JP2003520208A5 - - Google Patents
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- Publication number
- JP2003520208A5 JP2003520208A5 JP2001543559A JP2001543559A JP2003520208A5 JP 2003520208 A5 JP2003520208 A5 JP 2003520208A5 JP 2001543559 A JP2001543559 A JP 2001543559A JP 2001543559 A JP2001543559 A JP 2001543559A JP 2003520208 A5 JP2003520208 A5 JP 2003520208A5
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- JP
- Japan
- Prior art keywords
- compound according
- spacer
- formula
- atoms
- embedded image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 9
- 125000006850 spacer group Chemical group 0.000 description 5
- 0 C*C[C@]([C@@]1O)OC(C)=C[C@@]1C=O Chemical compound C*C[C@]([C@@]1O)OC(C)=C[C@@]1C=O 0.000 description 4
- PCJFEVUKVKQSSL-UHFFFAOYSA-N 2h-1,2,4-oxadiazol-5-one Chemical group O=C1N=CNO1 PCJFEVUKVKQSSL-UHFFFAOYSA-N 0.000 description 1
- MPCRDMGAPFBKFH-UHFFFAOYSA-N CC(C(NC(Cc(cc1)ccc1C(C)=C)C(N1CCCCC1)=O)=O)NC Chemical compound CC(C(NC(Cc(cc1)ccc1C(C)=C)C(N1CCCCC1)=O)=O)NC MPCRDMGAPFBKFH-UHFFFAOYSA-N 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- PXXJHWLDUBFPOL-UHFFFAOYSA-N benzamidine Chemical group NC(=N)C1=CC=CC=C1 PXXJHWLDUBFPOL-UHFFFAOYSA-N 0.000 description 1
- 125000000837 carbohydrate group Chemical group 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99204172.3 | 1999-12-07 | ||
| EP99204172 | 1999-12-07 | ||
| PCT/EP2000/012155 WO2001042262A2 (en) | 1999-12-07 | 2000-12-01 | Antithrombotic compound |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003520208A JP2003520208A (ja) | 2003-07-02 |
| JP2003520208A5 true JP2003520208A5 (https=) | 2008-01-10 |
| JP4820517B2 JP4820517B2 (ja) | 2011-11-24 |
Family
ID=8240976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001543559A Expired - Lifetime JP4820517B2 (ja) | 1999-12-07 | 2000-12-01 | 抗血栓性化合物 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6875755B2 (https=) |
| EP (1) | EP1237897B1 (https=) |
| JP (1) | JP4820517B2 (https=) |
| KR (1) | KR100776607B1 (https=) |
| CN (1) | CN1195767C (https=) |
| AR (1) | AR026726A1 (https=) |
| AU (1) | AU781846B2 (https=) |
| BR (1) | BR0016217A (https=) |
| CA (1) | CA2393042C (https=) |
| CO (1) | CO5251449A1 (https=) |
| CZ (1) | CZ303385B6 (https=) |
| HK (1) | HK1047593A1 (https=) |
| HU (1) | HUP0203471A3 (https=) |
| IL (2) | IL149628A0 (https=) |
| NO (1) | NO323059B1 (https=) |
| NZ (1) | NZ519100A (https=) |
| PE (1) | PE20010935A1 (https=) |
| PL (1) | PL202840B1 (https=) |
| RU (1) | RU2266913C2 (https=) |
| SK (1) | SK287682B6 (https=) |
| TW (1) | TWI289566B (https=) |
| WO (1) | WO2001042262A2 (https=) |
| ZA (1) | ZA200203799B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2423888T3 (es) * | 2001-09-07 | 2013-09-25 | Alchemia Limited | Pentasacáridos de heparina sintéticos |
| US7208498B2 (en) | 2002-07-15 | 2007-04-24 | Merck & Co., Inc. | Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes |
| ATE370141T1 (de) | 2002-10-07 | 2007-09-15 | Merck & Co Inc | Antidiabetische heterocyclische beta- aminoverbindungen als inhibitoren von dipeptidylpeptidase |
| EP1562925B1 (en) | 2002-11-07 | 2007-01-03 | Merck & Co., Inc. | Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| WO2004064778A2 (en) | 2003-01-17 | 2004-08-05 | Merck & Co. Inc. | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| WO2004069162A2 (en) | 2003-01-31 | 2004-08-19 | Merck & Co., Inc. | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| WO2004103276A2 (en) | 2003-05-14 | 2004-12-02 | Merck & Co., Inc. | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| WO2004110436A1 (en) | 2003-06-06 | 2004-12-23 | Merck & Co., Inc. | Fused indoles as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| CN1809544A (zh) | 2003-06-17 | 2006-07-26 | 麦克公司 | 作为二肽基肽酶抑制剂用于治疗或预防糖尿病的环己基甘氨酸衍生物 |
| AU2004261186A1 (en) | 2003-07-31 | 2005-02-10 | Merck & Co., Inc. | Hexahydrodiazepinones as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes |
| EP1574516A1 (en) * | 2004-03-05 | 2005-09-14 | Sanofi-Aventis | Antithrombotic compound |
| TW200621794A (en) * | 2004-10-06 | 2006-07-01 | Akzo Nobel Nv | Pulmonary administration of an antithrombotic compound |
| TWI403334B (zh) * | 2004-12-23 | 2013-08-01 | Merck Sharp & Dohme | 包含生物素殘基之抗血栓雙重抑制劑 |
| TWI376234B (en) | 2005-02-01 | 2012-11-11 | Msd Oss Bv | Conjugates of a polypeptide and an oligosaccharide |
| ATE500849T1 (de) * | 2005-10-10 | 2011-03-15 | Organon Nv | Antikoagulans/antithrombose-dual-hemmer mit einem biotin-label |
| BR112012015016B8 (pt) | 2009-12-18 | 2021-05-25 | Catalent France Beinheim Sa | formulação farmacêutica, forma de dosagem farmacêutica entérica e uso de uma formulação |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4115468A1 (de) * | 1991-05-11 | 1992-11-12 | Behringwerke Ag | Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien |
| DE4206858A1 (de) * | 1992-03-05 | 1993-09-09 | Behringwerke Ag | Glycopeptid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel |
| FR2704226B1 (fr) * | 1993-04-22 | 1995-07-21 | Sanofi Elf | 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| NZ264340A (en) * | 1993-09-01 | 1995-04-27 | Akzo Nobel Nv | Bisconjugate comprising two saccharides and a spacer, use in pharmaceutical compositions |
| IL126893A (en) * | 1997-11-19 | 2003-05-29 | Akzo Nobel Nv | Sulfated pentasaccharide derivatives and pharmaceutical compositions containing them |
| US6486129B1 (en) * | 1998-06-17 | 2002-11-26 | Akzo Nobel N.V. | Antithrombotic compounds |
-
2000
- 2000-11-21 TW TW089124693A patent/TWI289566B/zh not_active IP Right Cessation
- 2000-12-01 HK HK02109170.1A patent/HK1047593A1/zh unknown
- 2000-12-01 EP EP00983209.8A patent/EP1237897B1/en not_active Expired - Lifetime
- 2000-12-01 KR KR1020027007186A patent/KR100776607B1/ko not_active Expired - Fee Related
- 2000-12-01 SK SK794-2002A patent/SK287682B6/sk not_active IP Right Cessation
- 2000-12-01 WO PCT/EP2000/012155 patent/WO2001042262A2/en not_active Ceased
- 2000-12-01 AU AU20038/01A patent/AU781846B2/en not_active Expired
- 2000-12-01 BR BR0016217-5A patent/BR0016217A/pt active Search and Examination
- 2000-12-01 CN CNB008167753A patent/CN1195767C/zh not_active Expired - Fee Related
- 2000-12-01 IL IL14962800A patent/IL149628A0/xx unknown
- 2000-12-01 HU HU0203471A patent/HUP0203471A3/hu unknown
- 2000-12-01 US US10/148,868 patent/US6875755B2/en not_active Expired - Lifetime
- 2000-12-01 PL PL355484A patent/PL202840B1/pl not_active IP Right Cessation
- 2000-12-01 NZ NZ519100A patent/NZ519100A/en not_active IP Right Cessation
- 2000-12-01 CZ CZ20021958A patent/CZ303385B6/cs not_active IP Right Cessation
- 2000-12-01 RU RU2002118117/04A patent/RU2266913C2/ru not_active IP Right Cessation
- 2000-12-01 CA CA2393042A patent/CA2393042C/en not_active Expired - Lifetime
- 2000-12-01 JP JP2001543559A patent/JP4820517B2/ja not_active Expired - Lifetime
- 2000-12-06 AR ARP000106443A patent/AR026726A1/es active IP Right Grant
- 2000-12-06 PE PE2000001308A patent/PE20010935A1/es not_active Application Discontinuation
- 2000-12-06 CO CO00093231A patent/CO5251449A1/es not_active Application Discontinuation
-
2002
- 2002-05-13 ZA ZA200203799A patent/ZA200203799B/xx unknown
- 2002-05-14 IL IL149628A patent/IL149628A/en not_active IP Right Cessation
- 2002-06-06 NO NO20022689A patent/NO323059B1/no not_active IP Right Cessation
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