KR100681721B1 - 벤조(ｂ)티에핀-1,1-디옥사이드 유도체, 이의 제조방법, 및 이를 함유하는 약제학적 조성물 - Google Patents

벤조(ｂ)티에핀-1,1-디옥사이드 유도체, 이의 제조방법, 및 이를 함유하는 약제학적 조성물 Download PDF

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KR100681721B1
KR100681721B1 KR1020007013964A KR20007013964A KR100681721B1 KR 100681721 B1 KR100681721 B1 KR 100681721B1 KR 1020007013964 A KR1020007013964 A KR 1020007013964A KR 20007013964 A KR20007013964 A KR 20007013964A KR 100681721 B1 KR100681721 B1 KR 100681721B1
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acid
formula
compound
butyl
alanine
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Expired - Fee Related
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Korean (ko)
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KR20010052701A (ko
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프릭벤델린
엔젠알폰스
글롬빅하이너
호이어후베르트
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사노피-아벤티스 도이칠란트 게엠베하
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Publication of KR20010052701A publication Critical patent/KR20010052701A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020007013964A 1998-06-10 1999-05-28 벤조(ｂ)티에핀-1,1-디옥사이드 유도체, 이의 제조방법, 및 이를 함유하는 약제학적 조성물 Expired - Fee Related KR100681721B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19825804.6 1998-06-10
DE19825804A DE19825804C2 (de) 1998-06-10 1998-06-10 1,4-Benzothiepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel

Publications (2)

Publication Number Publication Date
KR20010052701A KR20010052701A (ko) 2001-06-25
KR100681721B1 true KR100681721B1 (ko) 2007-02-15

Family

ID=7870440

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020007013964A Expired - Fee Related KR100681721B1 (ko) 1998-06-10 1999-05-28 벤조(ｂ)티에핀-1,1-디옥사이드 유도체, 이의 제조방법, 및 이를 함유하는 약제학적 조성물
KR1020007013931A Expired - Lifetime KR100562184B1 (ko) 1998-06-10 1999-05-29 벤조티에핀-1,1-디옥사이드 유도체, 이의 제조방법 및 이를 함유하는 약제

Family Applications After (1)

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KR1020007013931A Expired - Lifetime KR100562184B1 (ko) 1998-06-10 1999-05-29 벤조티에핀-1,1-디옥사이드 유도체, 이의 제조방법 및 이를 함유하는 약제

Country Status (25)

Country Link
US (1) US6387944B1 (https=)
EP (2) EP1086092B1 (https=)
JP (2) JP4374426B2 (https=)
KR (2) KR100681721B1 (https=)
CN (2) CN1127497C (https=)
AR (2) AR018634A1 (https=)
AT (2) ATE227715T1 (https=)
AU (2) AU753275B2 (https=)
BR (2) BR9912188B1 (https=)
CA (2) CA2334775C (https=)
CZ (2) CZ297989B6 (https=)
DE (3) DE19825804C2 (https=)
DK (2) DK1086092T3 (https=)
ES (2) ES2182535T3 (https=)
HU (2) HU229761B1 (https=)
ID (2) ID28695A (https=)
IL (1) IL140078A (https=)
NO (1) NO327075B1 (https=)
NZ (1) NZ508681A (https=)
PL (2) PL196074B1 (https=)
PT (2) PT1086092E (https=)
RU (2) RU2215001C2 (https=)
TR (2) TR200003634T2 (https=)
WO (2) WO1999064410A1 (https=)
ZA (2) ZA200007060B (https=)

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Publication number Publication date
WO1999064409A2 (de) 1999-12-16
PT1086113E (pt) 2004-06-30
ZA200007060B (en) 2001-07-18
BR9912188B1 (pt) 2010-12-14
KR20010052682A (ko) 2001-06-25
DE59908522D1 (de) 2004-03-18
AU752633B2 (en) 2002-09-26
EP1086113B1 (de) 2004-02-11
AU4501999A (en) 1999-12-30
TR200003632T2 (tr) 2001-04-20
ES2182535T3 (es) 2003-03-01
HU229761B1 (hu) 2014-06-30
CZ20004591A3 (cs) 2001-04-11
PL196057B1 (pl) 2007-11-30
NZ508681A (en) 2002-06-28
ES2215387T3 (es) 2004-10-01
ATE227715T1 (de) 2002-11-15
EP1086113A2 (de) 2001-03-28
CN1152039C (zh) 2004-06-02
IL140078A (en) 2004-08-31
AU4503199A (en) 1999-12-30
JP3374129B2 (ja) 2003-02-04
TR200003634T2 (tr) 2001-06-21
CN1127497C (zh) 2003-11-12
HUP0102256A3 (en) 2002-04-29
HU228570B1 (en) 2013-04-29
BR9911123B1 (pt) 2010-12-14
ZA200007061B (en) 2001-07-18
IL140078A0 (en) 2002-02-10
AR018633A1 (es) 2001-11-28
CZ20004592A3 (cs) 2001-04-11
CZ297989B6 (cs) 2007-05-16
JP2002517491A (ja) 2002-06-18
CA2334773A1 (en) 1999-12-16
AU753275B2 (en) 2002-10-10
JP2002517490A (ja) 2002-06-18
ATE259372T1 (de) 2004-02-15
ID28695A (id) 2001-06-28
NO20006251L (no) 2001-02-07
WO1999064409A3 (de) 2000-03-02
HUP0102256A1 (hu) 2001-12-28
EP1086092A1 (de) 2001-03-28
RU2220141C2 (ru) 2003-12-27
CA2334775C (en) 2009-10-13
HK1039490A1 (en) 2002-04-26
PT1086092E (pt) 2003-03-31
DK1086092T3 (da) 2003-03-10
HK1036799A1 (en) 2002-01-18
DE19825804C2 (de) 2000-08-24
HUP0102554A3 (en) 2002-12-28
EP1086092B1 (de) 2002-11-13
DK1086113T3 (da) 2004-05-24
CN1305487A (zh) 2001-07-25
KR100562184B1 (ko) 2006-03-20
PL345901A1 (en) 2002-01-14
BR9912188A (pt) 2001-04-10
BR9911123A (pt) 2006-01-03
NO20006251D0 (no) 2000-12-08
CN1305469A (zh) 2001-07-25
CA2334775A1 (en) 1999-12-16
AR018634A1 (es) 2001-11-28
PL196074B1 (pl) 2007-12-31
NO327075B1 (no) 2009-04-20
HUP0102554A1 (hu) 2001-10-28
ID26876A (id) 2001-02-15
DE59903411D1 (de) 2002-12-19
DE19825804A1 (de) 1999-12-16
US6387944B1 (en) 2002-05-14
CA2334773C (en) 2009-05-26
PL344827A1 (en) 2001-11-19
KR20010052701A (ko) 2001-06-25
WO1999064410A1 (de) 1999-12-16
JP4374426B2 (ja) 2009-12-02
CZ297925B6 (cs) 2007-05-02
RU2215001C2 (ru) 2003-10-27

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