JP2003513071A5 - - Google Patents
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- Publication number
- JP2003513071A5 JP2003513071A5 JP2001534771A JP2001534771A JP2003513071A5 JP 2003513071 A5 JP2003513071 A5 JP 2003513071A5 JP 2001534771 A JP2001534771 A JP 2001534771A JP 2001534771 A JP2001534771 A JP 2001534771A JP 2003513071 A5 JP2003513071 A5 JP 2003513071A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- disorder
- pharmaceutical composition
- composition according
- nicotine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000008194 pharmaceutical composition Substances 0.000 description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 10
- 230000006735 deficit Effects 0.000 description 8
- 229960002715 nicotine Drugs 0.000 description 8
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 7
- 208000035475 disorder Diseases 0.000 description 7
- 229910052739 hydrogen Inorganic materials 0.000 description 7
- 239000001257 hydrogen Substances 0.000 description 7
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 6
- 208000024827 Alzheimer disease Diseases 0.000 description 6
- 150000002431 hydrogen Chemical class 0.000 description 6
- 230000002265 prevention Effects 0.000 description 5
- 208000000044 Amnesia Diseases 0.000 description 4
- 208000019901 Anxiety disease Diseases 0.000 description 4
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 description 4
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 description 4
- 208000020925 Bipolar disease Diseases 0.000 description 4
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 description 4
- 206010009900 Colitis ulcerative Diseases 0.000 description 4
- 208000023105 Huntington disease Diseases 0.000 description 4
- 208000001456 Jet Lag Syndrome Diseases 0.000 description 4
- 208000009829 Lewy Body Disease Diseases 0.000 description 4
- 201000002832 Lewy body dementia Diseases 0.000 description 4
- 206010026749 Mania Diseases 0.000 description 4
- 208000026139 Memory disease Diseases 0.000 description 4
- 206010057852 Nicotine dependence Diseases 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 208000018737 Parkinson disease Diseases 0.000 description 4
- 208000025569 Tobacco Use disease Diseases 0.000 description 4
- 208000000323 Tourette Syndrome Diseases 0.000 description 4
- 208000016620 Tourette disease Diseases 0.000 description 4
- 201000006704 Ulcerative Colitis Diseases 0.000 description 4
- 230000036506 anxiety Effects 0.000 description 4
- 230000003935 attention Effects 0.000 description 4
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 description 4
- 208000028683 bipolar I disease Diseases 0.000 description 4
- 230000001713 cholinergic effect Effects 0.000 description 4
- 230000007278 cognition impairment Effects 0.000 description 4
- 208000033915 jet lag type circadian rhythm sleep disease Diseases 0.000 description 4
- 230000006984 memory degeneration Effects 0.000 description 4
- 208000023060 memory loss Diseases 0.000 description 4
- 208000015122 neurodegenerative disease Diseases 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 201000000980 schizophrenia Diseases 0.000 description 4
- 229910052717 sulfur Inorganic materials 0.000 description 4
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 208000036626 Mental retardation Diseases 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 125000001072 heteroaryl group Chemical group 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 208000020016 psychiatric disease Diseases 0.000 description 2
- 239000000018 receptor agonist Substances 0.000 description 2
- 229940044601 receptor agonist Drugs 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000005586 smoking cessation Effects 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- 210000000225 synapse Anatomy 0.000 description 2
- 230000007470 synaptic degeneration Effects 0.000 description 2
- NNUQNQHIDUAHFO-UHFFFAOYSA-N 1-(furan-2-ylmethyl)-3-(1h-indol-5-yl)thiourea Chemical compound C=1C=C2NC=CC2=CC=1NC(=S)NCC1=CC=CO1 NNUQNQHIDUAHFO-UHFFFAOYSA-N 0.000 description 1
- QCRHULZENHWRMA-UHFFFAOYSA-N 2-(1h-indol-5-yl)-n-phenylacetamide Chemical compound C=1C=C2NC=CC2=CC=1CC(=O)NC1=CC=CC=C1 QCRHULZENHWRMA-UHFFFAOYSA-N 0.000 description 1
- ADPRFNVFBYHCJQ-UHFFFAOYSA-N 2-(5-phenylmethoxy-1h-indol-3-yl)acetonitrile Chemical compound C1=C2C(CC#N)=CNC2=CC=C1OCC1=CC=CC=C1 ADPRFNVFBYHCJQ-UHFFFAOYSA-N 0.000 description 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 description 1
- CRJAGJQFPQEDGO-UHFFFAOYSA-N 5-(2-phenoxyethoxy)-1h-indole Chemical compound C=1C=C2NC=CC2=CC=1OCCOC1=CC=CC=C1 CRJAGJQFPQEDGO-UHFFFAOYSA-N 0.000 description 1
- LSOSOBIBHAOODO-UHFFFAOYSA-N 5-(naphthalen-2-ylmethoxy)-1h-indole Chemical compound C1=CC=CC2=CC(COC=3C=C4C=CNC4=CC=3)=CC=C21 LSOSOBIBHAOODO-UHFFFAOYSA-N 0.000 description 1
- -1 5-cinnamyloxindole Chemical compound 0.000 description 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9903997-6 | 1999-11-03 | ||
| SE9903997A SE9903997D0 (sv) | 1999-11-03 | 1999-11-03 | New compounds |
| PCT/SE2000/002148 WO2001032619A1 (en) | 1999-11-03 | 2000-11-01 | Positive modulators of nicotinic receptor agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003513071A JP2003513071A (ja) | 2003-04-08 |
| JP2003513071A5 true JP2003513071A5 (https=) | 2007-11-22 |
Family
ID=20417607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001534771A Abandoned JP2003513071A (ja) | 1999-11-03 | 2000-11-01 | ニコチン受容体作用薬の正のモジュレーター |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6750242B1 (https=) |
| EP (1) | EP1230216A1 (https=) |
| JP (1) | JP2003513071A (https=) |
| KR (1) | KR20020063176A (https=) |
| CN (1) | CN1239482C (https=) |
| AU (1) | AU783507B2 (https=) |
| BR (1) | BR0015195A (https=) |
| CA (1) | CA2387745A1 (https=) |
| CO (1) | CO5251458A1 (https=) |
| IL (1) | IL149098A0 (https=) |
| MX (1) | MXPA02004232A (https=) |
| NO (1) | NO323076B1 (https=) |
| NZ (2) | NZ518450A (https=) |
| SE (1) | SE9903997D0 (https=) |
| WO (1) | WO2001032619A1 (https=) |
| ZA (1) | ZA200203171B (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9903998D0 (sv) * | 1999-11-03 | 1999-11-03 | Astra Ab | New compounds |
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| DE10234424A1 (de) * | 2002-07-29 | 2004-02-12 | Bayer Ag | Benzothiophen-, Benzofuran- und Indolharnstoffe |
| US7244745B2 (en) | 2002-08-30 | 2007-07-17 | Memory Pharmaceuticals Corp. | Heterocyclic compounds, methods for the preparation thereof, and uses thereof |
| MXPA05003317A (es) | 2002-09-25 | 2005-07-05 | Memory Pharm Corp | Indazoles, benzotiazoles y benzoisotiazoles asi como preparacion y usos de los mismos. |
| EP1735306A2 (en) | 2004-03-25 | 2006-12-27 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof |
| ZA200709038B (en) * | 2005-04-13 | 2009-01-28 | Neuraxon Inc | Substituted indole compounds having nos inhibitory activity |
| US20070134169A1 (en) * | 2005-12-11 | 2007-06-14 | Rabinoff Michael D | Methods for smoking cessation or alcohol cessation or other addiction cessation |
| CN101466709B (zh) * | 2006-04-13 | 2013-03-20 | 轴突公司 | 具有nos抑制活性的1,5和3,6-取代的吲哚化合物 |
| WO2009062318A1 (en) * | 2007-11-16 | 2009-05-22 | Neuraxon, Inc. | 3,5-substituted indole compounds having nos and norepinephrine reuptake inhibitory activity |
| EP2219449A4 (en) * | 2007-11-16 | 2010-10-27 | Univ Arizona State | METHOD FOR THE TREATMENT OF EXPOSURE TO DAMAGING |
| EA201000808A1 (ru) | 2007-11-16 | 2011-04-29 | Ньюраксон, Инк. | Индольные соединения и способы лечения висцеральной боли |
| US8383657B2 (en) | 2007-12-21 | 2013-02-26 | Abbott Laboratories | Thiazolylidine urea and amide derivatives and methods of use thereof |
| JP2011511800A (ja) * | 2008-02-07 | 2011-04-14 | アボット・ラボラトリーズ | 正のアロステリックな修飾物質としてのアミド誘導体およびこれらの使用方法 |
| TW201004939A (en) * | 2008-04-17 | 2010-02-01 | Glaxo Group Ltd | Novel compounds |
| EP2419420B1 (en) * | 2009-04-16 | 2013-03-13 | Proximagen Limited | Indole derivative modulators of the alpha 7 nachr |
| PE20170923A1 (es) * | 2010-05-17 | 2017-07-12 | Forum Pharmaceuticals Inc | Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida monohidratado |
| TW201245185A (en) | 2011-04-01 | 2012-11-16 | Lundbeck & Co As H | New positive allosteric modulators of nicotinic acetylcholine receptor |
| AR086791A1 (es) | 2011-07-01 | 2014-01-22 | Lundbeck & Co As H | Moduladores alostericos positivos del receptor de acetilcolina nicotinico |
| EP3461481A1 (en) | 2012-05-08 | 2019-04-03 | Forum Pharmaceuticals Inc. | Methods of maintaining, treating or improving cognitive function |
| WO2020045982A1 (ko) * | 2018-08-29 | 2020-03-05 | 숙명여자대학교산학협력단 | 치환된 인돌 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 PPARα, PPARγ 및 PPARδ 관련 질환의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2787551A (en) * | 1954-02-24 | 1957-04-02 | Eastman Kodak Co | Compositions stabilized with hydroxyindole |
| BE758766A (fr) * | 1969-11-17 | 1971-05-10 | Ici Ltd | Nouveaux derives de la morpholine et de la |
| US4704390A (en) * | 1986-02-13 | 1987-11-03 | Warner-Lambert Company | Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents |
| IE913204A1 (en) * | 1990-09-13 | 1992-02-25 | Beecham Group Plc | Novel compounds |
| HUT69705A (en) * | 1991-11-25 | 1995-09-28 | Pfizer | Indole derivatives |
| WO1993018026A1 (en) * | 1992-03-04 | 1993-09-16 | Beecham Group Plc | Indole ureas as 5-ht1c receptor antogonists |
| US5504101A (en) * | 1994-05-06 | 1996-04-02 | Allelix Biopharmaceuticals, Inc. | 5-HT-1D receptor ligands |
| FR2722686B1 (fr) * | 1994-07-22 | 1996-08-30 | Oreal | Set, procede, dispositif et composition de teinture des fibres keratiniques |
| US5576321A (en) * | 1995-01-17 | 1996-11-19 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
-
1999
- 1999-11-03 SE SE9903997A patent/SE9903997D0/xx unknown
-
2000
- 2000-11-01 CA CA002387745A patent/CA2387745A1/en not_active Abandoned
- 2000-11-01 JP JP2001534771A patent/JP2003513071A/ja not_active Abandoned
- 2000-11-01 BR BR0015195-5A patent/BR0015195A/pt not_active IP Right Cessation
- 2000-11-01 EP EP00976500A patent/EP1230216A1/en not_active Withdrawn
- 2000-11-01 US US10/111,027 patent/US6750242B1/en not_active Expired - Fee Related
- 2000-11-01 CN CNB008154414A patent/CN1239482C/zh not_active Expired - Fee Related
- 2000-11-01 NZ NZ518450A patent/NZ518450A/en unknown
- 2000-11-01 KR KR1020027005706A patent/KR20020063176A/ko not_active Ceased
- 2000-11-01 WO PCT/SE2000/002148 patent/WO2001032619A1/en not_active Ceased
- 2000-11-01 CO CO00083175A patent/CO5251458A1/es not_active Application Discontinuation
- 2000-11-01 IL IL14909800A patent/IL149098A0/xx unknown
- 2000-11-01 NZ NZ530161A patent/NZ530161A/en unknown
- 2000-11-01 MX MXPA02004232A patent/MXPA02004232A/es unknown
- 2000-11-01 AU AU14264/01A patent/AU783507B2/en not_active Ceased
-
2002
- 2002-04-22 ZA ZA200203171A patent/ZA200203171B/xx unknown
- 2002-04-26 NO NO20022009A patent/NO323076B1/no unknown
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