A5 true JP2005517677A5 (https=) | 2005-12-22 |
| JP4188839B2 JP4188839B2 (ja) | 2008-12-03 |
Family
ID=26993696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003556413A Expired - Fee Related JP4188839B2 (ja) | 2001-12-27 | 2002-12-27 | ホスファターゼインヒビーターとしてのピリミドトリアジン |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6642381B2 (https=) |
| EP (1) | EP1467996B1 (https=) |
| JP (1) | JP4188839B2 (https=) |
| KR (1) | KR100601769B1 (https=) |
| CN (1) | CN100402530C (https=) |
| AT (1) | ATE311388T1 (https=) |
| AU (1) | AU2002367190B2 (https=) |
| BR (1) | BR0215395A (https=) |
| CA (1) | CA2471265C (https=) |
| DE (1) | DE60207759T2 (https=) |
| ES (1) | ES2252554T3 (https=) |
| JO (1) | JO2242B1 (https=) |
| MX (1) | MXPA04006266A (https=) |
| PA (1) | PA8562901A1 (https=) |
| PE (1) | PE20030896A1 (https=) |
| PL (1) | PL371180A1 (https=) |
| TW (1) | TW200306313A (https=) |
| UY (1) | UY27606A1 (https=) |
| WO (1) | WO2003055883A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2463615C (en) * | 2001-10-30 | 2011-07-26 | Applied Research Systems Ars Holding N.V. | Oxindole hydrazide modulators of protein tyrosine phosphatases (ptps) |
| KR20050075028A (ko) | 2002-11-18 | 2005-07-19 | 에프. 호프만-라 로슈 아게 | 다이아지노피리미딘 |
| WO2004071448A2 (en) * | 2003-02-12 | 2004-08-26 | Transtech Pharma Inc. | Substituted azole derivatives as inhibitors of protein tyrosine phosphatases |
| CA2514363A1 (en) * | 2003-02-12 | 2004-08-26 | Transtech Pharma, Inc. | Substituted azole derivatives as therapeutic agents |
| CA2551909C (en) * | 2004-02-12 | 2011-10-11 | Transtech Pharma, Inc. | Substituted azole derivatives, compositions, and methods of use |
| EP1734963A4 (en) | 2004-04-02 | 2008-06-18 | Merck & Co Inc | METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER |
| NZ569329A (en) | 2006-01-30 | 2011-09-30 | Transtech Pharma Inc | Substituted imidazole derivatives and their use as PTPase inhibitors |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| MX354786B (es) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos. |
| ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| WO2010083645A1 (en) * | 2009-01-21 | 2010-07-29 | Shanghai Targetdrug Co., Ltd | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF |
| WO2012027331A1 (en) | 2010-08-27 | 2012-03-01 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| US9486433B2 (en) | 2012-10-12 | 2016-11-08 | Mochida Pharmaceuticals Co. Ltd. | Compositions and methods for treating non-alcoholic steatohepatitis |
| AU2014235215A1 (en) | 2013-03-15 | 2015-10-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| US10441560B2 (en) | 2013-03-15 | 2019-10-15 | Mochida Pharmaceutical Co., Ltd. | Compositions and methods for treating non-alcoholic steatohepatitis |
| AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
| US9889108B2 (en) | 2013-03-15 | 2018-02-13 | Mochida Pharmaceutical Co., Ltd. | Compositions and methods for treating non-alcoholic steatohepatitis |
| BR112015030326A2 (pt) | 2013-06-05 | 2017-08-29 | Synergy Pharmaceuticals Inc | Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6194410B1 (en) * | 1998-03-11 | 2001-02-27 | Hoffman-La Roche Inc. | Pyrazolopyrimidine and pyrazolines and process for preparation thereof |
| PA8474101A1 (es) | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| GB0022079D0 (en) | 2000-09-08 | 2000-10-25 | Inst Of Molecul & Cell Biology | Novel protein tyrosine phosphatase inhibitor |
-
2002
- 2002-12-10 US US10/315,769 patent/US6642381B2/en not_active Expired - Fee Related
- 2002-12-24 PA PA20028562901A patent/PA8562901A1/es unknown
- 2002-12-25 TW TW091137302A patent/TW200306313A/zh unknown
- 2002-12-26 UY UY27606A patent/UY27606A1/es not_active Application Discontinuation
- 2002-12-26 JO JO2002137A patent/JO2242B1/en active
- 2002-12-27 AT AT02805774T patent/ATE311388T1/de not_active IP Right Cessation
- 2002-12-27 DE DE60207759T patent/DE60207759T2/de not_active Expired - Lifetime
- 2002-12-27 EP EP02805774A patent/EP1467996B1/en not_active Expired - Lifetime
- 2002-12-27 CA CA2471265A patent/CA2471265C/en not_active Expired - Fee Related
- 2002-12-27 ES ES02805774T patent/ES2252554T3/es not_active Expired - Lifetime
- 2002-12-27 WO PCT/EP2002/014771 patent/WO2003055883A1/en not_active Ceased
- 2002-12-27 PL PL02371180A patent/PL371180A1/xx not_active Application Discontinuation
- 2002-12-27 AU AU2002367190A patent/AU2002367190B2/en not_active Ceased
- 2002-12-27 CN CNB028264223A patent/CN100402530C/zh not_active Expired - Fee Related
- 2002-12-27 MX MXPA04006266A patent/MXPA04006266A/es active IP Right Grant
- 2002-12-27 JP JP2003556413A patent/JP4188839B2/ja not_active Expired - Fee Related
- 2002-12-27 KR KR1020047010017A patent/KR100601769B1/ko not_active Expired - Fee Related
- 2002-12-27 BR BR0215395-5A patent/BR0215395A/pt not_active IP Right Cessation
-
2003
- 2003-01-06 PE PE2003000022A patent/PE20030896A1/es not_active Application Discontinuation
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