JP2006525944A5 - - Google Patents
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- Publication number
- JP2006525944A5 JP2006525944A5 JP2004570427A JP2004570427A JP2006525944A5 JP 2006525944 A5 JP2006525944 A5 JP 2006525944A5 JP 2004570427 A JP2004570427 A JP 2004570427A JP 2004570427 A JP2004570427 A JP 2004570427A JP 2006525944 A5 JP2006525944 A5 JP 2006525944A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- acceptable salt
- compound
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 25
- 150000001875 compounds Chemical class 0.000 claims 23
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
- 230000003474 anti-emetic effect Effects 0.000 claims 6
- 239000002111 antiemetic agent Substances 0.000 claims 6
- 229940121367 non-opioid analgesics Drugs 0.000 claims 6
- 239000000014 opioid analgesic Substances 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000005428 anthryl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C3C(*)=C([H])C([H])=C([H])C3=C([H])C2=C1[H] 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000001624 naphthyl group Chemical group 0.000 claims 5
- 125000005561 phenanthryl group Chemical group 0.000 claims 5
- 239000003793 antidiarrheal agent Substances 0.000 claims 4
- 108090000137 Opioid Receptors Proteins 0.000 claims 3
- 102000003840 Opioid Receptors Human genes 0.000 claims 3
- 229940125714 antidiarrheal agent Drugs 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 206010012735 Diarrhoea Diseases 0.000 claims 2
- 229940125683 antiemetic agent Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- -1 non-opioid analgesic Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 101100244562 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) oprD gene Proteins 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 108700023159 delta Opioid Receptors Proteins 0.000 claims 1
- 102000048124 delta Opioid Receptors Human genes 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 102000048260 kappa Opioid Receptors Human genes 0.000 claims 1
- 102000051367 mu Opioid Receptors Human genes 0.000 claims 1
- 108010020615 nociceptin receptor Proteins 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020001588 κ-opioid receptors Proteins 0.000 claims 1
- 108020001612 μ-opioid receptors Proteins 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42738102P | 2002-11-18 | 2002-11-18 | |
| US46027803P | 2003-04-03 | 2003-04-03 | |
| US48848803P | 2003-07-17 | 2003-07-17 | |
| US10/714,066 US7202259B2 (en) | 2002-11-18 | 2003-11-13 | Therapeutic agents useful for treating pain |
| PCT/US2003/036742 WO2004046132A1 (en) | 2002-11-18 | 2003-11-17 | 4-tetrazolyl-4phenylpiperidine derivatives for treating pain |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010056560A Division JP2010163452A (ja) | 2002-11-18 | 2010-03-12 | 疼痛治療用４−テトラゾリル−４フェニルピペリジン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006525944A JP2006525944A (ja) | 2006-11-16 |
| JP2006525944A5 true JP2006525944A5 (https=) | 2007-01-11 |
| JP4601429B2 JP4601429B2 (ja) | 2010-12-22 |
Family
ID=32777221
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004570427A Expired - Fee Related JP4601429B2 (ja) | 2002-11-18 | 2003-11-17 | 疼痛治療用４−テトラゾリル−４フェニルピペリジン誘導体 |
| JP2010056560A Pending JP2010163452A (ja) | 2002-11-18 | 2010-03-12 | 疼痛治療用４−テトラゾリル−４フェニルピペリジン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010056560A Pending JP2010163452A (ja) | 2002-11-18 | 2010-03-12 | 疼痛治療用４−テトラゾリル−４フェニルピペリジン誘導体 |
Country Status (36)
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7202259B2 (en) * | 2002-11-18 | 2007-04-10 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| KR101159828B1 (ko) | 2003-04-30 | 2012-07-04 | 퍼듀 퍼머 엘피 | 활성제 구성요소 및 활성제 층의 원위부에 억제제 구성요소를 포함하는 내변조성 경피제형 |
| US8790689B2 (en) * | 2003-04-30 | 2014-07-29 | Purdue Pharma L.P. | Tamper resistant transdermal dosage form |
| CA2552087C (en) | 2004-01-30 | 2011-01-25 | Euro-Celtique S.A. | Methods for making 4-tetrazolyl-4-phenylpiperidine compounds |
| SE0401656D0 (sv) * | 2004-06-24 | 2004-06-24 | Astrazeneca Ab | Chemical compounds |
| SI1951718T1 (sl) * | 2005-11-21 | 2012-06-29 | Purdue Pharma Lp | 4-oksadiazolil-piperidinske spojine in njihova uporaba |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| WO2011056561A1 (en) | 2009-10-27 | 2011-05-12 | Beth Israel Deaconess Medical Center | Methods and compositions for the generation and use of conformation-specific antibodies |
| ME02367B (me) | 2010-09-21 | 2016-06-20 | Purdue Pharma Lp | Analozi buprenorfina kao agonisti i/ili antagonisti opioidnog receptora |
| CN102648915B (zh) * | 2011-02-28 | 2015-04-15 | 鲁南制药集团股份有限公司 | 一种治疗或预防神经病理性疼痛的药物组合物 |
| WO2012149334A2 (en) | 2011-04-27 | 2012-11-01 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for the generation and use of conformation-specific antibodies |
| CA2890655A1 (en) | 2012-11-09 | 2014-05-15 | Purdue Pharma L.P. | Benzomorphan analogs and the use thereof |
| US9175000B2 (en) | 2012-12-07 | 2015-11-03 | Purdue Pharma L.P. | Buprenorphine analogs |
| ES2631197T3 (es) | 2012-12-14 | 2017-08-29 | Purdue Pharma Lp | Análogos de piridonamorfinano y actividad biológica sobre los receptores opiodes |
| EP2931726B1 (en) | 2012-12-14 | 2017-01-25 | Purdue Pharma LP | Spirocyclic morphinans and their use |
| WO2014118618A1 (en) | 2013-01-31 | 2014-08-07 | Purdue Pharma L.P. | Benzomorphan analogs and the use thereof |
| US8969358B2 (en) | 2013-03-15 | 2015-03-03 | Purdue Pharma L.P. | Buprenorphine analogs |
| EP3087078B1 (en) | 2013-12-26 | 2019-05-15 | Purdue Pharma LP | 7-beta-alkyl analogs of orvinols |
| US9340542B2 (en) | 2013-12-26 | 2016-05-17 | Purdue Pharma L.P. | Propellane-based compounds and the use thereof |
| EP3087057A4 (en) | 2013-12-26 | 2017-06-28 | Purdue Pharma LP | Ring-contracted morphinans and the use thereof |
| WO2015097545A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans |
| US9994571B2 (en) | 2013-12-26 | 2018-06-12 | Purdue Pharma L.P. | 10-substituted morphinan hydantoins |
| EP3086790A4 (en) | 2013-12-27 | 2017-07-19 | Purdue Pharma LP | 6-substituted and 7-substituted morphinan analogs and the use thereof |
| US10030021B2 (en) | 2014-05-27 | 2018-07-24 | Purdue Pharma L.P. | Spirocyclic morphinans and use thereof |
| EP3154972A4 (en) | 2014-06-13 | 2017-11-22 | Purdue Pharma L.P. | Azamophinan derivatives and use thereof |
| MA41125A (fr) | 2014-12-05 | 2017-10-10 | Purdue Pharma Lp | Dérivés de 6.7-cyclomorphinane et leur utilisation |
| AU2017238208B2 (en) | 2016-03-22 | 2022-01-06 | Regents Of The University Of Minnesota | Combination for treating pain |
| BR112019001398A2 (pt) | 2016-07-29 | 2019-05-07 | Janssen Pharmaceutica Nv | métodos para tratamento de câncer de próstata |
| WO2018125716A1 (en) | 2017-01-02 | 2018-07-05 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
| CN117750958A (zh) * | 2021-05-21 | 2024-03-22 | 普渡制药公司 | 治疗间质性膀胱炎/膀胱疼痛综合征的方法 |
| CA3258088A1 (en) * | 2022-06-24 | 2023-12-28 | Purdue Pharma L.P. | METHODS OF TREATMENT OR PREVENTION OF OVERACTIVE BLADDER SYNDROME |
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| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3598122A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| BE775611A (fr) | 1970-11-24 | 1972-03-16 | Synthelabo | Derives de la (diphenyl-3,3 propyl-1)-1 piperidine, leur preparation etles medicaments qui en contiennent |
| US4076717A (en) * | 1971-12-15 | 1978-02-28 | G. D. Searle & Co. | Derivatives of 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylic acid |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| DK162087D0 (da) * | 1987-03-31 | 1987-03-31 | Ferrosan As | Piperidinforbindelser, deres fremstilling og anvendelse |
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| IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
| US5849737A (en) | 1995-04-14 | 1998-12-15 | The Regents Of The University Of California | Compositions and methods for treating pain |
| US6166085A (en) | 1995-04-14 | 2000-12-26 | The Regents Of The University Of California | Method of producing analgesia |
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| US6486142B2 (en) | 1999-12-22 | 2002-11-26 | Merck Frosst Canada & Co. | Phosphonic acid derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B) |
| US6608052B2 (en) | 2000-02-16 | 2003-08-19 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as anti-inflammatory agents |
| US6703525B2 (en) | 2000-02-16 | 2004-03-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | Sulfonamide intermediates and methods of producing same |
| US6790854B2 (en) | 2000-03-24 | 2004-09-14 | Meiji Seika Kaisha, Ltd. | Diphenylalkylamine derivatives useful as opioid receptor agonists |
| US6544981B2 (en) | 2000-06-09 | 2003-04-08 | Bristol-Myers Squibb Company | Lactam inhibitors of factor Xa and method |
| CN1469862A (zh) | 2000-10-12 | 2004-01-21 | Ss制药株式会社 | 2,2-二苯基丁酰胺衍生物和含有它的药物 |
| WO2002038185A2 (en) | 2000-11-13 | 2002-05-16 | Atrix Laboratories, Inc. | Injectable sustained release delivery system with loperamide |
| US7202259B2 (en) * | 2002-11-18 | 2007-04-10 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| CA2552087C (en) | 2004-01-30 | 2011-01-25 | Euro-Celtique S.A. | Methods for making 4-tetrazolyl-4-phenylpiperidine compounds |
-
2003
- 2003-11-13 US US10/714,066 patent/US7202259B2/en not_active Expired - Lifetime
- 2003-11-17 RS YUP-2005/0375A patent/RS51047B/sr unknown
- 2003-11-17 NZ NZ572685A patent/NZ572685A/en not_active IP Right Cessation
- 2003-11-17 DE DE60322451T patent/DE60322451D1/de not_active Expired - Lifetime
- 2003-11-17 SI SI200331358T patent/SI1803718T1/sl unknown
- 2003-11-17 JP JP2004570427A patent/JP4601429B2/ja not_active Expired - Fee Related
- 2003-11-17 AT AT03789796T patent/ATE358674T1/de active
- 2003-11-17 EP EP03789796A patent/EP1562932B9/en not_active Expired - Lifetime
- 2003-11-17 ME MEP-481/08A patent/MEP48108A/xx unknown
- 2003-11-17 CN CNB2003801035027A patent/CN100567288C/zh not_active Expired - Fee Related
- 2003-11-17 MX MXPA05004669A patent/MXPA05004669A/es active IP Right Grant
- 2003-11-17 PT PT03789796T patent/PT1562932E/pt unknown
- 2003-11-17 CN CN200910173679A patent/CN101648941A/zh active Pending
- 2003-11-17 SG SG200703631-2A patent/SG165998A1/en unknown
- 2003-11-17 WO PCT/US2003/036742 patent/WO2004046132A1/en not_active Ceased
- 2003-11-17 EA EA200500726A patent/EA008621B1/ru not_active IP Right Cessation
- 2003-11-17 EP EP07006697A patent/EP1803718B1/en not_active Expired - Lifetime
- 2003-11-17 GE GEAP20038846A patent/GEP20084539B/en unknown
- 2003-11-17 ES ES03789796T patent/ES2285235T3/es not_active Expired - Lifetime
- 2003-11-17 OA OA1200500145A patent/OA13010A/en unknown
- 2003-11-17 AP AP2005003297A patent/AP2210A/xx active
- 2003-11-17 KR KR1020057008903A patent/KR20050115221A/ko not_active Abandoned
- 2003-11-17 CA CA2506242A patent/CA2506242C/en not_active Expired - Fee Related
- 2003-11-17 ES ES07006697T patent/ES2312150T3/es not_active Expired - Lifetime
- 2003-11-17 BR BR0316305-9A patent/BR0316305A/pt not_active IP Right Cessation
- 2003-11-17 DK DK07006697T patent/DK1803718T3/da active
- 2003-11-17 DE DE60313021T patent/DE60313021T2/de not_active Expired - Lifetime
- 2003-11-17 AT AT07006697T patent/ATE402167T1/de active
- 2003-11-17 DK DK03789796T patent/DK1562932T3/da active
- 2003-11-17 PT PT07006697T patent/PT1803718E/pt unknown
- 2003-11-17 NZ NZ540068A patent/NZ540068A/en not_active IP Right Cessation
- 2003-11-17 SI SI200330814T patent/SI1562932T1/sl unknown
- 2003-11-17 AU AU2003294313A patent/AU2003294313B2/en not_active Ceased
- 2003-11-18 TW TW092132303A patent/TWI343917B/zh not_active IP Right Cessation
- 2003-11-18 MY MYPI20034402A patent/MY135647A/en unknown
- 2003-11-18 TW TW096151468A patent/TW200819436A/zh unknown
- 2003-11-19 AR ARP030104269A patent/AR047008A1/es unknown
-
2005
- 2005-04-19 IS IS7812A patent/IS2720B/is unknown
- 2005-04-22 NI NI200500087A patent/NI200500087A/es unknown
- 2005-05-20 CO CO05048789A patent/CO5690588A2/es not_active Application Discontinuation
- 2005-06-07 EC EC2005005840A patent/ECSP055840A/es unknown
- 2005-06-13 MA MA28335A patent/MA27565A1/fr unknown
- 2005-06-14 NO NO20052894A patent/NO20052894L/no not_active Application Discontinuation
- 2005-06-16 CR CR7877A patent/CR7877A/es unknown
-
2007
- 2007-03-28 US US11/729,660 patent/US7687518B2/en not_active Expired - Lifetime
- 2007-06-21 CY CY20071100825T patent/CY1107682T1/el unknown
-
2008
- 2008-10-16 CY CY20081101151T patent/CY1108422T1/el unknown
-
2009
- 2009-09-21 CR CR11037A patent/CR11037A/es not_active Application Discontinuation
- 2009-11-10 US US12/615,510 patent/US8026254B2/en not_active Expired - Lifetime
-
2010
- 2010-03-12 JP JP2010056560A patent/JP2010163452A/ja active Pending
- 2010-07-21 IS IS8913A patent/IS8913A/is unknown
- 2010-11-16 IL IL209352A patent/IL209352A0/en unknown
- 2010-11-25 AU AU2010246411A patent/AU2010246411A1/en not_active Abandoned
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