JP2002517491A5 - - Google Patents
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- Publication number
- JP2002517491A5 JP2002517491A5 JP2000553419A JP2000553419A JP2002517491A5 JP 2002517491 A5 JP2002517491 A5 JP 2002517491A5 JP 2000553419 A JP2000553419 A JP 2000553419A JP 2000553419 A JP2000553419 A JP 2000553419A JP 2002517491 A5 JP2002517491 A5 JP 2002517491A5
- Authority
- JP
- Japan
- Prior art keywords
- acid group
- alkyl
- butyl
- ethyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002253 acid Substances 0.000 description 10
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 7
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 125000000539 amino acid group Chemical group 0.000 description 4
- 125000003275 alpha amino acid group Chemical group 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 208000017170 Lipid metabolism disease Diseases 0.000 description 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19825804.6 | 1998-06-10 | ||
| DE19825804A DE19825804C2 (de) | 1998-06-10 | 1998-06-10 | 1,4-Benzothiepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| PCT/EP1999/003701 WO1999064410A1 (de) | 1998-06-10 | 1999-05-28 | BENZO(b)THIEPIN-1,1-DIOXIDDERIVATE, VERFAHREN ZU DEREN HERSTELLUNG, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL UND DEREN VERWENDUNG |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002517491A JP2002517491A (ja) | 2002-06-18 |
| JP2002517491A5 true JP2002517491A5 (https=) | 2006-06-29 |
| JP4374426B2 JP4374426B2 (ja) | 2009-12-02 |
Family
ID=7870440
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000553419A Expired - Fee Related JP4374426B2 (ja) | 1998-06-10 | 1999-05-28 | ベンゾ（ｂ）チエピン−１，１−ジオキサイド誘導体、その製造方法、これらの化合物を含有する医薬およびその使用 |
| JP2000553418A Expired - Lifetime JP3374129B2 (ja) | 1998-06-10 | 1999-05-29 | ベンゾチエピン−１，１−ジオキサイド誘導体、その製造方法、これらの化合物を含有する医薬およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000553418A Expired - Lifetime JP3374129B2 (ja) | 1998-06-10 | 1999-05-29 | ベンゾチエピン−１，１−ジオキサイド誘導体、その製造方法、これらの化合物を含有する医薬およびその使用 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6387944B1 (https=) |
| EP (2) | EP1086092B1 (https=) |
| JP (2) | JP4374426B2 (https=) |
| KR (2) | KR100681721B1 (https=) |
| CN (2) | CN1127497C (https=) |
| AR (2) | AR018634A1 (https=) |
| AT (2) | ATE227715T1 (https=) |
| AU (2) | AU753275B2 (https=) |
| BR (2) | BR9912188B1 (https=) |
| CA (2) | CA2334775C (https=) |
| CZ (2) | CZ297989B6 (https=) |
| DE (3) | DE19825804C2 (https=) |
| DK (2) | DK1086092T3 (https=) |
| ES (2) | ES2182535T3 (https=) |
| HU (2) | HU229761B1 (https=) |
| ID (2) | ID28695A (https=) |
| IL (1) | IL140078A (https=) |
| NO (1) | NO327075B1 (https=) |
| NZ (1) | NZ508681A (https=) |
| PL (2) | PL196074B1 (https=) |
| PT (2) | PT1086092E (https=) |
| RU (2) | RU2215001C2 (https=) |
| TR (2) | TR200003634T2 (https=) |
| WO (2) | WO1999064410A1 (https=) |
| ZA (2) | ZA200007060B (https=) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
| US6221897B1 (en) * | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| WO2000038721A1 (en) | 1998-12-23 | 2000-07-06 | G.D. Searle Llc | Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications |
| SE0000772D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | Chemical compounds |
| EG26979A (en) | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
| DE10064402A1 (de) * | 2000-12-21 | 2002-06-27 | Aventis Pharma Gmbh | Diphenylazetidinonderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| EP1345895B1 (de) * | 2000-12-21 | 2006-12-27 | Sanofi-Aventis Deutschland GmbH | Neue diphenzylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung zur behandlung von lipidstoffwechselstörungen |
| RS11104A (sr) * | 2001-08-22 | 2006-12-15 | Sanofi Aventis Deutschland Gmbh. | Kombinovani preparati derivata 1,4-benzotiepin-1,1-dioksida sa drugim aktivnim supstancama i njihova primena |
| GB0121337D0 (en) | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
| GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| GB0121622D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| AU2002329387B2 (en) | 2001-09-08 | 2007-06-07 | Albireo Ab | Benzothiazepine and benzothiadiazepine derivatives with ileal bile acid transport (IBAT) inhibitory activity for the treatment hyperlipidaemia |
| US6852753B2 (en) | 2002-01-17 | 2005-02-08 | Pharmacia Corporation | Alkyl/aryl hydroxy or keto thiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake |
| GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| GB0213669D0 (en) | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
| SE0201937D0 (sv) | 2002-06-20 | 2002-06-20 | Astrazeneca Ab | Therapeutic agents |
| US20040138145A1 (en) * | 2002-12-12 | 2004-07-15 | Aventis Pharma S.A. | Application of intestinal biliary acid reuptake inhibitors for the prevention and treatment of alzheimer's disease |
| FR2848452B1 (fr) * | 2002-12-12 | 2007-04-06 | Aventis Pharma Sa | Application des inhibiteurs de recapture intestinale des acides biliaires pour la prevention et le traitement de la maladie d'alzheimer |
| GB0304194D0 (en) | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| DE102006053636B4 (de) * | 2006-11-14 | 2008-09-18 | Sanofi-Aventis Deutschland Gmbh | Neue mit Cyclohexylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate und deren Verwendung |
| DE102006053635B4 (de) * | 2006-11-14 | 2011-06-30 | Sanofi-Aventis Deutschland GmbH, 65929 | Neue mit Benzylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| US20100221513A1 (en) * | 2008-09-05 | 2010-09-02 | Wisconsin Alumni Research Foundation | Self sintering transparent nanoporous thin-films for use in self-cleaning, anti-fogging, anti-corrosion, anti-erosion electronic and optical applications |
| ES2552657T3 (es) | 2010-05-26 | 2015-12-01 | Satiogen Pharmaceuticals, Inc. | Inhibidores del reciclado de ácidos biliares y saciógenos para el tratamiento de diabetes, obesidad, y afecciones gastrointestinales inflamatorias |
| ES2687027T3 (es) | 2010-11-04 | 2018-10-23 | Albireo Ab | Inhibidores de ibat para el tratamiento de enfermedades hepáticas |
| DK2637646T3 (en) | 2010-11-08 | 2016-08-29 | Albireo Ab | PHARMACEUTICAL COMBINATION CONTAINING AN IBAT inhibitor and a bile acid binder |
| AU2012328526B2 (en) * | 2011-10-28 | 2017-05-25 | Shire Human Genetic Therapies, Inc. | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| US20130108573A1 (en) | 2011-10-28 | 2013-05-02 | Lumena Pharmaceuticals, Inc. | Bile Acid Recycling Inhibitors for Treatment of Hypercholemia and Cholestatic Liver Disease |
| CA2907230A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease |
| AU2014229050A1 (en) | 2013-03-15 | 2015-10-22 | Lumena Pharmaceuticals Llc | Bile acid recycling inhibitors for treatment of Barrett's esophagus and gastroesophageal reflux disease |
| JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
| CN106659726A (zh) | 2014-06-25 | 2017-05-10 | Ea制药株式会社 | 固体制剂及其着色防止或着色减少方法 |
| EP3012252A1 (en) | 2014-10-24 | 2016-04-27 | Ferring BV | Crystal modifications of elobixibat |
| WO2017138878A1 (en) | 2016-02-09 | 2017-08-17 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| CN108601739B (zh) | 2016-02-09 | 2022-01-04 | 阿尔比里奥公司 | 考来烯胺丸剂及其制备方法 |
| ES2874669T3 (es) | 2016-02-09 | 2021-11-05 | Albireo Ab | Formulación oral de colestiramina y uso de la misma |
| EP3664782B1 (en) | 2017-08-09 | 2025-01-29 | Albireo AB | Cholestyramine pellets, oral cholestyramine formulations and medical use thereof |
| CN111032019B (zh) | 2017-08-09 | 2022-07-05 | 阿尔比里奥公司 | 考来烯胺颗粒、口服考来烯胺制剂及其用途 |
| CN112449637B (zh) | 2018-06-05 | 2024-03-19 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| PL3810581T3 (pl) | 2018-06-20 | 2025-04-28 | Albireo Ab | Modyfikacje kryształu odewiksibatu |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| TWI835997B (zh) | 2019-02-06 | 2024-03-21 | 瑞典商艾爾比瑞歐公司 | 苯并噻氮呯化合物及其用作膽酸調節劑之用途 |
| CN118852054A (zh) | 2019-02-06 | 2024-10-29 | 阿尔比里奥公司 | 苯并硫杂二氮杂环庚三烯化合物及其用作胆汁酸调节剂的用途 |
| EP3923943B1 (en) | 2019-02-12 | 2024-07-31 | Mirum Pharmaceuticals, Inc. | Genotype and dose-dependent response to an asbti in patients with bile salt export pump deficiency |
| JP7696898B2 (ja) | 2019-12-04 | 2025-06-23 | アルビレオ・アクチボラグ | ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| EP4069247B1 (en) | 2019-12-04 | 2025-03-26 | Albireo AB | Benzothiadiazepine compounds and their use as bile acid modulators |
| WO2021110887A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| ES2973355T3 (es) | 2019-12-04 | 2024-06-19 | Albireo Ab | Compuestos de benzotia(di)azepina y su uso como moduladores del ácido biliar |
| TWI877263B (zh) | 2019-12-04 | 2025-03-21 | 瑞典商艾爾比瑞歐公司 | 苯并噻二氮呯化合物及其作為膽酸調節劑之用途 |
| IL293379B2 (en) | 2019-12-04 | 2026-04-01 | Albireo Ab | Benzothia(dia)azepine compounds and their use as bile acid modulators |
| WO2021110884A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| WO2021110883A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| AR120676A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como ácido biliar |
| WO2022029101A1 (en) | 2020-08-03 | 2022-02-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| EP4188541B1 (en) | 2020-08-03 | 2024-12-25 | Albireo AB | Benzothia(di)azepine compounds and their use as bile acid modulators |
| CA3196488A1 (en) | 2020-11-12 | 2022-05-19 | Albireo Ab | Odevixibat for treating progressive familial intrahepatic cholestasis (pfic) |
| BR112023010799A2 (pt) | 2020-12-04 | 2023-10-03 | Albireo Ab | Compostos de benzotia(di)azepina e seus usos como moduladores de ácidos biliares |
| TW202313579A (zh) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
| KR20250022025A (ko) | 2022-06-09 | 2025-02-14 | 알비레오 에이비 | 간염 치료 |
| CN119487013A (zh) | 2022-07-05 | 2025-02-18 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| AU2023390975A1 (en) | 2022-12-09 | 2025-06-05 | Albireo Ab | Asbt inhibitors in the treatment of renal diseases |
| WO2025146508A1 (en) | 2024-01-05 | 2025-07-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| WO2025146507A1 (en) | 2024-01-05 | 2025-07-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1084741C (zh) * | 1994-09-13 | 2002-05-15 | 孟山都公司 | 具有回肠胆汁酸转运和牛磺胆酸盐摄入抑制剂作用的新的苯并硫杂䓬 |
| US5994391A (en) * | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| HUP9903047A3 (en) * | 1996-03-11 | 2002-12-28 | G D Searle & Co Chicago | Novel benzothiazepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US6221897B1 (en) * | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| AU5301599A (en) * | 1998-08-20 | 2000-03-14 | Takeda Chemical Industries Ltd. | Quaternary ammonium salts and their use |
-
1998
- 1998-06-10 DE DE19825804A patent/DE19825804C2/de not_active Expired - Lifetime
-
1999
- 1999-05-28 AU AU45019/99A patent/AU753275B2/en not_active Ceased
- 1999-05-28 DE DE59903411T patent/DE59903411D1/de not_active Expired - Lifetime
- 1999-05-28 ES ES99927784T patent/ES2182535T3/es not_active Expired - Lifetime
- 1999-05-28 HU HU0102256 patent/HU229761B1/hu not_active IP Right Cessation
- 1999-05-28 JP JP2000553419A patent/JP4374426B2/ja not_active Expired - Fee Related
- 1999-05-28 DK DK99927784T patent/DK1086092T3/da active
- 1999-05-28 ID IDW20002562A patent/ID28695A/id unknown
- 1999-05-28 PL PL344827A patent/PL196074B1/pl unknown
- 1999-05-28 RU RU2001101491/04A patent/RU2215001C2/ru not_active IP Right Cessation
- 1999-05-28 CN CN99807171A patent/CN1127497C/zh not_active Expired - Fee Related
- 1999-05-28 CZ CZ20004592A patent/CZ297989B6/cs not_active IP Right Cessation
- 1999-05-28 AT AT99927784T patent/ATE227715T1/de active
- 1999-05-28 WO PCT/EP1999/003701 patent/WO1999064410A1/de not_active Ceased
- 1999-05-28 PT PT99927784T patent/PT1086092E/pt unknown
- 1999-05-28 KR KR1020007013964A patent/KR100681721B1/ko not_active Expired - Fee Related
- 1999-05-28 TR TR2000/03634T patent/TR200003634T2/xx unknown
- 1999-05-28 CA CA002334775A patent/CA2334775C/en not_active Expired - Fee Related
- 1999-05-28 EP EP99927784A patent/EP1086092B1/de not_active Expired - Lifetime
- 1999-05-28 BR BRPI9912188-3A patent/BR9912188B1/pt not_active IP Right Cessation
- 1999-05-28 US US09/719,047 patent/US6387944B1/en not_active Expired - Lifetime
- 1999-05-29 WO PCT/EP1999/003743 patent/WO1999064409A2/de not_active Ceased
- 1999-05-29 PL PL99345901A patent/PL196057B1/pl unknown
- 1999-05-29 ID IDW20002564A patent/ID26876A/id unknown
- 1999-05-29 ES ES99927802T patent/ES2215387T3/es not_active Expired - Lifetime
- 1999-05-29 CA CA002334773A patent/CA2334773C/en not_active Expired - Lifetime
- 1999-05-29 AU AU45031/99A patent/AU752633B2/en not_active Expired
- 1999-05-29 DK DK99927802T patent/DK1086113T3/da active
- 1999-05-29 CZ CZ20004591A patent/CZ297925B6/cs not_active IP Right Cessation
- 1999-05-29 DE DE59908522T patent/DE59908522D1/de not_active Expired - Lifetime
- 1999-05-29 NZ NZ508681A patent/NZ508681A/en not_active IP Right Cessation
- 1999-05-29 PT PT99927802T patent/PT1086113E/pt unknown
- 1999-05-29 HU HU0102554A patent/HU228570B1/hu unknown
- 1999-05-29 IL IL14007899A patent/IL140078A/en not_active IP Right Cessation
- 1999-05-29 TR TR2000/03632T patent/TR200003632T2/xx unknown
- 1999-05-29 CN CNB998071722A patent/CN1152039C/zh not_active Expired - Lifetime
- 1999-05-29 BR BRPI9911123-3A patent/BR9911123B1/pt not_active IP Right Cessation
- 1999-05-29 JP JP2000553418A patent/JP3374129B2/ja not_active Expired - Lifetime
- 1999-05-29 AT AT99927802T patent/ATE259372T1/de active
- 1999-05-29 EP EP99927802A patent/EP1086113B1/de not_active Expired - Lifetime
- 1999-05-29 RU RU2001101499/04A patent/RU2220141C2/ru active
- 1999-05-29 KR KR1020007013931A patent/KR100562184B1/ko not_active Expired - Lifetime
- 1999-06-08 AR ARP990102716A patent/AR018634A1/es active IP Right Grant
- 1999-06-08 AR ARP990102715A patent/AR018633A1/es active IP Right Grant
-
2000
- 2000-11-30 ZA ZA200007060A patent/ZA200007060B/xx unknown
- 2000-11-30 ZA ZA200007061A patent/ZA200007061B/en unknown
- 2000-12-08 NO NO20006251A patent/NO327075B1/no not_active IP Right Cessation
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