AU2002211863A1 - Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration - Google Patents
Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administrationInfo
- Publication number
- AU2002211863A1 AU2002211863A1 AU2002211863A AU1186302A AU2002211863A1 AU 2002211863 A1 AU2002211863 A1 AU 2002211863A1 AU 2002211863 A AU2002211863 A AU 2002211863A AU 1186302 A AU1186302 A AU 1186302A AU 2002211863 A1 AU2002211863 A1 AU 2002211863A1
- Authority
- AU
- Australia
- Prior art keywords
- bile
- drugs
- oral administration
- acid derived
- derived compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23875800P | 2000-10-06 | 2000-10-06 | |
US60238758 | 2000-10-06 | ||
US24980400P | 2000-11-17 | 2000-11-17 | |
US60249804 | 2000-11-17 | ||
US29759401P | 2001-06-11 | 2001-06-11 | |
US60297594 | 2001-06-11 | ||
PCT/US2001/042513 WO2002028881A1 (en) | 2000-10-06 | 2001-10-05 | Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2002211863A1 true AU2002211863A1 (en) | 2002-04-15 |
Family
ID=27399154
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002211863A Abandoned AU2002211863A1 (en) | 2000-10-06 | 2001-10-05 | Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration |
Country Status (4)
Country | Link |
---|---|
US (2) | US6992076B2 (en) |
EP (1) | EP1343805A4 (en) |
AU (1) | AU2002211863A1 (en) |
WO (1) | WO2002028881A1 (en) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6716452B1 (en) * | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
US7060708B2 (en) | 1999-03-10 | 2006-06-13 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
US7163918B2 (en) | 2000-08-22 | 2007-01-16 | New River Pharmaceuticals Inc. | Iodothyronine compositions |
US20020099013A1 (en) * | 2000-11-14 | 2002-07-25 | Thomas Piccariello | Active agent delivery systems and methods for protecting and administering active agents |
US20020098999A1 (en) * | 2000-10-06 | 2002-07-25 | Gallop Mark A. | Compounds for sustained release of orally delivered drugs |
WO2002032376A2 (en) * | 2000-10-06 | 2002-04-25 | Xenoport, Inc. | Bile-acid conjugates for providing sustained systemic concentrations of drugs |
US6992076B2 (en) * | 2000-10-06 | 2006-01-31 | Xenoport, Inc. | Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration |
WO2002044324A2 (en) * | 2000-10-06 | 2002-06-06 | Xenoport, Inc. | Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs |
US8394813B2 (en) | 2000-11-14 | 2013-03-12 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
NZ567711A (en) * | 2001-06-11 | 2009-10-30 | Xenoport Inc | Orally administered dosage forms of GABA analog prodrugs having reduced toxicity |
US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
AU2002345638A1 (en) | 2001-06-11 | 2002-12-23 | Xenoport, Inc. | Amino acid conjugates providing for sustained systemic concentrations of gaba analogues |
US20070066537A1 (en) * | 2002-02-22 | 2007-03-22 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
US20060014697A1 (en) | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
US7338939B2 (en) * | 2003-09-30 | 2008-03-04 | New River Pharmaceuticals Inc. | Abuse-resistant hydrocodone compounds |
US7169752B2 (en) * | 2003-09-30 | 2007-01-30 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
US7375082B2 (en) * | 2002-02-22 | 2008-05-20 | Shire Llc | Abuse-resistant hydrocodone compounds |
US7544681B2 (en) | 2001-09-27 | 2009-06-09 | Ramot At Tel Aviv University Ltd. | Conjugated psychotropic drugs and uses thereof |
ES2500117T3 (en) * | 2002-02-22 | 2014-09-30 | Shire Llc | Novel sustained release pharmaceutical compounds to prevent the abuse of controlled substances |
US7700561B2 (en) * | 2002-02-22 | 2010-04-20 | Shire Llc | Abuse-resistant amphetamine prodrugs |
US7105486B2 (en) * | 2002-02-22 | 2006-09-12 | New River Pharmaceuticals Inc. | Abuse-resistant amphetamine compounds |
IL163668A0 (en) * | 2002-02-22 | 2005-12-18 | New River Pharmaceuticals Inc | Use of peptide-drug conjugation to reduce inter-subject variability ofdrug serum levels |
US7659253B2 (en) * | 2002-02-22 | 2010-02-09 | Shire Llc | Abuse-resistant amphetamine prodrugs |
KR20050085563A (en) | 2002-12-13 | 2005-08-29 | 워너-램버트 캄파니 엘엘씨 | Alpha-2-delta ligand to treat lower urinary tract symptoms |
CA2451267A1 (en) | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
KR101170840B1 (en) * | 2003-05-29 | 2012-08-03 | 샤이어 엘엘씨 | Abuse resistant amphetamine compounds |
CN1832735A (en) * | 2003-07-29 | 2006-09-13 | 兰贝克赛实验室有限公司 | New dosage regimen in case of concurrent intake of gabapentin with food and an increased oral bioavailability therewith |
EP2354120A1 (en) | 2003-08-20 | 2011-08-10 | XenoPort, Inc. | Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof |
PT1660440E (en) * | 2003-08-20 | 2012-05-15 | Xenoport Inc | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
EP1670451A4 (en) | 2003-09-11 | 2009-10-21 | Xenoport Inc | Treating and/or preventing urinary incontinence using prodrugs of gaba analogs |
BRPI0414343A (en) | 2003-09-12 | 2006-11-07 | Pfizer | combinations comprising alpha-2-delta ligands and serotonin / norepinephrine reuptake inhibitors |
EP1677812A4 (en) | 2003-09-17 | 2010-03-24 | Xenoport Inc | Treating or preventing restless legs syndrome using prodrugs of gaba analogs |
EP1675555A4 (en) * | 2003-09-30 | 2011-03-09 | Shire Llc | Pharmaceutical compositions for prevention of overdose or abuse |
MXPA06004088A (en) | 2003-10-14 | 2006-06-27 | Xenoport Inc | Crystalline form of gamma-aminobutyric acid analog. |
ITMI20032165A1 (en) * | 2003-11-11 | 2005-05-12 | Zambon Spa | GABAPENTINE PREPARATION PROCESS |
US20070049626A1 (en) * | 2005-08-26 | 2007-03-01 | Tran Pierre V | Treating premature ejaculation using gabapentin and pregabalin prodrugs |
AU2007274583B2 (en) | 2006-07-17 | 2012-11-01 | Bar-Ilan University | Conjugates comprising a psychotropic drug or a GABA agonist and an organic acid and their use in treating pain and other CNS disorders |
US20080161400A1 (en) * | 2006-10-26 | 2008-07-03 | Xenoport, Inc. | Use of forms of propofol for treating diseases associated with oxidative stress |
EP2101752A1 (en) * | 2006-12-08 | 2009-09-23 | Xenoport, Inc. | Use of prodrugs of gaba analogs for treating diseases |
JP5308350B2 (en) | 2006-12-22 | 2013-10-09 | レコルダーティ アイルランド リミテッド | Combination therapy of lower urinary tract dysfunction using α2δ ligand and NSAID |
CA2674610C (en) * | 2007-01-11 | 2013-06-18 | Xenoport, Inc. | Sustained release oral dosage forms of a prodrug of r-baclofen and methods of treatment |
WO2008103319A2 (en) | 2007-02-16 | 2008-08-28 | Ark Diagnostics, Inc. | Compounds and methods for use in detecting gabapentin |
US20100137442A2 (en) * | 2008-02-01 | 2010-06-03 | Xenoport, Inc. | Sustained Release Particulate Oral Dosage Forms of (R)-Baclofen and Methods of Treatment |
WO2009101616A1 (en) | 2008-02-11 | 2009-08-20 | Ramot At Tel Aviv University Ltd. | Novel conjugates for treating neurodegenerative diseases and disorders |
SG176464A1 (en) | 2008-05-09 | 2011-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
EP2349335B1 (en) | 2008-10-24 | 2013-08-07 | ARK Diagnostics, Inc. | Levetiracetam immunoassays |
CN102341099A (en) * | 2009-03-03 | 2012-02-01 | 什诺波特有限公司 | Sustained release oral dosage forms of an R-baclofen prodrug |
GB0903818D0 (en) * | 2009-03-05 | 2009-04-22 | Seps Pharma | Carbonyl-containing tertiary alcoholic derivatives useful as medicaments |
BR112012013639A2 (en) | 2009-12-09 | 2017-04-04 | Bar-Ilan Univ | "methods to improve cognitive functions" |
WO2012038963A1 (en) | 2010-09-22 | 2012-03-29 | Ramot At Tel-Aviv University Ltd. | An acid addition salt of a nortriptyline-gaba conjugate and a process of preparing same |
CN107050456B (en) | 2010-09-28 | 2022-08-12 | 加利福尼亚大学董事会 | GABA agonists for the treatment of diseases associated with metabolic syndrome and GABA combinations for the treatment or prevention of type I diabetes |
WO2013023155A1 (en) | 2011-08-11 | 2013-02-14 | Xenoport, Inc. | Anhydrous and hemihydrate crystalline forms of an (r)-baclofen prodrug, methods of synthesis and methods of use |
US8741882B2 (en) * | 2012-01-20 | 2014-06-03 | Sen Capital, Llc. | Anti-diabetic compounds |
EP2945942B1 (en) | 2013-01-18 | 2018-05-09 | ARK Diagnostics, Inc. | Voriconazole immunoassays |
US9920136B2 (en) | 2013-02-13 | 2018-03-20 | Ark Diagnostics, Inc. | Posaconazole immunoassays |
US9580459B2 (en) * | 2013-04-26 | 2017-02-28 | Metselex, Inc. | Water-soluble ursodeoxycholic acid prodrugs |
JP2017533923A (en) | 2014-11-06 | 2017-11-16 | エナンタ ファーマシューティカルズ インコーポレイテッド | Bile acid analogs as FXR / TGR5 agonists and methods of use thereof |
US11578097B2 (en) | 2014-11-26 | 2023-02-14 | Enanta Pharmaceuticals, Inc. | Tetrazole derivatives of bile acids as FXR/TGR5 agonists and methods of use thereof |
RU2017121457A (en) | 2014-11-26 | 2018-12-26 | Энанта Фармасьютикалс, Инк. | BILIC ACID ANALOGUES AS FXR / TGR5 AGONISTS AND WAYS OF THEIR APPLICATION |
US10208081B2 (en) | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
SG10201910670RA (en) | 2015-03-31 | 2020-01-30 | Enanta Pharm Inc | Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof |
US10323060B2 (en) | 2016-02-23 | 2019-06-18 | Enanta Pharmaceuticals, Inc. | Benzoic acid derivatives of bile acid as FXR/TGR5 agonists and methods of use thereof |
CN110121347A (en) | 2016-11-29 | 2019-08-13 | 英安塔制药有限公司 | The method for preparing sulfonylureas bile acid derivative |
WO2018187804A1 (en) | 2017-04-07 | 2018-10-11 | Enanta Pharmaceuticals, Inc. | Process for preparation of sulfonyl carbamate bile acid derivatives |
JP6925080B2 (en) * | 2017-08-25 | 2021-08-25 | ▲広▼州市恒▲諾▼康医▲薬▼科技有限公司Guangzhou Henovcom Bioscience Co., Ltd | Long-acting Lasagirin prodrug, its manufacturing method and applications |
CN114539343B (en) * | 2022-03-10 | 2024-03-19 | 江苏东南纳米材料有限公司 | Preparation method of glycocholic acid |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1294961B (en) * | 1963-03-21 | 1969-08-21 | Merck Ag E | Process for the preparation of 22-azacholestane derivatives and their acid addition salts |
DE2460891C2 (en) | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-aminomethyl-1-cycloalkaneacetic acids and their esters, processes for their preparation and medicaments containing these compounds |
US4560512A (en) * | 1982-09-30 | 1985-12-24 | Merck & Co., Inc. | Derivatives of steroid compounds linked to cyotoxic agents |
US4508728A (en) | 1984-05-24 | 1985-04-02 | Kineshiro Nagai | Method of treating inflammatory diseases |
DE3689508T2 (en) | 1985-10-14 | 1994-05-11 | Nippon Zoki Pharmaceutical Co | Peptides. |
CH674369A5 (en) | 1986-11-26 | 1990-05-31 | Jago Res Ag | |
US4908353A (en) | 1987-10-16 | 1990-03-13 | Nippon Zoki Pharmaceutical Co., Ltd. | Novel dipeptide useful as a plant growth regulator |
US5094848A (en) | 1989-06-30 | 1992-03-10 | Neorx Corporation | Cleavable diphosphate and amidated diphosphate linkers |
DE3930696A1 (en) | 1989-09-14 | 1991-03-28 | Hoechst Ag | GALLENSAEUREDERIVATE, METHOD FOR THE PRODUCTION THEREOF, USE AS MEDICAMENT |
US6197819B1 (en) | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
WO1992009560A1 (en) | 1990-11-27 | 1992-06-11 | Northwestern University | Gaba and l-glutamic acid analogs for antiseizure treatment |
DK0641330T3 (en) | 1992-05-20 | 2001-12-03 | Univ Northwestern | Gaba and L-glutamic acid analogues for anticonvulsant therapy |
US5541348A (en) | 1994-03-10 | 1996-07-30 | National Research Council Of Canada | Bile acids for biological and chemical applications and processes for the production thereof |
US5684018A (en) | 1994-12-13 | 1997-11-04 | Merck & Co., Inc. | Acyloxyisopropyl carbamates as prodrugs for amine drugs |
RU2107691C1 (en) | 1995-03-02 | 1998-03-27 | Дейгин Владислав Исакович | Peptide and method for its preparation |
US6143738A (en) | 1995-06-07 | 2000-11-07 | Magainin Pharmaceuticals, Inc. | Therapeutic uses for an aminosterol compound |
ES2176668T3 (en) | 1996-02-07 | 2002-12-01 | Warner Lambert Co | NEW CYCLING AMINO ACIDS AS PHARMACEUTICAL AGENTS. |
CZ287598A3 (en) | 1996-03-14 | 1999-02-17 | Warner-Lambert Company | Bridged cyclic amino acids |
KR100512506B1 (en) | 1996-03-14 | 2005-12-21 | 워너-램버트 캄파니 엘엘씨 | Novel Substituted Cyclic Amino Acids as Pharmaceutical Agents |
AU733896B2 (en) | 1996-10-23 | 2001-05-31 | Warner-Lambert Company | Substituted gamma aminobutyric acids as pharmaceutical agents |
AU8668598A (en) | 1997-08-20 | 1999-03-08 | University Of Oklahoma, The | Gaba analogs to prevent and treat gastrointestinal damage |
US6635673B1 (en) | 1997-10-27 | 2003-10-21 | Warner-Lambert Company | Cyclic amino acids and derivatives thereof useful as pharmaceutical agents |
KR20010033154A (en) | 1997-12-16 | 2001-04-25 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | Novel Amines as Pharmaceutical Agents |
EP1047678B1 (en) | 1997-12-16 | 2004-09-08 | Warner-Lambert Company LLC | 1-substituted-1-aminomethyl-cycloalkane derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders |
TR200001800T2 (en) | 1997-12-16 | 2001-03-21 | Warner-Lambert Company | -4 (3) -Substituted -4 (3) - aminomethyl- (thio) pyran or- piperidine derivatives (= Gabapentin analogs), their preparation and use in the treatment of neurological diseases |
NZ506793A (en) | 1998-05-26 | 2003-03-28 | Warner Lambert Co | Conformationally constrained amino acid compounds and their use for treating epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain and neuropathological disorders |
AU5478799A (en) | 1998-09-14 | 2000-04-03 | Warner-Lambert Company | Branched alkyl pyrrolidine-3-carboxylic acids |
EP1121114B1 (en) | 1998-10-16 | 2007-01-10 | Warner-Lambert Company Llc | Use of gaba analogs for the manufacture of a medicament for the treatment of mania and bipolar disorders |
AU1602100A (en) | 1998-11-25 | 2000-06-13 | Warner-Lambert Company | Improved gamma amino butyric acid analogs |
EP1031350A1 (en) | 1999-02-23 | 2000-08-30 | Warner-Lambert Company | Use of a gabapentin-analog for the manufacture of a medicament for preventing and treating visceral pain |
JP2003530329A (en) * | 2000-04-07 | 2003-10-14 | ユニヴァーシティ オブ メリーランド,ボルチモア | Bile acid-containing prodrugs with increased bioavailability |
WO2002044324A2 (en) * | 2000-10-06 | 2002-06-06 | Xenoport, Inc. | Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs |
WO2002032376A2 (en) * | 2000-10-06 | 2002-04-25 | Xenoport, Inc. | Bile-acid conjugates for providing sustained systemic concentrations of drugs |
US6992076B2 (en) * | 2000-10-06 | 2006-01-31 | Xenoport, Inc. | Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration |
NZ567711A (en) * | 2001-06-11 | 2009-10-30 | Xenoport Inc | Orally administered dosage forms of GABA analog prodrugs having reduced toxicity |
US7053076B2 (en) * | 2001-08-29 | 2006-05-30 | Xenoport, Inc. | Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs |
-
2001
- 2001-10-05 US US09/972,425 patent/US6992076B2/en not_active Expired - Fee Related
- 2001-10-05 AU AU2002211863A patent/AU2002211863A1/en not_active Abandoned
- 2001-10-05 EP EP01979953A patent/EP1343805A4/en not_active Withdrawn
- 2001-10-05 WO PCT/US2001/042513 patent/WO2002028881A1/en active Application Filing
-
2005
- 2005-07-19 US US11/183,911 patent/US7601708B2/en not_active Expired - Fee Related
Also Published As
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EP1343805A4 (en) | 2005-07-20 |
US7601708B2 (en) | 2009-10-13 |
EP1343805A1 (en) | 2003-09-17 |
WO2002028881A1 (en) | 2002-04-11 |
US6992076B2 (en) | 2006-01-31 |
US20050272710A1 (en) | 2005-12-08 |
US20020151529A1 (en) | 2002-10-17 |
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