CN100402530C - 作为磷酸酶抑制剂的嘧啶并三嗪 - Google Patents

作为磷酸酶抑制剂的嘧啶并三嗪 Download PDF

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Publication number
CN100402530C
CN100402530C CNB028264223A CN02826422A CN100402530C CN 100402530 C CN100402530 C CN 100402530C CN B028264223 A CNB028264223 A CN B028264223A CN 02826422 A CN02826422 A CN 02826422A CN 100402530 C CN100402530 C CN 100402530C
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CN
China
Prior art keywords
ylmethyl
pyrimido
triazine
alkyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB028264223A
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English (en)
Chinese (zh)
Other versions
CN1610683A (zh
Inventor
K·R·格廷
L·Q·塞蒂
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CN1610683A publication Critical patent/CN1610683A/zh
Application granted granted Critical
Publication of CN100402530C publication Critical patent/CN100402530C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)
CNB028264223A 2001-12-27 2002-12-27 作为磷酸酶抑制剂的嘧啶并三嗪 Expired - Fee Related CN100402530C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US34393701P 2001-12-27 2001-12-27
US60/343,937 2001-12-27
US39911002P 2002-07-26 2002-07-26
US60/399,110 2002-07-26

Publications (2)

Publication Number Publication Date
CN1610683A CN1610683A (zh) 2005-04-27
CN100402530C true CN100402530C (zh) 2008-07-16

Family

ID=26993696

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028264223A Expired - Fee Related CN100402530C (zh) 2001-12-27 2002-12-27 作为磷酸酶抑制剂的嘧啶并三嗪

Country Status (19)

Country Link
US (1) US6642381B2 (https=)
EP (1) EP1467996B1 (https=)
JP (1) JP4188839B2 (https=)
KR (1) KR100601769B1 (https=)
CN (1) CN100402530C (https=)
AT (1) ATE311388T1 (https=)
AU (1) AU2002367190B2 (https=)
BR (1) BR0215395A (https=)
CA (1) CA2471265C (https=)
DE (1) DE60207759T2 (https=)
ES (1) ES2252554T3 (https=)
JO (1) JO2242B1 (https=)
MX (1) MXPA04006266A (https=)
PA (1) PA8562901A1 (https=)
PE (1) PE20030896A1 (https=)
PL (1) PL371180A1 (https=)
TW (1) TW200306313A (https=)
UY (1) UY27606A1 (https=)
WO (1) WO2003055883A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7696231B2 (en) * 2001-10-30 2010-04-13 Laboratoires Serono Sa Oxindole hydrazide modulators of protein tyrosine phosphatases (PTPs)
BR0316375A (pt) 2002-11-18 2005-10-04 Hoffmann La Roche Diazinopirimidinas
JP2006518738A (ja) * 2003-02-12 2006-08-17 トランス　テック　ファーマ，インコーポレイテッド 治療薬としての置換アゾール誘導体
WO2004071448A2 (en) * 2003-02-12 2004-08-26 Transtech Pharma Inc. Substituted azole derivatives as inhibitors of protein tyrosine phosphatases
JP4898458B2 (ja) * 2004-02-12 2012-03-14 トランス テック ファーマ，インコーポレイテッド 置換アゾール誘導体、組成物及び使用方法
US20080125403A1 (en) 2004-04-02 2008-05-29 Merck & Co., Inc. Method of Treating Men with Metabolic and Anthropometric Disorders
BRPI0707338A2 (pt) 2006-01-30 2011-05-03 Transtech Pharma Inc derivados de imidazol, composições, e métodos substituìdos de uso como inibidores de ptpase
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2527360B1 (en) 2007-06-04 2015-10-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2810951B1 (en) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
WO2010083645A1 (en) * 2009-01-21 2010-07-29 Shanghai Targetdrug Co., Ltd PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2014057522A1 (en) 2012-10-12 2014-04-17 Mochida Pharmaceutical Co., Ltd. Compositions and methods for treating non-alcoholic steatohepatitis
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
SG11201507288UA (en) 2013-03-15 2015-10-29 Mochida Pharm Co Ltd Compositions and methods for treating non-alcoholic steatohepatitis
US10441560B2 (en) 2013-03-15 2019-10-15 Mochida Pharmaceutical Co., Ltd. Compositions and methods for treating non-alcoholic steatohepatitis
SI3004138T1 (sl) 2013-06-05 2024-07-31 Bausch Health Ireland Limited Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1236780A (zh) * 1998-03-11 1999-12-01 弗·哈夫曼-拉罗切有限公司 吡唑并嘧啶和吡唑并三嗪
WO1999065909A1 (en) * 1998-06-19 1999-12-23 Pfizer Products Inc. PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0022079D0 (en) 2000-09-08 2000-10-25 Inst Of Molecul & Cell Biology Novel protein tyrosine phosphatase inhibitor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1236780A (zh) * 1998-03-11 1999-12-01 弗·哈夫曼-拉罗切有限公司 吡唑并嘧啶和吡唑并三嗪
WO1999065909A1 (en) * 1998-06-19 1999-12-23 Pfizer Products Inc. PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
. HENRIK SUNE ANDERSEN ET AL.J. BIO. CHEM.,Vol.275 No.10. 2000 *

Also Published As

Publication number Publication date
EP1467996B1 (en) 2005-11-30
DE60207759D1 (de) 2006-01-05
PA8562901A1 (es) 2003-07-28
US6642381B2 (en) 2003-11-04
MXPA04006266A (es) 2004-09-27
US20030153756A1 (en) 2003-08-14
JO2242B1 (en) 2004-10-07
ATE311388T1 (de) 2005-12-15
PL371180A1 (en) 2005-06-13
EP1467996A1 (en) 2004-10-20
DE60207759T2 (de) 2006-08-03
KR20040068981A (ko) 2004-08-02
KR100601769B1 (ko) 2006-07-19
CA2471265A1 (en) 2003-07-10
BR0215395A (pt) 2004-12-07
CN1610683A (zh) 2005-04-27
PE20030896A1 (es) 2003-11-05
CA2471265C (en) 2010-02-09
WO2003055883A1 (en) 2003-07-10
JP2005517677A (ja) 2005-06-16
AU2002367190B2 (en) 2006-10-05
TW200306313A (en) 2003-11-16
AU2002367190A1 (en) 2003-07-15
UY27606A1 (es) 2003-06-30
ES2252554T3 (es) 2006-05-16
JP4188839B2 (ja) 2008-12-03

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
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GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20080716

Termination date: 20111227